The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation

<p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-met...
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Autor*in:	Musso Francesco [verfasserIn] Warbrick Tracy [verfasserIn] Steffens Michael [verfasserIn] Toliat Mohammad R [verfasserIn] Thiele Holger [verfasserIn] Brinkmeyer Juergen [verfasserIn] Mobascher Arian [verfasserIn] Wittsack Hans-Joerg [verfasserIn] Saleh Andreas [verfasserIn] Schnitzler Alfons [verfasserIn] Winterer Georg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Übergeordnetes Werk:	In: Molecular Pain - SAGE Publishing, 2005, 6(2010), 1, p 32
Übergeordnetes Werk:	volume:6 ; year:2010 ; number:1, p 32

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1744-8069-6-32

Katalog-ID:	DOAJ063844079

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allfields	10.1186/1744-8069-6-32 doi (DE-627)DOAJ063844079 (DE-599)DOAJ9c970bb32e21464f866a93f0c0952cbf DE-627 ger DE-627 rakwb eng RB1-214 Musso Francesco verfasserin aut The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p< Pathology Warbrick Tracy verfasserin aut Steffens Michael verfasserin aut Toliat Mohammad R verfasserin aut Thiele Holger verfasserin aut Brinkmeyer Juergen verfasserin aut Mobascher Arian verfasserin aut Wittsack Hans-Joerg verfasserin aut Saleh Andreas verfasserin aut Schnitzler Alfons verfasserin aut Winterer Georg verfasserin aut In Molecular Pain SAGE Publishing, 2005 6(2010), 1, p 32 (DE-627)47753368X (DE-600)2174252-2 17448069 nnns volume:6 year:2010 number:1, p 32 https://doi.org/10.1186/1744-8069-6-32 kostenfrei https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf kostenfrei http://www.molecularpain.com/content/6/1/32 kostenfrei https://doaj.org/toc/1744-8069 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1, p 32
spelling	10.1186/1744-8069-6-32 doi (DE-627)DOAJ063844079 (DE-599)DOAJ9c970bb32e21464f866a93f0c0952cbf DE-627 ger DE-627 rakwb eng RB1-214 Musso Francesco verfasserin aut The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p< Pathology Warbrick Tracy verfasserin aut Steffens Michael verfasserin aut Toliat Mohammad R verfasserin aut Thiele Holger verfasserin aut Brinkmeyer Juergen verfasserin aut Mobascher Arian verfasserin aut Wittsack Hans-Joerg verfasserin aut Saleh Andreas verfasserin aut Schnitzler Alfons verfasserin aut Winterer Georg verfasserin aut In Molecular Pain SAGE Publishing, 2005 6(2010), 1, p 32 (DE-627)47753368X (DE-600)2174252-2 17448069 nnns volume:6 year:2010 number:1, p 32 https://doi.org/10.1186/1744-8069-6-32 kostenfrei https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf kostenfrei http://www.molecularpain.com/content/6/1/32 kostenfrei https://doaj.org/toc/1744-8069 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1, p 32
allfields_unstemmed	10.1186/1744-8069-6-32 doi (DE-627)DOAJ063844079 (DE-599)DOAJ9c970bb32e21464f866a93f0c0952cbf DE-627 ger DE-627 rakwb eng RB1-214 Musso Francesco verfasserin aut The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p< Pathology Warbrick Tracy verfasserin aut Steffens Michael verfasserin aut Toliat Mohammad R verfasserin aut Thiele Holger verfasserin aut Brinkmeyer Juergen verfasserin aut Mobascher Arian verfasserin aut Wittsack Hans-Joerg verfasserin aut Saleh Andreas verfasserin aut Schnitzler Alfons verfasserin aut Winterer Georg verfasserin aut In Molecular Pain SAGE Publishing, 2005 6(2010), 1, p 32 (DE-627)47753368X (DE-600)2174252-2 17448069 nnns volume:6 year:2010 number:1, p 32 https://doi.org/10.1186/1744-8069-6-32 kostenfrei https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf kostenfrei http://www.molecularpain.com/content/6/1/32 kostenfrei https://doaj.org/toc/1744-8069 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1, p 32
allfieldsGer	10.1186/1744-8069-6-32 doi (DE-627)DOAJ063844079 (DE-599)DOAJ9c970bb32e21464f866a93f0c0952cbf DE-627 ger DE-627 rakwb eng RB1-214 Musso Francesco verfasserin aut The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p< Pathology Warbrick Tracy verfasserin aut Steffens Michael verfasserin aut Toliat Mohammad R verfasserin aut Thiele Holger verfasserin aut Brinkmeyer Juergen verfasserin aut Mobascher Arian verfasserin aut Wittsack Hans-Joerg verfasserin aut Saleh Andreas verfasserin aut Schnitzler Alfons verfasserin aut Winterer Georg verfasserin aut In Molecular Pain SAGE Publishing, 2005 6(2010), 1, p 32 (DE-627)47753368X (DE-600)2174252-2 17448069 nnns volume:6 year:2010 number:1, p 32 https://doi.org/10.1186/1744-8069-6-32 kostenfrei https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf kostenfrei http://www.molecularpain.com/content/6/1/32 kostenfrei https://doaj.org/toc/1744-8069 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1, p 32
allfieldsSound	10.1186/1744-8069-6-32 doi (DE-627)DOAJ063844079 (DE-599)DOAJ9c970bb32e21464f866a93f0c0952cbf DE-627 ger DE-627 rakwb eng RB1-214 Musso Francesco verfasserin aut The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p< Pathology Warbrick Tracy verfasserin aut Steffens Michael verfasserin aut Toliat Mohammad R verfasserin aut Thiele Holger verfasserin aut Brinkmeyer Juergen verfasserin aut Mobascher Arian verfasserin aut Wittsack Hans-Joerg verfasserin aut Saleh Andreas verfasserin aut Schnitzler Alfons verfasserin aut Winterer Georg verfasserin aut In Molecular Pain SAGE Publishing, 2005 6(2010), 1, p 32 (DE-627)47753368X (DE-600)2174252-2 17448069 nnns volume:6 year:2010 number:1, p 32 https://doi.org/10.1186/1744-8069-6-32 kostenfrei https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf kostenfrei http://www.molecularpain.com/content/6/1/32 kostenfrei https://doaj.org/toc/1744-8069 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1, p 32
language	English
source	In Molecular Pain 6(2010), 1, p 32 volume:6 year:2010 number:1, p 32
sourceStr	In Molecular Pain 6(2010), 1, p 32 volume:6 year:2010 number:1, p 32
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pathology
isfreeaccess_bool	true
container_title	Molecular Pain
authorswithroles_txt_mv	Musso Francesco @@aut@@ Warbrick Tracy @@aut@@ Steffens Michael @@aut@@ Toliat Mohammad R @@aut@@ Thiele Holger @@aut@@ Brinkmeyer Juergen @@aut@@ Mobascher Arian @@aut@@ Wittsack Hans-Joerg @@aut@@ Saleh Andreas @@aut@@ Schnitzler Alfons @@aut@@ Winterer Georg @@aut@@
publishDateDaySort_date	2010-01-01T00:00:00Z
hierarchy_top_id	47753368X
id	DOAJ063844079
language_de	englisch
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callnumber-first	R - Medicine
author	Musso Francesco
spellingShingle	Musso Francesco misc RB1-214 misc Pathology The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
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topic_title	RB1-214 The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
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title	The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
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title_full	The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
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author_browse	Musso Francesco Warbrick Tracy Steffens Michael Toliat Mohammad R Thiele Holger Brinkmeyer Juergen Mobascher Arian Wittsack Hans-Joerg Saleh Andreas Schnitzler Alfons Winterer Georg
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title_sort	val<sup<158</sup<met polymorphism of human catechol-o-methyltransferase (<it<comt</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
callnumber	RB1-214
title_auth	The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
abstract	<p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (<it<COMT</it<) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val<sup<158</sup<met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the <it<COMT </it<val<sup<158</sup<met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.</p< <p<Results</p< <p<57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele.</p< <p<Conclusion</p< <p<This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the <it<COMT </it<val<sup<158</sup<met polymorphism on cerebral pain processing.</p<
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title_short	The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation
url	https://doi.org/10.1186/1744-8069-6-32 https://doaj.org/article/9c970bb32e21464f866a93f0c0952cbf http://www.molecularpain.com/content/6/1/32 https://doaj.org/toc/1744-8069
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The val<sup<158</sup<met polymorphism of human catechol-O-methyltransferase (<it<COMT</it<) affects anterior cingulate cortex activation in response to painful laser stimulation

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