Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice

Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, w...
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Gespeichert in:

Autor*in:	Aron Baumann [verfasserIn] Carlos G. Moreira [verfasserIn] Marta M. Morawska [verfasserIn] Sophie Masneuf [verfasserIn] Christian R. Baumann [verfasserIn] Daniela Noain [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Apathy Depression Vesicular monoamine transporter 2 PD mice goal-directed behaviors

Übergeordnetes Werk:	In: Frontiers in Human Neuroscience - Frontiers Media S.A., 2008, 10(2016)
Übergeordnetes Werk:	volume:10 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnhum.2016.00587

Katalog-ID:	DOAJ065408683

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allfieldsGer	10.3389/fnhum.2016.00587 doi (DE-627)DOAJ065408683 (DE-599)DOAJ7d066e7ffe31461ba9e69b39e200f1ef DE-627 ger DE-627 rakwb eng RC321-571 Aron Baumann verfasserin aut Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP) claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2). Apathetic-like behavior in VMAT2 deficient (LO) mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD. Apathy Depression Vesicular monoamine transporter 2 PD mice goal-directed behaviors Neurosciences. Biological psychiatry. Neuropsychiatry Carlos G. Moreira verfasserin aut Marta M. Morawska verfasserin aut Sophie Masneuf verfasserin aut Christian R. Baumann verfasserin aut Daniela Noain verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 10(2016) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:10 year:2016 https://doi.org/10.3389/fnhum.2016.00587 kostenfrei https://doaj.org/article/7d066e7ffe31461ba9e69b39e200f1ef kostenfrei http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00587/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016
allfieldsSound	10.3389/fnhum.2016.00587 doi (DE-627)DOAJ065408683 (DE-599)DOAJ7d066e7ffe31461ba9e69b39e200f1ef DE-627 ger DE-627 rakwb eng RC321-571 Aron Baumann verfasserin aut Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP) claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2). Apathetic-like behavior in VMAT2 deficient (LO) mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD. Apathy Depression Vesicular monoamine transporter 2 PD mice goal-directed behaviors Neurosciences. Biological psychiatry. Neuropsychiatry Carlos G. Moreira verfasserin aut Marta M. Morawska verfasserin aut Sophie Masneuf verfasserin aut Christian R. Baumann verfasserin aut Daniela Noain verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 10(2016) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:10 year:2016 https://doi.org/10.3389/fnhum.2016.00587 kostenfrei https://doaj.org/article/7d066e7ffe31461ba9e69b39e200f1ef kostenfrei http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00587/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016
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authorswithroles_txt_mv	Aron Baumann @@aut@@ Carlos G. Moreira @@aut@@ Marta M. Morawska @@aut@@ Sophie Masneuf @@aut@@ Christian R. Baumann @@aut@@ Daniela Noain @@aut@@
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callnumber-first	R - Medicine
author	Aron Baumann
spellingShingle	Aron Baumann misc RC321-571 misc Apathy misc Depression misc Vesicular monoamine transporter 2 misc PD mice misc goal-directed behaviors misc Neurosciences. Biological psychiatry. Neuropsychiatry Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
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topic_title	RC321-571 Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice Apathy Depression Vesicular monoamine transporter 2 PD mice goal-directed behaviors
topic	misc RC321-571 misc Apathy misc Depression misc Vesicular monoamine transporter 2 misc PD mice misc goal-directed behaviors misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Apathy misc Depression misc Vesicular monoamine transporter 2 misc PD mice misc goal-directed behaviors misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Apathy misc Depression misc Vesicular monoamine transporter 2 misc PD mice misc goal-directed behaviors misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
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title_full	Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
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title_sort	preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
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title_auth	Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
abstract	Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP) claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2). Apathetic-like behavior in VMAT2 deficient (LO) mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD.
abstractGer	Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP) claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2). Apathetic-like behavior in VMAT2 deficient (LO) mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD.
abstract_unstemmed	Apathy is considered to be a core feature of Parkinson’s disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP) claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2). Apathetic-like behavior in VMAT2 deficient (LO) mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD.
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title_short	Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice
url	https://doi.org/10.3389/fnhum.2016.00587 https://doaj.org/article/7d066e7ffe31461ba9e69b39e200f1ef http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00587/full https://doaj.org/toc/1662-5161
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Preliminary evidence of apathetic-like behavior in aged vesicular monoamine transporter 2 deficient mice

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