Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia

Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differ...
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Autor*in:	Ilaria Maggio [verfasserIn] Lisa Manuzzi [verfasserIn] Giuseppe Lamberti [verfasserIn] Angela Dalia Ricci [verfasserIn] Nastassja Tober [verfasserIn] Davide Campana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 4, p 832
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:4, p 832

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12040832

Katalog-ID:	DOAJ064539571

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spelling	10.3390/cancers12040832 doi (DE-627)DOAJ064539571 (DE-599)DOAJ6acc5f6d633b453893916a64a1b3e509 DE-627 ger DE-627 rakwb eng RC254-282 Ilaria Maggio verfasserin aut Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors. neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lisa Manuzzi verfasserin aut Giuseppe Lamberti verfasserin aut Angela Dalia Ricci verfasserin aut Nastassja Tober verfasserin aut Davide Campana verfasserin aut In Cancers MDPI AG, 2010 12(2020), 4, p 832 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:4, p 832 https://doi.org/10.3390/cancers12040832 kostenfrei https://doaj.org/article/6acc5f6d633b453893916a64a1b3e509 kostenfrei https://www.mdpi.com/2072-6694/12/4/832 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 4, p 832
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allfieldsGer	10.3390/cancers12040832 doi (DE-627)DOAJ064539571 (DE-599)DOAJ6acc5f6d633b453893916a64a1b3e509 DE-627 ger DE-627 rakwb eng RC254-282 Ilaria Maggio verfasserin aut Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors. neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lisa Manuzzi verfasserin aut Giuseppe Lamberti verfasserin aut Angela Dalia Ricci verfasserin aut Nastassja Tober verfasserin aut Davide Campana verfasserin aut In Cancers MDPI AG, 2010 12(2020), 4, p 832 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:4, p 832 https://doi.org/10.3390/cancers12040832 kostenfrei https://doaj.org/article/6acc5f6d633b453893916a64a1b3e509 kostenfrei https://www.mdpi.com/2072-6694/12/4/832 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 4, p 832
allfieldsSound	10.3390/cancers12040832 doi (DE-627)DOAJ064539571 (DE-599)DOAJ6acc5f6d633b453893916a64a1b3e509 DE-627 ger DE-627 rakwb eng RC254-282 Ilaria Maggio verfasserin aut Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors. neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lisa Manuzzi verfasserin aut Giuseppe Lamberti verfasserin aut Angela Dalia Ricci verfasserin aut Nastassja Tober verfasserin aut Davide Campana verfasserin aut In Cancers MDPI AG, 2010 12(2020), 4, p 832 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:4, p 832 https://doi.org/10.3390/cancers12040832 kostenfrei https://doaj.org/article/6acc5f6d633b453893916a64a1b3e509 kostenfrei https://www.mdpi.com/2072-6694/12/4/832 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 4, p 832
language	English
source	In Cancers 12(2020), 4, p 832 volume:12 year:2020 number:4, p 832
sourceStr	In Cancers 12(2020), 4, p 832 volume:12 year:2020 number:4, p 832
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Ilaria Maggio @@aut@@ Lisa Manuzzi @@aut@@ Giuseppe Lamberti @@aut@@ Angela Dalia Ricci @@aut@@ Nastassja Tober @@aut@@ Davide Campana @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Ilaria Maggio
spellingShingle	Ilaria Maggio misc RC254-282 misc neuroendocrine tumors misc immunotherapy misc neuroendocrine neoplasia misc neuroendocrine carcinoma misc immune checkpoint inhibitors misc Merkel cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia
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topic_title	RC254-282 Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia neuroendocrine tumors immunotherapy neuroendocrine neoplasia neuroendocrine carcinoma immune checkpoint inhibitors Merkel cell carcinoma
topic	misc RC254-282 misc neuroendocrine tumors misc immunotherapy misc neuroendocrine neoplasia misc neuroendocrine carcinoma misc immune checkpoint inhibitors misc Merkel cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc neuroendocrine tumors misc immunotherapy misc neuroendocrine neoplasia misc neuroendocrine carcinoma misc immune checkpoint inhibitors misc Merkel cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc neuroendocrine tumors misc immunotherapy misc neuroendocrine neoplasia misc neuroendocrine carcinoma misc immune checkpoint inhibitors misc Merkel cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia
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title_full	Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia
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author_browse	Ilaria Maggio Lisa Manuzzi Giuseppe Lamberti Angela Dalia Ricci Nastassja Tober Davide Campana
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title_sort	landscape and future perspectives of immunotherapy in neuroendocrine neoplasia
callnumber	RC254-282
title_auth	Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia
abstract	Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors.
abstractGer	Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors.
abstract_unstemmed	Background: Neuroendocrine neoplasms are rare entities consisting of a heterogeneous group of tumors that can originate from neuroendocrine cells present in the whole body. Their different behavior, metastatic potential, and prognosis are highly variable, depending on site of origin, grade of differentiation, and proliferative index. The aim of our work is to summarize the current knowledge of immunotherapy in different neuroendocrine neoplasms and its implication in clinical practice. Results: Several studies evaluated the efficacy and safety of immunotherapy in neuroendocrine neoplasms, in any setting of treatment, alone or in combination. Studies led to approval in neuroendocrine neoplasia of the lung, in combination with chemotherapy as first-line treatment or as a single-agent in a third-line setting, and Merkel cell carcinoma as a single agent. Results in other settings have been disappointing so far. Conclusions: Immunotherapy seems a valid treatment option for high grade, poorly differentiated neoplasms. Future trials should explore the combination of immunotherapy with other agents, such as anti-angiogenic or other immunotherapy agents, in order to evaluate potential efficacy in low and intermediate grades, well differentiated tumors.
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title_short	Landscape and Future Perspectives of Immunotherapy in Neuroendocrine Neoplasia
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author2	Lisa Manuzzi Giuseppe Lamberti Angela Dalia Ricci Nastassja Tober Davide Campana
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