Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis

Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Carla Cristina Souza Gomez [verfasserIn] Fernando Augusto Lima Marson [verfasserIn] Maria Fátima Servidoni [verfasserIn] Antônio Fernando Ribeiro [verfasserIn] Maria Ângela Gonçalves Oliveira Ribeiro [verfasserIn] Veruska Acioli Lopes Gama [verfasserIn] Eduardo Tavares Costa [verfasserIn] José Dirceu Ribeiro [verfasserIn] Francisco Ubaldo Vieira Junior [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current

Übergeordnetes Werk:	In: BMC Pulmonary Medicine - BMC, 2003, 18(2018), 1, Seite 16
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12890-018-0696-3

Katalog-ID:	DOAJ063832216

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520			\|a Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study.
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allfields	10.1186/s12890-018-0696-3 doi (DE-627)DOAJ063832216 (DE-599)DOAJ3315d37f07cf4809855d7c6697b46006 DE-627 ger DE-627 rakwb eng RC705-779 Carla Cristina Souza Gomez verfasserin aut Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system Fernando Augusto Lima Marson verfasserin aut Maria Fátima Servidoni verfasserin aut Antônio Fernando Ribeiro verfasserin aut Maria Ângela Gonçalves Oliveira Ribeiro verfasserin aut Veruska Acioli Lopes Gama verfasserin aut Eduardo Tavares Costa verfasserin aut José Dirceu Ribeiro verfasserin aut Francisco Ubaldo Vieira Junior verfasserin aut In BMC Pulmonary Medicine BMC, 2003 18(2018), 1, Seite 16 (DE-627)335489125 (DE-600)2059871-3 14712466 nnns volume:18 year:2018 number:1 pages:16 https://doi.org/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 kostenfrei http://link.springer.com/article/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/toc/1471-2466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 16
spelling	10.1186/s12890-018-0696-3 doi (DE-627)DOAJ063832216 (DE-599)DOAJ3315d37f07cf4809855d7c6697b46006 DE-627 ger DE-627 rakwb eng RC705-779 Carla Cristina Souza Gomez verfasserin aut Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system Fernando Augusto Lima Marson verfasserin aut Maria Fátima Servidoni verfasserin aut Antônio Fernando Ribeiro verfasserin aut Maria Ângela Gonçalves Oliveira Ribeiro verfasserin aut Veruska Acioli Lopes Gama verfasserin aut Eduardo Tavares Costa verfasserin aut José Dirceu Ribeiro verfasserin aut Francisco Ubaldo Vieira Junior verfasserin aut In BMC Pulmonary Medicine BMC, 2003 18(2018), 1, Seite 16 (DE-627)335489125 (DE-600)2059871-3 14712466 nnns volume:18 year:2018 number:1 pages:16 https://doi.org/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 kostenfrei http://link.springer.com/article/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/toc/1471-2466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 16
allfields_unstemmed	10.1186/s12890-018-0696-3 doi (DE-627)DOAJ063832216 (DE-599)DOAJ3315d37f07cf4809855d7c6697b46006 DE-627 ger DE-627 rakwb eng RC705-779 Carla Cristina Souza Gomez verfasserin aut Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system Fernando Augusto Lima Marson verfasserin aut Maria Fátima Servidoni verfasserin aut Antônio Fernando Ribeiro verfasserin aut Maria Ângela Gonçalves Oliveira Ribeiro verfasserin aut Veruska Acioli Lopes Gama verfasserin aut Eduardo Tavares Costa verfasserin aut José Dirceu Ribeiro verfasserin aut Francisco Ubaldo Vieira Junior verfasserin aut In BMC Pulmonary Medicine BMC, 2003 18(2018), 1, Seite 16 (DE-627)335489125 (DE-600)2059871-3 14712466 nnns volume:18 year:2018 number:1 pages:16 https://doi.org/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 kostenfrei http://link.springer.com/article/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/toc/1471-2466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 16
allfieldsGer	10.1186/s12890-018-0696-3 doi (DE-627)DOAJ063832216 (DE-599)DOAJ3315d37f07cf4809855d7c6697b46006 DE-627 ger DE-627 rakwb eng RC705-779 Carla Cristina Souza Gomez verfasserin aut Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system Fernando Augusto Lima Marson verfasserin aut Maria Fátima Servidoni verfasserin aut Antônio Fernando Ribeiro verfasserin aut Maria Ângela Gonçalves Oliveira Ribeiro verfasserin aut Veruska Acioli Lopes Gama verfasserin aut Eduardo Tavares Costa verfasserin aut José Dirceu Ribeiro verfasserin aut Francisco Ubaldo Vieira Junior verfasserin aut In BMC Pulmonary Medicine BMC, 2003 18(2018), 1, Seite 16 (DE-627)335489125 (DE-600)2059871-3 14712466 nnns volume:18 year:2018 number:1 pages:16 https://doi.org/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 kostenfrei http://link.springer.com/article/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/toc/1471-2466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 16
allfieldsSound	10.1186/s12890-018-0696-3 doi (DE-627)DOAJ063832216 (DE-599)DOAJ3315d37f07cf4809855d7c6697b46006 DE-627 ger DE-627 rakwb eng RC705-779 Carla Cristina Souza Gomez verfasserin aut Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study. Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system Fernando Augusto Lima Marson verfasserin aut Maria Fátima Servidoni verfasserin aut Antônio Fernando Ribeiro verfasserin aut Maria Ângela Gonçalves Oliveira Ribeiro verfasserin aut Veruska Acioli Lopes Gama verfasserin aut Eduardo Tavares Costa verfasserin aut José Dirceu Ribeiro verfasserin aut Francisco Ubaldo Vieira Junior verfasserin aut In BMC Pulmonary Medicine BMC, 2003 18(2018), 1, Seite 16 (DE-627)335489125 (DE-600)2059871-3 14712466 nnns volume:18 year:2018 number:1 pages:16 https://doi.org/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 kostenfrei http://link.springer.com/article/10.1186/s12890-018-0696-3 kostenfrei https://doaj.org/toc/1471-2466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 16
language	English
source	In BMC Pulmonary Medicine 18(2018), 1, Seite 16 volume:18 year:2018 number:1 pages:16
sourceStr	In BMC Pulmonary Medicine 18(2018), 1, Seite 16 volume:18 year:2018 number:1 pages:16
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current Diseases of the respiratory system
isfreeaccess_bool	true
container_title	BMC Pulmonary Medicine
authorswithroles_txt_mv	Carla Cristina Souza Gomez @@aut@@ Fernando Augusto Lima Marson @@aut@@ Maria Fátima Servidoni @@aut@@ Antônio Fernando Ribeiro @@aut@@ Maria Ângela Gonçalves Oliveira Ribeiro @@aut@@ Veruska Acioli Lopes Gama @@aut@@ Eduardo Tavares Costa @@aut@@ José Dirceu Ribeiro @@aut@@ Francisco Ubaldo Vieira Junior @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	335489125
id	DOAJ063832216
language_de	englisch
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However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. 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callnumber-first	R - Medicine
author	Carla Cristina Souza Gomez
spellingShingle	Carla Cristina Souza Gomez misc RC705-779 misc Continuous constant current misc Continuous pulsed current misc Sweat test misc Sinusoidal pulsed current misc Triangular pulsed current misc Diseases of the respiratory system Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
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topic_title	RC705-779 Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis Continuous constant current Continuous pulsed current Sweat test Sinusoidal pulsed current Triangular pulsed current
topic	misc RC705-779 misc Continuous constant current misc Continuous pulsed current misc Sweat test misc Sinusoidal pulsed current misc Triangular pulsed current misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc Continuous constant current misc Continuous pulsed current misc Sweat test misc Sinusoidal pulsed current misc Triangular pulsed current misc Diseases of the respiratory system
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title	Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
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title_full	Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
author_sort	Carla Cristina Souza Gomez
journal	BMC Pulmonary Medicine
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author_browse	Carla Cristina Souza Gomez Fernando Augusto Lima Marson Maria Fátima Servidoni Antônio Fernando Ribeiro Maria Ângela Gonçalves Oliveira Ribeiro Veruska Acioli Lopes Gama Eduardo Tavares Costa José Dirceu Ribeiro Francisco Ubaldo Vieira Junior
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author-letter	Carla Cristina Souza Gomez
doi_str_mv	10.1186/s12890-018-0696-3
author2-role	verfasserin
title_sort	evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
callnumber	RC705-779
title_auth	Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
abstract	Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study.
abstractGer	Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study.
abstract_unstemmed	Abstract Background The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective was to develop a device to induce sweat and compare the use of continuous constant current (CCC) and continuous pulsed current (CPC) in individuals with CF and healthy controls. Methods A prospective cross-sectional study with experimental intervention. The variables of gender, ethnicity, age, and body mass index (BMI) were considered. The method of Gibson and Cooke was used, and the following markers were evaluated: sweat weight, electrical impedance, sufficient sweat amount, and CF diagnosis. Triangular (TPC) or sinusoidal (SPC) pulsed current was applied to the right arm, and CCC was applied to the left arm. Results The study analyzed 260 individuals, 141/213 (54.2%) were female participants, 135/260 (51.9%) were Caucasians. The distribution of individuals by concentration of chloride at the ST was: (CF) 26/260 (10%); (borderlines) 109/260 (41.9%); (healthy) 97/260 (37.3%); (insufficient weight in sweat) 28/260 (10.8%). No association was observed between the sufficient sweat amount to perform the ST when we compared the currents. However, the SPC showed a higher amount of sweat weight. Using Bland and Altman plot considering the agreement between the sweat chloride values achieved from CPC [SPC and TPC] and CCC, there was no proportional bias and mean values are unrelated and only explain less than 8% of the variation. Moreover, TPC presented higher electrical impedance when compared with SPC and CCC. SPC presented lower electrical impedance and higher sweat weight than CCC. Male participants presented lower electrical impedance and higher sweat weight with CCC and TPC, and higher sweat weight with SPC. Conclusions The evaluated currents are safe and able to induce and produce sweat in sufficient quantities for the ST. SPC presented lower electrical impedance when compared with other currents. The use of SPC is recommended to induce sweat in patients with sweat problems. Finally, ethnicity, gender, age and BMI did not influence sweat induction at the ST, and no side effect was observed in our study.
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title_short	Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis
url	https://doi.org/10.1186/s12890-018-0696-3 https://doaj.org/article/3315d37f07cf4809855d7c6697b46006 http://link.springer.com/article/10.1186/s12890-018-0696-3 https://doaj.org/toc/1471-2466
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author2	Fernando Augusto Lima Marson Maria Fátima Servidoni Antônio Fernando Ribeiro Maria Ângela Gonçalves Oliveira Ribeiro Veruska Acioli Lopes Gama Eduardo Tavares Costa José Dirceu Ribeiro Francisco Ubaldo Vieira Junior
author2Str	Fernando Augusto Lima Marson Maria Fátima Servidoni Antônio Fernando Ribeiro Maria Ângela Gonçalves Oliveira Ribeiro Veruska Acioli Lopes Gama Eduardo Tavares Costa José Dirceu Ribeiro Francisco Ubaldo Vieira Junior
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up_date	2024-07-03T19:47:07.915Z
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Evaluation of continuous constant current and continuous pulsed current in sweat induction for cystic fibrosis diagnosis

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