Identification of genetic loci shared between schizophrenia and the Big Five personality traits

Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian s...
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Autor*in:	Olav B. Smeland [verfasserIn] Yunpeng Wang [verfasserIn] Min-Tzu Lo [verfasserIn] Wen Li [verfasserIn] Oleksandr Frei [verfasserIn] Aree Witoelar [verfasserIn] Martin Tesli [verfasserIn] David A. Hinds [verfasserIn] Joyce Y. Tung [verfasserIn] Srdjan Djurovic [verfasserIn] Chi-Hua Chen [verfasserIn] Anders M. Dale [verfasserIn] Ole A. Andreassen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 7(2017), 1, Seite 9
Übergeordnetes Werk:	volume:7 ; year:2017 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-017-02346-3

Katalog-ID:	DOAJ063411237

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author	Olav B. Smeland
spellingShingle	Olav B. Smeland misc Medicine misc R misc Science misc Q Identification of genetic loci shared between schizophrenia and the Big Five personality traits
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title	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
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title_full	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
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author_browse	Olav B. Smeland Yunpeng Wang Min-Tzu Lo Wen Li Oleksandr Frei Aree Witoelar Martin Tesli David A. Hinds Joyce Y. Tung Srdjan Djurovic Chi-Hua Chen Anders M. Dale Ole A. Andreassen
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title_sort	identification of genetic loci shared between schizophrenia and the big five personality traits
title_auth	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
abstract	Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
abstractGer	Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
abstract_unstemmed	Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
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title_short	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
url	https://doi.org/10.1038/s41598-017-02346-3 https://doaj.org/article/78c98f40c1774248bc2eca70bc80f09b https://doaj.org/toc/2045-2322
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Identification of genetic loci shared between schizophrenia and the Big Five personality traits

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