Wound healing activity of ointment containing essential oils of yarrow floodplain herb
It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
S. D. Trzhetsinsky [verfasserIn] V. I. Mozul [verfasserIn] G. A. Gernova [verfasserIn] N. S. Fursa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki - Zaporozhye State Medical University, 2016, (2014), 2, Seite 50-53 |
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| Übergeordnetes Werk: |
year:2014 ; number:2 ; pages:50-53 |
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Link aufrufen |
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| DOI / URN: |
10.14739/2409-2932.2014.2.26163 |
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| Katalog-ID: |
DOAJ064872084 |
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| 520 | |a It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. | ||
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10.14739/2409-2932.2014.2.26163 doi (DE-627)DOAJ064872084 (DE-599)DOAJ52fa984aab284c188e0a36a240e796e5 DE-627 ger DE-627 rakwb eng rus ukr RS1-441 S. D. Trzhetsinsky verfasserin aut Wound healing activity of ointment containing essential oils of yarrow floodplain herb 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. Achillea Volatile Oils Gas Chromatography-mass Spectrometry Wound Healing Pharmacy and materia medica V. I. Mozul verfasserin aut G. A. Gernova verfasserin aut N. S. Fursa verfasserin aut In Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Zaporozhye State Medical University, 2016 (2014), 2, Seite 50-53 (DE-627)1760603511 24092932 nnns year:2014 number:2 pages:50-53 https://doi.org/10.14739/2409-2932.2014.2.26163 kostenfrei https://doaj.org/article/52fa984aab284c188e0a36a240e796e5 kostenfrei http://pharmed.zsmu.edu.ua/article/view/26163/23621 kostenfrei https://doaj.org/toc/2306-8094 Journal toc kostenfrei https://doaj.org/toc/2409-2932 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2014 2 50-53 |
| spelling |
10.14739/2409-2932.2014.2.26163 doi (DE-627)DOAJ064872084 (DE-599)DOAJ52fa984aab284c188e0a36a240e796e5 DE-627 ger DE-627 rakwb eng rus ukr RS1-441 S. D. Trzhetsinsky verfasserin aut Wound healing activity of ointment containing essential oils of yarrow floodplain herb 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. Achillea Volatile Oils Gas Chromatography-mass Spectrometry Wound Healing Pharmacy and materia medica V. I. Mozul verfasserin aut G. A. Gernova verfasserin aut N. S. Fursa verfasserin aut In Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Zaporozhye State Medical University, 2016 (2014), 2, Seite 50-53 (DE-627)1760603511 24092932 nnns year:2014 number:2 pages:50-53 https://doi.org/10.14739/2409-2932.2014.2.26163 kostenfrei https://doaj.org/article/52fa984aab284c188e0a36a240e796e5 kostenfrei http://pharmed.zsmu.edu.ua/article/view/26163/23621 kostenfrei https://doaj.org/toc/2306-8094 Journal toc kostenfrei https://doaj.org/toc/2409-2932 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2014 2 50-53 |
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10.14739/2409-2932.2014.2.26163 doi (DE-627)DOAJ064872084 (DE-599)DOAJ52fa984aab284c188e0a36a240e796e5 DE-627 ger DE-627 rakwb eng rus ukr RS1-441 S. D. Trzhetsinsky verfasserin aut Wound healing activity of ointment containing essential oils of yarrow floodplain herb 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. Achillea Volatile Oils Gas Chromatography-mass Spectrometry Wound Healing Pharmacy and materia medica V. I. Mozul verfasserin aut G. A. Gernova verfasserin aut N. S. Fursa verfasserin aut In Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Zaporozhye State Medical University, 2016 (2014), 2, Seite 50-53 (DE-627)1760603511 24092932 nnns year:2014 number:2 pages:50-53 https://doi.org/10.14739/2409-2932.2014.2.26163 kostenfrei https://doaj.org/article/52fa984aab284c188e0a36a240e796e5 kostenfrei http://pharmed.zsmu.edu.ua/article/view/26163/23621 kostenfrei https://doaj.org/toc/2306-8094 Journal toc kostenfrei https://doaj.org/toc/2409-2932 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2014 2 50-53 |
| allfieldsGer |
10.14739/2409-2932.2014.2.26163 doi (DE-627)DOAJ064872084 (DE-599)DOAJ52fa984aab284c188e0a36a240e796e5 DE-627 ger DE-627 rakwb eng rus ukr RS1-441 S. D. Trzhetsinsky verfasserin aut Wound healing activity of ointment containing essential oils of yarrow floodplain herb 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. Achillea Volatile Oils Gas Chromatography-mass Spectrometry Wound Healing Pharmacy and materia medica V. I. Mozul verfasserin aut G. A. Gernova verfasserin aut N. S. Fursa verfasserin aut In Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Zaporozhye State Medical University, 2016 (2014), 2, Seite 50-53 (DE-627)1760603511 24092932 nnns year:2014 number:2 pages:50-53 https://doi.org/10.14739/2409-2932.2014.2.26163 kostenfrei https://doaj.org/article/52fa984aab284c188e0a36a240e796e5 kostenfrei http://pharmed.zsmu.edu.ua/article/view/26163/23621 kostenfrei https://doaj.org/toc/2306-8094 Journal toc kostenfrei https://doaj.org/toc/2409-2932 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2014 2 50-53 |
| allfieldsSound |
10.14739/2409-2932.2014.2.26163 doi (DE-627)DOAJ064872084 (DE-599)DOAJ52fa984aab284c188e0a36a240e796e5 DE-627 ger DE-627 rakwb eng rus ukr RS1-441 S. D. Trzhetsinsky verfasserin aut Wound healing activity of ointment containing essential oils of yarrow floodplain herb 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. Achillea Volatile Oils Gas Chromatography-mass Spectrometry Wound Healing Pharmacy and materia medica V. I. Mozul verfasserin aut G. A. Gernova verfasserin aut N. S. Fursa verfasserin aut In Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Zaporozhye State Medical University, 2016 (2014), 2, Seite 50-53 (DE-627)1760603511 24092932 nnns year:2014 number:2 pages:50-53 https://doi.org/10.14739/2409-2932.2014.2.26163 kostenfrei https://doaj.org/article/52fa984aab284c188e0a36a240e796e5 kostenfrei http://pharmed.zsmu.edu.ua/article/view/26163/23621 kostenfrei https://doaj.org/toc/2306-8094 Journal toc kostenfrei https://doaj.org/toc/2409-2932 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2014 2 50-53 |
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Wound healing activity of ointment containing essential oils of yarrow floodplain herb |
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It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. |
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It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. |
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It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ064872084</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309042821.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.14739/2409-2932.2014.2.26163</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ064872084</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ52fa984aab284c188e0a36a240e796e5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">rus</subfield><subfield code="a">ukr</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RS1-441</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">S. 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Trzhetsinsky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Wound healing activity of ointment containing essential oils of yarrow floodplain herb</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">It has been revealed by the method of chromatography-mass spectrometry that in the essential oil of yarrow floodplain dominate sesquiterpenoids, such as hamazulen (23,23%), karyophyllenoxydу (15,18%), β-karyophyllene (6,03 %). As a result, pharmacological studies has revealed the healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric. The search of effective treatments for infected wound processes is one of the important problems of medicine. As a result of many years research in the flora of southern Ukraine we found genus Achillea promising for the use in medicine, due to its contents of various groups of biologically active substances. The purpose of this study was to examine the wound healing activity of an ointment containing 10 % of yarrow floodplain essential oil. Materials and methods. Aboveground plant parts in Zaporizhzhya region and Crimea during mass flowering have been harvested for essential oil. The essential oil obtained by method of hydrodistillation. Analysis of essential oils has been carried out on a chromatograph Agilent Technology – 6890 with mass spectrometric detector 5973 N. The study has been conducted in a wound healing activity in vivo experiments on 21 white male rats of Wistar line, weight 220.0 ± 20.0 g with no external signs of disease. Wound defect has been formed by conditioning shaved area of the skin by 20 % alcoholic solution of sulfuric acid. Results and discussion. For an objective assessment rate of wound healing by the area changing, we used planimetric method of L.N. Popov, calculating the average area (M ± m), the percentage of reduction of the wounds area in relation to the original size (that is the percentage of wound healing) and the rate of wound healing (that is the percentage of reduction of area per day). By chromatography-mass spectrometry in the essential oil of yarrow herb floodplain 62 components have been found, from which 34 components have been identified, they have antiseptic, anti-inflammatory, wound healing, immune-stimulating, regenerative properties according to the literature data. Pharmacological studies of wound healing ability of yarrow floodplain essential oil showed a significant increasing of the rate of skin defect regeneration. The study has found significant differences in the percentage of wound surface area reduction between the control animals and rats treated by 10% ointment of yarrow floodplain essentia. The maximum difference in terms of percentage between the experimental and control group recorded on the 10th day of the experiment, accounting for 41.08 %. It should be noted that in addition to wound healing activity of the ointment with essential oils of yarrow stimulated the restoration of damaged hair in experimental animals. It is also important to note that in the experimental group edema of the tissue surrounding the wound decreased significantly starting from the 4th day of the experiment, whereas in the control group, the edema and inflammation around the wounds have been maintained for 7-8 days. During the experiment, wound healing effect has been observed in the control animals to 18 days of experiment, while the use of an ointment containing essential oil of yarrow floodplain has contributed significantly to the acceleration of the regeneration. Healing of the defect with using the proposed agent has been observed a week earlier. Conclusions: 1. As a result, pharmacological studies has revealed healing action of an ointment containing essential oil of yarrow floodplain that showed significant increasing rate of regeneration in defect of the skin, caused by an alcoholic solution of sulfuric acid. 2. The obtained results indicate the prospects of further study the ointment containing essential oil of yarrow floodplain in order to create an effective drug with a wound healing activity.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Achillea</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Volatile Oils</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gas Chromatography-mass Spectrometry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Wound Healing</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pharmacy and materia medica</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">V. I. Mozul</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">G. A. Gernova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">N. S. Fursa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki</subfield><subfield code="d">Zaporozhye State Medical University, 2016</subfield><subfield code="g">(2014), 2, Seite 50-53</subfield><subfield code="w">(DE-627)1760603511</subfield><subfield code="x">24092932</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">year:2014</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:50-53</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.14739/2409-2932.2014.2.26163</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/52fa984aab284c188e0a36a240e796e5</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://pharmed.zsmu.edu.ua/article/view/26163/23621</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2306-8094</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2409-2932</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="j">2014</subfield><subfield code="e">2</subfield><subfield code="h">50-53</subfield></datafield></record></collection>
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