Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat

Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucid...
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Autor*in:	Ka-Yeon Lee [verfasserIn] Jae-Hyun Kim [verfasserIn] Eun-Young Kim [verfasserIn] Mijung Yeom [verfasserIn] Hyuk-Sang Jung [verfasserIn] Youngjoo Sohn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat

Übergeordnetes Werk:	In: BMC Complementary and Alternative Medicine - BMC, 2003, 19(2019), 1, Seite 12
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12906-019-2611-8

Katalog-ID:	DOAJ064610802

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520			\|a Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis.
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author_variant	k y l kyl j h k jhk e y k eyk m y my h s j hsj y s ys
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allfields	10.1186/s12906-019-2611-8 doi (DE-627)DOAJ064610802 (DE-599)DOAJ5110a33b6f4d445685617f5038d6db5a DE-627 ger DE-627 rakwb eng RZ201-999 Ka-Yeon Lee verfasserin aut Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis. Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat Other systems of medicine Jae-Hyun Kim verfasserin aut Eun-Young Kim verfasserin aut Mijung Yeom verfasserin aut Hyuk-Sang Jung verfasserin aut Youngjoo Sohn verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 19(2019), 1, Seite 12 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:19 year:2019 number:1 pages:12 https://doi.org/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a kostenfrei http://link.springer.com/article/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 12
spelling	10.1186/s12906-019-2611-8 doi (DE-627)DOAJ064610802 (DE-599)DOAJ5110a33b6f4d445685617f5038d6db5a DE-627 ger DE-627 rakwb eng RZ201-999 Ka-Yeon Lee verfasserin aut Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis. Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat Other systems of medicine Jae-Hyun Kim verfasserin aut Eun-Young Kim verfasserin aut Mijung Yeom verfasserin aut Hyuk-Sang Jung verfasserin aut Youngjoo Sohn verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 19(2019), 1, Seite 12 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:19 year:2019 number:1 pages:12 https://doi.org/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a kostenfrei http://link.springer.com/article/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 12
allfields_unstemmed	10.1186/s12906-019-2611-8 doi (DE-627)DOAJ064610802 (DE-599)DOAJ5110a33b6f4d445685617f5038d6db5a DE-627 ger DE-627 rakwb eng RZ201-999 Ka-Yeon Lee verfasserin aut Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis. Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat Other systems of medicine Jae-Hyun Kim verfasserin aut Eun-Young Kim verfasserin aut Mijung Yeom verfasserin aut Hyuk-Sang Jung verfasserin aut Youngjoo Sohn verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 19(2019), 1, Seite 12 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:19 year:2019 number:1 pages:12 https://doi.org/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a kostenfrei http://link.springer.com/article/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 12
allfieldsGer	10.1186/s12906-019-2611-8 doi (DE-627)DOAJ064610802 (DE-599)DOAJ5110a33b6f4d445685617f5038d6db5a DE-627 ger DE-627 rakwb eng RZ201-999 Ka-Yeon Lee verfasserin aut Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis. Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat Other systems of medicine Jae-Hyun Kim verfasserin aut Eun-Young Kim verfasserin aut Mijung Yeom verfasserin aut Hyuk-Sang Jung verfasserin aut Youngjoo Sohn verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 19(2019), 1, Seite 12 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:19 year:2019 number:1 pages:12 https://doi.org/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a kostenfrei http://link.springer.com/article/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 12
allfieldsSound	10.1186/s12906-019-2611-8 doi (DE-627)DOAJ064610802 (DE-599)DOAJ5110a33b6f4d445685617f5038d6db5a DE-627 ger DE-627 rakwb eng RZ201-999 Ka-Yeon Lee verfasserin aut Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis. Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat Other systems of medicine Jae-Hyun Kim verfasserin aut Eun-Young Kim verfasserin aut Mijung Yeom verfasserin aut Hyuk-Sang Jung verfasserin aut Youngjoo Sohn verfasserin aut In BMC Complementary and Alternative Medicine BMC, 2003 19(2019), 1, Seite 12 (DE-627)331018713 (DE-600)2050429-9 14726882 nnns volume:19 year:2019 number:1 pages:12 https://doi.org/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a kostenfrei http://link.springer.com/article/10.1186/s12906-019-2611-8 kostenfrei https://doaj.org/toc/1472-6882 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 12
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Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. 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callnumber-first	R - Medicine
author	Ka-Yeon Lee
spellingShingle	Ka-Yeon Lee misc RZ201-999 misc Cnidii Rhizoma misc Osteoclast, NFATc1, c-Fos misc Ovariectomized-rat misc Other systems of medicine Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat
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topic_title	RZ201-999 Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat Cnidii Rhizoma Osteoclast, NFATc1, c-Fos Ovariectomized-rat
topic	misc RZ201-999 misc Cnidii Rhizoma misc Osteoclast, NFATc1, c-Fos misc Ovariectomized-rat misc Other systems of medicine
topic_unstemmed	misc RZ201-999 misc Cnidii Rhizoma misc Osteoclast, NFATc1, c-Fos misc Ovariectomized-rat misc Other systems of medicine
topic_browse	misc RZ201-999 misc Cnidii Rhizoma misc Osteoclast, NFATc1, c-Fos misc Ovariectomized-rat misc Other systems of medicine
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title	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat
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title_full	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat
author_sort	Ka-Yeon Lee
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author_browse	Ka-Yeon Lee Jae-Hyun Kim Eun-Young Kim Mijung Yeom Hyuk-Sang Jung Youngjoo Sohn
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author-letter	Ka-Yeon Lee
doi_str_mv	10.1186/s12906-019-2611-8
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title_sort	water extract of cnidii rhizoma suppresses rankl-induced osteoclastogenesis in raw 264.7 cell by inhibiting nfatc1/c-fos signaling and prevents ovariectomized bone loss in sd-rat
callnumber	RZ201-999
title_auth	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat
abstract	Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis.
abstractGer	Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis.
abstract_unstemmed	Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway. Methods The anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats. Results CR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats. Conclusion These results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis.
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title_short	Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat
url	https://doi.org/10.1186/s12906-019-2611-8 https://doaj.org/article/5110a33b6f4d445685617f5038d6db5a http://link.springer.com/article/10.1186/s12906-019-2611-8 https://doaj.org/toc/1472-6882
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author2	Jae-Hyun Kim Eun-Young Kim Mijung Yeom Hyuk-Sang Jung Youngjoo Sohn
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up_date	2024-07-03T23:40:04.386Z
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Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat

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