Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diag...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alberto Julius Alves Wainstein [verfasserIn] João Pedreira Duprat Neto [verfasserIn] Mauro Yoshiaki Enokihara [verfasserIn] Eduard René Brechtbühl [verfasserIn] Felice Riccardi [verfasserIn] Gilles Landman [verfasserIn] Andreia Cristina de Melo [verfasserIn] Vinicius de Lima Vazquez [verfasserIn] Rodrigo Ramella Munhoz [verfasserIn] Ivan Dunshee De Abranches Oliveira Santos Filho [verfasserIn] Eduardo Bertolli [verfasserIn] Ana Paula Drummond-Lage [verfasserIn] Bianca Costa Soares de Sá [verfasserIn] Luciane Botelho [verfasserIn] Jose Higino Steck [verfasserIn] Francisco Aparecido Belfort [verfasserIn] Marcus Maia [verfasserIn] Renato Marchiori Bakos [verfasserIn] Elimar Elias Gomes [verfasserIn] Rafael Schmerling [verfasserIn] Flavio Cavarsan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
In: JCO Global Oncology - American Society of Clinical Oncology, 2021, (2020), 6, Seite 575-582 |
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| Übergeordnetes Werk: |
year:2020 ; number:6 ; pages:575-582 |
| Links: |
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| DOI / URN: |
10.1200/JGO.20.00005 |
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| Katalog-ID: |
DOAJ064501639 |
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| 520 | |a PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. | ||
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10.1200/JGO.20.00005 doi (DE-627)DOAJ064501639 (DE-599)DOAJa3745a9fdc1b4a15b08b5fbebb55a959 DE-627 ger DE-627 rakwb eng RC254-282 Alberto Julius Alves Wainstein verfasserin aut Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens João Pedreira Duprat Neto verfasserin aut Mauro Yoshiaki Enokihara verfasserin aut Eduard René Brechtbühl verfasserin aut Felice Riccardi verfasserin aut Gilles Landman verfasserin aut Andreia Cristina de Melo verfasserin aut Vinicius de Lima Vazquez verfasserin aut Rodrigo Ramella Munhoz verfasserin aut Ivan Dunshee De Abranches Oliveira Santos Filho verfasserin aut Eduardo Bertolli verfasserin aut Ana Paula Drummond-Lage verfasserin aut Bianca Costa Soares de Sá verfasserin aut Luciane Botelho verfasserin aut Jose Higino Steck verfasserin aut Francisco Aparecido Belfort verfasserin aut Marcus Maia verfasserin aut Renato Marchiori Bakos verfasserin aut Elimar Elias Gomes verfasserin aut Rafael Schmerling verfasserin aut Flavio Cavarsan verfasserin aut In JCO Global Oncology American Society of Clinical Oncology, 2021 (2020), 6, Seite 575-582 (DE-627)1696314941 26878941 nnns year:2020 number:6 pages:575-582 https://doi.org/10.1200/JGO.20.00005 kostenfrei https://doaj.org/article/a3745a9fdc1b4a15b08b5fbebb55a959 kostenfrei https://ascopubs.org/doi/10.1200/JGO.20.00005 kostenfrei https://doaj.org/toc/2687-8941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 6 575-582 |
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10.1200/JGO.20.00005 doi (DE-627)DOAJ064501639 (DE-599)DOAJa3745a9fdc1b4a15b08b5fbebb55a959 DE-627 ger DE-627 rakwb eng RC254-282 Alberto Julius Alves Wainstein verfasserin aut Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens João Pedreira Duprat Neto verfasserin aut Mauro Yoshiaki Enokihara verfasserin aut Eduard René Brechtbühl verfasserin aut Felice Riccardi verfasserin aut Gilles Landman verfasserin aut Andreia Cristina de Melo verfasserin aut Vinicius de Lima Vazquez verfasserin aut Rodrigo Ramella Munhoz verfasserin aut Ivan Dunshee De Abranches Oliveira Santos Filho verfasserin aut Eduardo Bertolli verfasserin aut Ana Paula Drummond-Lage verfasserin aut Bianca Costa Soares de Sá verfasserin aut Luciane Botelho verfasserin aut Jose Higino Steck verfasserin aut Francisco Aparecido Belfort verfasserin aut Marcus Maia verfasserin aut Renato Marchiori Bakos verfasserin aut Elimar Elias Gomes verfasserin aut Rafael Schmerling verfasserin aut Flavio Cavarsan verfasserin aut In JCO Global Oncology American Society of Clinical Oncology, 2021 (2020), 6, Seite 575-582 (DE-627)1696314941 26878941 nnns year:2020 number:6 pages:575-582 https://doi.org/10.1200/JGO.20.00005 kostenfrei https://doaj.org/article/a3745a9fdc1b4a15b08b5fbebb55a959 kostenfrei https://ascopubs.org/doi/10.1200/JGO.20.00005 kostenfrei https://doaj.org/toc/2687-8941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 6 575-582 |
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10.1200/JGO.20.00005 doi (DE-627)DOAJ064501639 (DE-599)DOAJa3745a9fdc1b4a15b08b5fbebb55a959 DE-627 ger DE-627 rakwb eng RC254-282 Alberto Julius Alves Wainstein verfasserin aut Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens João Pedreira Duprat Neto verfasserin aut Mauro Yoshiaki Enokihara verfasserin aut Eduard René Brechtbühl verfasserin aut Felice Riccardi verfasserin aut Gilles Landman verfasserin aut Andreia Cristina de Melo verfasserin aut Vinicius de Lima Vazquez verfasserin aut Rodrigo Ramella Munhoz verfasserin aut Ivan Dunshee De Abranches Oliveira Santos Filho verfasserin aut Eduardo Bertolli verfasserin aut Ana Paula Drummond-Lage verfasserin aut Bianca Costa Soares de Sá verfasserin aut Luciane Botelho verfasserin aut Jose Higino Steck verfasserin aut Francisco Aparecido Belfort verfasserin aut Marcus Maia verfasserin aut Renato Marchiori Bakos verfasserin aut Elimar Elias Gomes verfasserin aut Rafael Schmerling verfasserin aut Flavio Cavarsan verfasserin aut In JCO Global Oncology American Society of Clinical Oncology, 2021 (2020), 6, Seite 575-582 (DE-627)1696314941 26878941 nnns year:2020 number:6 pages:575-582 https://doi.org/10.1200/JGO.20.00005 kostenfrei https://doaj.org/article/a3745a9fdc1b4a15b08b5fbebb55a959 kostenfrei https://ascopubs.org/doi/10.1200/JGO.20.00005 kostenfrei https://doaj.org/toc/2687-8941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 6 575-582 |
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10.1200/JGO.20.00005 doi (DE-627)DOAJ064501639 (DE-599)DOAJa3745a9fdc1b4a15b08b5fbebb55a959 DE-627 ger DE-627 rakwb eng RC254-282 Alberto Julius Alves Wainstein verfasserin aut Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens João Pedreira Duprat Neto verfasserin aut Mauro Yoshiaki Enokihara verfasserin aut Eduard René Brechtbühl verfasserin aut Felice Riccardi verfasserin aut Gilles Landman verfasserin aut Andreia Cristina de Melo verfasserin aut Vinicius de Lima Vazquez verfasserin aut Rodrigo Ramella Munhoz verfasserin aut Ivan Dunshee De Abranches Oliveira Santos Filho verfasserin aut Eduardo Bertolli verfasserin aut Ana Paula Drummond-Lage verfasserin aut Bianca Costa Soares de Sá verfasserin aut Luciane Botelho verfasserin aut Jose Higino Steck verfasserin aut Francisco Aparecido Belfort verfasserin aut Marcus Maia verfasserin aut Renato Marchiori Bakos verfasserin aut Elimar Elias Gomes verfasserin aut Rafael Schmerling verfasserin aut Flavio Cavarsan verfasserin aut In JCO Global Oncology American Society of Clinical Oncology, 2021 (2020), 6, Seite 575-582 (DE-627)1696314941 26878941 nnns year:2020 number:6 pages:575-582 https://doi.org/10.1200/JGO.20.00005 kostenfrei https://doaj.org/article/a3745a9fdc1b4a15b08b5fbebb55a959 kostenfrei https://ascopubs.org/doi/10.1200/JGO.20.00005 kostenfrei https://doaj.org/toc/2687-8941 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 6 575-582 |
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Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database |
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Alberto Julius Alves Wainstein |
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JCO Global Oncology |
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Alberto Julius Alves Wainstein João Pedreira Duprat Neto Mauro Yoshiaki Enokihara Eduard René Brechtbühl Felice Riccardi Gilles Landman Andreia Cristina de Melo Vinicius de Lima Vazquez Rodrigo Ramella Munhoz Ivan Dunshee De Abranches Oliveira Santos Filho Eduardo Bertolli Ana Paula Drummond-Lage Bianca Costa Soares de Sá Luciane Botelho Jose Higino Steck Francisco Aparecido Belfort Marcus Maia Renato Marchiori Bakos Elimar Elias Gomes Rafael Schmerling Flavio Cavarsan |
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Alberto Julius Alves Wainstein |
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demographic, clinical, and pathologic features of patients with cutaneous melanoma: final analysis of the brazilian melanoma group database |
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Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database |
| abstract |
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. |
| abstractGer |
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. |
| abstract_unstemmed |
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. |
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Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database |
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https://doi.org/10.1200/JGO.20.00005 https://doaj.org/article/a3745a9fdc1b4a15b08b5fbebb55a959 https://ascopubs.org/doi/10.1200/JGO.20.00005 https://doaj.org/toc/2687-8941 |
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João Pedreira Duprat Neto Mauro Yoshiaki Enokihara Eduard René Brechtbühl Felice Riccardi Gilles Landman Andreia Cristina de Melo Vinicius de Lima Vazquez Rodrigo Ramella Munhoz Ivan Dunshee De Abranches Oliveira Santos Filho Eduardo Bertolli Ana Paula Drummond-Lage Bianca Costa Soares de Sá Luciane Botelho Jose Higino Steck Francisco Aparecido Belfort Marcus Maia Renato Marchiori Bakos Elimar Elias Gomes Rafael Schmerling Flavio Cavarsan |
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