Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study

Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people w...
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Autor*in:	Anxin Wang [verfasserIn] Yang Sun [verfasserIn] Xiaoxue Liu [verfasserIn] Zhaoping Su [verfasserIn] Junjuan Li [verfasserIn] Yanxia Luo [verfasserIn] Shuohua Chen [verfasserIn] Jianli Wang [verfasserIn] Xia Li [verfasserIn] Zhan Zhao [verfasserIn] Huiping Zhu [verfasserIn] Shouling Wu [verfasserIn] Xiuhua Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Myocardial infarction Proteinuria Diabetes Pre-diabetes

Übergeordnetes Werk:	In: Cardiovascular Diabetology - BMC, 2003, 16(2017), 1, Seite 9
Übergeordnetes Werk:	volume:16 ; year:2017 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12933-017-0586-7

Katalog-ID:	DOAJ064579921

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520			\|a Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes.
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650		4	\|a Proteinuria
650		4	\|a Diabetes
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700	0		\|a Yang Sun \|e verfasserin \|4 aut
700	0		\|a Xiaoxue Liu \|e verfasserin \|4 aut
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700	0		\|a Junjuan Li \|e verfasserin \|4 aut
700	0		\|a Yanxia Luo \|e verfasserin \|4 aut
700	0		\|a Shuohua Chen \|e verfasserin \|4 aut
700	0		\|a Jianli Wang \|e verfasserin \|4 aut
700	0		\|a Xia Li \|e verfasserin \|4 aut
700	0		\|a Zhan Zhao \|e verfasserin \|4 aut
700	0		\|a Huiping Zhu \|e verfasserin \|4 aut
700	0		\|a Shouling Wu \|e verfasserin \|4 aut
700	0		\|a Xiuhua Guo \|e verfasserin \|4 aut
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allfields	10.1186/s12933-017-0586-7 doi (DE-627)DOAJ064579921 (DE-599)DOAJb59d248af0b14a76823ae6dea7664c17 DE-627 ger DE-627 rakwb eng RC666-701 Anxin Wang verfasserin aut Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes. Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system Yang Sun verfasserin aut Xiaoxue Liu verfasserin aut Zhaoping Su verfasserin aut Junjuan Li verfasserin aut Yanxia Luo verfasserin aut Shuohua Chen verfasserin aut Jianli Wang verfasserin aut Xia Li verfasserin aut Zhan Zhao verfasserin aut Huiping Zhu verfasserin aut Shouling Wu verfasserin aut Xiuhua Guo verfasserin aut In Cardiovascular Diabetology BMC, 2003 16(2017), 1, Seite 9 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:16 year:2017 number:1 pages:9 https://doi.org/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 kostenfrei http://link.springer.com/article/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 9
spelling	10.1186/s12933-017-0586-7 doi (DE-627)DOAJ064579921 (DE-599)DOAJb59d248af0b14a76823ae6dea7664c17 DE-627 ger DE-627 rakwb eng RC666-701 Anxin Wang verfasserin aut Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes. Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system Yang Sun verfasserin aut Xiaoxue Liu verfasserin aut Zhaoping Su verfasserin aut Junjuan Li verfasserin aut Yanxia Luo verfasserin aut Shuohua Chen verfasserin aut Jianli Wang verfasserin aut Xia Li verfasserin aut Zhan Zhao verfasserin aut Huiping Zhu verfasserin aut Shouling Wu verfasserin aut Xiuhua Guo verfasserin aut In Cardiovascular Diabetology BMC, 2003 16(2017), 1, Seite 9 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:16 year:2017 number:1 pages:9 https://doi.org/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 kostenfrei http://link.springer.com/article/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 9
allfields_unstemmed	10.1186/s12933-017-0586-7 doi (DE-627)DOAJ064579921 (DE-599)DOAJb59d248af0b14a76823ae6dea7664c17 DE-627 ger DE-627 rakwb eng RC666-701 Anxin Wang verfasserin aut Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes. Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system Yang Sun verfasserin aut Xiaoxue Liu verfasserin aut Zhaoping Su verfasserin aut Junjuan Li verfasserin aut Yanxia Luo verfasserin aut Shuohua Chen verfasserin aut Jianli Wang verfasserin aut Xia Li verfasserin aut Zhan Zhao verfasserin aut Huiping Zhu verfasserin aut Shouling Wu verfasserin aut Xiuhua Guo verfasserin aut In Cardiovascular Diabetology BMC, 2003 16(2017), 1, Seite 9 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:16 year:2017 number:1 pages:9 https://doi.org/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 kostenfrei http://link.springer.com/article/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 9
allfieldsGer	10.1186/s12933-017-0586-7 doi (DE-627)DOAJ064579921 (DE-599)DOAJb59d248af0b14a76823ae6dea7664c17 DE-627 ger DE-627 rakwb eng RC666-701 Anxin Wang verfasserin aut Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes. Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system Yang Sun verfasserin aut Xiaoxue Liu verfasserin aut Zhaoping Su verfasserin aut Junjuan Li verfasserin aut Yanxia Luo verfasserin aut Shuohua Chen verfasserin aut Jianli Wang verfasserin aut Xia Li verfasserin aut Zhan Zhao verfasserin aut Huiping Zhu verfasserin aut Shouling Wu verfasserin aut Xiuhua Guo verfasserin aut In Cardiovascular Diabetology BMC, 2003 16(2017), 1, Seite 9 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:16 year:2017 number:1 pages:9 https://doi.org/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 kostenfrei http://link.springer.com/article/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 9
allfieldsSound	10.1186/s12933-017-0586-7 doi (DE-627)DOAJ064579921 (DE-599)DOAJb59d248af0b14a76823ae6dea7664c17 DE-627 ger DE-627 rakwb eng RC666-701 Anxin Wang verfasserin aut Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes. Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system Yang Sun verfasserin aut Xiaoxue Liu verfasserin aut Zhaoping Su verfasserin aut Junjuan Li verfasserin aut Yanxia Luo verfasserin aut Shuohua Chen verfasserin aut Jianli Wang verfasserin aut Xia Li verfasserin aut Zhan Zhao verfasserin aut Huiping Zhu verfasserin aut Shouling Wu verfasserin aut Xiuhua Guo verfasserin aut In Cardiovascular Diabetology BMC, 2003 16(2017), 1, Seite 9 (DE-627)356593665 (DE-600)2093769-6 14752840 nnns volume:16 year:2017 number:1 pages:9 https://doi.org/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 kostenfrei http://link.springer.com/article/10.1186/s12933-017-0586-7 kostenfrei https://doaj.org/toc/1475-2840 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 9
language	English
source	In Cardiovascular Diabetology 16(2017), 1, Seite 9 volume:16 year:2017 number:1 pages:9
sourceStr	In Cardiovascular Diabetology 16(2017), 1, Seite 9 volume:16 year:2017 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Myocardial infarction Proteinuria Diabetes Pre-diabetes Diseases of the circulatory (Cardiovascular) system
isfreeaccess_bool	true
container_title	Cardiovascular Diabetology
authorswithroles_txt_mv	Anxin Wang @@aut@@ Yang Sun @@aut@@ Xiaoxue Liu @@aut@@ Zhaoping Su @@aut@@ Junjuan Li @@aut@@ Yanxia Luo @@aut@@ Shuohua Chen @@aut@@ Jianli Wang @@aut@@ Xia Li @@aut@@ Zhan Zhao @@aut@@ Huiping Zhu @@aut@@ Shouling Wu @@aut@@ Xiuhua Guo @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	356593665
id	DOAJ064579921
language_de	englisch
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We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. 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callnumber-first	R - Medicine
author	Anxin Wang
spellingShingle	Anxin Wang misc RC666-701 misc Myocardial infarction misc Proteinuria misc Diabetes misc Pre-diabetes misc Diseases of the circulatory (Cardiovascular) system Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
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topic_title	RC666-701 Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study Myocardial infarction Proteinuria Diabetes Pre-diabetes
topic	misc RC666-701 misc Myocardial infarction misc Proteinuria misc Diabetes misc Pre-diabetes misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc Myocardial infarction misc Proteinuria misc Diabetes misc Pre-diabetes misc Diseases of the circulatory (Cardiovascular) system
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title	Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
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title_full	Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
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author_browse	Anxin Wang Yang Sun Xiaoxue Liu Zhaoping Su Junjuan Li Yanxia Luo Shuohua Chen Jianli Wang Xia Li Zhan Zhao Huiping Zhu Shouling Wu Xiuhua Guo
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title_sort	changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
callnumber	RC666-701
title_auth	Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
abstract	Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes.
abstractGer	Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes.
abstract_unstemmed	Abstract Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year period in the incidence of MI in people with diabetes or pre-diabetes. Methods Based on the baseline and 2-year dipstick screening results from the Kailuan prospective cohort study, participants were divided into four categories: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Four multivariable Cox proportional hazard models were built to adjust for the effects of different confounding covariates. Results Among the 17,625 participants in this study, there were a total of 238 incidents of MI during a median follow-up of 6.69 years. After adjusting for demography factors and laboratory indices, the association between persistent proteinuria and MI incidence was maintained (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.48–4.22). Every decrease of proteinuria from 2006 to 2008 was observed to be responsible for a 21% decline of MI incidence (HR 0.79, 95% CI 0.68–0.90). The interaction between changes in proteinuria and diabetes was confirmed with no effect on MI (P = 0.3371). Conclusions Persistent proteinuria is an independent risk factor for MI incidence in the pre-diabetic and diabetic population. These findings may help clinicians to interpret proteinuria changes in the outpatient setting and provide possible preventive approaches for people with pre-diabetes or diabetes.
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title_short	Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study
url	https://doi.org/10.1186/s12933-017-0586-7 https://doaj.org/article/b59d248af0b14a76823ae6dea7664c17 http://link.springer.com/article/10.1186/s12933-017-0586-7 https://doaj.org/toc/1475-2840
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Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study

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