Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

<p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this stu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kovalchuka Lilija [verfasserIn] Eglite Jelena [verfasserIn] Lucenko Irina [verfasserIn] Zalite Mara [verfasserIn] Viksna Ludmila [verfasserIn] Krumiņa Angelika [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Lyme borreliosis HLA alleles PCR

Übergeordnetes Werk:	In: BMC Research Notes - BMC, 2008, 5(2012), 1, p 438
Übergeordnetes Werk:	volume:5 ; year:2012 ; number:1, p 438

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1756-0500-5-438

Katalog-ID:	DOAJ063886529

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p<
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author_variant	k l kl e j ej l i li z m zm v l vl k a ka
matchkey_str	article:17560500:2012----::soitosfldadqoeuewtlmbreis
hierarchy_sort_str	2012
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allfields	10.1186/1756-0500-5-438 doi (DE-627)DOAJ063886529 (DE-599)DOAJ7e9f71c7a59a4efbbb4bfd9048a23f89 DE-627 ger DE-627 rakwb eng QH301-705.5 Q1-390 Kovalchuka Lilija verfasserin aut Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p< Lyme borreliosis HLA alleles PCR Medicine R Biology (General) Science (General) Eglite Jelena verfasserin aut Lucenko Irina verfasserin aut Zalite Mara verfasserin aut Viksna Ludmila verfasserin aut Krumiņa Angelika verfasserin aut In BMC Research Notes BMC, 2008 5(2012), 1, p 438 (DE-627)559431805 (DE-600)2413336-X 17560500 nnns volume:5 year:2012 number:1, p 438 https://doi.org/10.1186/1756-0500-5-438 kostenfrei https://doaj.org/article/7e9f71c7a59a4efbbb4bfd9048a23f89 kostenfrei http://www.biomedcentral.com/1756-0500/5/438 kostenfrei https://doaj.org/toc/1756-0500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1, p 438
spelling	10.1186/1756-0500-5-438 doi (DE-627)DOAJ063886529 (DE-599)DOAJ7e9f71c7a59a4efbbb4bfd9048a23f89 DE-627 ger DE-627 rakwb eng QH301-705.5 Q1-390 Kovalchuka Lilija verfasserin aut Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p< Lyme borreliosis HLA alleles PCR Medicine R Biology (General) Science (General) Eglite Jelena verfasserin aut Lucenko Irina verfasserin aut Zalite Mara verfasserin aut Viksna Ludmila verfasserin aut Krumiņa Angelika verfasserin aut In BMC Research Notes BMC, 2008 5(2012), 1, p 438 (DE-627)559431805 (DE-600)2413336-X 17560500 nnns volume:5 year:2012 number:1, p 438 https://doi.org/10.1186/1756-0500-5-438 kostenfrei https://doaj.org/article/7e9f71c7a59a4efbbb4bfd9048a23f89 kostenfrei http://www.biomedcentral.com/1756-0500/5/438 kostenfrei https://doaj.org/toc/1756-0500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1, p 438
allfields_unstemmed	10.1186/1756-0500-5-438 doi (DE-627)DOAJ063886529 (DE-599)DOAJ7e9f71c7a59a4efbbb4bfd9048a23f89 DE-627 ger DE-627 rakwb eng QH301-705.5 Q1-390 Kovalchuka Lilija verfasserin aut Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p< Lyme borreliosis HLA alleles PCR Medicine R Biology (General) Science (General) Eglite Jelena verfasserin aut Lucenko Irina verfasserin aut Zalite Mara verfasserin aut Viksna Ludmila verfasserin aut Krumiņa Angelika verfasserin aut In BMC Research Notes BMC, 2008 5(2012), 1, p 438 (DE-627)559431805 (DE-600)2413336-X 17560500 nnns volume:5 year:2012 number:1, p 438 https://doi.org/10.1186/1756-0500-5-438 kostenfrei https://doaj.org/article/7e9f71c7a59a4efbbb4bfd9048a23f89 kostenfrei http://www.biomedcentral.com/1756-0500/5/438 kostenfrei https://doaj.org/toc/1756-0500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1, p 438
allfieldsGer	10.1186/1756-0500-5-438 doi (DE-627)DOAJ063886529 (DE-599)DOAJ7e9f71c7a59a4efbbb4bfd9048a23f89 DE-627 ger DE-627 rakwb eng QH301-705.5 Q1-390 Kovalchuka Lilija verfasserin aut Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p< Lyme borreliosis HLA alleles PCR Medicine R Biology (General) Science (General) Eglite Jelena verfasserin aut Lucenko Irina verfasserin aut Zalite Mara verfasserin aut Viksna Ludmila verfasserin aut Krumiņa Angelika verfasserin aut In BMC Research Notes BMC, 2008 5(2012), 1, p 438 (DE-627)559431805 (DE-600)2413336-X 17560500 nnns volume:5 year:2012 number:1, p 438 https://doi.org/10.1186/1756-0500-5-438 kostenfrei https://doaj.org/article/7e9f71c7a59a4efbbb4bfd9048a23f89 kostenfrei http://www.biomedcentral.com/1756-0500/5/438 kostenfrei https://doaj.org/toc/1756-0500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1, p 438
allfieldsSound	10.1186/1756-0500-5-438 doi (DE-627)DOAJ063886529 (DE-599)DOAJ7e9f71c7a59a4efbbb4bfd9048a23f89 DE-627 ger DE-627 rakwb eng QH301-705.5 Q1-390 Kovalchuka Lilija verfasserin aut Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p< Lyme borreliosis HLA alleles PCR Medicine R Biology (General) Science (General) Eglite Jelena verfasserin aut Lucenko Irina verfasserin aut Zalite Mara verfasserin aut Viksna Ludmila verfasserin aut Krumiņa Angelika verfasserin aut In BMC Research Notes BMC, 2008 5(2012), 1, p 438 (DE-627)559431805 (DE-600)2413336-X 17560500 nnns volume:5 year:2012 number:1, p 438 https://doi.org/10.1186/1756-0500-5-438 kostenfrei https://doaj.org/article/7e9f71c7a59a4efbbb4bfd9048a23f89 kostenfrei http://www.biomedcentral.com/1756-0500/5/438 kostenfrei https://doaj.org/toc/1756-0500 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1, p 438
language	English
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author	Kovalchuka Lilija
spellingShingle	Kovalchuka Lilija misc QH301-705.5 misc Q1-390 misc Lyme borreliosis misc HLA alleles misc PCR misc Medicine misc R misc Biology (General) misc Science (General) Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
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topic_title	QH301-705.5 Q1-390 Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients Lyme borreliosis HLA alleles PCR
topic	misc QH301-705.5 misc Q1-390 misc Lyme borreliosis misc HLA alleles misc PCR misc Medicine misc R misc Biology (General) misc Science (General)
topic_unstemmed	misc QH301-705.5 misc Q1-390 misc Lyme borreliosis misc HLA alleles misc PCR misc Medicine misc R misc Biology (General) misc Science (General)
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title	Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
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title_sort	associations of hla dr and dq molecules with lyme borreliosis in latvian patients
callnumber	QH301-705.5
title_auth	Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
abstract	<p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect.</p< <p<Conclusions</p< <p<HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB104 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population</p<
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author2Str	Eglite Jelena Lucenko Irina Zalite Mara Viksna Ludmila Krumiņa Angelika
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doi_str	10.1186/1756-0500-5-438
callnumber-a	QH301-705.5
up_date	2024-07-03T20:04:27.527Z
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This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of <it<Borrelia burgdorferi</it< infection. The study included 25 patients with clinical stage <it<– erythema migrans</it< and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers.</p< <p<Results</p< <p<The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 04 (OR 11.24; p < 0.007) and HLA-DRB1 17 (03) (OR 8.05; p < 0.033) were increased in the Lyme disease patients. And the frequency of allele DRB113 (OR 0.12; p < 0.017) was lower in Borreliosis patients and higher in control group. 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Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

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