Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides
Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. Howeve...
Ausführliche Beschreibung
Autor*in: |
Anri Hirai [verfasserIn] Shouta Sugio [verfasserIn] Collins Nimako [verfasserIn] Shouta M. M. Nakayama [verfasserIn] Keisuke Kato [verfasserIn] Keisuke Takahashi [verfasserIn] Koji Arizono [verfasserIn] Tetsushi Hirano [verfasserIn] Nobuhiko Hoshi [verfasserIn] Kazutoshi Fujioka [verfasserIn] Kumiko Taira [verfasserIn] Mayumi Ishizuka [verfasserIn] Hiroaki Wake [verfasserIn] Yoshinori Ikenaka [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Scientific Reports - Nature Portfolio, 2011, 12(2022), 1, Seite 13 |
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Übergeordnetes Werk: |
volume:12 ; year:2022 ; number:1 ; pages:13 |
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DOI / URN: |
10.1038/s41598-022-09038-7 |
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Katalog-ID: |
DOAJ064559114 |
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10.1038/s41598-022-09038-7 doi (DE-627)DOAJ064559114 (DE-599)DOAJ043eedf362e04a0e9e9345834d4e69da DE-627 ger DE-627 rakwb eng Anri Hirai verfasserin aut Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. Medicine R Science Q Shouta Sugio verfasserin aut Collins Nimako verfasserin aut Shouta M. M. Nakayama verfasserin aut Keisuke Kato verfasserin aut Keisuke Takahashi verfasserin aut Koji Arizono verfasserin aut Tetsushi Hirano verfasserin aut Nobuhiko Hoshi verfasserin aut Kazutoshi Fujioka verfasserin aut Kumiko Taira verfasserin aut Mayumi Ishizuka verfasserin aut Hiroaki Wake verfasserin aut Yoshinori Ikenaka verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 13 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:13 https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/article/043eedf362e04a0e9e9345834d4e69da kostenfrei https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 13 |
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10.1038/s41598-022-09038-7 doi (DE-627)DOAJ064559114 (DE-599)DOAJ043eedf362e04a0e9e9345834d4e69da DE-627 ger DE-627 rakwb eng Anri Hirai verfasserin aut Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. Medicine R Science Q Shouta Sugio verfasserin aut Collins Nimako verfasserin aut Shouta M. M. Nakayama verfasserin aut Keisuke Kato verfasserin aut Keisuke Takahashi verfasserin aut Koji Arizono verfasserin aut Tetsushi Hirano verfasserin aut Nobuhiko Hoshi verfasserin aut Kazutoshi Fujioka verfasserin aut Kumiko Taira verfasserin aut Mayumi Ishizuka verfasserin aut Hiroaki Wake verfasserin aut Yoshinori Ikenaka verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 13 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:13 https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/article/043eedf362e04a0e9e9345834d4e69da kostenfrei https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 13 |
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10.1038/s41598-022-09038-7 doi (DE-627)DOAJ064559114 (DE-599)DOAJ043eedf362e04a0e9e9345834d4e69da DE-627 ger DE-627 rakwb eng Anri Hirai verfasserin aut Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. Medicine R Science Q Shouta Sugio verfasserin aut Collins Nimako verfasserin aut Shouta M. M. Nakayama verfasserin aut Keisuke Kato verfasserin aut Keisuke Takahashi verfasserin aut Koji Arizono verfasserin aut Tetsushi Hirano verfasserin aut Nobuhiko Hoshi verfasserin aut Kazutoshi Fujioka verfasserin aut Kumiko Taira verfasserin aut Mayumi Ishizuka verfasserin aut Hiroaki Wake verfasserin aut Yoshinori Ikenaka verfasserin aut In Scientific Reports Nature Portfolio, 2011 12(2022), 1, Seite 13 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:12 year:2022 number:1 pages:13 https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/article/043eedf362e04a0e9e9345834d4e69da kostenfrei https://doi.org/10.1038/s41598-022-09038-7 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 13 |
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Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides |
abstract |
Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. |
abstractGer |
Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. |
abstract_unstemmed |
Abstract Neonicotinoid pesticides are a class of insecticides that reportedly have harmful effects on bees and dragonflies, causing a reduction in their numbers. Neonicotinoids act as neuroreceptor modulators, and some studies have reported their association with neurodevelopmental disorders. However, the precise effect of neonicotinoids on the central nervous system has not yet been identified. Herein, we conducted in vivo Ca2+ imaging using a two-photon microscope to detect the abnormal activity of neuronal circuits in the brain after neonicotinoid application. The oral administration of acetamiprid (ACE) (20 mg/kg body weight (BW) in mature mice with a quantity less than the no-observed-adverse-effect level (NOAEL) and a tenth or half of the median lethal dose (LD50) of nicotine (0.33 or 1.65 mg/kg BW, respectively), as a typical nicotinic acetylcholine receptor (nAChR) agonist, increased anxiety-like behavior associated with altered activities of the neuronal population in the somatosensory cortex. Furthermore, we detected ACE and its metabolites in the brain, 1 h after ACE administration. The results suggested that in vivo Ca2+ imaging using a two-photon microscope enabled the highly sensitive detection of neurotoxicant-mediated brain disturbance of nerves. |
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container_issue |
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title_short |
Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides |
url |
https://doi.org/10.1038/s41598-022-09038-7 https://doaj.org/article/043eedf362e04a0e9e9345834d4e69da https://doaj.org/toc/2045-2322 |
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author2 |
Shouta Sugio Collins Nimako Shouta M. M. Nakayama Keisuke Kato Keisuke Takahashi Koji Arizono Tetsushi Hirano Nobuhiko Hoshi Kazutoshi Fujioka Kumiko Taira Mayumi Ishizuka Hiroaki Wake Yoshinori Ikenaka |
author2Str |
Shouta Sugio Collins Nimako Shouta M. M. Nakayama Keisuke Kato Keisuke Takahashi Koji Arizono Tetsushi Hirano Nobuhiko Hoshi Kazutoshi Fujioka Kumiko Taira Mayumi Ishizuka Hiroaki Wake Yoshinori Ikenaka |
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doi_str |
10.1038/s41598-022-09038-7 |
up_date |
2024-07-03T23:26:50.431Z |
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