Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes

BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Gianluca Rosso [verfasserIn] Elena Aragno [verfasserIn] Emina Mehanović [verfasserIn] Gabriele Di Salvo [verfasserIn] Giuseppe Maina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	bipolar disorder women reproductive cycles menarche peripartum episodes

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2020.00851

Katalog-ID:	DOAJ065336089

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520			\|a BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies.
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allfields	10.3389/fpsyt.2020.00851 doi (DE-627)DOAJ065336089 (DE-599)DOAJ533a6a13b49445458ce8b63e60f0a2f0 DE-627 ger DE-627 rakwb eng RC435-571 Gianluca Rosso verfasserin aut Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. bipolar disorder women reproductive cycles menarche peripartum episodes Psychiatry Gianluca Rosso verfasserin aut Elena Aragno verfasserin aut Emina Mehanović verfasserin aut Gabriele Di Salvo verfasserin aut Giuseppe Maina verfasserin aut Giuseppe Maina verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 11(2020) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:11 year:2020 https://doi.org/10.3389/fpsyt.2020.00851 kostenfrei https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
spelling	10.3389/fpsyt.2020.00851 doi (DE-627)DOAJ065336089 (DE-599)DOAJ533a6a13b49445458ce8b63e60f0a2f0 DE-627 ger DE-627 rakwb eng RC435-571 Gianluca Rosso verfasserin aut Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. bipolar disorder women reproductive cycles menarche peripartum episodes Psychiatry Gianluca Rosso verfasserin aut Elena Aragno verfasserin aut Emina Mehanović verfasserin aut Gabriele Di Salvo verfasserin aut Giuseppe Maina verfasserin aut Giuseppe Maina verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 11(2020) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:11 year:2020 https://doi.org/10.3389/fpsyt.2020.00851 kostenfrei https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfields_unstemmed	10.3389/fpsyt.2020.00851 doi (DE-627)DOAJ065336089 (DE-599)DOAJ533a6a13b49445458ce8b63e60f0a2f0 DE-627 ger DE-627 rakwb eng RC435-571 Gianluca Rosso verfasserin aut Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. bipolar disorder women reproductive cycles menarche peripartum episodes Psychiatry Gianluca Rosso verfasserin aut Elena Aragno verfasserin aut Emina Mehanović verfasserin aut Gabriele Di Salvo verfasserin aut Giuseppe Maina verfasserin aut Giuseppe Maina verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 11(2020) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:11 year:2020 https://doi.org/10.3389/fpsyt.2020.00851 kostenfrei https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsGer	10.3389/fpsyt.2020.00851 doi (DE-627)DOAJ065336089 (DE-599)DOAJ533a6a13b49445458ce8b63e60f0a2f0 DE-627 ger DE-627 rakwb eng RC435-571 Gianluca Rosso verfasserin aut Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. bipolar disorder women reproductive cycles menarche peripartum episodes Psychiatry Gianluca Rosso verfasserin aut Elena Aragno verfasserin aut Emina Mehanović verfasserin aut Gabriele Di Salvo verfasserin aut Giuseppe Maina verfasserin aut Giuseppe Maina verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 11(2020) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:11 year:2020 https://doi.org/10.3389/fpsyt.2020.00851 kostenfrei https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsSound	10.3389/fpsyt.2020.00851 doi (DE-627)DOAJ065336089 (DE-599)DOAJ533a6a13b49445458ce8b63e60f0a2f0 DE-627 ger DE-627 rakwb eng RC435-571 Gianluca Rosso verfasserin aut Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies. bipolar disorder women reproductive cycles menarche peripartum episodes Psychiatry Gianluca Rosso verfasserin aut Elena Aragno verfasserin aut Emina Mehanović verfasserin aut Gabriele Di Salvo verfasserin aut Giuseppe Maina verfasserin aut Giuseppe Maina verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 11(2020) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:11 year:2020 https://doi.org/10.3389/fpsyt.2020.00851 kostenfrei https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. 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callnumber-first	R - Medicine
author	Gianluca Rosso
spellingShingle	Gianluca Rosso misc RC435-571 misc bipolar disorder misc women misc reproductive cycles misc menarche misc peripartum episodes misc Psychiatry Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes
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topic_title	RC435-571 Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes bipolar disorder women reproductive cycles menarche peripartum episodes
topic	misc RC435-571 misc bipolar disorder misc women misc reproductive cycles misc menarche misc peripartum episodes misc Psychiatry
topic_unstemmed	misc RC435-571 misc bipolar disorder misc women misc reproductive cycles misc menarche misc peripartum episodes misc Psychiatry
topic_browse	misc RC435-571 misc bipolar disorder misc women misc reproductive cycles misc menarche misc peripartum episodes misc Psychiatry
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title	Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes
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title_full	Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes
author_sort	Gianluca Rosso
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author_browse	Gianluca Rosso Elena Aragno Emina Mehanović Gabriele Di Salvo Giuseppe Maina
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title_sort	age at menarche in women with bipolar disorder: correlation with clinical features and peripartum episodes
callnumber	RC435-571
title_auth	Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes
abstract	BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies.
abstractGer	BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies.
abstract_unstemmed	BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies.
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title_short	Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes
url	https://doi.org/10.3389/fpsyt.2020.00851 https://doaj.org/article/533a6a13b49445458ce8b63e60f0a2f0 https://www.frontiersin.org/article/10.3389/fpsyt.2020.00851/full https://doaj.org/toc/1664-0640
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However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. 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Age at Menarche in Women With Bipolar Disorder: Correlation With Clinical Features and Peripartum Episodes

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