The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against ga...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mohammad Javad Khoshnoud [verfasserIn] Majid Keshavarzi [verfasserIn] Neda Mokhtari [verfasserIn] Amirhossein Sakhteman [verfasserIn] Amin Derakhshanfar [verfasserIn] Marzieh Rashedinia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Iranian Journal of Toxicology - Arak University of Medical Sciences, 2013, 14(2020), 3, Seite 155-164 |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2020 ; number:3 ; pages:155-164 |
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DOAJ065393112 |
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| 520 | |a Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. | ||
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(DE-627)DOAJ065393112 (DE-599)DOAJ55617e2cade443c4895e7b5ddfd270a9 DE-627 ger DE-627 rakwb eng RA1190-1270 Mohammad Javad Khoshnoud verfasserin aut The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. indomethacin cold-shock response nortriptyline stomach oxidative stress Toxicology. Poisons Majid Keshavarzi verfasserin aut Neda Mokhtari verfasserin aut Amirhossein Sakhteman verfasserin aut Amin Derakhshanfar verfasserin aut Marzieh Rashedinia verfasserin aut In Iranian Journal of Toxicology Arak University of Medical Sciences, 2013 14(2020), 3, Seite 155-164 (DE-627)1760597635 22519459 nnns volume:14 year:2020 number:3 pages:155-164 https://doaj.org/article/55617e2cade443c4895e7b5ddfd270a9 kostenfrei http://ijt.arakmu.ac.ir/article-1-809-en.html kostenfrei https://doaj.org/toc/2008-2967 Journal toc kostenfrei https://doaj.org/toc/2251-9459 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2055 GBV_ILN_2111 AR 14 2020 3 155-164 |
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(DE-627)DOAJ065393112 (DE-599)DOAJ55617e2cade443c4895e7b5ddfd270a9 DE-627 ger DE-627 rakwb eng RA1190-1270 Mohammad Javad Khoshnoud verfasserin aut The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. indomethacin cold-shock response nortriptyline stomach oxidative stress Toxicology. Poisons Majid Keshavarzi verfasserin aut Neda Mokhtari verfasserin aut Amirhossein Sakhteman verfasserin aut Amin Derakhshanfar verfasserin aut Marzieh Rashedinia verfasserin aut In Iranian Journal of Toxicology Arak University of Medical Sciences, 2013 14(2020), 3, Seite 155-164 (DE-627)1760597635 22519459 nnns volume:14 year:2020 number:3 pages:155-164 https://doaj.org/article/55617e2cade443c4895e7b5ddfd270a9 kostenfrei http://ijt.arakmu.ac.ir/article-1-809-en.html kostenfrei https://doaj.org/toc/2008-2967 Journal toc kostenfrei https://doaj.org/toc/2251-9459 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2055 GBV_ILN_2111 AR 14 2020 3 155-164 |
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(DE-627)DOAJ065393112 (DE-599)DOAJ55617e2cade443c4895e7b5ddfd270a9 DE-627 ger DE-627 rakwb eng RA1190-1270 Mohammad Javad Khoshnoud verfasserin aut The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. indomethacin cold-shock response nortriptyline stomach oxidative stress Toxicology. Poisons Majid Keshavarzi verfasserin aut Neda Mokhtari verfasserin aut Amirhossein Sakhteman verfasserin aut Amin Derakhshanfar verfasserin aut Marzieh Rashedinia verfasserin aut In Iranian Journal of Toxicology Arak University of Medical Sciences, 2013 14(2020), 3, Seite 155-164 (DE-627)1760597635 22519459 nnns volume:14 year:2020 number:3 pages:155-164 https://doaj.org/article/55617e2cade443c4895e7b5ddfd270a9 kostenfrei http://ijt.arakmu.ac.ir/article-1-809-en.html kostenfrei https://doaj.org/toc/2008-2967 Journal toc kostenfrei https://doaj.org/toc/2251-9459 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2055 GBV_ILN_2111 AR 14 2020 3 155-164 |
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(DE-627)DOAJ065393112 (DE-599)DOAJ55617e2cade443c4895e7b5ddfd270a9 DE-627 ger DE-627 rakwb eng RA1190-1270 Mohammad Javad Khoshnoud verfasserin aut The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. indomethacin cold-shock response nortriptyline stomach oxidative stress Toxicology. Poisons Majid Keshavarzi verfasserin aut Neda Mokhtari verfasserin aut Amirhossein Sakhteman verfasserin aut Amin Derakhshanfar verfasserin aut Marzieh Rashedinia verfasserin aut In Iranian Journal of Toxicology Arak University of Medical Sciences, 2013 14(2020), 3, Seite 155-164 (DE-627)1760597635 22519459 nnns volume:14 year:2020 number:3 pages:155-164 https://doaj.org/article/55617e2cade443c4895e7b5ddfd270a9 kostenfrei http://ijt.arakmu.ac.ir/article-1-809-en.html kostenfrei https://doaj.org/toc/2008-2967 Journal toc kostenfrei https://doaj.org/toc/2251-9459 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2055 GBV_ILN_2111 AR 14 2020 3 155-164 |
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The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats |
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The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats |
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Mohammad Javad Khoshnoud |
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Iranian Journal of Toxicology |
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Mohammad Javad Khoshnoud Majid Keshavarzi Neda Mokhtari Amirhossein Sakhteman Amin Derakhshanfar Marzieh Rashedinia |
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Mohammad Javad Khoshnoud |
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protective effect of nortriptyline against gastric lesions induced by indomethacin and cold-shock stress in rats |
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RA1190-1270 |
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The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats |
| abstract |
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. |
| abstractGer |
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. |
| abstract_unstemmed |
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples. Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock. Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property. |
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The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats |
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