Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy

Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphi...
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Autor*in:	Chunbo Wang [verfasserIn] Depeng Yang [verfasserIn] Xiaoqing Zhang [verfasserIn] Xiaohan Zhang [verfasserIn] Lijun Yang [verfasserIn] Pingping Wang [verfasserIn] Wenyang Zhou [verfasserIn] Huaxin Li [verfasserIn] Yiqun Li [verfasserIn] Huan Nie [verfasserIn] Yu Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SCLC PFS radio-chemotherapy rs2299939 PTEN

Übergeordnetes Werk:	In: Frontiers in Genetics - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fgene.2020.00298

Katalog-ID:	DOAJ064345556

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520			\|a Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment.
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spelling	10.3389/fgene.2020.00298 doi (DE-627)DOAJ064345556 (DE-599)DOAJ6ac42ef1e5604a1e9f37990a7ec8b98c DE-627 ger DE-627 rakwb eng QH426-470 Chunbo Wang verfasserin aut Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment. SCLC PFS radio-chemotherapy rs2299939 PTEN Genetics Chunbo Wang verfasserin aut Depeng Yang verfasserin aut Xiaoqing Zhang verfasserin aut Xiaohan Zhang verfasserin aut Lijun Yang verfasserin aut Pingping Wang verfasserin aut Wenyang Zhou verfasserin aut Huaxin Li verfasserin aut Yiqun Li verfasserin aut Huan Nie verfasserin aut Yu Li verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 11(2020) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:11 year:2020 https://doi.org/10.3389/fgene.2020.00298 kostenfrei https://doaj.org/article/6ac42ef1e5604a1e9f37990a7ec8b98c kostenfrei https://www.frontiersin.org/article/10.3389/fgene.2020.00298/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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allfieldsSound	10.3389/fgene.2020.00298 doi (DE-627)DOAJ064345556 (DE-599)DOAJ6ac42ef1e5604a1e9f37990a7ec8b98c DE-627 ger DE-627 rakwb eng QH426-470 Chunbo Wang verfasserin aut Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment. SCLC PFS radio-chemotherapy rs2299939 PTEN Genetics Chunbo Wang verfasserin aut Depeng Yang verfasserin aut Xiaoqing Zhang verfasserin aut Xiaohan Zhang verfasserin aut Lijun Yang verfasserin aut Pingping Wang verfasserin aut Wenyang Zhou verfasserin aut Huaxin Li verfasserin aut Yiqun Li verfasserin aut Huan Nie verfasserin aut Yu Li verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 11(2020) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:11 year:2020 https://doi.org/10.3389/fgene.2020.00298 kostenfrei https://doaj.org/article/6ac42ef1e5604a1e9f37990a7ec8b98c kostenfrei https://www.frontiersin.org/article/10.3389/fgene.2020.00298/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
language	English
source	In Frontiers in Genetics 11(2020) volume:11 year:2020
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topic_facet	SCLC PFS radio-chemotherapy rs2299939 PTEN Genetics
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container_title	Frontiers in Genetics
authorswithroles_txt_mv	Chunbo Wang @@aut@@ Depeng Yang @@aut@@ Xiaoqing Zhang @@aut@@ Xiaohan Zhang @@aut@@ Lijun Yang @@aut@@ Pingping Wang @@aut@@ Wenyang Zhou @@aut@@ Huaxin Li @@aut@@ Yiqun Li @@aut@@ Huan Nie @@aut@@ Yu Li @@aut@@
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callnumber-first	Q - Science
author	Chunbo Wang
spellingShingle	Chunbo Wang misc QH426-470 misc SCLC misc PFS misc radio-chemotherapy misc rs2299939 misc PTEN misc Genetics Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
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topic_title	QH426-470 Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy SCLC PFS radio-chemotherapy rs2299939 PTEN
topic	misc QH426-470 misc SCLC misc PFS misc radio-chemotherapy misc rs2299939 misc PTEN misc Genetics
topic_unstemmed	misc QH426-470 misc SCLC misc PFS misc radio-chemotherapy misc rs2299939 misc PTEN misc Genetics
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title	Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
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title_full	Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
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title_sort	association of pten gene snps rs2299939 with pfs in patients with small cell lung cancer treated with early radiotherapy
callnumber	QH426-470
title_auth	Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
abstract	Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment.
abstractGer	Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment.
abstract_unstemmed	Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment.
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title_short	Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
url	https://doi.org/10.3389/fgene.2020.00298 https://doaj.org/article/6ac42ef1e5604a1e9f37990a7ec8b98c https://www.frontiersin.org/article/10.3389/fgene.2020.00298/full https://doaj.org/toc/1664-8021
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doi_str	10.3389/fgene.2020.00298
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up_date	2024-07-03T22:26:15.383Z
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Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy

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