Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell respon...
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Autor*in:	Giulia Escobar [verfasserIn] Luigi Barbarossa [verfasserIn] Giulia Barbiera [verfasserIn] Margherita Norelli [verfasserIn] Marco Genua [verfasserIn] Anna Ranghetti [verfasserIn] Tiziana Plati [verfasserIn] Barbara Camisa [verfasserIn] Chiara Brombin [verfasserIn] Davide Cittaro [verfasserIn] Andrea Annoni [verfasserIn] Attilio Bondanza [verfasserIn] Renato Ostuni [verfasserIn] Bernhard Gentner [verfasserIn] Luigi Naldini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 16
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-05315-0

Katalog-ID:	DOAJ06346960X

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spelling	10.1038/s41467-018-05315-0 doi (DE-627)DOAJ06346960X (DE-599)DOAJd5447487f0d9463493bef78ed95681ca DE-627 ger DE-627 rakwb eng Giulia Escobar verfasserin aut Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses. Science Q Luigi Barbarossa verfasserin aut Giulia Barbiera verfasserin aut Margherita Norelli verfasserin aut Marco Genua verfasserin aut Anna Ranghetti verfasserin aut Tiziana Plati verfasserin aut Barbara Camisa verfasserin aut Chiara Brombin verfasserin aut Davide Cittaro verfasserin aut Andrea Annoni verfasserin aut Attilio Bondanza verfasserin aut Renato Ostuni verfasserin aut Bernhard Gentner verfasserin aut Luigi Naldini verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:16 https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/article/d5447487f0d9463493bef78ed95681ca kostenfrei https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 16
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allfieldsGer	10.1038/s41467-018-05315-0 doi (DE-627)DOAJ06346960X (DE-599)DOAJd5447487f0d9463493bef78ed95681ca DE-627 ger DE-627 rakwb eng Giulia Escobar verfasserin aut Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses. Science Q Luigi Barbarossa verfasserin aut Giulia Barbiera verfasserin aut Margherita Norelli verfasserin aut Marco Genua verfasserin aut Anna Ranghetti verfasserin aut Tiziana Plati verfasserin aut Barbara Camisa verfasserin aut Chiara Brombin verfasserin aut Davide Cittaro verfasserin aut Andrea Annoni verfasserin aut Attilio Bondanza verfasserin aut Renato Ostuni verfasserin aut Bernhard Gentner verfasserin aut Luigi Naldini verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:16 https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/article/d5447487f0d9463493bef78ed95681ca kostenfrei https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 16
allfieldsSound	10.1038/s41467-018-05315-0 doi (DE-627)DOAJ06346960X (DE-599)DOAJd5447487f0d9463493bef78ed95681ca DE-627 ger DE-627 rakwb eng Giulia Escobar verfasserin aut Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses. Science Q Luigi Barbarossa verfasserin aut Giulia Barbiera verfasserin aut Margherita Norelli verfasserin aut Marco Genua verfasserin aut Anna Ranghetti verfasserin aut Tiziana Plati verfasserin aut Barbara Camisa verfasserin aut Chiara Brombin verfasserin aut Davide Cittaro verfasserin aut Andrea Annoni verfasserin aut Attilio Bondanza verfasserin aut Renato Ostuni verfasserin aut Bernhard Gentner verfasserin aut Luigi Naldini verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:16 https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/article/d5447487f0d9463493bef78ed95681ca kostenfrei https://doi.org/10.1038/s41467-018-05315-0 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 16
language	English
source	In Nature Communications 9(2018), 1, Seite 16 volume:9 year:2018 number:1 pages:16
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author	Giulia Escobar
spellingShingle	Giulia Escobar misc Science misc Q Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
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title	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
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title_full	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
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author_browse	Giulia Escobar Luigi Barbarossa Giulia Barbiera Margherita Norelli Marco Genua Anna Ranghetti Tiziana Plati Barbara Camisa Chiara Brombin Davide Cittaro Andrea Annoni Attilio Bondanza Renato Ostuni Bernhard Gentner Luigi Naldini
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title_sort	interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
title_auth	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
abstract	An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.
abstractGer	An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.
abstract_unstemmed	An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.
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title_short	Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
url	https://doi.org/10.1038/s41467-018-05315-0 https://doaj.org/article/d5447487f0d9463493bef78ed95681ca https://doaj.org/toc/2041-1723
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Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

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