Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis

Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible de...
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Autor*in:	Cynthia Van der Hauwaert [verfasserIn] François Glowacki [verfasserIn] Nicolas Pottier [verfasserIn] Christelle Cauffiez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	non-coding RNAs microRNAs long non-coding RNAs renal fibrosis biomarkers therapeutics targets

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 8, p 1977
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:8, p 1977

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20081977

Katalog-ID:	DOAJ063973448

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allfieldsSound	10.3390/ijms20081977 doi (DE-627)DOAJ063973448 (DE-599)DOAJ8abbaf0df97b4956a2ebf9b1b0818996 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Cynthia Van der Hauwaert verfasserin aut Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions. non-coding RNAs microRNAs long non-coding RNAs renal fibrosis biomarkers therapeutics targets Biology (General) Chemistry François Glowacki verfasserin aut Nicolas Pottier verfasserin aut Christelle Cauffiez verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1977 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1977 https://doi.org/10.3390/ijms20081977 kostenfrei https://doaj.org/article/8abbaf0df97b4956a2ebf9b1b0818996 kostenfrei https://www.mdpi.com/1422-0067/20/8/1977 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1977
language	English
source	In International Journal of Molecular Sciences 20(2019), 8, p 1977 volume:20 year:2019 number:8, p 1977
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callnumber-first	Q - Science
author	Cynthia Van der Hauwaert
spellingShingle	Cynthia Van der Hauwaert misc QH301-705.5 misc QD1-999 misc non-coding RNAs misc microRNAs misc long non-coding RNAs misc renal fibrosis misc biomarkers misc therapeutics targets misc Biology (General) misc Chemistry Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis
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topic_title	QH301-705.5 QD1-999 Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis non-coding RNAs microRNAs long non-coding RNAs renal fibrosis biomarkers therapeutics targets
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title	Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis
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title_sort	non-coding rnas as new therapeutic targets in the context of renal fibrosis
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title_auth	Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis
abstract	Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions.
abstractGer	Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions.
abstract_unstemmed	Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions.
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title_short	Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis
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Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis

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