The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients
PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis...
Ausführliche Beschreibung
Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Frontiers in Oncology - Frontiers Media S.A., 2012, 12(2022) |
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Übergeordnetes Werk: |
volume:12 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fonc.2022.835626 |
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Katalog-ID: |
DOAJ064322157 |
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100 | 0 | |a Andrea Sabina Llera |e verfasserin |4 aut | |
245 | 1 | 4 | |a The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients |
264 | 1 | |c 2022 | |
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520 | |a PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). | ||
650 | 4 | |a breast cancer | |
650 | 4 | |a Latin America | |
650 | 4 | |a PAM50 subtypes | |
650 | 4 | |a risk of recurrence | |
650 | 4 | |a biological pathways | |
653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
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10.3389/fonc.2022.835626 doi (DE-627)DOAJ064322157 (DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e DE-627 ger DE-627 rakwb eng RC254-282 Andrea Sabina Llera verfasserin aut The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eliana Saul Furquim Werneck Abdelhay verfasserin aut Nora Artagaveytia verfasserin aut Adrián Daneri-Navarro verfasserin aut Bettina Müller verfasserin aut Carlos Velazquez verfasserin aut Elsa B. Alcoba verfasserin aut Isabel Alonso verfasserin aut Daniela B. Alves da Quinta verfasserin aut Daniela B. Alves da Quinta verfasserin aut Renata Binato verfasserin aut Alicia Inés Bravo verfasserin aut Natalia Camejo verfasserin aut Dirce Maria Carraro verfasserin aut Mónica Castro verfasserin aut Juan M. Castro-Cervantes verfasserin aut Sandra Cataldi verfasserin aut Alfonso Cayota verfasserin aut Mauricio Cerda verfasserin aut Alicia Colombo verfasserin aut Susanne Crocamo verfasserin aut Alicia Del Toro-Arreola verfasserin aut Raúl Delgadillo-Cisterna verfasserin aut Lucía Delgado verfasserin aut Marisa Dreyer-Breitenbach verfasserin aut Laura Fejerman verfasserin aut Elmer A. Fernández verfasserin aut Elmer A. Fernández verfasserin aut Jorge Fernández verfasserin aut Wanda Fernández verfasserin aut Ramón A. Franco-Topete verfasserin aut Carolina Gabay verfasserin aut Fancy Gaete verfasserin aut Adriana Garibay-Escobar verfasserin aut Jorge Gómez verfasserin aut Gonzalo Greif verfasserin aut Thomas G. Gross verfasserin aut Marisol Guerrero verfasserin aut Marianne K. Henderson verfasserin aut Miguel E. Lopez-Muñoz verfasserin aut Alejandra Lopez-Vazquez verfasserin aut Silvina Maldonado verfasserin aut Andrés J. Morán-Mendoza verfasserin aut Maria Aparecida Nagai verfasserin aut Antonio Oceguera-Villanueva verfasserin aut Miguel A. Ortiz-Martínez verfasserin aut Jael Quintero verfasserin aut Antonio Quintero-Ramos verfasserin aut Rui M. Reis verfasserin aut Javier Retamales verfasserin aut Ernesto Rivera-Claisse verfasserin aut Darío Rocha verfasserin aut Robinson Rodríguez verfasserin aut Cristina Rosales verfasserin aut Efrain Salas-González verfasserin aut Verónica Sanchotena verfasserin aut Laura Segovia verfasserin aut Juan Martín Sendoya verfasserin aut Aida A. Silva-García verfasserin aut Alejandra Trinchero verfasserin aut Olivia Valenzuela verfasserin aut Vidya Vedham verfasserin aut Livia Zagame verfasserin aut United States-Latin American Cancer Research Network (US-LACRN) verfasserin aut Osvaldo L. Podhajcer verfasserin aut Juan Abarca verfasserin aut Pamela Acevedo verfasserin aut Graciela Acosta verfasserin aut Gissel Acosta verfasserin aut Gabriela Acosta Haab verfasserin aut Ana Lilian Acosta Silva verfasserin aut Marta Aghazarian verfasserin aut Carola Aguayo verfasserin aut Bernardo Aizen verfasserin aut Gustavo Alarcon Lopez verfasserin aut Liz Almeida verfasserin aut Ana Alvarez verfasserin aut Viviane Andrade verfasserin aut Wenceslao Angeles-Bueno verfasserin aut Roberto Arai verfasserin aut Priscila Elvira Arambula Barreras verfasserin aut Ma. Isabel Aramburo Rubio verfasserin aut Gonzalo Ardao verfasserin aut Lilia A. Arellano-Jimenez verfasserin aut Claudia Arias verfasserin aut Ricardo Armisen verfasserin aut Mauricio Aspee verfasserin aut Rodrigo Assar verfasserin aut Itzel Reneé Astiazarán Rascón verfasserin aut Sebastian Astorga verfasserin aut Maxwell Aviles Rodriguez verfasserin aut Antônio Bailão Junior verfasserin aut Adolfo E. Barragan-Curiel verfasserin aut Adelfo Barragan-Ruiz verfasserin aut Fernanda Bermudez verfasserin aut Julia Bernachin verfasserin aut Wilfrido Bernal Herrera verfasserin aut Mara Bonet verfasserin aut Sarah Brnich verfasserin aut Claudio Bustamante verfasserin aut Miguel Angel Bustamante verfasserin aut Julio Bustos-Gomez verfasserin aut Felipe de J Bustos-Rodriguez verfasserin aut Janett Caballero Jasso verfasserin aut Angie Calfuman verfasserin aut Antonio Hugo José Froes Marques verfasserin aut Mónica Campos verfasserin aut Soledad Cano verfasserin aut Juan C. 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Filassi verfasserin aut Natalia Filgueiras verfasserin aut Diego Flaks verfasserin aut Edgar G. Flores-Ayala verfasserin aut Maria R. Flores-Marquez verfasserin aut David Franco Hughes verfasserin aut Karina Franco-Topete verfasserin aut Jimena Freire verfasserin aut Cristobal Fresno verfasserin aut Romina Gabrielli verfasserin aut Mario Gallegos verfasserin aut Jorge Gamboa verfasserin aut Daiana Ganiewich verfasserin aut Carlos Garbovesky verfasserin aut Ruben Alejandro Garcia Munguia verfasserin aut Ricardo Garcia-Gaeta verfasserin aut Alma C. Garcia-Martinez verfasserin aut Liliana Gimenez verfasserin aut Hector Gómez Silveira verfasserin aut Mariana M. Gomez-Del Toro verfasserin aut Marcela Gonzalez verfasserin aut Alicia Gonzalez verfasserin aut Germán González verfasserin aut Cesar Osbaldo Gonzalez Mondaca verfasserin aut Leivy P. Gonzalez-Ramirez verfasserin aut Beatriz Gonzalez-Ulloa verfasserin aut Susana Gorostidy verfasserin aut Mariela Grass verfasserin aut Alfonso G. 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Martinez-Arriaga verfasserin aut Hector R. Martinez-Ramirez verfasserin aut Marcela Martins verfasserin aut Alma G. Maya-Gonzalez verfasserin aut Brenda Mazzaferri verfasserin aut Yadira Medina-Mora verfasserin aut Mariana Menini verfasserin aut Silvia Míguez verfasserin aut Soledad Milans verfasserin aut Soledad Montes verfasserin aut Ana Verónica Morales Hernández verfasserin aut Giberto Morga-Villela verfasserin aut Carla Morong verfasserin aut Homero Muñoz verfasserin aut Ignacio Miguel Muse verfasserin aut Carina Mussetti verfasserin aut Eduardo Mussetti verfasserin aut Luis J. Najar-Acosta verfasserin aut Elisa Napolitano e Ferreira verfasserin aut Nancy E. Navarro-Ruiz verfasserin aut Cristina Noblía verfasserin aut João Soares Nunes verfasserin aut Daniela Núñez verfasserin aut Fabiola Núñez verfasserin aut Nilton Onari verfasserin aut Emma M. Oropeza-De Anda verfasserin aut David Ortega Tirado verfasserin aut Cynthia Aparecida Bueno de Toledo Osório verfasserin aut Carlos Eduardo Paiva verfasserin aut Paulina Peñaloza verfasserin aut Miguel Peredo-Navarro verfasserin aut David Pereira verfasserin aut Laura Perez Michel verfasserin aut Francisca Pino verfasserin aut Tania Pino verfasserin aut Natalia Pinto verfasserin aut Jessica Pizarro verfasserin aut Carlos Pressa verfasserin aut Enrique Ramirez verfasserin aut Gladys E. Ramirez-Rosales verfasserin aut Claudia Ramis verfasserin aut Maritza Ramos-Ramirez verfasserin aut Adela Rascon Alcantar verfasserin aut Silvana Ravaglio verfasserin aut Francois Richard verfasserin aut Omar Rios Méndez verfasserin aut Ramón Enrique Robles Zepeda verfasserin aut Iara Santana Rocha verfasserin aut Natalia Rodriguez verfasserin aut Vilma Rodriguez verfasserin aut Maria Teresa Rodriguez verfasserin aut Diego Rodriguez-Gonzalez verfasserin aut Rosemeire A Roela verfasserin aut Ana M Romero-Gomez verfasserin aut Ana M Rosales-Sandoval verfasserin aut Omar V Rubio-Plascencia verfasserin aut Florencia Russo verfasserin aut Gaciela Sabini verfasserin aut Isabel Saffie verfasserin aut Helena Salina Dias verfasserin aut Brenda Guadalupe Samaniego Soto verfasserin aut Julio San Martino verfasserin aut Benito Sanchez-Llamas verfasserin aut Daniel Sat-Muñoz verfasserin aut Mariana Savignano verfasserin aut Cristovam Scapulatempo Neto verfasserin aut Max Mano Senna verfasserin aut Carolina Silva verfasserin aut Jaime Silvera verfasserin aut Isabele Small verfasserin aut Fernando Soares verfasserin aut Iberê Soares verfasserin aut Silvana Soares dos Santos verfasserin aut Evandro Sobrosa de Mello verfasserin aut José Antonio Sola verfasserin aut Irene Sorín verfasserin aut Alejandra Sosa verfasserin aut Anabella Sosa verfasserin aut Claudio Sosa verfasserin aut Sandra Soto verfasserin aut Cristiano de Pádua Souza verfasserin aut Lucía Spangenberg verfasserin aut Gustavo Steffanof verfasserin aut Florencia Straminsky verfasserin aut Mónica Tapia verfasserin aut Raziel O. Tapia-Llanos verfasserin aut Geronimo M. Tavares-Macias verfasserin aut Guillermo Temperley verfasserin aut Veronica Terzieff verfasserin aut Vicente Teti verfasserin aut Javier Tognarelli verfasserin aut Verónica Toledo verfasserin aut Paulina Toro verfasserin aut Roberto Torres verfasserin aut Mariana Torres-Palomares verfasserin aut Rogelio Troyo-San Roman verfasserin aut Hernan Urbano verfasserin aut Nicolas Vacca verfasserin aut Daniel Vaimberg verfasserin aut María Lourdes Valencia Peña verfasserin aut Maria Lujan Vaselevich verfasserin aut Jaime Vazquez-Nares verfasserin aut Ezequiel Velez-Gomez verfasserin aut Laura N. Venegas-Godinez verfasserin aut Patricia Vercelli verfasserin aut Ricardo Verdugo verfasserin aut René Aloisio da Costa Vieira verfasserin aut Marta Vilensky verfasserin aut María José Villarubias verfasserin aut Manuel Isaac Villegas Gómez verfasserin aut Stella Viña verfasserin aut Silvia Vornetti verfasserin aut Anapaula Hidemi Uema Watanabe verfasserin aut Carlos Zamorano verfasserin aut Luis Zapata verfasserin aut Zdenka Zlatar verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.835626 kostenfrei https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
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10.3389/fonc.2022.835626 doi (DE-627)DOAJ064322157 (DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e DE-627 ger DE-627 rakwb eng RC254-282 Andrea Sabina Llera verfasserin aut The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eliana Saul Furquim Werneck Abdelhay verfasserin aut Nora Artagaveytia verfasserin aut Adrián Daneri-Navarro verfasserin aut Bettina Müller verfasserin aut Carlos Velazquez verfasserin aut Elsa B. Alcoba verfasserin aut Isabel Alonso verfasserin aut Daniela B. Alves da Quinta verfasserin aut Daniela B. Alves da Quinta verfasserin aut Renata Binato verfasserin aut Alicia Inés Bravo verfasserin aut Natalia Camejo verfasserin aut Dirce Maria Carraro verfasserin aut Mónica Castro verfasserin aut Juan M. Castro-Cervantes verfasserin aut Sandra Cataldi verfasserin aut Alfonso Cayota verfasserin aut Mauricio Cerda verfasserin aut Alicia Colombo verfasserin aut Susanne Crocamo verfasserin aut Alicia Del Toro-Arreola verfasserin aut Raúl Delgadillo-Cisterna verfasserin aut Lucía Delgado verfasserin aut Marisa Dreyer-Breitenbach verfasserin aut Laura Fejerman verfasserin aut Elmer A. Fernández verfasserin aut Elmer A. Fernández verfasserin aut Jorge Fernández verfasserin aut Wanda Fernández verfasserin aut Ramón A. Franco-Topete verfasserin aut Carolina Gabay verfasserin aut Fancy Gaete verfasserin aut Adriana Garibay-Escobar verfasserin aut Jorge Gómez verfasserin aut Gonzalo Greif verfasserin aut Thomas G. Gross verfasserin aut Marisol Guerrero verfasserin aut Marianne K. Henderson verfasserin aut Miguel E. Lopez-Muñoz verfasserin aut Alejandra Lopez-Vazquez verfasserin aut Silvina Maldonado verfasserin aut Andrés J. Morán-Mendoza verfasserin aut Maria Aparecida Nagai verfasserin aut Antonio Oceguera-Villanueva verfasserin aut Miguel A. Ortiz-Martínez verfasserin aut Jael Quintero verfasserin aut Antonio Quintero-Ramos verfasserin aut Rui M. Reis verfasserin aut Javier Retamales verfasserin aut Ernesto Rivera-Claisse verfasserin aut Darío Rocha verfasserin aut Robinson Rodríguez verfasserin aut Cristina Rosales verfasserin aut Efrain Salas-González verfasserin aut Verónica Sanchotena verfasserin aut Laura Segovia verfasserin aut Juan Martín Sendoya verfasserin aut Aida A. Silva-García verfasserin aut Alejandra Trinchero verfasserin aut Olivia Valenzuela verfasserin aut Vidya Vedham verfasserin aut Livia Zagame verfasserin aut United States-Latin American Cancer Research Network (US-LACRN) verfasserin aut Osvaldo L. Podhajcer verfasserin aut Juan Abarca verfasserin aut Pamela Acevedo verfasserin aut Graciela Acosta verfasserin aut Gissel Acosta verfasserin aut Gabriela Acosta Haab verfasserin aut Ana Lilian Acosta Silva verfasserin aut Marta Aghazarian verfasserin aut Carola Aguayo verfasserin aut Bernardo Aizen verfasserin aut Gustavo Alarcon Lopez verfasserin aut Liz Almeida verfasserin aut Ana Alvarez verfasserin aut Viviane Andrade verfasserin aut Wenceslao Angeles-Bueno verfasserin aut Roberto Arai verfasserin aut Priscila Elvira Arambula Barreras verfasserin aut Ma. Isabel Aramburo Rubio verfasserin aut Gonzalo Ardao verfasserin aut Lilia A. Arellano-Jimenez verfasserin aut Claudia Arias verfasserin aut Ricardo Armisen verfasserin aut Mauricio Aspee verfasserin aut Rodrigo Assar verfasserin aut Itzel Reneé Astiazarán Rascón verfasserin aut Sebastian Astorga verfasserin aut Maxwell Aviles Rodriguez verfasserin aut Antônio Bailão Junior verfasserin aut Adolfo E. Barragan-Curiel verfasserin aut Adelfo Barragan-Ruiz verfasserin aut Fernanda Bermudez verfasserin aut Julia Bernachin verfasserin aut Wilfrido Bernal Herrera verfasserin aut Mara Bonet verfasserin aut Sarah Brnich verfasserin aut Claudio Bustamante verfasserin aut Miguel Angel Bustamante verfasserin aut Julio Bustos-Gomez verfasserin aut Felipe de J Bustos-Rodriguez verfasserin aut Janett Caballero Jasso verfasserin aut Angie Calfuman verfasserin aut Antonio Hugo José Froes Marques verfasserin aut Mónica Campos verfasserin aut Soledad Cano verfasserin aut Juan C. Canton-Romero verfasserin aut Ricardo Cappetta verfasserin aut Paulina Carmona verfasserin aut Fernando Carrizo verfasserin aut André Lopes Carvalho verfasserin aut Erika Carvallo verfasserin aut Julio Carzoglio verfasserin aut Monica Casalnuovo verfasserin aut Benedicta Caserta verfasserin aut Alvaro Castillo verfasserin aut César Castillo verfasserin aut Roger Chammas verfasserin aut Mario Alberto Chavez Zamudio verfasserin aut Loreto Chia verfasserin aut Elisa Chiarello verfasserin aut Daniela Chirico verfasserin aut Esther Cisneros-Quirarter verfasserin aut Minor Raul Cordero Bautista verfasserin aut Valeria Cornejo verfasserin aut Baldemar Corral Villegas verfasserin aut Andrés Cortés verfasserin aut Sandra Cortés verfasserin aut Laura Cortes-Sanabria verfasserin aut German Salvador Cortez Zamorano verfasserin aut Alejandro Corvalan verfasserin aut Adolfo Cruz verfasserin aut Alba d'Aurora verfasserin aut Sandra De la Fuente verfasserin aut Soledad De la Peña verfasserin aut Roberto de Leon Caballero verfasserin aut Mirian de Souza verfasserin aut César Del Castillo verfasserin aut Azucena Del-Toro-Valero verfasserin aut Mirtha Di Pretoro verfasserin aut Andrea Digonzelli verfasserin aut Jose El Ters verfasserin aut Paula Escobar verfasserin aut Marcela Estolaza verfasserin aut Adriane Feijo Evangelista verfasserin aut Marcelo Fanelli verfasserin aut Paulo Farias verfasserin aut Graciela Fernandez verfasserin aut José R. Filassi verfasserin aut Natalia Filgueiras verfasserin aut Diego Flaks verfasserin aut Edgar G. Flores-Ayala verfasserin aut Maria R. Flores-Marquez verfasserin aut David Franco Hughes verfasserin aut Karina Franco-Topete verfasserin aut Jimena Freire verfasserin aut Cristobal Fresno verfasserin aut Romina Gabrielli verfasserin aut Mario Gallegos verfasserin aut Jorge Gamboa verfasserin aut Daiana Ganiewich verfasserin aut Carlos Garbovesky verfasserin aut Ruben Alejandro Garcia Munguia verfasserin aut Ricardo Garcia-Gaeta verfasserin aut Alma C. Garcia-Martinez verfasserin aut Liliana Gimenez verfasserin aut Hector Gómez Silveira verfasserin aut Mariana M. Gomez-Del Toro verfasserin aut Marcela Gonzalez verfasserin aut Alicia Gonzalez verfasserin aut Germán González verfasserin aut Cesar Osbaldo Gonzalez Mondaca verfasserin aut Leivy P. Gonzalez-Ramirez verfasserin aut Beatriz Gonzalez-Ulloa verfasserin aut Susana Gorostidy verfasserin aut Mariela Grass verfasserin aut Alfonso G. Guevara Torres verfasserin aut Lorena Gutierrez verfasserin aut Susan A. Gutierrez-Rubio verfasserin aut Adrián Hannois verfasserin aut Andrew Hart verfasserin aut Steffen Härtel verfasserin aut Marcos Henriquez verfasserin aut Rafael Hernandez Guevara verfasserin aut Miriam E. Hernandez-Franco verfasserin aut Manuel I. Herrera-Miramontes verfasserin aut Graciela Horton verfasserin aut Gladys Ibañez verfasserin aut Martín Ipiña verfasserin aut Beatriz Jalfin verfasserin aut Lilian Jara verfasserin aut Raul Jara verfasserin aut Maria Luisa Jaramillo verfasserin aut David Javalera-Castro verfasserin aut Maria Eugenia Jimenez verfasserin aut Hugo Ju verfasserin aut Nazareth Juárez Rusjan verfasserin aut Karen Juneman verfasserin aut Ligia Maria Kerr verfasserin aut Alejandra Krupelis verfasserin aut Flor Esmeralda Larios-Jimenez verfasserin aut Jose Domingo Latorre verfasserin aut Guillermo Laviña verfasserin aut Fernando Lavista verfasserin aut Irma Leticia León Duarte verfasserin aut Alberto Lescano verfasserin aut Verónica Lezano verfasserin aut Rossana Mendoza Lopez verfasserin aut Jose Guillermo Lopez Cervantes verfasserin aut Miguel Enrique Lopez Muñoz verfasserin aut Dora Loria verfasserin aut Alejandra Luque verfasserin aut Alejandro Maass verfasserin aut Maria do Socorro Maciel verfasserin aut Flavia Rotea Mangone verfasserin aut Jorge Mansilla verfasserin aut Katherine Marcelain verfasserin aut Carolina Mariani verfasserin aut Marcia Maria Chiquitelli Marques verfasserin aut Reyna J. Martinez-Arriaga verfasserin aut Hector R. Martinez-Ramirez verfasserin aut Marcela Martins verfasserin aut Alma G. Maya-Gonzalez verfasserin aut Brenda Mazzaferri verfasserin aut Yadira Medina-Mora verfasserin aut Mariana Menini verfasserin aut Silvia Míguez verfasserin aut Soledad Milans verfasserin aut Soledad Montes verfasserin aut Ana Verónica Morales Hernández verfasserin aut Giberto Morga-Villela verfasserin aut Carla Morong verfasserin aut Homero Muñoz verfasserin aut Ignacio Miguel Muse verfasserin aut Carina Mussetti verfasserin aut Eduardo Mussetti verfasserin aut Luis J. Najar-Acosta verfasserin aut Elisa Napolitano e Ferreira verfasserin aut Nancy E. Navarro-Ruiz verfasserin aut Cristina Noblía verfasserin aut João Soares Nunes verfasserin aut Daniela Núñez verfasserin aut Fabiola Núñez verfasserin aut Nilton Onari verfasserin aut Emma M. Oropeza-De Anda verfasserin aut David Ortega Tirado verfasserin aut Cynthia Aparecida Bueno de Toledo Osório verfasserin aut Carlos Eduardo Paiva verfasserin aut Paulina Peñaloza verfasserin aut Miguel Peredo-Navarro verfasserin aut David Pereira verfasserin aut Laura Perez Michel verfasserin aut Francisca Pino verfasserin aut Tania Pino verfasserin aut Natalia Pinto verfasserin aut Jessica Pizarro verfasserin aut Carlos Pressa verfasserin aut Enrique Ramirez verfasserin aut Gladys E. Ramirez-Rosales verfasserin aut Claudia Ramis verfasserin aut Maritza Ramos-Ramirez verfasserin aut Adela Rascon Alcantar verfasserin aut Silvana Ravaglio verfasserin aut Francois Richard verfasserin aut Omar Rios Méndez verfasserin aut Ramón Enrique Robles Zepeda verfasserin aut Iara Santana Rocha verfasserin aut Natalia Rodriguez verfasserin aut Vilma Rodriguez verfasserin aut Maria Teresa Rodriguez verfasserin aut Diego Rodriguez-Gonzalez verfasserin aut Rosemeire A Roela verfasserin aut Ana M Romero-Gomez verfasserin aut Ana M Rosales-Sandoval verfasserin aut Omar V Rubio-Plascencia verfasserin aut Florencia Russo verfasserin aut Gaciela Sabini verfasserin aut Isabel Saffie verfasserin aut Helena Salina Dias verfasserin aut Brenda Guadalupe Samaniego Soto verfasserin aut Julio San Martino verfasserin aut Benito Sanchez-Llamas verfasserin aut Daniel Sat-Muñoz verfasserin aut Mariana Savignano verfasserin aut Cristovam Scapulatempo Neto verfasserin aut Max Mano Senna verfasserin aut Carolina Silva verfasserin aut Jaime Silvera verfasserin aut Isabele Small verfasserin aut Fernando Soares verfasserin aut Iberê Soares verfasserin aut Silvana Soares dos Santos verfasserin aut Evandro Sobrosa de Mello verfasserin aut José Antonio Sola verfasserin aut Irene Sorín verfasserin aut Alejandra Sosa verfasserin aut Anabella Sosa verfasserin aut Claudio Sosa verfasserin aut Sandra Soto verfasserin aut Cristiano de Pádua Souza verfasserin aut Lucía Spangenberg verfasserin aut Gustavo Steffanof verfasserin aut Florencia Straminsky verfasserin aut Mónica Tapia verfasserin aut Raziel O. Tapia-Llanos verfasserin aut Geronimo M. Tavares-Macias verfasserin aut Guillermo Temperley verfasserin aut Veronica Terzieff verfasserin aut Vicente Teti verfasserin aut Javier Tognarelli verfasserin aut Verónica Toledo verfasserin aut Paulina Toro verfasserin aut Roberto Torres verfasserin aut Mariana Torres-Palomares verfasserin aut Rogelio Troyo-San Roman verfasserin aut Hernan Urbano verfasserin aut Nicolas Vacca verfasserin aut Daniel Vaimberg verfasserin aut María Lourdes Valencia Peña verfasserin aut Maria Lujan Vaselevich verfasserin aut Jaime Vazquez-Nares verfasserin aut Ezequiel Velez-Gomez verfasserin aut Laura N. Venegas-Godinez verfasserin aut Patricia Vercelli verfasserin aut Ricardo Verdugo verfasserin aut René Aloisio da Costa Vieira verfasserin aut Marta Vilensky verfasserin aut María José Villarubias verfasserin aut Manuel Isaac Villegas Gómez verfasserin aut Stella Viña verfasserin aut Silvia Vornetti verfasserin aut Anapaula Hidemi Uema Watanabe verfasserin aut Carlos Zamorano verfasserin aut Luis Zapata verfasserin aut Zdenka Zlatar verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.835626 kostenfrei https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
allfields_unstemmed |
10.3389/fonc.2022.835626 doi (DE-627)DOAJ064322157 (DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e DE-627 ger DE-627 rakwb eng RC254-282 Andrea Sabina Llera verfasserin aut The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eliana Saul Furquim Werneck Abdelhay verfasserin aut Nora Artagaveytia verfasserin aut Adrián Daneri-Navarro verfasserin aut Bettina Müller verfasserin aut Carlos Velazquez verfasserin aut Elsa B. Alcoba verfasserin aut Isabel Alonso verfasserin aut Daniela B. Alves da Quinta verfasserin aut Daniela B. Alves da Quinta verfasserin aut Renata Binato verfasserin aut Alicia Inés Bravo verfasserin aut Natalia Camejo verfasserin aut Dirce Maria Carraro verfasserin aut Mónica Castro verfasserin aut Juan M. Castro-Cervantes verfasserin aut Sandra Cataldi verfasserin aut Alfonso Cayota verfasserin aut Mauricio Cerda verfasserin aut Alicia Colombo verfasserin aut Susanne Crocamo verfasserin aut Alicia Del Toro-Arreola verfasserin aut Raúl Delgadillo-Cisterna verfasserin aut Lucía Delgado verfasserin aut Marisa Dreyer-Breitenbach verfasserin aut Laura Fejerman verfasserin aut Elmer A. Fernández verfasserin aut Elmer A. Fernández verfasserin aut Jorge Fernández verfasserin aut Wanda Fernández verfasserin aut Ramón A. Franco-Topete verfasserin aut Carolina Gabay verfasserin aut Fancy Gaete verfasserin aut Adriana Garibay-Escobar verfasserin aut Jorge Gómez verfasserin aut Gonzalo Greif verfasserin aut Thomas G. Gross verfasserin aut Marisol Guerrero verfasserin aut Marianne K. Henderson verfasserin aut Miguel E. Lopez-Muñoz verfasserin aut Alejandra Lopez-Vazquez verfasserin aut Silvina Maldonado verfasserin aut Andrés J. Morán-Mendoza verfasserin aut Maria Aparecida Nagai verfasserin aut Antonio Oceguera-Villanueva verfasserin aut Miguel A. Ortiz-Martínez verfasserin aut Jael Quintero verfasserin aut Antonio Quintero-Ramos verfasserin aut Rui M. Reis verfasserin aut Javier Retamales verfasserin aut Ernesto Rivera-Claisse verfasserin aut Darío Rocha verfasserin aut Robinson Rodríguez verfasserin aut Cristina Rosales verfasserin aut Efrain Salas-González verfasserin aut Verónica Sanchotena verfasserin aut Laura Segovia verfasserin aut Juan Martín Sendoya verfasserin aut Aida A. Silva-García verfasserin aut Alejandra Trinchero verfasserin aut Olivia Valenzuela verfasserin aut Vidya Vedham verfasserin aut Livia Zagame verfasserin aut United States-Latin American Cancer Research Network (US-LACRN) verfasserin aut Osvaldo L. Podhajcer verfasserin aut Juan Abarca verfasserin aut Pamela Acevedo verfasserin aut Graciela Acosta verfasserin aut Gissel Acosta verfasserin aut Gabriela Acosta Haab verfasserin aut Ana Lilian Acosta Silva verfasserin aut Marta Aghazarian verfasserin aut Carola Aguayo verfasserin aut Bernardo Aizen verfasserin aut Gustavo Alarcon Lopez verfasserin aut Liz Almeida verfasserin aut Ana Alvarez verfasserin aut Viviane Andrade verfasserin aut Wenceslao Angeles-Bueno verfasserin aut Roberto Arai verfasserin aut Priscila Elvira Arambula Barreras verfasserin aut Ma. Isabel Aramburo Rubio verfasserin aut Gonzalo Ardao verfasserin aut Lilia A. Arellano-Jimenez verfasserin aut Claudia Arias verfasserin aut Ricardo Armisen verfasserin aut Mauricio Aspee verfasserin aut Rodrigo Assar verfasserin aut Itzel Reneé Astiazarán Rascón verfasserin aut Sebastian Astorga verfasserin aut Maxwell Aviles Rodriguez verfasserin aut Antônio Bailão Junior verfasserin aut Adolfo E. Barragan-Curiel verfasserin aut Adelfo Barragan-Ruiz verfasserin aut Fernanda Bermudez verfasserin aut Julia Bernachin verfasserin aut Wilfrido Bernal Herrera verfasserin aut Mara Bonet verfasserin aut Sarah Brnich verfasserin aut Claudio Bustamante verfasserin aut Miguel Angel Bustamante verfasserin aut Julio Bustos-Gomez verfasserin aut Felipe de J Bustos-Rodriguez verfasserin aut Janett Caballero Jasso verfasserin aut Angie Calfuman verfasserin aut Antonio Hugo José Froes Marques verfasserin aut Mónica Campos verfasserin aut Soledad Cano verfasserin aut Juan C. Canton-Romero verfasserin aut Ricardo Cappetta verfasserin aut Paulina Carmona verfasserin aut Fernando Carrizo verfasserin aut André Lopes Carvalho verfasserin aut Erika Carvallo verfasserin aut Julio Carzoglio verfasserin aut Monica Casalnuovo verfasserin aut Benedicta Caserta verfasserin aut Alvaro Castillo verfasserin aut César Castillo verfasserin aut Roger Chammas verfasserin aut Mario Alberto Chavez Zamudio verfasserin aut Loreto Chia verfasserin aut Elisa Chiarello verfasserin aut Daniela Chirico verfasserin aut Esther Cisneros-Quirarter verfasserin aut Minor Raul Cordero Bautista verfasserin aut Valeria Cornejo verfasserin aut Baldemar Corral Villegas verfasserin aut Andrés Cortés verfasserin aut Sandra Cortés verfasserin aut Laura Cortes-Sanabria verfasserin aut German Salvador Cortez Zamorano verfasserin aut Alejandro Corvalan verfasserin aut Adolfo Cruz verfasserin aut Alba d'Aurora verfasserin aut Sandra De la Fuente verfasserin aut Soledad De la Peña verfasserin aut Roberto de Leon Caballero verfasserin aut Mirian de Souza verfasserin aut César Del Castillo verfasserin aut Azucena Del-Toro-Valero verfasserin aut Mirtha Di Pretoro verfasserin aut Andrea Digonzelli verfasserin aut Jose El Ters verfasserin aut Paula Escobar verfasserin aut Marcela Estolaza verfasserin aut Adriane Feijo Evangelista verfasserin aut Marcelo Fanelli verfasserin aut Paulo Farias verfasserin aut Graciela Fernandez verfasserin aut José R. Filassi verfasserin aut Natalia Filgueiras verfasserin aut Diego Flaks verfasserin aut Edgar G. Flores-Ayala verfasserin aut Maria R. Flores-Marquez verfasserin aut David Franco Hughes verfasserin aut Karina Franco-Topete verfasserin aut Jimena Freire verfasserin aut Cristobal Fresno verfasserin aut Romina Gabrielli verfasserin aut Mario Gallegos verfasserin aut Jorge Gamboa verfasserin aut Daiana Ganiewich verfasserin aut Carlos Garbovesky verfasserin aut Ruben Alejandro Garcia Munguia verfasserin aut Ricardo Garcia-Gaeta verfasserin aut Alma C. Garcia-Martinez verfasserin aut Liliana Gimenez verfasserin aut Hector Gómez Silveira verfasserin aut Mariana M. Gomez-Del Toro verfasserin aut Marcela Gonzalez verfasserin aut Alicia Gonzalez verfasserin aut Germán González verfasserin aut Cesar Osbaldo Gonzalez Mondaca verfasserin aut Leivy P. Gonzalez-Ramirez verfasserin aut Beatriz Gonzalez-Ulloa verfasserin aut Susana Gorostidy verfasserin aut Mariela Grass verfasserin aut Alfonso G. Guevara Torres verfasserin aut Lorena Gutierrez verfasserin aut Susan A. Gutierrez-Rubio verfasserin aut Adrián Hannois verfasserin aut Andrew Hart verfasserin aut Steffen Härtel verfasserin aut Marcos Henriquez verfasserin aut Rafael Hernandez Guevara verfasserin aut Miriam E. Hernandez-Franco verfasserin aut Manuel I. Herrera-Miramontes verfasserin aut Graciela Horton verfasserin aut Gladys Ibañez verfasserin aut Martín Ipiña verfasserin aut Beatriz Jalfin verfasserin aut Lilian Jara verfasserin aut Raul Jara verfasserin aut Maria Luisa Jaramillo verfasserin aut David Javalera-Castro verfasserin aut Maria Eugenia Jimenez verfasserin aut Hugo Ju verfasserin aut Nazareth Juárez Rusjan verfasserin aut Karen Juneman verfasserin aut Ligia Maria Kerr verfasserin aut Alejandra Krupelis verfasserin aut Flor Esmeralda Larios-Jimenez verfasserin aut Jose Domingo Latorre verfasserin aut Guillermo Laviña verfasserin aut Fernando Lavista verfasserin aut Irma Leticia León Duarte verfasserin aut Alberto Lescano verfasserin aut Verónica Lezano verfasserin aut Rossana Mendoza Lopez verfasserin aut Jose Guillermo Lopez Cervantes verfasserin aut Miguel Enrique Lopez Muñoz verfasserin aut Dora Loria verfasserin aut Alejandra Luque verfasserin aut Alejandro Maass verfasserin aut Maria do Socorro Maciel verfasserin aut Flavia Rotea Mangone verfasserin aut Jorge Mansilla verfasserin aut Katherine Marcelain verfasserin aut Carolina Mariani verfasserin aut Marcia Maria Chiquitelli Marques verfasserin aut Reyna J. Martinez-Arriaga verfasserin aut Hector R. Martinez-Ramirez verfasserin aut Marcela Martins verfasserin aut Alma G. Maya-Gonzalez verfasserin aut Brenda Mazzaferri verfasserin aut Yadira Medina-Mora verfasserin aut Mariana Menini verfasserin aut Silvia Míguez verfasserin aut Soledad Milans verfasserin aut Soledad Montes verfasserin aut Ana Verónica Morales Hernández verfasserin aut Giberto Morga-Villela verfasserin aut Carla Morong verfasserin aut Homero Muñoz verfasserin aut Ignacio Miguel Muse verfasserin aut Carina Mussetti verfasserin aut Eduardo Mussetti verfasserin aut Luis J. Najar-Acosta verfasserin aut Elisa Napolitano e Ferreira verfasserin aut Nancy E. Navarro-Ruiz verfasserin aut Cristina Noblía verfasserin aut João Soares Nunes verfasserin aut Daniela Núñez verfasserin aut Fabiola Núñez verfasserin aut Nilton Onari verfasserin aut Emma M. Oropeza-De Anda verfasserin aut David Ortega Tirado verfasserin aut Cynthia Aparecida Bueno de Toledo Osório verfasserin aut Carlos Eduardo Paiva verfasserin aut Paulina Peñaloza verfasserin aut Miguel Peredo-Navarro verfasserin aut David Pereira verfasserin aut Laura Perez Michel verfasserin aut Francisca Pino verfasserin aut Tania Pino verfasserin aut Natalia Pinto verfasserin aut Jessica Pizarro verfasserin aut Carlos Pressa verfasserin aut Enrique Ramirez verfasserin aut Gladys E. Ramirez-Rosales verfasserin aut Claudia Ramis verfasserin aut Maritza Ramos-Ramirez verfasserin aut Adela Rascon Alcantar verfasserin aut Silvana Ravaglio verfasserin aut Francois Richard verfasserin aut Omar Rios Méndez verfasserin aut Ramón Enrique Robles Zepeda verfasserin aut Iara Santana Rocha verfasserin aut Natalia Rodriguez verfasserin aut Vilma Rodriguez verfasserin aut Maria Teresa Rodriguez verfasserin aut Diego Rodriguez-Gonzalez verfasserin aut Rosemeire A Roela verfasserin aut Ana M Romero-Gomez verfasserin aut Ana M Rosales-Sandoval verfasserin aut Omar V Rubio-Plascencia verfasserin aut Florencia Russo verfasserin aut Gaciela Sabini verfasserin aut Isabel Saffie verfasserin aut Helena Salina Dias verfasserin aut Brenda Guadalupe Samaniego Soto verfasserin aut Julio San Martino verfasserin aut Benito Sanchez-Llamas verfasserin aut Daniel Sat-Muñoz verfasserin aut Mariana Savignano verfasserin aut Cristovam Scapulatempo Neto verfasserin aut Max Mano Senna verfasserin aut Carolina Silva verfasserin aut Jaime Silvera verfasserin aut Isabele Small verfasserin aut Fernando Soares verfasserin aut Iberê Soares verfasserin aut Silvana Soares dos Santos verfasserin aut Evandro Sobrosa de Mello verfasserin aut José Antonio Sola verfasserin aut Irene Sorín verfasserin aut Alejandra Sosa verfasserin aut Anabella Sosa verfasserin aut Claudio Sosa verfasserin aut Sandra Soto verfasserin aut Cristiano de Pádua Souza verfasserin aut Lucía Spangenberg verfasserin aut Gustavo Steffanof verfasserin aut Florencia Straminsky verfasserin aut Mónica Tapia verfasserin aut Raziel O. Tapia-Llanos verfasserin aut Geronimo M. Tavares-Macias verfasserin aut Guillermo Temperley verfasserin aut Veronica Terzieff verfasserin aut Vicente Teti verfasserin aut Javier Tognarelli verfasserin aut Verónica Toledo verfasserin aut Paulina Toro verfasserin aut Roberto Torres verfasserin aut Mariana Torres-Palomares verfasserin aut Rogelio Troyo-San Roman verfasserin aut Hernan Urbano verfasserin aut Nicolas Vacca verfasserin aut Daniel Vaimberg verfasserin aut María Lourdes Valencia Peña verfasserin aut Maria Lujan Vaselevich verfasserin aut Jaime Vazquez-Nares verfasserin aut Ezequiel Velez-Gomez verfasserin aut Laura N. Venegas-Godinez verfasserin aut Patricia Vercelli verfasserin aut Ricardo Verdugo verfasserin aut René Aloisio da Costa Vieira verfasserin aut Marta Vilensky verfasserin aut María José Villarubias verfasserin aut Manuel Isaac Villegas Gómez verfasserin aut Stella Viña verfasserin aut Silvia Vornetti verfasserin aut Anapaula Hidemi Uema Watanabe verfasserin aut Carlos Zamorano verfasserin aut Luis Zapata verfasserin aut Zdenka Zlatar verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.835626 kostenfrei https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
allfieldsGer |
10.3389/fonc.2022.835626 doi (DE-627)DOAJ064322157 (DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e DE-627 ger DE-627 rakwb eng RC254-282 Andrea Sabina Llera verfasserin aut The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eliana Saul Furquim Werneck Abdelhay verfasserin aut Nora Artagaveytia verfasserin aut Adrián Daneri-Navarro verfasserin aut Bettina Müller verfasserin aut Carlos Velazquez verfasserin aut Elsa B. Alcoba verfasserin aut Isabel Alonso verfasserin aut Daniela B. Alves da Quinta verfasserin aut Daniela B. Alves da Quinta verfasserin aut Renata Binato verfasserin aut Alicia Inés Bravo verfasserin aut Natalia Camejo verfasserin aut Dirce Maria Carraro verfasserin aut Mónica Castro verfasserin aut Juan M. Castro-Cervantes verfasserin aut Sandra Cataldi verfasserin aut Alfonso Cayota verfasserin aut Mauricio Cerda verfasserin aut Alicia Colombo verfasserin aut Susanne Crocamo verfasserin aut Alicia Del Toro-Arreola verfasserin aut Raúl Delgadillo-Cisterna verfasserin aut Lucía Delgado verfasserin aut Marisa Dreyer-Breitenbach verfasserin aut Laura Fejerman verfasserin aut Elmer A. Fernández verfasserin aut Elmer A. Fernández verfasserin aut Jorge Fernández verfasserin aut Wanda Fernández verfasserin aut Ramón A. Franco-Topete verfasserin aut Carolina Gabay verfasserin aut Fancy Gaete verfasserin aut Adriana Garibay-Escobar verfasserin aut Jorge Gómez verfasserin aut Gonzalo Greif verfasserin aut Thomas G. Gross verfasserin aut Marisol Guerrero verfasserin aut Marianne K. Henderson verfasserin aut Miguel E. Lopez-Muñoz verfasserin aut Alejandra Lopez-Vazquez verfasserin aut Silvina Maldonado verfasserin aut Andrés J. Morán-Mendoza verfasserin aut Maria Aparecida Nagai verfasserin aut Antonio Oceguera-Villanueva verfasserin aut Miguel A. Ortiz-Martínez verfasserin aut Jael Quintero verfasserin aut Antonio Quintero-Ramos verfasserin aut Rui M. Reis verfasserin aut Javier Retamales verfasserin aut Ernesto Rivera-Claisse verfasserin aut Darío Rocha verfasserin aut Robinson Rodríguez verfasserin aut Cristina Rosales verfasserin aut Efrain Salas-González verfasserin aut Verónica Sanchotena verfasserin aut Laura Segovia verfasserin aut Juan Martín Sendoya verfasserin aut Aida A. Silva-García verfasserin aut Alejandra Trinchero verfasserin aut Olivia Valenzuela verfasserin aut Vidya Vedham verfasserin aut Livia Zagame verfasserin aut United States-Latin American Cancer Research Network (US-LACRN) verfasserin aut Osvaldo L. Podhajcer verfasserin aut Juan Abarca verfasserin aut Pamela Acevedo verfasserin aut Graciela Acosta verfasserin aut Gissel Acosta verfasserin aut Gabriela Acosta Haab verfasserin aut Ana Lilian Acosta Silva verfasserin aut Marta Aghazarian verfasserin aut Carola Aguayo verfasserin aut Bernardo Aizen verfasserin aut Gustavo Alarcon Lopez verfasserin aut Liz Almeida verfasserin aut Ana Alvarez verfasserin aut Viviane Andrade verfasserin aut Wenceslao Angeles-Bueno verfasserin aut Roberto Arai verfasserin aut Priscila Elvira Arambula Barreras verfasserin aut Ma. Isabel Aramburo Rubio verfasserin aut Gonzalo Ardao verfasserin aut Lilia A. Arellano-Jimenez verfasserin aut Claudia Arias verfasserin aut Ricardo Armisen verfasserin aut Mauricio Aspee verfasserin aut Rodrigo Assar verfasserin aut Itzel Reneé Astiazarán Rascón verfasserin aut Sebastian Astorga verfasserin aut Maxwell Aviles Rodriguez verfasserin aut Antônio Bailão Junior verfasserin aut Adolfo E. Barragan-Curiel verfasserin aut Adelfo Barragan-Ruiz verfasserin aut Fernanda Bermudez verfasserin aut Julia Bernachin verfasserin aut Wilfrido Bernal Herrera verfasserin aut Mara Bonet verfasserin aut Sarah Brnich verfasserin aut Claudio Bustamante verfasserin aut Miguel Angel Bustamante verfasserin aut Julio Bustos-Gomez verfasserin aut Felipe de J Bustos-Rodriguez verfasserin aut Janett Caballero Jasso verfasserin aut Angie Calfuman verfasserin aut Antonio Hugo José Froes Marques verfasserin aut Mónica Campos verfasserin aut Soledad Cano verfasserin aut Juan C. Canton-Romero verfasserin aut Ricardo Cappetta verfasserin aut Paulina Carmona verfasserin aut Fernando Carrizo verfasserin aut André Lopes Carvalho verfasserin aut Erika Carvallo verfasserin aut Julio Carzoglio verfasserin aut Monica Casalnuovo verfasserin aut Benedicta Caserta verfasserin aut Alvaro Castillo verfasserin aut César Castillo verfasserin aut Roger Chammas verfasserin aut Mario Alberto Chavez Zamudio verfasserin aut Loreto Chia verfasserin aut Elisa Chiarello verfasserin aut Daniela Chirico verfasserin aut Esther Cisneros-Quirarter verfasserin aut Minor Raul Cordero Bautista verfasserin aut Valeria Cornejo verfasserin aut Baldemar Corral Villegas verfasserin aut Andrés Cortés verfasserin aut Sandra Cortés verfasserin aut Laura Cortes-Sanabria verfasserin aut German Salvador Cortez Zamorano verfasserin aut Alejandro Corvalan verfasserin aut Adolfo Cruz verfasserin aut Alba d'Aurora verfasserin aut Sandra De la Fuente verfasserin aut Soledad De la Peña verfasserin aut Roberto de Leon Caballero verfasserin aut Mirian de Souza verfasserin aut César Del Castillo verfasserin aut Azucena Del-Toro-Valero verfasserin aut Mirtha Di Pretoro verfasserin aut Andrea Digonzelli verfasserin aut Jose El Ters verfasserin aut Paula Escobar verfasserin aut Marcela Estolaza verfasserin aut Adriane Feijo Evangelista verfasserin aut Marcelo Fanelli verfasserin aut Paulo Farias verfasserin aut Graciela Fernandez verfasserin aut José R. Filassi verfasserin aut Natalia Filgueiras verfasserin aut Diego Flaks verfasserin aut Edgar G. Flores-Ayala verfasserin aut Maria R. Flores-Marquez verfasserin aut David Franco Hughes verfasserin aut Karina Franco-Topete verfasserin aut Jimena Freire verfasserin aut Cristobal Fresno verfasserin aut Romina Gabrielli verfasserin aut Mario Gallegos verfasserin aut Jorge Gamboa verfasserin aut Daiana Ganiewich verfasserin aut Carlos Garbovesky verfasserin aut Ruben Alejandro Garcia Munguia verfasserin aut Ricardo Garcia-Gaeta verfasserin aut Alma C. Garcia-Martinez verfasserin aut Liliana Gimenez verfasserin aut Hector Gómez Silveira verfasserin aut Mariana M. Gomez-Del Toro verfasserin aut Marcela Gonzalez verfasserin aut Alicia Gonzalez verfasserin aut Germán González verfasserin aut Cesar Osbaldo Gonzalez Mondaca verfasserin aut Leivy P. Gonzalez-Ramirez verfasserin aut Beatriz Gonzalez-Ulloa verfasserin aut Susana Gorostidy verfasserin aut Mariela Grass verfasserin aut Alfonso G. Guevara Torres verfasserin aut Lorena Gutierrez verfasserin aut Susan A. Gutierrez-Rubio verfasserin aut Adrián Hannois verfasserin aut Andrew Hart verfasserin aut Steffen Härtel verfasserin aut Marcos Henriquez verfasserin aut Rafael Hernandez Guevara verfasserin aut Miriam E. Hernandez-Franco verfasserin aut Manuel I. Herrera-Miramontes verfasserin aut Graciela Horton verfasserin aut Gladys Ibañez verfasserin aut Martín Ipiña verfasserin aut Beatriz Jalfin verfasserin aut Lilian Jara verfasserin aut Raul Jara verfasserin aut Maria Luisa Jaramillo verfasserin aut David Javalera-Castro verfasserin aut Maria Eugenia Jimenez verfasserin aut Hugo Ju verfasserin aut Nazareth Juárez Rusjan verfasserin aut Karen Juneman verfasserin aut Ligia Maria Kerr verfasserin aut Alejandra Krupelis verfasserin aut Flor Esmeralda Larios-Jimenez verfasserin aut Jose Domingo Latorre verfasserin aut Guillermo Laviña verfasserin aut Fernando Lavista verfasserin aut Irma Leticia León Duarte verfasserin aut Alberto Lescano verfasserin aut Verónica Lezano verfasserin aut Rossana Mendoza Lopez verfasserin aut Jose Guillermo Lopez Cervantes verfasserin aut Miguel Enrique Lopez Muñoz verfasserin aut Dora Loria verfasserin aut Alejandra Luque verfasserin aut Alejandro Maass verfasserin aut Maria do Socorro Maciel verfasserin aut Flavia Rotea Mangone verfasserin aut Jorge Mansilla verfasserin aut Katherine Marcelain verfasserin aut Carolina Mariani verfasserin aut Marcia Maria Chiquitelli Marques verfasserin aut Reyna J. Martinez-Arriaga verfasserin aut Hector R. Martinez-Ramirez verfasserin aut Marcela Martins verfasserin aut Alma G. Maya-Gonzalez verfasserin aut Brenda Mazzaferri verfasserin aut Yadira Medina-Mora verfasserin aut Mariana Menini verfasserin aut Silvia Míguez verfasserin aut Soledad Milans verfasserin aut Soledad Montes verfasserin aut Ana Verónica Morales Hernández verfasserin aut Giberto Morga-Villela verfasserin aut Carla Morong verfasserin aut Homero Muñoz verfasserin aut Ignacio Miguel Muse verfasserin aut Carina Mussetti verfasserin aut Eduardo Mussetti verfasserin aut Luis J. Najar-Acosta verfasserin aut Elisa Napolitano e Ferreira verfasserin aut Nancy E. Navarro-Ruiz verfasserin aut Cristina Noblía verfasserin aut João Soares Nunes verfasserin aut Daniela Núñez verfasserin aut Fabiola Núñez verfasserin aut Nilton Onari verfasserin aut Emma M. Oropeza-De Anda verfasserin aut David Ortega Tirado verfasserin aut Cynthia Aparecida Bueno de Toledo Osório verfasserin aut Carlos Eduardo Paiva verfasserin aut Paulina Peñaloza verfasserin aut Miguel Peredo-Navarro verfasserin aut David Pereira verfasserin aut Laura Perez Michel verfasserin aut Francisca Pino verfasserin aut Tania Pino verfasserin aut Natalia Pinto verfasserin aut Jessica Pizarro verfasserin aut Carlos Pressa verfasserin aut Enrique Ramirez verfasserin aut Gladys E. Ramirez-Rosales verfasserin aut Claudia Ramis verfasserin aut Maritza Ramos-Ramirez verfasserin aut Adela Rascon Alcantar verfasserin aut Silvana Ravaglio verfasserin aut Francois Richard verfasserin aut Omar Rios Méndez verfasserin aut Ramón Enrique Robles Zepeda verfasserin aut Iara Santana Rocha verfasserin aut Natalia Rodriguez verfasserin aut Vilma Rodriguez verfasserin aut Maria Teresa Rodriguez verfasserin aut Diego Rodriguez-Gonzalez verfasserin aut Rosemeire A Roela verfasserin aut Ana M Romero-Gomez verfasserin aut Ana M Rosales-Sandoval verfasserin aut Omar V Rubio-Plascencia verfasserin aut Florencia Russo verfasserin aut Gaciela Sabini verfasserin aut Isabel Saffie verfasserin aut Helena Salina Dias verfasserin aut Brenda Guadalupe Samaniego Soto verfasserin aut Julio San Martino verfasserin aut Benito Sanchez-Llamas verfasserin aut Daniel Sat-Muñoz verfasserin aut Mariana Savignano verfasserin aut Cristovam Scapulatempo Neto verfasserin aut Max Mano Senna verfasserin aut Carolina Silva verfasserin aut Jaime Silvera verfasserin aut Isabele Small verfasserin aut Fernando Soares verfasserin aut Iberê Soares verfasserin aut Silvana Soares dos Santos verfasserin aut Evandro Sobrosa de Mello verfasserin aut José Antonio Sola verfasserin aut Irene Sorín verfasserin aut Alejandra Sosa verfasserin aut Anabella Sosa verfasserin aut Claudio Sosa verfasserin aut Sandra Soto verfasserin aut Cristiano de Pádua Souza verfasserin aut Lucía Spangenberg verfasserin aut Gustavo Steffanof verfasserin aut Florencia Straminsky verfasserin aut Mónica Tapia verfasserin aut Raziel O. Tapia-Llanos verfasserin aut Geronimo M. Tavares-Macias verfasserin aut Guillermo Temperley verfasserin aut Veronica Terzieff verfasserin aut Vicente Teti verfasserin aut Javier Tognarelli verfasserin aut Verónica Toledo verfasserin aut Paulina Toro verfasserin aut Roberto Torres verfasserin aut Mariana Torres-Palomares verfasserin aut Rogelio Troyo-San Roman verfasserin aut Hernan Urbano verfasserin aut Nicolas Vacca verfasserin aut Daniel Vaimberg verfasserin aut María Lourdes Valencia Peña verfasserin aut Maria Lujan Vaselevich verfasserin aut Jaime Vazquez-Nares verfasserin aut Ezequiel Velez-Gomez verfasserin aut Laura N. Venegas-Godinez verfasserin aut Patricia Vercelli verfasserin aut Ricardo Verdugo verfasserin aut René Aloisio da Costa Vieira verfasserin aut Marta Vilensky verfasserin aut María José Villarubias verfasserin aut Manuel Isaac Villegas Gómez verfasserin aut Stella Viña verfasserin aut Silvia Vornetti verfasserin aut Anapaula Hidemi Uema Watanabe verfasserin aut Carlos Zamorano verfasserin aut Luis Zapata verfasserin aut Zdenka Zlatar verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.835626 kostenfrei https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
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10.3389/fonc.2022.835626 doi (DE-627)DOAJ064322157 (DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e DE-627 ger DE-627 rakwb eng RC254-282 Andrea Sabina Llera verfasserin aut The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways Neoplasms. Tumors. Oncology. Including cancer and carcinogens Eliana Saul Furquim Werneck Abdelhay verfasserin aut Nora Artagaveytia verfasserin aut Adrián Daneri-Navarro verfasserin aut Bettina Müller verfasserin aut Carlos Velazquez verfasserin aut Elsa B. Alcoba verfasserin aut Isabel Alonso verfasserin aut Daniela B. Alves da Quinta verfasserin aut Daniela B. Alves da Quinta verfasserin aut Renata Binato verfasserin aut Alicia Inés Bravo verfasserin aut Natalia Camejo verfasserin aut Dirce Maria Carraro verfasserin aut Mónica Castro verfasserin aut Juan M. Castro-Cervantes verfasserin aut Sandra Cataldi verfasserin aut Alfonso Cayota verfasserin aut Mauricio Cerda verfasserin aut Alicia Colombo verfasserin aut Susanne Crocamo verfasserin aut Alicia Del Toro-Arreola verfasserin aut Raúl Delgadillo-Cisterna verfasserin aut Lucía Delgado verfasserin aut Marisa Dreyer-Breitenbach verfasserin aut Laura Fejerman verfasserin aut Elmer A. Fernández verfasserin aut Elmer A. Fernández verfasserin aut Jorge Fernández verfasserin aut Wanda Fernández verfasserin aut Ramón A. Franco-Topete verfasserin aut Carolina Gabay verfasserin aut Fancy Gaete verfasserin aut Adriana Garibay-Escobar verfasserin aut Jorge Gómez verfasserin aut Gonzalo Greif verfasserin aut Thomas G. Gross verfasserin aut Marisol Guerrero verfasserin aut Marianne K. Henderson verfasserin aut Miguel E. Lopez-Muñoz verfasserin aut Alejandra Lopez-Vazquez verfasserin aut Silvina Maldonado verfasserin aut Andrés J. Morán-Mendoza verfasserin aut Maria Aparecida Nagai verfasserin aut Antonio Oceguera-Villanueva verfasserin aut Miguel A. Ortiz-Martínez verfasserin aut Jael Quintero verfasserin aut Antonio Quintero-Ramos verfasserin aut Rui M. Reis verfasserin aut Javier Retamales verfasserin aut Ernesto Rivera-Claisse verfasserin aut Darío Rocha verfasserin aut Robinson Rodríguez verfasserin aut Cristina Rosales verfasserin aut Efrain Salas-González verfasserin aut Verónica Sanchotena verfasserin aut Laura Segovia verfasserin aut Juan Martín Sendoya verfasserin aut Aida A. Silva-García verfasserin aut Alejandra Trinchero verfasserin aut Olivia Valenzuela verfasserin aut Vidya Vedham verfasserin aut Livia Zagame verfasserin aut United States-Latin American Cancer Research Network (US-LACRN) verfasserin aut Osvaldo L. Podhajcer verfasserin aut Juan Abarca verfasserin aut Pamela Acevedo verfasserin aut Graciela Acosta verfasserin aut Gissel Acosta verfasserin aut Gabriela Acosta Haab verfasserin aut Ana Lilian Acosta Silva verfasserin aut Marta Aghazarian verfasserin aut Carola Aguayo verfasserin aut Bernardo Aizen verfasserin aut Gustavo Alarcon Lopez verfasserin aut Liz Almeida verfasserin aut Ana Alvarez verfasserin aut Viviane Andrade verfasserin aut Wenceslao Angeles-Bueno verfasserin aut Roberto Arai verfasserin aut Priscila Elvira Arambula Barreras verfasserin aut Ma. Isabel Aramburo Rubio verfasserin aut Gonzalo Ardao verfasserin aut Lilia A. Arellano-Jimenez verfasserin aut Claudia Arias verfasserin aut Ricardo Armisen verfasserin aut Mauricio Aspee verfasserin aut Rodrigo Assar verfasserin aut Itzel Reneé Astiazarán Rascón verfasserin aut Sebastian Astorga verfasserin aut Maxwell Aviles Rodriguez verfasserin aut Antônio Bailão Junior verfasserin aut Adolfo E. Barragan-Curiel verfasserin aut Adelfo Barragan-Ruiz verfasserin aut Fernanda Bermudez verfasserin aut Julia Bernachin verfasserin aut Wilfrido Bernal Herrera verfasserin aut Mara Bonet verfasserin aut Sarah Brnich verfasserin aut Claudio Bustamante verfasserin aut Miguel Angel Bustamante verfasserin aut Julio Bustos-Gomez verfasserin aut Felipe de J Bustos-Rodriguez verfasserin aut Janett Caballero Jasso verfasserin aut Angie Calfuman verfasserin aut Antonio Hugo José Froes Marques verfasserin aut Mónica Campos verfasserin aut Soledad Cano verfasserin aut Juan C. Canton-Romero verfasserin aut Ricardo Cappetta verfasserin aut Paulina Carmona verfasserin aut Fernando Carrizo verfasserin aut André Lopes Carvalho verfasserin aut Erika Carvallo verfasserin aut Julio Carzoglio verfasserin aut Monica Casalnuovo verfasserin aut Benedicta Caserta verfasserin aut Alvaro Castillo verfasserin aut César Castillo verfasserin aut Roger Chammas verfasserin aut Mario Alberto Chavez Zamudio verfasserin aut Loreto Chia verfasserin aut Elisa Chiarello verfasserin aut Daniela Chirico verfasserin aut Esther Cisneros-Quirarter verfasserin aut Minor Raul Cordero Bautista verfasserin aut Valeria Cornejo verfasserin aut Baldemar Corral Villegas verfasserin aut Andrés Cortés verfasserin aut Sandra Cortés verfasserin aut Laura Cortes-Sanabria verfasserin aut German Salvador Cortez Zamorano verfasserin aut Alejandro Corvalan verfasserin aut Adolfo Cruz verfasserin aut Alba d'Aurora verfasserin aut Sandra De la Fuente verfasserin aut Soledad De la Peña verfasserin aut Roberto de Leon Caballero verfasserin aut Mirian de Souza verfasserin aut César Del Castillo verfasserin aut Azucena Del-Toro-Valero verfasserin aut Mirtha Di Pretoro verfasserin aut Andrea Digonzelli verfasserin aut Jose El Ters verfasserin aut Paula Escobar verfasserin aut Marcela Estolaza verfasserin aut Adriane Feijo Evangelista verfasserin aut Marcelo Fanelli verfasserin aut Paulo Farias verfasserin aut Graciela Fernandez verfasserin aut José R. Filassi verfasserin aut Natalia Filgueiras verfasserin aut Diego Flaks verfasserin aut Edgar G. Flores-Ayala verfasserin aut Maria R. Flores-Marquez verfasserin aut David Franco Hughes verfasserin aut Karina Franco-Topete verfasserin aut Jimena Freire verfasserin aut Cristobal Fresno verfasserin aut Romina Gabrielli verfasserin aut Mario Gallegos verfasserin aut Jorge Gamboa verfasserin aut Daiana Ganiewich verfasserin aut Carlos Garbovesky verfasserin aut Ruben Alejandro Garcia Munguia verfasserin aut Ricardo Garcia-Gaeta verfasserin aut Alma C. Garcia-Martinez verfasserin aut Liliana Gimenez verfasserin aut Hector Gómez Silveira verfasserin aut Mariana M. Gomez-Del Toro verfasserin aut Marcela Gonzalez verfasserin aut Alicia Gonzalez verfasserin aut Germán González verfasserin aut Cesar Osbaldo Gonzalez Mondaca verfasserin aut Leivy P. Gonzalez-Ramirez verfasserin aut Beatriz Gonzalez-Ulloa verfasserin aut Susana Gorostidy verfasserin aut Mariela Grass verfasserin aut Alfonso G. Guevara Torres verfasserin aut Lorena Gutierrez verfasserin aut Susan A. Gutierrez-Rubio verfasserin aut Adrián Hannois verfasserin aut Andrew Hart verfasserin aut Steffen Härtel verfasserin aut Marcos Henriquez verfasserin aut Rafael Hernandez Guevara verfasserin aut Miriam E. Hernandez-Franco verfasserin aut Manuel I. Herrera-Miramontes verfasserin aut Graciela Horton verfasserin aut Gladys Ibañez verfasserin aut Martín Ipiña verfasserin aut Beatriz Jalfin verfasserin aut Lilian Jara verfasserin aut Raul Jara verfasserin aut Maria Luisa Jaramillo verfasserin aut David Javalera-Castro verfasserin aut Maria Eugenia Jimenez verfasserin aut Hugo Ju verfasserin aut Nazareth Juárez Rusjan verfasserin aut Karen Juneman verfasserin aut Ligia Maria Kerr verfasserin aut Alejandra Krupelis verfasserin aut Flor Esmeralda Larios-Jimenez verfasserin aut Jose Domingo Latorre verfasserin aut Guillermo Laviña verfasserin aut Fernando Lavista verfasserin aut Irma Leticia León Duarte verfasserin aut Alberto Lescano verfasserin aut Verónica Lezano verfasserin aut Rossana Mendoza Lopez verfasserin aut Jose Guillermo Lopez Cervantes verfasserin aut Miguel Enrique Lopez Muñoz verfasserin aut Dora Loria verfasserin aut Alejandra Luque verfasserin aut Alejandro Maass verfasserin aut Maria do Socorro Maciel verfasserin aut Flavia Rotea Mangone verfasserin aut Jorge Mansilla verfasserin aut Katherine Marcelain verfasserin aut Carolina Mariani verfasserin aut Marcia Maria Chiquitelli Marques verfasserin aut Reyna J. Martinez-Arriaga verfasserin aut Hector R. Martinez-Ramirez verfasserin aut Marcela Martins verfasserin aut Alma G. Maya-Gonzalez verfasserin aut Brenda Mazzaferri verfasserin aut Yadira Medina-Mora verfasserin aut Mariana Menini verfasserin aut Silvia Míguez verfasserin aut Soledad Milans verfasserin aut Soledad Montes verfasserin aut Ana Verónica Morales Hernández verfasserin aut Giberto Morga-Villela verfasserin aut Carla Morong verfasserin aut Homero Muñoz verfasserin aut Ignacio Miguel Muse verfasserin aut Carina Mussetti verfasserin aut Eduardo Mussetti verfasserin aut Luis J. Najar-Acosta verfasserin aut Elisa Napolitano e Ferreira verfasserin aut Nancy E. Navarro-Ruiz verfasserin aut Cristina Noblía verfasserin aut João Soares Nunes verfasserin aut Daniela Núñez verfasserin aut Fabiola Núñez verfasserin aut Nilton Onari verfasserin aut Emma M. Oropeza-De Anda verfasserin aut David Ortega Tirado verfasserin aut Cynthia Aparecida Bueno de Toledo Osório verfasserin aut Carlos Eduardo Paiva verfasserin aut Paulina Peñaloza verfasserin aut Miguel Peredo-Navarro verfasserin aut David Pereira verfasserin aut Laura Perez Michel verfasserin aut Francisca Pino verfasserin aut Tania Pino verfasserin aut Natalia Pinto verfasserin aut Jessica Pizarro verfasserin aut Carlos Pressa verfasserin aut Enrique Ramirez verfasserin aut Gladys E. Ramirez-Rosales verfasserin aut Claudia Ramis verfasserin aut Maritza Ramos-Ramirez verfasserin aut Adela Rascon Alcantar verfasserin aut Silvana Ravaglio verfasserin aut Francois Richard verfasserin aut Omar Rios Méndez verfasserin aut Ramón Enrique Robles Zepeda verfasserin aut Iara Santana Rocha verfasserin aut Natalia Rodriguez verfasserin aut Vilma Rodriguez verfasserin aut Maria Teresa Rodriguez verfasserin aut Diego Rodriguez-Gonzalez verfasserin aut Rosemeire A Roela verfasserin aut Ana M Romero-Gomez verfasserin aut Ana M Rosales-Sandoval verfasserin aut Omar V Rubio-Plascencia verfasserin aut Florencia Russo verfasserin aut Gaciela Sabini verfasserin aut Isabel Saffie verfasserin aut Helena Salina Dias verfasserin aut Brenda Guadalupe Samaniego Soto verfasserin aut Julio San Martino verfasserin aut Benito Sanchez-Llamas verfasserin aut Daniel Sat-Muñoz verfasserin aut Mariana Savignano verfasserin aut Cristovam Scapulatempo Neto verfasserin aut Max Mano Senna verfasserin aut Carolina Silva verfasserin aut Jaime Silvera verfasserin aut Isabele Small verfasserin aut Fernando Soares verfasserin aut Iberê Soares verfasserin aut Silvana Soares dos Santos verfasserin aut Evandro Sobrosa de Mello verfasserin aut José Antonio Sola verfasserin aut Irene Sorín verfasserin aut Alejandra Sosa verfasserin aut Anabella Sosa verfasserin aut Claudio Sosa verfasserin aut Sandra Soto verfasserin aut Cristiano de Pádua Souza verfasserin aut Lucía Spangenberg verfasserin aut Gustavo Steffanof verfasserin aut Florencia Straminsky verfasserin aut Mónica Tapia verfasserin aut Raziel O. Tapia-Llanos verfasserin aut Geronimo M. Tavares-Macias verfasserin aut Guillermo Temperley verfasserin aut Veronica Terzieff verfasserin aut Vicente Teti verfasserin aut Javier Tognarelli verfasserin aut Verónica Toledo verfasserin aut Paulina Toro verfasserin aut Roberto Torres verfasserin aut Mariana Torres-Palomares verfasserin aut Rogelio Troyo-San Roman verfasserin aut Hernan Urbano verfasserin aut Nicolas Vacca verfasserin aut Daniel Vaimberg verfasserin aut María Lourdes Valencia Peña verfasserin aut Maria Lujan Vaselevich verfasserin aut Jaime Vazquez-Nares verfasserin aut Ezequiel Velez-Gomez verfasserin aut Laura N. Venegas-Godinez verfasserin aut Patricia Vercelli verfasserin aut Ricardo Verdugo verfasserin aut René Aloisio da Costa Vieira verfasserin aut Marta Vilensky verfasserin aut María José Villarubias verfasserin aut Manuel Isaac Villegas Gómez verfasserin aut Stella Viña verfasserin aut Silvia Vornetti verfasserin aut Anapaula Hidemi Uema Watanabe verfasserin aut Carlos Zamorano verfasserin aut Luis Zapata verfasserin aut Zdenka Zlatar verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.835626 kostenfrei https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 |
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Andrea Sabina Llera @@aut@@ Eliana Saul Furquim Werneck Abdelhay @@aut@@ Nora Artagaveytia @@aut@@ Adrián Daneri-Navarro @@aut@@ Bettina Müller @@aut@@ Carlos Velazquez @@aut@@ Elsa B. Alcoba @@aut@@ Isabel Alonso @@aut@@ Daniela B. Alves da Quinta @@aut@@ Renata Binato @@aut@@ Alicia Inés Bravo @@aut@@ Natalia Camejo @@aut@@ Dirce Maria Carraro @@aut@@ Mónica Castro @@aut@@ Juan M. Castro-Cervantes @@aut@@ Sandra Cataldi @@aut@@ Alfonso Cayota @@aut@@ Mauricio Cerda @@aut@@ Alicia Colombo @@aut@@ Susanne Crocamo @@aut@@ Alicia Del Toro-Arreola @@aut@@ Raúl Delgadillo-Cisterna @@aut@@ Lucía Delgado @@aut@@ Marisa Dreyer-Breitenbach @@aut@@ Laura Fejerman @@aut@@ Elmer A. Fernández @@aut@@ Jorge Fernández @@aut@@ Wanda Fernández @@aut@@ Ramón A. Franco-Topete @@aut@@ Carolina Gabay @@aut@@ Fancy Gaete @@aut@@ Adriana Garibay-Escobar @@aut@@ Jorge Gómez @@aut@@ Gonzalo Greif @@aut@@ Thomas G. Gross @@aut@@ Marisol Guerrero @@aut@@ Marianne K. Henderson @@aut@@ Miguel E. Lopez-Muñoz @@aut@@ Alejandra Lopez-Vazquez @@aut@@ Silvina Maldonado @@aut@@ Andrés J. Morán-Mendoza @@aut@@ Maria Aparecida Nagai @@aut@@ Antonio Oceguera-Villanueva @@aut@@ Miguel A. Ortiz-Martínez @@aut@@ Jael Quintero @@aut@@ Antonio Quintero-Ramos @@aut@@ Rui M. Reis @@aut@@ Javier Retamales @@aut@@ Ernesto Rivera-Claisse @@aut@@ Darío Rocha @@aut@@ Robinson Rodríguez @@aut@@ Cristina Rosales @@aut@@ Efrain Salas-González @@aut@@ Verónica Sanchotena @@aut@@ Laura Segovia @@aut@@ Juan Martín Sendoya @@aut@@ Aida A. Silva-García @@aut@@ Alejandra Trinchero @@aut@@ Olivia Valenzuela @@aut@@ Vidya Vedham @@aut@@ Livia Zagame @@aut@@ United States-Latin American Cancer Research Network (US-LACRN) @@aut@@ Osvaldo L. Podhajcer @@aut@@ Juan Abarca @@aut@@ Pamela Acevedo @@aut@@ Graciela Acosta @@aut@@ Gissel Acosta @@aut@@ Gabriela Acosta Haab @@aut@@ Ana Lilian Acosta Silva @@aut@@ Marta Aghazarian @@aut@@ Carola Aguayo @@aut@@ Bernardo Aizen @@aut@@ Gustavo Alarcon Lopez @@aut@@ Liz Almeida @@aut@@ Ana Alvarez @@aut@@ Viviane Andrade @@aut@@ Wenceslao Angeles-Bueno @@aut@@ Roberto Arai @@aut@@ Priscila Elvira Arambula Barreras @@aut@@ Ma. Isabel Aramburo Rubio @@aut@@ Gonzalo Ardao @@aut@@ Lilia A. Arellano-Jimenez @@aut@@ Claudia Arias @@aut@@ Ricardo Armisen @@aut@@ Mauricio Aspee @@aut@@ Rodrigo Assar @@aut@@ Itzel Reneé Astiazarán Rascón @@aut@@ Sebastian Astorga @@aut@@ Maxwell Aviles Rodriguez @@aut@@ Antônio Bailão Junior @@aut@@ Adolfo E. Barragan-Curiel @@aut@@ Adelfo Barragan-Ruiz @@aut@@ Fernanda Bermudez @@aut@@ Julia Bernachin @@aut@@ Wilfrido Bernal Herrera @@aut@@ Mara Bonet @@aut@@ Sarah Brnich @@aut@@ Claudio Bustamante @@aut@@ Miguel Angel Bustamante @@aut@@ Julio Bustos-Gomez @@aut@@ Felipe de J Bustos-Rodriguez @@aut@@ Janett Caballero Jasso @@aut@@ Angie Calfuman @@aut@@ Antonio Hugo José Froes Marques @@aut@@ Mónica Campos @@aut@@ Soledad Cano @@aut@@ Juan C. Canton-Romero @@aut@@ Ricardo Cappetta @@aut@@ Paulina Carmona @@aut@@ Fernando Carrizo @@aut@@ André Lopes Carvalho @@aut@@ Erika Carvallo @@aut@@ Julio Carzoglio @@aut@@ Monica Casalnuovo @@aut@@ Benedicta Caserta @@aut@@ Alvaro Castillo @@aut@@ César Castillo @@aut@@ Roger Chammas @@aut@@ Mario Alberto Chavez Zamudio @@aut@@ Loreto Chia @@aut@@ Elisa Chiarello @@aut@@ Daniela Chirico @@aut@@ Esther Cisneros-Quirarter @@aut@@ Minor Raul Cordero Bautista @@aut@@ Valeria Cornejo @@aut@@ Baldemar Corral Villegas @@aut@@ Andrés Cortés @@aut@@ Sandra Cortés @@aut@@ Laura Cortes-Sanabria @@aut@@ German Salvador Cortez Zamorano @@aut@@ Alejandro Corvalan @@aut@@ Adolfo Cruz @@aut@@ Alba d'Aurora @@aut@@ Sandra De la Fuente @@aut@@ Soledad De la Peña @@aut@@ Roberto de Leon Caballero @@aut@@ Mirian de Souza @@aut@@ César Del Castillo @@aut@@ Azucena Del-Toro-Valero @@aut@@ Mirtha Di Pretoro @@aut@@ Andrea Digonzelli @@aut@@ Jose El Ters @@aut@@ Paula Escobar @@aut@@ Marcela Estolaza @@aut@@ Adriane Feijo Evangelista @@aut@@ Marcelo Fanelli @@aut@@ Paulo Farias @@aut@@ Graciela Fernandez @@aut@@ José R. Filassi @@aut@@ Natalia Filgueiras @@aut@@ Diego Flaks @@aut@@ Edgar G. Flores-Ayala @@aut@@ Maria R. Flores-Marquez @@aut@@ David Franco Hughes @@aut@@ Karina Franco-Topete @@aut@@ Jimena Freire @@aut@@ Cristobal Fresno @@aut@@ Romina Gabrielli @@aut@@ Mario Gallegos @@aut@@ Jorge Gamboa @@aut@@ Daiana Ganiewich @@aut@@ Carlos Garbovesky @@aut@@ Ruben Alejandro Garcia Munguia @@aut@@ Ricardo Garcia-Gaeta @@aut@@ Alma C. Garcia-Martinez @@aut@@ Liliana Gimenez @@aut@@ Hector Gómez Silveira @@aut@@ Mariana M. Gomez-Del Toro @@aut@@ Marcela Gonzalez @@aut@@ Alicia Gonzalez @@aut@@ Germán González @@aut@@ Cesar Osbaldo Gonzalez Mondaca @@aut@@ Leivy P. Gonzalez-Ramirez @@aut@@ Beatriz Gonzalez-Ulloa @@aut@@ Susana Gorostidy @@aut@@ Mariela Grass @@aut@@ Alfonso G. Guevara Torres @@aut@@ Lorena Gutierrez @@aut@@ Susan A. Gutierrez-Rubio @@aut@@ Adrián Hannois @@aut@@ Andrew Hart @@aut@@ Steffen Härtel @@aut@@ Marcos Henriquez @@aut@@ Rafael Hernandez Guevara @@aut@@ Miriam E. Hernandez-Franco @@aut@@ Manuel I. Herrera-Miramontes @@aut@@ Graciela Horton @@aut@@ Gladys Ibañez @@aut@@ Martín Ipiña @@aut@@ Beatriz Jalfin @@aut@@ Lilian Jara @@aut@@ Raul Jara @@aut@@ Maria Luisa Jaramillo @@aut@@ David Javalera-Castro @@aut@@ Maria Eugenia Jimenez @@aut@@ Hugo Ju @@aut@@ Nazareth Juárez Rusjan @@aut@@ Karen Juneman @@aut@@ Ligia Maria Kerr @@aut@@ Alejandra Krupelis @@aut@@ Flor Esmeralda Larios-Jimenez @@aut@@ Jose Domingo Latorre @@aut@@ Guillermo Laviña @@aut@@ Fernando Lavista @@aut@@ Irma Leticia León Duarte @@aut@@ Alberto Lescano @@aut@@ Verónica Lezano @@aut@@ Rossana Mendoza Lopez @@aut@@ Jose Guillermo Lopez Cervantes @@aut@@ Miguel Enrique Lopez Muñoz @@aut@@ Dora Loria @@aut@@ Alejandra Luque @@aut@@ Alejandro Maass @@aut@@ Maria do Socorro Maciel @@aut@@ Flavia Rotea Mangone @@aut@@ Jorge Mansilla @@aut@@ Katherine Marcelain @@aut@@ Carolina Mariani @@aut@@ Marcia Maria Chiquitelli Marques @@aut@@ Reyna J. Martinez-Arriaga @@aut@@ Hector R. Martinez-Ramirez @@aut@@ Marcela Martins @@aut@@ Alma G. Maya-Gonzalez @@aut@@ Brenda Mazzaferri @@aut@@ Yadira Medina-Mora @@aut@@ Mariana Menini @@aut@@ Silvia Míguez @@aut@@ Soledad Milans @@aut@@ Soledad Montes @@aut@@ Ana Verónica Morales Hernández @@aut@@ Giberto Morga-Villela @@aut@@ Carla Morong @@aut@@ Homero Muñoz @@aut@@ Ignacio Miguel Muse @@aut@@ Carina Mussetti @@aut@@ Eduardo Mussetti @@aut@@ Luis J. Najar-Acosta @@aut@@ Elisa Napolitano e Ferreira @@aut@@ Nancy E. Navarro-Ruiz @@aut@@ Cristina Noblía @@aut@@ João Soares Nunes @@aut@@ Daniela Núñez @@aut@@ Fabiola Núñez @@aut@@ Nilton Onari @@aut@@ Emma M. Oropeza-De Anda @@aut@@ David Ortega Tirado @@aut@@ Cynthia Aparecida Bueno de Toledo Osório @@aut@@ Carlos Eduardo Paiva @@aut@@ Paulina Peñaloza @@aut@@ Miguel Peredo-Navarro @@aut@@ David Pereira @@aut@@ Laura Perez Michel @@aut@@ Francisca Pino @@aut@@ Tania Pino @@aut@@ Natalia Pinto @@aut@@ Jessica Pizarro @@aut@@ Carlos Pressa @@aut@@ Enrique Ramirez @@aut@@ Gladys E. Ramirez-Rosales @@aut@@ Claudia Ramis @@aut@@ Maritza Ramos-Ramirez @@aut@@ Adela Rascon Alcantar @@aut@@ Silvana Ravaglio @@aut@@ Francois Richard @@aut@@ Omar Rios Méndez @@aut@@ Ramón Enrique Robles Zepeda @@aut@@ Iara Santana Rocha @@aut@@ Natalia Rodriguez @@aut@@ Vilma Rodriguez @@aut@@ Maria Teresa Rodriguez @@aut@@ Diego Rodriguez-Gonzalez @@aut@@ Rosemeire A Roela @@aut@@ Ana M Romero-Gomez @@aut@@ Ana M Rosales-Sandoval @@aut@@ Omar V Rubio-Plascencia @@aut@@ Florencia Russo @@aut@@ Gaciela Sabini @@aut@@ Isabel Saffie @@aut@@ Helena Salina Dias @@aut@@ Brenda Guadalupe Samaniego Soto @@aut@@ Julio San Martino @@aut@@ Benito Sanchez-Llamas @@aut@@ Daniel Sat-Muñoz @@aut@@ Mariana Savignano @@aut@@ Cristovam Scapulatempo Neto @@aut@@ Max Mano Senna @@aut@@ Carolina Silva @@aut@@ Jaime Silvera @@aut@@ Isabele Small @@aut@@ Fernando Soares @@aut@@ Iberê Soares @@aut@@ Silvana Soares dos Santos @@aut@@ Evandro Sobrosa de Mello @@aut@@ José Antonio Sola @@aut@@ Irene Sorín @@aut@@ Alejandra Sosa @@aut@@ Anabella Sosa @@aut@@ Claudio Sosa @@aut@@ Sandra Soto @@aut@@ Cristiano de Pádua Souza @@aut@@ Lucía Spangenberg @@aut@@ Gustavo Steffanof @@aut@@ Florencia Straminsky @@aut@@ Mónica Tapia @@aut@@ Raziel O. Tapia-Llanos @@aut@@ Geronimo M. Tavares-Macias @@aut@@ Guillermo Temperley @@aut@@ Veronica Terzieff @@aut@@ Vicente Teti @@aut@@ Javier Tognarelli @@aut@@ Verónica Toledo @@aut@@ Paulina Toro @@aut@@ Roberto Torres @@aut@@ Mariana Torres-Palomares @@aut@@ Rogelio Troyo-San Roman @@aut@@ Hernan Urbano @@aut@@ Nicolas Vacca @@aut@@ Daniel Vaimberg @@aut@@ María Lourdes Valencia Peña @@aut@@ Maria Lujan Vaselevich @@aut@@ Jaime Vazquez-Nares @@aut@@ Ezequiel Velez-Gomez @@aut@@ Laura N. Venegas-Godinez @@aut@@ Patricia Vercelli @@aut@@ Ricardo Verdugo @@aut@@ René Aloisio da Costa Vieira @@aut@@ Marta Vilensky @@aut@@ María José Villarubias @@aut@@ Manuel Isaac Villegas Gómez @@aut@@ Stella Viña @@aut@@ Silvia Vornetti @@aut@@ Anapaula Hidemi Uema Watanabe @@aut@@ Carlos Zamorano @@aut@@ Luis Zapata @@aut@@ Zdenka Zlatar @@aut@@ |
publishDateDaySort_date |
2022-01-01T00:00:00Z |
hierarchy_top_id |
684965518 |
id |
DOAJ064322157 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ064322157</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309035341.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fonc.2022.835626</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ064322157</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ0b418eab6e3842b191a694b2962d0b6e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Andrea Sabina Llera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">breast cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Latin America</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PAM50 subtypes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">risk of recurrence</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">biological pathways</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eliana Saul Furquim Werneck Abdelhay</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nora Artagaveytia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adrián Daneri-Navarro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bettina Müller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Velazquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elsa B. Alcoba</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isabel Alonso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela B. Alves da Quinta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela B. 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Silva-García</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Trinchero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olivia Valenzuela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vidya Vedham</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Livia Zagame</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">United States-Latin American Cancer Research Network (US-LACRN)</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Osvaldo L. Podhajcer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan Abarca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pamela Acevedo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Acosta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gissel Acosta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela Acosta Haab</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Lilian Acosta Silva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Aghazarian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carola Aguayo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bernardo Aizen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Alarcon Lopez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liz Almeida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Alvarez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Viviane Andrade</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wenceslao Angeles-Bueno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Arai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Priscila Elvira Arambula Barreras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ma. Isabel Aramburo Rubio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gonzalo Ardao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilia A. Arellano-Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudia Arias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Armisen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauricio Aspee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rodrigo Assar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Itzel Reneé Astiazarán Rascón</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sebastian Astorga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maxwell Aviles Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antônio Bailão Junior</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adolfo E. Barragan-Curiel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adelfo Barragan-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernanda Bermudez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Bernachin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wilfrido Bernal Herrera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mara Bonet</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarah Brnich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Bustamante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel Angel Bustamante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julio Bustos-Gomez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Felipe de J Bustos-Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Janett Caballero Jasso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angie Calfuman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Hugo José Froes Marques</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Campos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Cano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan C. Canton-Romero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Cappetta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paulina Carmona</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernando Carrizo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">André Lopes Carvalho</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erika Carvallo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julio Carzoglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monica Casalnuovo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benedicta Caserta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alvaro Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">César Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roger Chammas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mario Alberto Chavez Zamudio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loreto Chia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisa Chiarello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Chirico</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Esther Cisneros-Quirarter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Minor Raul Cordero Bautista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Valeria Cornejo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baldemar Corral Villegas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrés Cortés</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra Cortés</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Cortes-Sanabria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">German Salvador Cortez Zamorano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandro Corvalan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adolfo Cruz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alba d'Aurora</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra De la Fuente</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad De la Peña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto de Leon Caballero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mirian de Souza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">César Del Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azucena Del-Toro-Valero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mirtha Di Pretoro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Digonzelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose El Ters</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paula Escobar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Estolaza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adriane Feijo Evangelista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcelo Fanelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paulo Farias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Fernandez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José R. Filassi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Filgueiras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Diego Flaks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edgar G. Flores-Ayala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria R. Flores-Marquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Franco Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karina Franco-Topete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jimena Freire</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristobal Fresno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Romina Gabrielli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mario Gallegos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Gamboa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daiana Ganiewich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Garbovesky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruben Alejandro Garcia Munguia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Garcia-Gaeta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alma C. Garcia-Martinez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liliana Gimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hector Gómez Silveira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariana M. Gomez-Del Toro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicia Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Germán González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cesar Osbaldo Gonzalez Mondaca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leivy P. Gonzalez-Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatriz Gonzalez-Ulloa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susana Gorostidy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariela Grass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alfonso G. Guevara Torres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorena Gutierrez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan A. Gutierrez-Rubio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adrián Hannois</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew Hart</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steffen Härtel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcos Henriquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafael Hernandez Guevara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miriam E. Hernandez-Franco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manuel I. Herrera-Miramontes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Horton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gladys Ibañez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Martín Ipiña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatriz Jalfin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilian Jara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raul Jara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Luisa Jaramillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Javalera-Castro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Eugenia Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hugo Ju</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nazareth Juárez Rusjan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karen Juneman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ligia Maria Kerr</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Krupelis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Flor Esmeralda Larios-Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Domingo Latorre</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guillermo Laviña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernando Lavista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Irma Leticia León Duarte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alberto Lescano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Verónica Lezano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossana Mendoza Lopez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Guillermo Lopez Cervantes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel Enrique Lopez Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dora Loria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Luque</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandro Maass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria do Socorro Maciel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Flavia Rotea Mangone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Mansilla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katherine Marcelain</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Mariani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcia Maria Chiquitelli Marques</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Reyna J. Martinez-Arriaga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hector R. Martinez-Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Martins</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alma G. Maya-Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brenda Mazzaferri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yadira Medina-Mora</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariana Menini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Míguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Milans</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Montes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Verónica Morales Hernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giberto Morga-Villela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carla Morong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Homero Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ignacio Miguel Muse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carina Mussetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eduardo Mussetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luis J. Najar-Acosta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisa Napolitano e Ferreira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nancy E. Navarro-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristina Noblía</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">João Soares Nunes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Núñez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fabiola Núñez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nilton Onari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emma M. Oropeza-De Anda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Ortega Tirado</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cynthia Aparecida Bueno de Toledo Osório</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Eduardo Paiva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paulina Peñaloza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel Peredo-Navarro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Pereira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Perez Michel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francisca Pino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tania Pino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Pinto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jessica Pizarro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Pressa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Enrique Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gladys E. Ramirez-Rosales</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudia Ramis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maritza Ramos-Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adela Rascon Alcantar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvana Ravaglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francois Richard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Omar Rios Méndez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ramón Enrique Robles Zepeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Iara Santana Rocha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vilma Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Teresa Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Diego Rodriguez-Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rosemeire A Roela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana M Romero-Gomez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana M Rosales-Sandoval</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Omar V Rubio-Plascencia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Florencia Russo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaciela Sabini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isabel Saffie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Helena Salina Dias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brenda Guadalupe Samaniego Soto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julio San Martino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benito Sanchez-Llamas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel Sat-Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariana Savignano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristovam Scapulatempo Neto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Max Mano Senna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Silva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jaime Silvera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isabele Small</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernando Soares</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Iberê Soares</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvana Soares dos Santos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Evandro Sobrosa de Mello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José Antonio Sola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Irene Sorín</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Sosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anabella Sosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Sosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra Soto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristiano de Pádua Souza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lucía Spangenberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Steffanof</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Florencia Straminsky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Tapia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" 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RC254-282 The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients breast cancer Latin America PAM50 subtypes risk of recurrence biological pathways |
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The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients |
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The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients |
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Andrea Sabina Llera Eliana Saul Furquim Werneck Abdelhay Nora Artagaveytia Adrián Daneri-Navarro Bettina Müller Carlos Velazquez Elsa B. Alcoba Isabel Alonso Daniela B. Alves da Quinta Renata Binato Alicia Inés Bravo Natalia Camejo Dirce Maria Carraro Mónica Castro Juan M. Castro-Cervantes Sandra Cataldi Alfonso Cayota Mauricio Cerda Alicia Colombo Susanne Crocamo Alicia Del Toro-Arreola Raúl Delgadillo-Cisterna Lucía Delgado Marisa Dreyer-Breitenbach Laura Fejerman Elmer A. Fernández Jorge Fernández Wanda Fernández Ramón A. Franco-Topete Carolina Gabay Fancy Gaete Adriana Garibay-Escobar Jorge Gómez Gonzalo Greif Thomas G. Gross Marisol Guerrero Marianne K. Henderson Miguel E. Lopez-Muñoz Alejandra Lopez-Vazquez Silvina Maldonado Andrés J. Morán-Mendoza Maria Aparecida Nagai Antonio Oceguera-Villanueva Miguel A. Ortiz-Martínez Jael Quintero Antonio Quintero-Ramos Rui M. Reis Javier Retamales Ernesto Rivera-Claisse Darío Rocha Robinson Rodríguez Cristina Rosales Efrain Salas-González Verónica Sanchotena Laura Segovia Juan Martín Sendoya Aida A. Silva-García Alejandra Trinchero Olivia Valenzuela Vidya Vedham Livia Zagame United States-Latin American Cancer Research Network (US-LACRN) Osvaldo L. Podhajcer Juan Abarca Pamela Acevedo Graciela Acosta Gissel Acosta Gabriela Acosta Haab Ana Lilian Acosta Silva Marta Aghazarian Carola Aguayo Bernardo Aizen Gustavo Alarcon Lopez Liz Almeida Ana Alvarez Viviane Andrade Wenceslao Angeles-Bueno Roberto Arai Priscila Elvira Arambula Barreras Ma. Isabel Aramburo Rubio Gonzalo Ardao Lilia A. Arellano-Jimenez Claudia Arias Ricardo Armisen Mauricio Aspee Rodrigo Assar Itzel Reneé Astiazarán Rascón Sebastian Astorga Maxwell Aviles Rodriguez Antônio Bailão Junior Adolfo E. Barragan-Curiel Adelfo Barragan-Ruiz Fernanda Bermudez Julia Bernachin Wilfrido Bernal Herrera Mara Bonet Sarah Brnich Claudio Bustamante Miguel Angel Bustamante Julio Bustos-Gomez Felipe de J Bustos-Rodriguez Janett Caballero Jasso Angie Calfuman Antonio Hugo José Froes Marques Mónica Campos Soledad Cano Juan C. Canton-Romero Ricardo Cappetta Paulina Carmona Fernando Carrizo André Lopes Carvalho Erika Carvallo Julio Carzoglio Monica Casalnuovo Benedicta Caserta Alvaro Castillo César Castillo Roger Chammas Mario Alberto Chavez Zamudio Loreto Chia Elisa Chiarello Daniela Chirico Esther Cisneros-Quirarter Minor Raul Cordero Bautista Valeria Cornejo Baldemar Corral Villegas Andrés Cortés Sandra Cortés Laura Cortes-Sanabria German Salvador Cortez Zamorano Alejandro Corvalan Adolfo Cruz Alba d'Aurora Sandra De la Fuente Soledad De la Peña Roberto de Leon Caballero Mirian de Souza César Del Castillo Azucena Del-Toro-Valero Mirtha Di Pretoro Andrea Digonzelli Jose El Ters Paula Escobar Marcela Estolaza Adriane Feijo Evangelista Marcelo Fanelli Paulo Farias Graciela Fernandez José R. Filassi Natalia Filgueiras Diego Flaks Edgar G. Flores-Ayala Maria R. Flores-Marquez David Franco Hughes Karina Franco-Topete Jimena Freire Cristobal Fresno Romina Gabrielli Mario Gallegos Jorge Gamboa Daiana Ganiewich Carlos Garbovesky Ruben Alejandro Garcia Munguia Ricardo Garcia-Gaeta Alma C. Garcia-Martinez Liliana Gimenez Hector Gómez Silveira Mariana M. Gomez-Del Toro Marcela Gonzalez Alicia Gonzalez Germán González Cesar Osbaldo Gonzalez Mondaca Leivy P. Gonzalez-Ramirez Beatriz Gonzalez-Ulloa Susana Gorostidy Mariela Grass Alfonso G. Guevara Torres Lorena Gutierrez Susan A. Gutierrez-Rubio Adrián Hannois Andrew Hart Steffen Härtel Marcos Henriquez Rafael Hernandez Guevara Miriam E. Hernandez-Franco Manuel I. Herrera-Miramontes Graciela Horton Gladys Ibañez Martín Ipiña Beatriz Jalfin Lilian Jara Raul Jara Maria Luisa Jaramillo David Javalera-Castro Maria Eugenia Jimenez Hugo Ju Nazareth Juárez Rusjan Karen Juneman Ligia Maria Kerr Alejandra Krupelis Flor Esmeralda Larios-Jimenez Jose Domingo Latorre Guillermo Laviña Fernando Lavista Irma Leticia León Duarte Alberto Lescano Verónica Lezano Rossana Mendoza Lopez Jose Guillermo Lopez Cervantes Miguel Enrique Lopez Muñoz Dora Loria Alejandra Luque Alejandro Maass Maria do Socorro Maciel Flavia Rotea Mangone Jorge Mansilla Katherine Marcelain Carolina Mariani Marcia Maria Chiquitelli Marques Reyna J. Martinez-Arriaga Hector R. Martinez-Ramirez Marcela Martins Alma G. Maya-Gonzalez Brenda Mazzaferri Yadira Medina-Mora Mariana Menini Silvia Míguez Soledad Milans Soledad Montes Ana Verónica Morales Hernández Giberto Morga-Villela Carla Morong Homero Muñoz Ignacio Miguel Muse Carina Mussetti Eduardo Mussetti Luis J. Najar-Acosta Elisa Napolitano e Ferreira Nancy E. Navarro-Ruiz Cristina Noblía João Soares Nunes Daniela Núñez Fabiola Núñez Nilton Onari Emma M. Oropeza-De Anda David Ortega Tirado Cynthia Aparecida Bueno de Toledo Osório Carlos Eduardo Paiva Paulina Peñaloza Miguel Peredo-Navarro David Pereira Laura Perez Michel Francisca Pino Tania Pino Natalia Pinto Jessica Pizarro Carlos Pressa Enrique Ramirez Gladys E. Ramirez-Rosales Claudia Ramis Maritza Ramos-Ramirez Adela Rascon Alcantar Silvana Ravaglio Francois Richard Omar Rios Méndez Ramón Enrique Robles Zepeda Iara Santana Rocha Natalia Rodriguez Vilma Rodriguez Maria Teresa Rodriguez Diego Rodriguez-Gonzalez Rosemeire A Roela Ana M Romero-Gomez Ana M Rosales-Sandoval Omar V Rubio-Plascencia Florencia Russo Gaciela Sabini Isabel Saffie Helena Salina Dias Brenda Guadalupe Samaniego Soto Julio San Martino Benito Sanchez-Llamas Daniel Sat-Muñoz Mariana Savignano Cristovam Scapulatempo Neto Max Mano Senna Carolina Silva Jaime Silvera Isabele Small Fernando Soares Iberê Soares Silvana Soares dos Santos Evandro Sobrosa de Mello José Antonio Sola Irene Sorín Alejandra Sosa Anabella Sosa Claudio Sosa Sandra Soto Cristiano de Pádua Souza Lucía Spangenberg Gustavo Steffanof Florencia Straminsky Mónica Tapia Raziel O. Tapia-Llanos Geronimo M. Tavares-Macias Guillermo Temperley Veronica Terzieff Vicente Teti Javier Tognarelli Verónica Toledo Paulina Toro Roberto Torres Mariana Torres-Palomares Rogelio Troyo-San Roman Hernan Urbano Nicolas Vacca Daniel Vaimberg María Lourdes Valencia Peña Maria Lujan Vaselevich Jaime Vazquez-Nares Ezequiel Velez-Gomez Laura N. Venegas-Godinez Patricia Vercelli Ricardo Verdugo René Aloisio da Costa Vieira Marta Vilensky María José Villarubias Manuel Isaac Villegas Gómez Stella Viña Silvia Vornetti Anapaula Hidemi Uema Watanabe Carlos Zamorano Luis Zapata Zdenka Zlatar |
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Elektronische Aufsätze |
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Andrea Sabina Llera |
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10.3389/fonc.2022.835626 |
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verfasserin |
title_sort |
transcriptomic portrait of locally advanced breast cancer and its prognostic value in a multi-country cohort of latin american patients |
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RC254-282 |
title_auth |
The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients |
abstract |
PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). |
abstractGer |
PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). |
abstract_unstemmed |
PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857). |
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The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients |
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https://doi.org/10.3389/fonc.2022.835626 https://doaj.org/article/0b418eab6e3842b191a694b2962d0b6e https://www.frontiersin.org/articles/10.3389/fonc.2022.835626/full https://doaj.org/toc/2234-943X |
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Eliana Saul Furquim Werneck Abdelhay Nora Artagaveytia Adrián Daneri-Navarro Bettina Müller Carlos Velazquez Elsa B. Alcoba Isabel Alonso Daniela B. Alves da Quinta Renata Binato Alicia Inés Bravo Natalia Camejo Dirce Maria Carraro Mónica Castro Juan M. Castro-Cervantes Sandra Cataldi Alfonso Cayota Mauricio Cerda Alicia Colombo Susanne Crocamo Alicia Del Toro-Arreola Raúl Delgadillo-Cisterna Lucía Delgado Marisa Dreyer-Breitenbach Laura Fejerman Elmer A. Fernández Jorge Fernández Wanda Fernández Ramón A. Franco-Topete Carolina Gabay Fancy Gaete Adriana Garibay-Escobar Jorge Gómez Gonzalo Greif Thomas G. Gross Marisol Guerrero Marianne K. Henderson Miguel E. Lopez-Muñoz Alejandra Lopez-Vazquez Silvina Maldonado Andrés J. Morán-Mendoza Maria Aparecida Nagai Antonio Oceguera-Villanueva Miguel A. Ortiz-Martínez Jael Quintero Antonio Quintero-Ramos Rui M. Reis Javier Retamales Ernesto Rivera-Claisse Darío Rocha Robinson Rodríguez Cristina Rosales Efrain Salas-González Verónica Sanchotena Laura Segovia Juan Martín Sendoya Aida A. Silva-García Alejandra Trinchero Olivia Valenzuela Vidya Vedham Livia Zagame United States-Latin American Cancer Research Network (US-LACRN) Osvaldo L. Podhajcer Juan Abarca Pamela Acevedo Graciela Acosta Gissel Acosta Gabriela Acosta Haab Ana Lilian Acosta Silva Marta Aghazarian Carola Aguayo Bernardo Aizen Gustavo Alarcon Lopez Liz Almeida Ana Alvarez Viviane Andrade Wenceslao Angeles-Bueno Roberto Arai Priscila Elvira Arambula Barreras Ma. Isabel Aramburo Rubio Gonzalo Ardao Lilia A. Arellano-Jimenez Claudia Arias Ricardo Armisen Mauricio Aspee Rodrigo Assar Itzel Reneé Astiazarán Rascón Sebastian Astorga Maxwell Aviles Rodriguez Antônio Bailão Junior Adolfo E. Barragan-Curiel Adelfo Barragan-Ruiz Fernanda Bermudez Julia Bernachin Wilfrido Bernal Herrera Mara Bonet Sarah Brnich Claudio Bustamante Miguel Angel Bustamante Julio Bustos-Gomez Felipe de J Bustos-Rodriguez Janett Caballero Jasso Angie Calfuman Antonio Hugo José Froes Marques Mónica Campos Soledad Cano Juan C. Canton-Romero Ricardo Cappetta Paulina Carmona Fernando Carrizo André Lopes Carvalho Erika Carvallo Julio Carzoglio Monica Casalnuovo Benedicta Caserta Alvaro Castillo César Castillo Roger Chammas Mario Alberto Chavez Zamudio Loreto Chia Elisa Chiarello Daniela Chirico Esther Cisneros-Quirarter Minor Raul Cordero Bautista Valeria Cornejo Baldemar Corral Villegas Andrés Cortés Sandra Cortés Laura Cortes-Sanabria German Salvador Cortez Zamorano Alejandro Corvalan Adolfo Cruz Alba d'Aurora Sandra De la Fuente Soledad De la Peña Roberto de Leon Caballero Mirian de Souza César Del Castillo Azucena Del-Toro-Valero Mirtha Di Pretoro Andrea Digonzelli Jose El Ters Paula Escobar Marcela Estolaza Adriane Feijo Evangelista Marcelo Fanelli Paulo Farias Graciela Fernandez José R. Filassi Natalia Filgueiras Diego Flaks Edgar G. Flores-Ayala Maria R. Flores-Marquez David Franco Hughes Karina Franco-Topete Jimena Freire Cristobal Fresno Romina Gabrielli Mario Gallegos Jorge Gamboa Daiana Ganiewich Carlos Garbovesky Ruben Alejandro Garcia Munguia Ricardo Garcia-Gaeta Alma C. Garcia-Martinez Liliana Gimenez Hector Gómez Silveira Mariana M. Gomez-Del Toro Marcela Gonzalez Alicia Gonzalez Germán González Cesar Osbaldo Gonzalez Mondaca Leivy P. Gonzalez-Ramirez Beatriz Gonzalez-Ulloa Susana Gorostidy Mariela Grass Alfonso G. Guevara Torres Lorena Gutierrez Susan A. Gutierrez-Rubio Adrián Hannois Andrew Hart Steffen Härtel Marcos Henriquez Rafael Hernandez Guevara Miriam E. Hernandez-Franco Manuel I. Herrera-Miramontes Graciela Horton Gladys Ibañez Martín Ipiña Beatriz Jalfin Lilian Jara Raul Jara Maria Luisa Jaramillo David Javalera-Castro Maria Eugenia Jimenez Hugo Ju Nazareth Juárez Rusjan Karen Juneman Ligia Maria Kerr Alejandra Krupelis Flor Esmeralda Larios-Jimenez Jose Domingo Latorre Guillermo Laviña Fernando Lavista Irma Leticia León Duarte Alberto Lescano Verónica Lezano Rossana Mendoza Lopez Jose Guillermo Lopez Cervantes Miguel Enrique Lopez Muñoz Dora Loria Alejandra Luque Alejandro Maass Maria do Socorro Maciel Flavia Rotea Mangone Jorge Mansilla Katherine Marcelain Carolina Mariani Marcia Maria Chiquitelli Marques Reyna J. Martinez-Arriaga Hector R. Martinez-Ramirez Marcela Martins Alma G. Maya-Gonzalez Brenda Mazzaferri Yadira Medina-Mora Mariana Menini Silvia Míguez Soledad Milans Soledad Montes Ana Verónica Morales Hernández Giberto Morga-Villela Carla Morong Homero Muñoz Ignacio Miguel Muse Carina Mussetti Eduardo Mussetti Luis J. Najar-Acosta Elisa Napolitano e Ferreira Nancy E. Navarro-Ruiz Cristina Noblía João Soares Nunes Daniela Núñez Fabiola Núñez Nilton Onari Emma M. Oropeza-De Anda David Ortega Tirado Cynthia Aparecida Bueno de Toledo Osório Carlos Eduardo Paiva Paulina Peñaloza Miguel Peredo-Navarro David Pereira Laura Perez Michel Francisca Pino Tania Pino Natalia Pinto Jessica Pizarro Carlos Pressa Enrique Ramirez Gladys E. Ramirez-Rosales Claudia Ramis Maritza Ramos-Ramirez Adela Rascon Alcantar Silvana Ravaglio Francois Richard Omar Rios Méndez Ramón Enrique Robles Zepeda Iara Santana Rocha Natalia Rodriguez Vilma Rodriguez Maria Teresa Rodriguez Diego Rodriguez-Gonzalez Rosemeire A Roela Ana M Romero-Gomez Ana M Rosales-Sandoval Omar V Rubio-Plascencia Florencia Russo Gaciela Sabini Isabel Saffie Helena Salina Dias Brenda Guadalupe Samaniego Soto Julio San Martino Benito Sanchez-Llamas Daniel Sat-Muñoz Mariana Savignano Cristovam Scapulatempo Neto Max Mano Senna Carolina Silva Jaime Silvera Isabele Small Fernando Soares Iberê Soares Silvana Soares dos Santos Evandro Sobrosa de Mello José Antonio Sola Irene Sorín Alejandra Sosa Anabella Sosa Claudio Sosa Sandra Soto Cristiano de Pádua Souza Lucía Spangenberg Gustavo Steffanof Florencia Straminsky Mónica Tapia Raziel O. Tapia-Llanos Geronimo M. Tavares-Macias Guillermo Temperley Veronica Terzieff Vicente Teti Javier Tognarelli Verónica Toledo Paulina Toro Roberto Torres Mariana Torres-Palomares Rogelio Troyo-San Roman Hernan Urbano Nicolas Vacca Daniel Vaimberg María Lourdes Valencia Peña Maria Lujan Vaselevich Jaime Vazquez-Nares Ezequiel Velez-Gomez Laura N. Venegas-Godinez Patricia Vercelli Ricardo Verdugo René Aloisio da Costa Vieira Marta Vilensky María José Villarubias Manuel Isaac Villegas Gómez Stella Viña Silvia Vornetti Anapaula Hidemi Uema Watanabe Carlos Zamorano Luis Zapata Zdenka Zlatar |
author2Str |
Eliana Saul Furquim Werneck Abdelhay Nora Artagaveytia Adrián Daneri-Navarro Bettina Müller Carlos Velazquez Elsa B. Alcoba Isabel Alonso Daniela B. Alves da Quinta Renata Binato Alicia Inés Bravo Natalia Camejo Dirce Maria Carraro Mónica Castro Juan M. Castro-Cervantes Sandra Cataldi Alfonso Cayota Mauricio Cerda Alicia Colombo Susanne Crocamo Alicia Del Toro-Arreola Raúl Delgadillo-Cisterna Lucía Delgado Marisa Dreyer-Breitenbach Laura Fejerman Elmer A. Fernández Jorge Fernández Wanda Fernández Ramón A. Franco-Topete Carolina Gabay Fancy Gaete Adriana Garibay-Escobar Jorge Gómez Gonzalo Greif Thomas G. Gross Marisol Guerrero Marianne K. Henderson Miguel E. Lopez-Muñoz Alejandra Lopez-Vazquez Silvina Maldonado Andrés J. Morán-Mendoza Maria Aparecida Nagai Antonio Oceguera-Villanueva Miguel A. Ortiz-Martínez Jael Quintero Antonio Quintero-Ramos Rui M. Reis Javier Retamales Ernesto Rivera-Claisse Darío Rocha Robinson Rodríguez Cristina Rosales Efrain Salas-González Verónica Sanchotena Laura Segovia Juan Martín Sendoya Aida A. Silva-García Alejandra Trinchero Olivia Valenzuela Vidya Vedham Livia Zagame United States-Latin American Cancer Research Network (US-LACRN) Osvaldo L. Podhajcer Juan Abarca Pamela Acevedo Graciela Acosta Gissel Acosta Gabriela Acosta Haab Ana Lilian Acosta Silva Marta Aghazarian Carola Aguayo Bernardo Aizen Gustavo Alarcon Lopez Liz Almeida Ana Alvarez Viviane Andrade Wenceslao Angeles-Bueno Roberto Arai Priscila Elvira Arambula Barreras Ma. Isabel Aramburo Rubio Gonzalo Ardao Lilia A. Arellano-Jimenez Claudia Arias Ricardo Armisen Mauricio Aspee Rodrigo Assar Itzel Reneé Astiazarán Rascón Sebastian Astorga Maxwell Aviles Rodriguez Antônio Bailão Junior Adolfo E. Barragan-Curiel Adelfo Barragan-Ruiz Fernanda Bermudez Julia Bernachin Wilfrido Bernal Herrera Mara Bonet Sarah Brnich Claudio Bustamante Miguel Angel Bustamante Julio Bustos-Gomez Felipe de J Bustos-Rodriguez Janett Caballero Jasso Angie Calfuman Antonio Hugo José Froes Marques Mónica Campos Soledad Cano Juan C. Canton-Romero Ricardo Cappetta Paulina Carmona Fernando Carrizo André Lopes Carvalho Erika Carvallo Julio Carzoglio Monica Casalnuovo Benedicta Caserta Alvaro Castillo César Castillo Roger Chammas Mario Alberto Chavez Zamudio Loreto Chia Elisa Chiarello Daniela Chirico Esther Cisneros-Quirarter Minor Raul Cordero Bautista Valeria Cornejo Baldemar Corral Villegas Andrés Cortés Sandra Cortés Laura Cortes-Sanabria German Salvador Cortez Zamorano Alejandro Corvalan Adolfo Cruz Alba d'Aurora Sandra De la Fuente Soledad De la Peña Roberto de Leon Caballero Mirian de Souza César Del Castillo Azucena Del-Toro-Valero Mirtha Di Pretoro Andrea Digonzelli Jose El Ters Paula Escobar Marcela Estolaza Adriane Feijo Evangelista Marcelo Fanelli Paulo Farias Graciela Fernandez José R. Filassi Natalia Filgueiras Diego Flaks Edgar G. Flores-Ayala Maria R. Flores-Marquez David Franco Hughes Karina Franco-Topete Jimena Freire Cristobal Fresno Romina Gabrielli Mario Gallegos Jorge Gamboa Daiana Ganiewich Carlos Garbovesky Ruben Alejandro Garcia Munguia Ricardo Garcia-Gaeta Alma C. Garcia-Martinez Liliana Gimenez Hector Gómez Silveira Mariana M. Gomez-Del Toro Marcela Gonzalez Alicia Gonzalez Germán González Cesar Osbaldo Gonzalez Mondaca Leivy P. Gonzalez-Ramirez Beatriz Gonzalez-Ulloa Susana Gorostidy Mariela Grass Alfonso G. Guevara Torres Lorena Gutierrez Susan A. Gutierrez-Rubio Adrián Hannois Andrew Hart Steffen Härtel Marcos Henriquez Rafael Hernandez Guevara Miriam E. Hernandez-Franco Manuel I. Herrera-Miramontes Graciela Horton Gladys Ibañez Martín Ipiña Beatriz Jalfin Lilian Jara Raul Jara Maria Luisa Jaramillo David Javalera-Castro Maria Eugenia Jimenez Hugo Ju Nazareth Juárez Rusjan Karen Juneman Ligia Maria Kerr Alejandra Krupelis Flor Esmeralda Larios-Jimenez Jose Domingo Latorre Guillermo Laviña Fernando Lavista Irma Leticia León Duarte Alberto Lescano Verónica Lezano Rossana Mendoza Lopez Jose Guillermo Lopez Cervantes Miguel Enrique Lopez Muñoz Dora Loria Alejandra Luque Alejandro Maass Maria do Socorro Maciel Flavia Rotea Mangone Jorge Mansilla Katherine Marcelain Carolina Mariani Marcia Maria Chiquitelli Marques Reyna J. Martinez-Arriaga Hector R. Martinez-Ramirez Marcela Martins Alma G. Maya-Gonzalez Brenda Mazzaferri Yadira Medina-Mora Mariana Menini Silvia Míguez Soledad Milans Soledad Montes Ana Verónica Morales Hernández Giberto Morga-Villela Carla Morong Homero Muñoz Ignacio Miguel Muse Carina Mussetti Eduardo Mussetti Luis J. Najar-Acosta Elisa Napolitano e Ferreira Nancy E. Navarro-Ruiz Cristina Noblía João Soares Nunes Daniela Núñez Fabiola Núñez Nilton Onari Emma M. Oropeza-De Anda David Ortega Tirado Cynthia Aparecida Bueno de Toledo Osório Carlos Eduardo Paiva Paulina Peñaloza Miguel Peredo-Navarro David Pereira Laura Perez Michel Francisca Pino Tania Pino Natalia Pinto Jessica Pizarro Carlos Pressa Enrique Ramirez Gladys E. Ramirez-Rosales Claudia Ramis Maritza Ramos-Ramirez Adela Rascon Alcantar Silvana Ravaglio Francois Richard Omar Rios Méndez Ramón Enrique Robles Zepeda Iara Santana Rocha Natalia Rodriguez Vilma Rodriguez Maria Teresa Rodriguez Diego Rodriguez-Gonzalez Rosemeire A Roela Ana M Romero-Gomez Ana M Rosales-Sandoval Omar V Rubio-Plascencia Florencia Russo Gaciela Sabini Isabel Saffie Helena Salina Dias Brenda Guadalupe Samaniego Soto Julio San Martino Benito Sanchez-Llamas Daniel Sat-Muñoz Mariana Savignano Cristovam Scapulatempo Neto Max Mano Senna Carolina Silva Jaime Silvera Isabele Small Fernando Soares Iberê Soares Silvana Soares dos Santos Evandro Sobrosa de Mello José Antonio Sola Irene Sorín Alejandra Sosa Anabella Sosa Claudio Sosa Sandra Soto Cristiano de Pádua Souza Lucía Spangenberg Gustavo Steffanof Florencia Straminsky Mónica Tapia Raziel O. Tapia-Llanos Geronimo M. Tavares-Macias Guillermo Temperley Veronica Terzieff Vicente Teti Javier Tognarelli Verónica Toledo Paulina Toro Roberto Torres Mariana Torres-Palomares Rogelio Troyo-San Roman Hernan Urbano Nicolas Vacca Daniel Vaimberg María Lourdes Valencia Peña Maria Lujan Vaselevich Jaime Vazquez-Nares Ezequiel Velez-Gomez Laura N. Venegas-Godinez Patricia Vercelli Ricardo Verdugo René Aloisio da Costa Vieira Marta Vilensky María José Villarubias Manuel Isaac Villegas Gómez Stella Viña Silvia Vornetti Anapaula Hidemi Uema Watanabe Carlos Zamorano Luis Zapata Zdenka Zlatar |
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Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. 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Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eliana Saul Furquim Werneck Abdelhay</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nora Artagaveytia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adrián Daneri-Navarro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bettina Müller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Velazquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elsa B. Alcoba</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isabel Alonso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela B. Alves da Quinta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela B. Alves da Quinta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Renata Binato</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicia Inés Bravo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Camejo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dirce Maria Carraro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Castro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan M. Castro-Cervantes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra Cataldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alfonso Cayota</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauricio Cerda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicia Colombo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susanne Crocamo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicia Del Toro-Arreola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raúl Delgadillo-Cisterna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lucía Delgado</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marisa Dreyer-Breitenbach</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Fejerman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elmer A. Fernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elmer A. Fernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Fernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wanda Fernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ramón A. Franco-Topete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Gabay</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fancy Gaete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adriana Garibay-Escobar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Gómez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gonzalo Greif</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thomas G. Gross</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marisol Guerrero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marianne K. Henderson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel E. Lopez-Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Lopez-Vazquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvina Maldonado</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrés J. Morán-Mendoza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Aparecida Nagai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Oceguera-Villanueva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel A. Ortiz-Martínez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jael Quintero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Quintero-Ramos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rui M. Reis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Javier Retamales</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernesto Rivera-Claisse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Darío Rocha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robinson Rodríguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristina Rosales</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Efrain Salas-González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Verónica Sanchotena</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Segovia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan Martín Sendoya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aida A. Silva-García</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Trinchero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olivia Valenzuela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vidya Vedham</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Livia Zagame</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">United States-Latin American Cancer Research Network (US-LACRN)</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Osvaldo L. Podhajcer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan Abarca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pamela Acevedo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Acosta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gissel Acosta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela Acosta Haab</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Lilian Acosta Silva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Aghazarian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carola Aguayo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bernardo Aizen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Alarcon Lopez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liz Almeida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Alvarez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Viviane Andrade</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wenceslao Angeles-Bueno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Arai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Priscila Elvira Arambula Barreras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ma. Isabel Aramburo Rubio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gonzalo Ardao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilia A. Arellano-Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudia Arias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Armisen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauricio Aspee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rodrigo Assar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Itzel Reneé Astiazarán Rascón</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sebastian Astorga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maxwell Aviles Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antônio Bailão Junior</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adolfo E. Barragan-Curiel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adelfo Barragan-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernanda Bermudez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Bernachin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wilfrido Bernal Herrera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mara Bonet</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarah Brnich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Bustamante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel Angel Bustamante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julio Bustos-Gomez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Felipe de J Bustos-Rodriguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Janett Caballero Jasso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angie Calfuman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Hugo José Froes Marques</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Campos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Cano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan C. Canton-Romero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Cappetta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paulina Carmona</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernando Carrizo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">André Lopes Carvalho</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erika Carvallo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julio Carzoglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monica Casalnuovo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benedicta Caserta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alvaro Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">César Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roger Chammas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mario Alberto Chavez Zamudio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loreto Chia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisa Chiarello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Chirico</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Esther Cisneros-Quirarter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Minor Raul Cordero Bautista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Valeria Cornejo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baldemar Corral Villegas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrés Cortés</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra Cortés</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Cortes-Sanabria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">German Salvador Cortez Zamorano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandro Corvalan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adolfo Cruz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alba d'Aurora</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandra De la Fuente</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad De la Peña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto de Leon Caballero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mirian de Souza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">César Del Castillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azucena Del-Toro-Valero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mirtha Di Pretoro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Digonzelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose El Ters</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paula Escobar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Estolaza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adriane Feijo Evangelista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcelo Fanelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paulo Farias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Fernandez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José R. Filassi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Filgueiras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Diego Flaks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edgar G. Flores-Ayala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria R. Flores-Marquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Franco Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karina Franco-Topete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jimena Freire</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristobal Fresno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Romina Gabrielli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mario Gallegos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Gamboa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daiana Ganiewich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Garbovesky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruben Alejandro Garcia Munguia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ricardo Garcia-Gaeta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alma C. Garcia-Martinez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liliana Gimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hector Gómez Silveira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariana M. Gomez-Del Toro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicia Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Germán González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cesar Osbaldo Gonzalez Mondaca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leivy P. Gonzalez-Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatriz Gonzalez-Ulloa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susana Gorostidy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariela Grass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alfonso G. Guevara Torres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorena Gutierrez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan A. Gutierrez-Rubio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adrián Hannois</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew Hart</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steffen Härtel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcos Henriquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafael Hernandez Guevara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miriam E. Hernandez-Franco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manuel I. Herrera-Miramontes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graciela Horton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gladys Ibañez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Martín Ipiña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatriz Jalfin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilian Jara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raul Jara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Luisa Jaramillo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Javalera-Castro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Eugenia Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hugo Ju</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nazareth Juárez Rusjan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karen Juneman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ligia Maria Kerr</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Krupelis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Flor Esmeralda Larios-Jimenez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Domingo Latorre</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guillermo Laviña</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fernando Lavista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Irma Leticia León Duarte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alberto Lescano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Verónica Lezano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossana Mendoza Lopez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Guillermo Lopez Cervantes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel Enrique Lopez Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dora Loria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandra Luque</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alejandro Maass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria do Socorro Maciel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Flavia Rotea Mangone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jorge Mansilla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katherine Marcelain</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Mariani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcia Maria Chiquitelli Marques</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Reyna J. Martinez-Arriaga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hector R. Martinez-Ramirez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcela Martins</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alma G. Maya-Gonzalez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brenda Mazzaferri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yadira Medina-Mora</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariana Menini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Míguez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Milans</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soledad Montes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Verónica Morales Hernández</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giberto Morga-Villela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carla Morong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Homero Muñoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ignacio Miguel Muse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carina Mussetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eduardo Mussetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luis J. 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|
score |
7.400609 |