Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls

ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy control...
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Autor*in:	Chen Zhan [verfasserIn] Rong Xu [verfasserIn] Bizhou Li [verfasserIn] Jiaxing Liu [verfasserIn] Wanqin Liang [verfasserIn] Shengfang Zhang [verfasserIn] Liman Fang [verfasserIn] Shuxin Zhong [verfasserIn] S. Dushinka Shaniya Helen de Silva [verfasserIn] Dhinesan Sivapalan [verfasserIn] Wei Luo [verfasserIn] Jing Li [verfasserIn] Kefang Lai [verfasserIn] Nanshan Zhong [verfasserIn] Roma Sehmi [verfasserIn] Paul M. O’Byrne [verfasserIn] Ruchong Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.737968

Katalog-ID:	DOAJ064524868

Internformat


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245	1	0	\|a Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
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520			\|a ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.
650		4	\|a non-asthmatic eosinophilic bronchitis
650		4	\|a hematopoietic progenitor cells
650		4	\|a eosinophil progenitors
650		4	\|a airway inflammation
650		4	\|a eosinophil
653		0	\|a Immunologic diseases. Allergy
700	0		\|a Rong Xu \|e verfasserin \|4 aut
700	0		\|a Bizhou Li \|e verfasserin \|4 aut
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700	0		\|a Jiaxing Liu \|e verfasserin \|4 aut
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700	0		\|a Shengfang Zhang \|e verfasserin \|4 aut
700	0		\|a Liman Fang \|e verfasserin \|4 aut
700	0		\|a Shuxin Zhong \|e verfasserin \|4 aut
700	0		\|a S. Dushinka Shaniya Helen de Silva \|e verfasserin \|4 aut
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700	0		\|a Dhinesan Sivapalan \|e verfasserin \|4 aut
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700	0		\|a Jing Li \|e verfasserin \|4 aut
700	0		\|a Kefang Lai \|e verfasserin \|4 aut
700	0		\|a Nanshan Zhong \|e verfasserin \|4 aut
700	0		\|a Roma Sehmi \|e verfasserin \|4 aut
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700	0		\|a Ruchong Chen \|e verfasserin \|4 aut
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allfields	10.3389/fimmu.2022.737968 doi (DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1 DE-627 ger DE-627 rakwb eng RC581-607 Chen Zhan verfasserin aut Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB. non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy Rong Xu verfasserin aut Bizhou Li verfasserin aut Bizhou Li verfasserin aut Jiaxing Liu verfasserin aut Wanqin Liang verfasserin aut Shengfang Zhang verfasserin aut Liman Fang verfasserin aut Shuxin Zhong verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut Dhinesan Sivapalan verfasserin aut Dhinesan Sivapalan verfasserin aut Wei Luo verfasserin aut Jing Li verfasserin aut Kefang Lai verfasserin aut Nanshan Zhong verfasserin aut Roma Sehmi verfasserin aut Paul M. O’Byrne verfasserin aut Ruchong Chen verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.737968 kostenfrei https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fimmu.2022.737968 doi (DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1 DE-627 ger DE-627 rakwb eng RC581-607 Chen Zhan verfasserin aut Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB. non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy Rong Xu verfasserin aut Bizhou Li verfasserin aut Bizhou Li verfasserin aut Jiaxing Liu verfasserin aut Wanqin Liang verfasserin aut Shengfang Zhang verfasserin aut Liman Fang verfasserin aut Shuxin Zhong verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut Dhinesan Sivapalan verfasserin aut Dhinesan Sivapalan verfasserin aut Wei Luo verfasserin aut Jing Li verfasserin aut Kefang Lai verfasserin aut Nanshan Zhong verfasserin aut Roma Sehmi verfasserin aut Paul M. O’Byrne verfasserin aut Ruchong Chen verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.737968 kostenfrei https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fimmu.2022.737968 doi (DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1 DE-627 ger DE-627 rakwb eng RC581-607 Chen Zhan verfasserin aut Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB. non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy Rong Xu verfasserin aut Bizhou Li verfasserin aut Bizhou Li verfasserin aut Jiaxing Liu verfasserin aut Wanqin Liang verfasserin aut Shengfang Zhang verfasserin aut Liman Fang verfasserin aut Shuxin Zhong verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut Dhinesan Sivapalan verfasserin aut Dhinesan Sivapalan verfasserin aut Wei Luo verfasserin aut Jing Li verfasserin aut Kefang Lai verfasserin aut Nanshan Zhong verfasserin aut Roma Sehmi verfasserin aut Paul M. O’Byrne verfasserin aut Ruchong Chen verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.737968 kostenfrei https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fimmu.2022.737968 doi (DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1 DE-627 ger DE-627 rakwb eng RC581-607 Chen Zhan verfasserin aut Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB. non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy Rong Xu verfasserin aut Bizhou Li verfasserin aut Bizhou Li verfasserin aut Jiaxing Liu verfasserin aut Wanqin Liang verfasserin aut Shengfang Zhang verfasserin aut Liman Fang verfasserin aut Shuxin Zhong verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut Dhinesan Sivapalan verfasserin aut Dhinesan Sivapalan verfasserin aut Wei Luo verfasserin aut Jing Li verfasserin aut Kefang Lai verfasserin aut Nanshan Zhong verfasserin aut Roma Sehmi verfasserin aut Paul M. O’Byrne verfasserin aut Ruchong Chen verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.737968 kostenfrei https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fimmu.2022.737968 doi (DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1 DE-627 ger DE-627 rakwb eng RC581-607 Chen Zhan verfasserin aut Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB. non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy Rong Xu verfasserin aut Bizhou Li verfasserin aut Bizhou Li verfasserin aut Jiaxing Liu verfasserin aut Wanqin Liang verfasserin aut Shengfang Zhang verfasserin aut Liman Fang verfasserin aut Shuxin Zhong verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut S. Dushinka Shaniya Helen de Silva verfasserin aut Dhinesan Sivapalan verfasserin aut Dhinesan Sivapalan verfasserin aut Wei Luo verfasserin aut Jing Li verfasserin aut Kefang Lai verfasserin aut Nanshan Zhong verfasserin aut Roma Sehmi verfasserin aut Paul M. O’Byrne verfasserin aut Ruchong Chen verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.737968 kostenfrei https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Immunology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Chen Zhan @@aut@@ Rong Xu @@aut@@ Bizhou Li @@aut@@ Jiaxing Liu @@aut@@ Wanqin Liang @@aut@@ Shengfang Zhang @@aut@@ Liman Fang @@aut@@ Shuxin Zhong @@aut@@ S. Dushinka Shaniya Helen de Silva @@aut@@ Dhinesan Sivapalan @@aut@@ Wei Luo @@aut@@ Jing Li @@aut@@ Kefang Lai @@aut@@ Nanshan Zhong @@aut@@ Roma Sehmi @@aut@@ Paul M. O’Byrne @@aut@@ Ruchong Chen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ064524868
language_de	englisch
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Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p&lt;0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">non-asthmatic eosinophilic bronchitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hematopoietic progenitor cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">eosinophil progenitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">airway inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">eosinophil</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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callnumber-first	R - Medicine
author	Chen Zhan
spellingShingle	Chen Zhan misc RC581-607 misc non-asthmatic eosinophilic bronchitis misc hematopoietic progenitor cells misc eosinophil progenitors misc airway inflammation misc eosinophil misc Immunologic diseases. Allergy Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
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topic_title	RC581-607 Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls non-asthmatic eosinophilic bronchitis hematopoietic progenitor cells eosinophil progenitors airway inflammation eosinophil
topic	misc RC581-607 misc non-asthmatic eosinophilic bronchitis misc hematopoietic progenitor cells misc eosinophil progenitors misc airway inflammation misc eosinophil misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc non-asthmatic eosinophilic bronchitis misc hematopoietic progenitor cells misc eosinophil progenitors misc airway inflammation misc eosinophil misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc non-asthmatic eosinophilic bronchitis misc hematopoietic progenitor cells misc eosinophil progenitors misc airway inflammation misc eosinophil misc Immunologic diseases. Allergy
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title	Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
ctrlnum	(DE-627)DOAJ064524868 (DE-599)DOAJf426ac6d95754e7ca084270c398cabf1
title_full	Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
author_sort	Chen Zhan
journal	Frontiers in Immunology
journalStr	Frontiers in Immunology
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author_browse	Chen Zhan Rong Xu Bizhou Li Jiaxing Liu Wanqin Liang Shengfang Zhang Liman Fang Shuxin Zhong S. Dushinka Shaniya Helen de Silva Dhinesan Sivapalan Wei Luo Jing Li Kefang Lai Nanshan Zhong Roma Sehmi Paul M. O’Byrne Ruchong Chen
container_volume	13
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format_se	Elektronische Aufsätze
author-letter	Chen Zhan
doi_str_mv	10.3389/fimmu.2022.737968
author2-role	verfasserin
title_sort	eosinophil progenitors in patients with non-asthmatic eosinophilic bronchitis, eosinophilic asthma, and normal controls
callnumber	RC581-607
title_auth	Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
abstract	ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.
abstractGer	ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.
abstract_unstemmed	ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant.ConclusionsNAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.
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title_short	Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls
url	https://doi.org/10.3389/fimmu.2022.737968 https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1 https://www.frontiersin.org/articles/10.3389/fimmu.2022.737968/full https://doaj.org/toc/1664-3224
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author2	Rong Xu Bizhou Li Jiaxing Liu Wanqin Liang Shengfang Zhang Liman Fang Shuxin Zhong S. Dushinka Shaniya Helen de Silva Dhinesan Sivapalan Wei Luo Jing Li Kefang Lai Nanshan Zhong Roma Sehmi Paul M. O’Byrne Ruchong Chen
author2Str	Rong Xu Bizhou Li Jiaxing Liu Wanqin Liang Shengfang Zhang Liman Fang Shuxin Zhong S. Dushinka Shaniya Helen de Silva Dhinesan Sivapalan Wei Luo Jing Li Kefang Lai Nanshan Zhong Roma Sehmi Paul M. O’Byrne Ruchong Chen
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doi_str	10.3389/fimmu.2022.737968
callnumber-a	RC581-607
up_date	2024-07-03T23:17:25.985Z
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Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls

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