BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resili...
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| Autor*in: |
Renata B. Peters [verfasserIn] Janaína Xavier [verfasserIn] Thaíse C. Mondin [verfasserIn] Taiane de A. Cardoso [verfasserIn] Fabiana B. Ferreira [verfasserIn] Liana Teixeira [verfasserIn] Kiane Gräeff [verfasserIn] Luciana de A. Quevedo [verfasserIn] Karen Jansen [verfasserIn] Luciano D. Souza [verfasserIn] Jean P. Oses [verfasserIn] Ricardo T. Pinheiro [verfasserIn] Ricardo A. da Silva [verfasserIn] Gabriele Ghisleni [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Portugiesisch |
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In: Brazilian Journal of Psychiatry - Associação Brasileira de Psiquiatria (ABP), 2004 |
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Link aufrufen |
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| DOI / URN: |
10.1590/1516-4446-2019-0726 |
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| Katalog-ID: |
DOAJ064381137 |
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| 520 | |a Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. | ||
| 650 | 4 | |a Resilience | |
| 650 | 4 | |a Val66Met polymorphism | |
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| 700 | 0 | |a Janaína Xavier |e verfasserin |4 aut | |
| 700 | 0 | |a Thaíse C. Mondin |e verfasserin |4 aut | |
| 700 | 0 | |a Taiane de A. Cardoso |e verfasserin |4 aut | |
| 700 | 0 | |a Fabiana B. Ferreira |e verfasserin |4 aut | |
| 700 | 0 | |a Liana Teixeira |e verfasserin |4 aut | |
| 700 | 0 | |a Kiane Gräeff |e verfasserin |4 aut | |
| 700 | 0 | |a Luciana de A. Quevedo |e verfasserin |4 aut | |
| 700 | 0 | |a Karen Jansen |e verfasserin |4 aut | |
| 700 | 0 | |a Luciano D. Souza |e verfasserin |4 aut | |
| 700 | 0 | |a Jean P. Oses |e verfasserin |4 aut | |
| 700 | 0 | |a Ricardo T. Pinheiro |e verfasserin |4 aut | |
| 700 | 0 | |a Ricardo A. da Silva |e verfasserin |4 aut | |
| 700 | 0 | |a Gabriele Ghisleni |e verfasserin |4 aut | |
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10.1590/1516-4446-2019-0726 doi (DE-627)DOAJ064381137 (DE-599)DOAJa1c68762b68a403aaf41dd2282d16d04 DE-627 ger DE-627 rakwb eng por RC435-571 Renata B. Peters verfasserin aut BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. Resilience Val66Met polymorphism psychotherapy Psychiatry Janaína Xavier verfasserin aut Thaíse C. Mondin verfasserin aut Taiane de A. Cardoso verfasserin aut Fabiana B. Ferreira verfasserin aut Liana Teixeira verfasserin aut Kiane Gräeff verfasserin aut Luciana de A. Quevedo verfasserin aut Karen Jansen verfasserin aut Luciano D. Souza verfasserin aut Jean P. Oses verfasserin aut Ricardo T. Pinheiro verfasserin aut Ricardo A. da Silva verfasserin aut Gabriele Ghisleni verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns https://doi.org/10.1590/1516-4446-2019-0726 kostenfrei https://doaj.org/article/a1c68762b68a403aaf41dd2282d16d04 kostenfrei http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190726.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100006&tlng=en kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1516-4446-2019-0726 doi (DE-627)DOAJ064381137 (DE-599)DOAJa1c68762b68a403aaf41dd2282d16d04 DE-627 ger DE-627 rakwb eng por RC435-571 Renata B. Peters verfasserin aut BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. Resilience Val66Met polymorphism psychotherapy Psychiatry Janaína Xavier verfasserin aut Thaíse C. Mondin verfasserin aut Taiane de A. Cardoso verfasserin aut Fabiana B. Ferreira verfasserin aut Liana Teixeira verfasserin aut Kiane Gräeff verfasserin aut Luciana de A. Quevedo verfasserin aut Karen Jansen verfasserin aut Luciano D. Souza verfasserin aut Jean P. Oses verfasserin aut Ricardo T. Pinheiro verfasserin aut Ricardo A. da Silva verfasserin aut Gabriele Ghisleni verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns https://doi.org/10.1590/1516-4446-2019-0726 kostenfrei https://doaj.org/article/a1c68762b68a403aaf41dd2282d16d04 kostenfrei http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190726.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100006&tlng=en kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1516-4446-2019-0726 doi (DE-627)DOAJ064381137 (DE-599)DOAJa1c68762b68a403aaf41dd2282d16d04 DE-627 ger DE-627 rakwb eng por RC435-571 Renata B. Peters verfasserin aut BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. Resilience Val66Met polymorphism psychotherapy Psychiatry Janaína Xavier verfasserin aut Thaíse C. Mondin verfasserin aut Taiane de A. Cardoso verfasserin aut Fabiana B. Ferreira verfasserin aut Liana Teixeira verfasserin aut Kiane Gräeff verfasserin aut Luciana de A. Quevedo verfasserin aut Karen Jansen verfasserin aut Luciano D. Souza verfasserin aut Jean P. Oses verfasserin aut Ricardo T. Pinheiro verfasserin aut Ricardo A. da Silva verfasserin aut Gabriele Ghisleni verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns https://doi.org/10.1590/1516-4446-2019-0726 kostenfrei https://doaj.org/article/a1c68762b68a403aaf41dd2282d16d04 kostenfrei http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190726.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100006&tlng=en kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1516-4446-2019-0726 doi (DE-627)DOAJ064381137 (DE-599)DOAJa1c68762b68a403aaf41dd2282d16d04 DE-627 ger DE-627 rakwb eng por RC435-571 Renata B. Peters verfasserin aut BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. Resilience Val66Met polymorphism psychotherapy Psychiatry Janaína Xavier verfasserin aut Thaíse C. Mondin verfasserin aut Taiane de A. Cardoso verfasserin aut Fabiana B. Ferreira verfasserin aut Liana Teixeira verfasserin aut Kiane Gräeff verfasserin aut Luciana de A. Quevedo verfasserin aut Karen Jansen verfasserin aut Luciano D. Souza verfasserin aut Jean P. Oses verfasserin aut Ricardo T. Pinheiro verfasserin aut Ricardo A. da Silva verfasserin aut Gabriele Ghisleni verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns https://doi.org/10.1590/1516-4446-2019-0726 kostenfrei https://doaj.org/article/a1c68762b68a403aaf41dd2282d16d04 kostenfrei http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190726.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100006&tlng=en kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1516-4446-2019-0726 doi (DE-627)DOAJ064381137 (DE-599)DOAJa1c68762b68a403aaf41dd2282d16d04 DE-627 ger DE-627 rakwb eng por RC435-571 Renata B. Peters verfasserin aut BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. Resilience Val66Met polymorphism psychotherapy Psychiatry Janaína Xavier verfasserin aut Thaíse C. Mondin verfasserin aut Taiane de A. Cardoso verfasserin aut Fabiana B. Ferreira verfasserin aut Liana Teixeira verfasserin aut Kiane Gräeff verfasserin aut Luciana de A. Quevedo verfasserin aut Karen Jansen verfasserin aut Luciano D. Souza verfasserin aut Jean P. Oses verfasserin aut Ricardo T. Pinheiro verfasserin aut Ricardo A. da Silva verfasserin aut Gabriele Ghisleni verfasserin aut In Brazilian Journal of Psychiatry Associação Brasileira de Psiquiatria (ABP), 2004 (DE-627)320632717 (DE-600)2024119-7 1809452X nnns https://doi.org/10.1590/1516-4446-2019-0726 kostenfrei https://doaj.org/article/a1c68762b68a403aaf41dd2282d16d04 kostenfrei http://www.scielo.br/pdf/rbp/v43n1/1516-4446-rbp-1516444620190726.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000100006&tlng=en kostenfrei https://doaj.org/toc/1809-452X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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Renata B. Peters @@aut@@ Janaína Xavier @@aut@@ Thaíse C. Mondin @@aut@@ Taiane de A. Cardoso @@aut@@ Fabiana B. Ferreira @@aut@@ Liana Teixeira @@aut@@ Kiane Gräeff @@aut@@ Luciana de A. Quevedo @@aut@@ Karen Jansen @@aut@@ Luciano D. Souza @@aut@@ Jean P. Oses @@aut@@ Ricardo T. Pinheiro @@aut@@ Ricardo A. da Silva @@aut@@ Gabriele Ghisleni @@aut@@ |
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BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy |
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Renata B. Peters Janaína Xavier Thaíse C. Mondin Taiane de A. Cardoso Fabiana B. Ferreira Liana Teixeira Kiane Gräeff Luciana de A. Quevedo Karen Jansen Luciano D. Souza Jean P. Oses Ricardo T. Pinheiro Ricardo A. da Silva Gabriele Ghisleni |
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bdnf val66met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy |
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BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy |
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Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. |
| abstractGer |
Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. |
| abstract_unstemmed |
Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis. Results: The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008). Conclusion: Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism. |
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BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy |
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Janaína Xavier Thaíse C. Mondin Taiane de A. Cardoso Fabiana B. Ferreira Liana Teixeira Kiane Gräeff Luciana de A. Quevedo Karen Jansen Luciano D. Souza Jean P. Oses Ricardo T. Pinheiro Ricardo A. da Silva Gabriele Ghisleni |
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