Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability

The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. Wi...
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Autor*in:	Sandeep Kumar Dey [verfasserIn] Avijeet Kamle [verfasserIn] Ram Reddy Dereddi [verfasserIn] Shiju M. Thomas [verfasserIn] Shashi Rekha Thummala [verfasserIn] Arvind Kumar [verfasserIn] Sumana Chakravarty [verfasserIn] Rachel A. Jesudasan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Y-deleted mouse behavior anxiety neurogenesis Y chromosomal homology

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 12(2018)
Übergeordnetes Werk:	volume:12 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2018.00215

Katalog-ID:	DOAJ064227332

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allfieldsSound	10.3389/fnbeh.2018.00215 doi (DE-627)DOAJ064227332 (DE-599)DOAJ240b804384e94ea88024622715c80f38 DE-627 ger DE-627 rakwb eng RC321-571 Sandeep Kumar Dey verfasserin aut Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability of a Y-deleted mouse model, that is subfertile, we studied the effect of a partial deletion of Y-chromosomal heterochromatin on mouse behavior when compared to its wild type. The partial Y-deleted mice exhibited anxiety like phenotype under stress when different anxiety (open field test and elevated plus maze, EPM test) and depression related tests (tail suspension and force swim) were performed. The mutant mice also showed reduction in hippocampal neurogenesis and altered expression of neurogenesis markers such as Nestin, Sox2, Gfap, NeuroD1 and Dcx using quantitative real time PCR (qPCR) analysis. The genes with altered expression contained short stretches of homology to Y-derived transcripts only in their Untranslated Regions (UTRs). Our study suggests putative regulation of these genes by the Y chromosome in mouse brain altering stress related behavior. Y-deleted mouse behavior anxiety neurogenesis Y chromosomal homology Neurosciences. Biological psychiatry. Neuropsychiatry Sandeep Kumar Dey verfasserin aut Avijeet Kamle verfasserin aut Ram Reddy Dereddi verfasserin aut Shiju M. Thomas verfasserin aut Shashi Rekha Thummala verfasserin aut Arvind Kumar verfasserin aut Sumana Chakravarty verfasserin aut Rachel A. Jesudasan verfasserin aut In Frontiers in Behavioral Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)579826392 (DE-600)2452960-6 16625153 nnns volume:12 year:2018 https://doi.org/10.3389/fnbeh.2018.00215 kostenfrei https://doaj.org/article/240b804384e94ea88024622715c80f38 kostenfrei https://www.frontiersin.org/article/10.3389/fnbeh.2018.00215/full kostenfrei https://doaj.org/toc/1662-5153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
language	English
source	In Frontiers in Behavioral Neuroscience 12(2018) volume:12 year:2018
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topic_facet	Y-deleted mouse behavior anxiety neurogenesis Y chromosomal homology Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Behavioral Neuroscience
authorswithroles_txt_mv	Sandeep Kumar Dey @@aut@@ Avijeet Kamle @@aut@@ Ram Reddy Dereddi @@aut@@ Shiju M. Thomas @@aut@@ Shashi Rekha Thummala @@aut@@ Arvind Kumar @@aut@@ Sumana Chakravarty @@aut@@ Rachel A. Jesudasan @@aut@@
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callnumber-first	R - Medicine
author	Sandeep Kumar Dey
spellingShingle	Sandeep Kumar Dey misc RC321-571 misc Y-deleted mouse misc behavior misc anxiety misc neurogenesis misc Y chromosomal homology misc Neurosciences. Biological psychiatry. Neuropsychiatry Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability
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topic_title	RC321-571 Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability Y-deleted mouse behavior anxiety neurogenesis Y chromosomal homology
topic	misc RC321-571 misc Y-deleted mouse misc behavior misc anxiety misc neurogenesis misc Y chromosomal homology misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Y-deleted mouse misc behavior misc anxiety misc neurogenesis misc Y chromosomal homology misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Y-deleted mouse misc behavior misc anxiety misc neurogenesis misc Y chromosomal homology misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability
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title_full	Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability
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title_sort	mice with partial deletion of y-heterochromatin exhibits stress vulnerability
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title_auth	Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability
abstract	The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability of a Y-deleted mouse model, that is subfertile, we studied the effect of a partial deletion of Y-chromosomal heterochromatin on mouse behavior when compared to its wild type. The partial Y-deleted mice exhibited anxiety like phenotype under stress when different anxiety (open field test and elevated plus maze, EPM test) and depression related tests (tail suspension and force swim) were performed. The mutant mice also showed reduction in hippocampal neurogenesis and altered expression of neurogenesis markers such as Nestin, Sox2, Gfap, NeuroD1 and Dcx using quantitative real time PCR (qPCR) analysis. The genes with altered expression contained short stretches of homology to Y-derived transcripts only in their Untranslated Regions (UTRs). Our study suggests putative regulation of these genes by the Y chromosome in mouse brain altering stress related behavior.
abstractGer	The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability of a Y-deleted mouse model, that is subfertile, we studied the effect of a partial deletion of Y-chromosomal heterochromatin on mouse behavior when compared to its wild type. The partial Y-deleted mice exhibited anxiety like phenotype under stress when different anxiety (open field test and elevated plus maze, EPM test) and depression related tests (tail suspension and force swim) were performed. The mutant mice also showed reduction in hippocampal neurogenesis and altered expression of neurogenesis markers such as Nestin, Sox2, Gfap, NeuroD1 and Dcx using quantitative real time PCR (qPCR) analysis. The genes with altered expression contained short stretches of homology to Y-derived transcripts only in their Untranslated Regions (UTRs). Our study suggests putative regulation of these genes by the Y chromosome in mouse brain altering stress related behavior.
abstract_unstemmed	The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability of a Y-deleted mouse model, that is subfertile, we studied the effect of a partial deletion of Y-chromosomal heterochromatin on mouse behavior when compared to its wild type. The partial Y-deleted mice exhibited anxiety like phenotype under stress when different anxiety (open field test and elevated plus maze, EPM test) and depression related tests (tail suspension and force swim) were performed. The mutant mice also showed reduction in hippocampal neurogenesis and altered expression of neurogenesis markers such as Nestin, Sox2, Gfap, NeuroD1 and Dcx using quantitative real time PCR (qPCR) analysis. The genes with altered expression contained short stretches of homology to Y-derived transcripts only in their Untranslated Regions (UTRs). Our study suggests putative regulation of these genes by the Y chromosome in mouse brain altering stress related behavior.
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title_short	Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability
url	https://doi.org/10.3389/fnbeh.2018.00215 https://doaj.org/article/240b804384e94ea88024622715c80f38 https://www.frontiersin.org/article/10.3389/fnbeh.2018.00215/full https://doaj.org/toc/1662-5153
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author2	Sandeep Kumar Dey Avijeet Kamle Ram Reddy Dereddi Shiju M. Thomas Shashi Rekha Thummala Arvind Kumar Sumana Chakravarty Rachel A. Jesudasan
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up_date	2024-07-03T21:49:57.752Z
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