Hydrogen: An Endogenous Regulator of Liver Homeostasis

Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in h...
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Autor*in:	Yaxing Zhang [verfasserIn] Jingting Xu [verfasserIn] Hongzhi Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	gut microbiota oxidative stress inflammation apoptosis glucose homeostasis lipids homeostasis

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2020.00877

Katalog-ID:	DOAJ065371321

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allfieldsSound	10.3389/fphar.2020.00877 doi (DE-627)DOAJ065371321 (DE-599)DOAJ717227b72b174f3fa72daff85c93a740 DE-627 ger DE-627 rakwb eng RM1-950 Yaxing Zhang verfasserin aut Hydrogen: An Endogenous Regulator of Liver Homeostasis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in human body is mainly produced by anaerobic bacteria, such as Firmicutes and Bacteroides, in gut and other organs through the reversible oxidation reaction of 2 H+ + 2 e- ⇌ H2. Supplement of exogenous H2 can improve many kinds of liver injuries, modulate glucose and lipids metabolism in animal models or in human beings. Moreover, hepatic glycogen has strong ability to accumulate H2, thus, among the organs examined, liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo. The inadequate production of endogenous H2 play essential roles in brain, heart, and liver disorders, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Therefore, the endogenous H2 may play essential roles in maintaining liver homeostasis. gut microbiota oxidative stress inflammation apoptosis glucose homeostasis lipids homeostasis Therapeutics. Pharmacology Yaxing Zhang verfasserin aut Jingting Xu verfasserin aut Hongzhi Yang verfasserin aut Hongzhi Yang verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 11(2020) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:11 year:2020 https://doi.org/10.3389/fphar.2020.00877 kostenfrei https://doaj.org/article/717227b72b174f3fa72daff85c93a740 kostenfrei https://www.frontiersin.org/article/10.3389/fphar.2020.00877/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
language	English
source	In Frontiers in Pharmacology 11(2020) volume:11 year:2020
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topic_facet	gut microbiota oxidative stress inflammation apoptosis glucose homeostasis lipids homeostasis Therapeutics. Pharmacology
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container_title	Frontiers in Pharmacology
authorswithroles_txt_mv	Yaxing Zhang @@aut@@ Jingting Xu @@aut@@ Hongzhi Yang @@aut@@
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callnumber-first	R - Medicine
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spellingShingle	Yaxing Zhang misc RM1-950 misc gut microbiota misc oxidative stress misc inflammation misc apoptosis misc glucose homeostasis misc lipids homeostasis misc Therapeutics. Pharmacology Hydrogen: An Endogenous Regulator of Liver Homeostasis
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topic_title	RM1-950 Hydrogen: An Endogenous Regulator of Liver Homeostasis gut microbiota oxidative stress inflammation apoptosis glucose homeostasis lipids homeostasis
topic	misc RM1-950 misc gut microbiota misc oxidative stress misc inflammation misc apoptosis misc glucose homeostasis misc lipids homeostasis misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc gut microbiota misc oxidative stress misc inflammation misc apoptosis misc glucose homeostasis misc lipids homeostasis misc Therapeutics. Pharmacology
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title	Hydrogen: An Endogenous Regulator of Liver Homeostasis
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title_full	Hydrogen: An Endogenous Regulator of Liver Homeostasis
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title_sort	hydrogen: an endogenous regulator of liver homeostasis
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title_auth	Hydrogen: An Endogenous Regulator of Liver Homeostasis
abstract	Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in human body is mainly produced by anaerobic bacteria, such as Firmicutes and Bacteroides, in gut and other organs through the reversible oxidation reaction of 2 H+ + 2 e- ⇌ H2. Supplement of exogenous H2 can improve many kinds of liver injuries, modulate glucose and lipids metabolism in animal models or in human beings. Moreover, hepatic glycogen has strong ability to accumulate H2, thus, among the organs examined, liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo. The inadequate production of endogenous H2 play essential roles in brain, heart, and liver disorders, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Therefore, the endogenous H2 may play essential roles in maintaining liver homeostasis.
abstractGer	Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in human body is mainly produced by anaerobic bacteria, such as Firmicutes and Bacteroides, in gut and other organs through the reversible oxidation reaction of 2 H+ + 2 e- ⇌ H2. Supplement of exogenous H2 can improve many kinds of liver injuries, modulate glucose and lipids metabolism in animal models or in human beings. Moreover, hepatic glycogen has strong ability to accumulate H2, thus, among the organs examined, liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo. The inadequate production of endogenous H2 play essential roles in brain, heart, and liver disorders, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Therefore, the endogenous H2 may play essential roles in maintaining liver homeostasis.
abstract_unstemmed	Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in human body is mainly produced by anaerobic bacteria, such as Firmicutes and Bacteroides, in gut and other organs through the reversible oxidation reaction of 2 H+ + 2 e- ⇌ H2. Supplement of exogenous H2 can improve many kinds of liver injuries, modulate glucose and lipids metabolism in animal models or in human beings. Moreover, hepatic glycogen has strong ability to accumulate H2, thus, among the organs examined, liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo. The inadequate production of endogenous H2 play essential roles in brain, heart, and liver disorders, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Therefore, the endogenous H2 may play essential roles in maintaining liver homeostasis.
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title_short	Hydrogen: An Endogenous Regulator of Liver Homeostasis
url	https://doi.org/10.3389/fphar.2020.00877 https://doaj.org/article/717227b72b174f3fa72daff85c93a740 https://www.frontiersin.org/article/10.3389/fphar.2020.00877/full https://doaj.org/toc/1663-9812
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