On the occasion of the 50th anniversary of A. M. Ugolev's current theory of digestion
In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: ca...
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| Autor*in: |
Asfol'd Ivanovich Parfenov [verfasserIn] A I Parfenov [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2010 |
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In: Терапевтический архив - "Consilium Medicum" Publishing house, 2018, 82(2010), 2, Seite 5-10 |
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volume:82 ; year:2010 ; number:2 ; pages:5-10 |
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| 520 | |a In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: cavity digestion - MD - absorption has given an insight into the mechanism responsible for an extremely high food assimilation rate in the gastrointestinal tract and become as the basis of the current digestion theory stated by Academician A. M. Ugolev. Membrane maldigestion results from atrophic changes in the small bowel mucosa in gluten-sensitivity celiac disease, enteric infections, excessive small intestinal microflora growth, and intestinal damages induced by nonsteroidal anti-inflammatory drugs, some antibiotics, and antimetabolites. Clinically, it presents with poor tolerability of nutrients containing oligomers, whose digestion is impaired, and with malabsorption symptoms. Indirect (load) and direct (perfusion) tests, as well as biochemical and histological studies of the activity of membrane enzymes are proposed for the diagnosis of membrane maldigestion. The detection and elimination of agents that damage the intestinal mucosa (gluten, lactose, pathogenic microflora, and pharmacologicals) form the basis for the etiotropic treatment of patients with impaired MD. A. M. Ugolev's discovery has led not only to the major general biological generalization - the current theory of digestion, but also to the revision of the pathogenesis, clinical signs, and treatment of diseases accompanied by enteric food malassimilation. | ||
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(DE-627)DOAJ064389561 (DE-599)DOAJ93d836d433924fa89b06f9a254ce749a DE-627 ger DE-627 rakwb rus Asfol'd Ivanovich Parfenov verfasserin aut On the occasion of the 50th anniversary of A. M. Ugolev's current theory of digestion 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: cavity digestion - MD - absorption has given an insight into the mechanism responsible for an extremely high food assimilation rate in the gastrointestinal tract and become as the basis of the current digestion theory stated by Academician A. M. Ugolev. Membrane maldigestion results from atrophic changes in the small bowel mucosa in gluten-sensitivity celiac disease, enteric infections, excessive small intestinal microflora growth, and intestinal damages induced by nonsteroidal anti-inflammatory drugs, some antibiotics, and antimetabolites. Clinically, it presents with poor tolerability of nutrients containing oligomers, whose digestion is impaired, and with malabsorption symptoms. Indirect (load) and direct (perfusion) tests, as well as biochemical and histological studies of the activity of membrane enzymes are proposed for the diagnosis of membrane maldigestion. The detection and elimination of agents that damage the intestinal mucosa (gluten, lactose, pathogenic microflora, and pharmacologicals) form the basis for the etiotropic treatment of patients with impaired MD. A. M. Ugolev's discovery has led not only to the major general biological generalization - the current theory of digestion, but also to the revision of the pathogenesis, clinical signs, and treatment of diseases accompanied by enteric food malassimilation. digestion theory cavity digestion membrane digestion absorption digestive transport conveyor throphology Medicine R A I Parfenov verfasserin aut In Терапевтический архив "Consilium Medicum" Publishing house, 2018 82(2010), 2, Seite 5-10 (DE-627)1760620270 23095342 nnns volume:82 year:2010 number:2 pages:5-10 https://doaj.org/article/93d836d433924fa89b06f9a254ce749a kostenfrei https://ter-arkhiv.ru/0040-3660/article/view/30531 kostenfrei https://doaj.org/toc/0040-3660 Journal toc kostenfrei https://doaj.org/toc/2309-5342 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 82 2010 2 5-10 |
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On the occasion of the 50th anniversary of A. M. Ugolev's current theory of digestion |
| abstract |
In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: cavity digestion - MD - absorption has given an insight into the mechanism responsible for an extremely high food assimilation rate in the gastrointestinal tract and become as the basis of the current digestion theory stated by Academician A. M. Ugolev. Membrane maldigestion results from atrophic changes in the small bowel mucosa in gluten-sensitivity celiac disease, enteric infections, excessive small intestinal microflora growth, and intestinal damages induced by nonsteroidal anti-inflammatory drugs, some antibiotics, and antimetabolites. Clinically, it presents with poor tolerability of nutrients containing oligomers, whose digestion is impaired, and with malabsorption symptoms. Indirect (load) and direct (perfusion) tests, as well as biochemical and histological studies of the activity of membrane enzymes are proposed for the diagnosis of membrane maldigestion. The detection and elimination of agents that damage the intestinal mucosa (gluten, lactose, pathogenic microflora, and pharmacologicals) form the basis for the etiotropic treatment of patients with impaired MD. A. M. Ugolev's discovery has led not only to the major general biological generalization - the current theory of digestion, but also to the revision of the pathogenesis, clinical signs, and treatment of diseases accompanied by enteric food malassimilation. |
| abstractGer |
In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: cavity digestion - MD - absorption has given an insight into the mechanism responsible for an extremely high food assimilation rate in the gastrointestinal tract and become as the basis of the current digestion theory stated by Academician A. M. Ugolev. Membrane maldigestion results from atrophic changes in the small bowel mucosa in gluten-sensitivity celiac disease, enteric infections, excessive small intestinal microflora growth, and intestinal damages induced by nonsteroidal anti-inflammatory drugs, some antibiotics, and antimetabolites. Clinically, it presents with poor tolerability of nutrients containing oligomers, whose digestion is impaired, and with malabsorption symptoms. Indirect (load) and direct (perfusion) tests, as well as biochemical and histological studies of the activity of membrane enzymes are proposed for the diagnosis of membrane maldigestion. The detection and elimination of agents that damage the intestinal mucosa (gluten, lactose, pathogenic microflora, and pharmacologicals) form the basis for the etiotropic treatment of patients with impaired MD. A. M. Ugolev's discovery has led not only to the major general biological generalization - the current theory of digestion, but also to the revision of the pathogenesis, clinical signs, and treatment of diseases accompanied by enteric food malassimilation. |
| abstract_unstemmed |
In 1958, A. M. Ugolev (1926-1991) discovered parietal (membrane) digestion (MD) that differs fundamentally from cavity and intracellular digestion in the strictly directed arrangement of active centers of enzymes and in coupling to the membrane transport systems. The three-stage sequential triad: cavity digestion - MD - absorption has given an insight into the mechanism responsible for an extremely high food assimilation rate in the gastrointestinal tract and become as the basis of the current digestion theory stated by Academician A. M. Ugolev. Membrane maldigestion results from atrophic changes in the small bowel mucosa in gluten-sensitivity celiac disease, enteric infections, excessive small intestinal microflora growth, and intestinal damages induced by nonsteroidal anti-inflammatory drugs, some antibiotics, and antimetabolites. Clinically, it presents with poor tolerability of nutrients containing oligomers, whose digestion is impaired, and with malabsorption symptoms. Indirect (load) and direct (perfusion) tests, as well as biochemical and histological studies of the activity of membrane enzymes are proposed for the diagnosis of membrane maldigestion. The detection and elimination of agents that damage the intestinal mucosa (gluten, lactose, pathogenic microflora, and pharmacologicals) form the basis for the etiotropic treatment of patients with impaired MD. A. M. Ugolev's discovery has led not only to the major general biological generalization - the current theory of digestion, but also to the revision of the pathogenesis, clinical signs, and treatment of diseases accompanied by enteric food malassimilation. |
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On the occasion of the 50th anniversary of A. M. Ugolev's current theory of digestion |
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https://doaj.org/article/93d836d433924fa89b06f9a254ce749a https://ter-arkhiv.ru/0040-3660/article/view/30531 https://doaj.org/toc/0040-3660 https://doaj.org/toc/2309-5342 |
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