Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke

Neurovascular units (NVUs) are basic functional units in the central nervous system and include neurons, astrocytes and vascular compartments. Ischemic stroke triggers not only neuronal damage, but also dissonance of intercellular crosstalk within the NVU. Stroke is sexually dimorphic, but the sex-a...
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Autor*in:	Tianchi Tang [verfasserIn] Libin Hu [verfasserIn] Yang Liu [verfasserIn] Xiongjie Fu [verfasserIn] Jianru Li [verfasserIn] Feng Yan [verfasserIn] Shenglong Cao [verfasserIn] Gao Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	ischemic stroke neurovascular unit sex dimorphism gonadal hormone neuroinflammation genetic

Übergeordnetes Werk:	In: Frontiers in Molecular Neuroscience - Frontiers Media S.A., 2008, 15(2022)
Übergeordnetes Werk:	volume:15 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnmol.2022.860959

Katalog-ID:	DOAJ064283631

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520			\|a Neurovascular units (NVUs) are basic functional units in the central nervous system and include neurons, astrocytes and vascular compartments. Ischemic stroke triggers not only neuronal damage, but also dissonance of intercellular crosstalk within the NVU. Stroke is sexually dimorphic, but the sex-associated differences involved in stroke-induced neurovascular dysfunction are studied in a limited extend. Preclinical studies have found that in rodent models of stroke, females have less neuronal loss, stronger repairing potential of astrocytes and more stable vascular conjunction; these properties are highly related to the cerebroprotective effects of female hormones. However, in humans, these research findings may be applicable only to premenopausal stroke patients. Women who have had a stroke usually have poorer outcomes compared to men, and because stoke is age-related, hormone replacement therapy for postmenopausal women may exacerbate stroke symptoms, which contradicts the findings of most preclinical studies. This stark contrast between clinical and laboratory findings suggests that understanding of neurovascular differences between the sexes is limited. Actually, apart from gonadal hormones, differences in neuroinflammation as well as genetics and epigenetics promote the sexual dimorphism of NVU functions. In this review, we summarize the confirmed sex-associated differences in NVUs during ischemic stroke and the possible contributing mechanisms. We also describe the gap between clinical and preclinical studies in terms of sexual dimorphism.
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source	In Frontiers in Molecular Neuroscience 15(2022) volume:15 year:2022
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callnumber-first	R - Medicine
author	Tianchi Tang
spellingShingle	Tianchi Tang misc RC321-571 misc ischemic stroke misc neurovascular unit misc sex dimorphism misc gonadal hormone misc neuroinflammation misc genetic misc Neurosciences. Biological psychiatry. Neuropsychiatry Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke
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topic_title	RC321-571 Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke ischemic stroke neurovascular unit sex dimorphism gonadal hormone neuroinflammation genetic
topic	misc RC321-571 misc ischemic stroke misc neurovascular unit misc sex dimorphism misc gonadal hormone misc neuroinflammation misc genetic misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc ischemic stroke misc neurovascular unit misc sex dimorphism misc gonadal hormone misc neuroinflammation misc genetic misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc ischemic stroke misc neurovascular unit misc sex dimorphism misc gonadal hormone misc neuroinflammation misc genetic misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke
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title_full	Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke
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title_sort	sex-associated differences in neurovascular dysfunction during ischemic stroke
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title_auth	Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke
abstract	Neurovascular units (NVUs) are basic functional units in the central nervous system and include neurons, astrocytes and vascular compartments. Ischemic stroke triggers not only neuronal damage, but also dissonance of intercellular crosstalk within the NVU. Stroke is sexually dimorphic, but the sex-associated differences involved in stroke-induced neurovascular dysfunction are studied in a limited extend. Preclinical studies have found that in rodent models of stroke, females have less neuronal loss, stronger repairing potential of astrocytes and more stable vascular conjunction; these properties are highly related to the cerebroprotective effects of female hormones. However, in humans, these research findings may be applicable only to premenopausal stroke patients. Women who have had a stroke usually have poorer outcomes compared to men, and because stoke is age-related, hormone replacement therapy for postmenopausal women may exacerbate stroke symptoms, which contradicts the findings of most preclinical studies. This stark contrast between clinical and laboratory findings suggests that understanding of neurovascular differences between the sexes is limited. Actually, apart from gonadal hormones, differences in neuroinflammation as well as genetics and epigenetics promote the sexual dimorphism of NVU functions. In this review, we summarize the confirmed sex-associated differences in NVUs during ischemic stroke and the possible contributing mechanisms. We also describe the gap between clinical and preclinical studies in terms of sexual dimorphism.
abstractGer	Neurovascular units (NVUs) are basic functional units in the central nervous system and include neurons, astrocytes and vascular compartments. Ischemic stroke triggers not only neuronal damage, but also dissonance of intercellular crosstalk within the NVU. Stroke is sexually dimorphic, but the sex-associated differences involved in stroke-induced neurovascular dysfunction are studied in a limited extend. Preclinical studies have found that in rodent models of stroke, females have less neuronal loss, stronger repairing potential of astrocytes and more stable vascular conjunction; these properties are highly related to the cerebroprotective effects of female hormones. However, in humans, these research findings may be applicable only to premenopausal stroke patients. Women who have had a stroke usually have poorer outcomes compared to men, and because stoke is age-related, hormone replacement therapy for postmenopausal women may exacerbate stroke symptoms, which contradicts the findings of most preclinical studies. This stark contrast between clinical and laboratory findings suggests that understanding of neurovascular differences between the sexes is limited. Actually, apart from gonadal hormones, differences in neuroinflammation as well as genetics and epigenetics promote the sexual dimorphism of NVU functions. In this review, we summarize the confirmed sex-associated differences in NVUs during ischemic stroke and the possible contributing mechanisms. We also describe the gap between clinical and preclinical studies in terms of sexual dimorphism.
abstract_unstemmed	Neurovascular units (NVUs) are basic functional units in the central nervous system and include neurons, astrocytes and vascular compartments. Ischemic stroke triggers not only neuronal damage, but also dissonance of intercellular crosstalk within the NVU. Stroke is sexually dimorphic, but the sex-associated differences involved in stroke-induced neurovascular dysfunction are studied in a limited extend. Preclinical studies have found that in rodent models of stroke, females have less neuronal loss, stronger repairing potential of astrocytes and more stable vascular conjunction; these properties are highly related to the cerebroprotective effects of female hormones. However, in humans, these research findings may be applicable only to premenopausal stroke patients. Women who have had a stroke usually have poorer outcomes compared to men, and because stoke is age-related, hormone replacement therapy for postmenopausal women may exacerbate stroke symptoms, which contradicts the findings of most preclinical studies. This stark contrast between clinical and laboratory findings suggests that understanding of neurovascular differences between the sexes is limited. Actually, apart from gonadal hormones, differences in neuroinflammation as well as genetics and epigenetics promote the sexual dimorphism of NVU functions. In this review, we summarize the confirmed sex-associated differences in NVUs during ischemic stroke and the possible contributing mechanisms. We also describe the gap between clinical and preclinical studies in terms of sexual dimorphism.
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title_short	Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke
url	https://doi.org/10.3389/fnmol.2022.860959 https://doaj.org/article/e58fa21d24f2451e82ec930c50eb1ba0 https://www.frontiersin.org/articles/10.3389/fnmol.2022.860959/full https://doaj.org/toc/1662-5099
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up_date	2024-07-03T22:07:13.755Z
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Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke

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