Preparation and characterization of gelatin sponge millispheres injectable through microcatheters

Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motook...
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Autor*in:	Noboru Yamashita [verfasserIn] Katsumi Saitou [verfasserIn] Akira Takagi [verfasserIn] Atsushi Maruyama [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: Medical Devices: Evidence and Research - Dove Medical Press, 2009, (2009), default, Seite 19-25
Übergeordnetes Werk:	year:2009 ; number:default ; pages:19-25

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ065503422

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520			\|a Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter
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allfields	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e DE-627 ger DE-627 rakwb eng R855-855.5 Noboru Yamashita verfasserin aut Preparation and characterization of gelatin sponge millispheres injectable through microcatheters 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter Medical technology Katsumi Saitou verfasserin aut Akira Takagi verfasserin aut Atsushi Maruyama verfasserin aut In Medical Devices: Evidence and Research Dove Medical Press, 2009 (2009), default, Seite 19-25 (DE-627)611726149 (DE-600)2520731-3 11791470 nnns year:2009 number:default pages:19-25 https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e kostenfrei http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 kostenfrei https://doaj.org/toc/1179-1470 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2009 default 19-25
spelling	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e DE-627 ger DE-627 rakwb eng R855-855.5 Noboru Yamashita verfasserin aut Preparation and characterization of gelatin sponge millispheres injectable through microcatheters 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter Medical technology Katsumi Saitou verfasserin aut Akira Takagi verfasserin aut Atsushi Maruyama verfasserin aut In Medical Devices: Evidence and Research Dove Medical Press, 2009 (2009), default, Seite 19-25 (DE-627)611726149 (DE-600)2520731-3 11791470 nnns year:2009 number:default pages:19-25 https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e kostenfrei http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 kostenfrei https://doaj.org/toc/1179-1470 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2009 default 19-25
allfields_unstemmed	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e DE-627 ger DE-627 rakwb eng R855-855.5 Noboru Yamashita verfasserin aut Preparation and characterization of gelatin sponge millispheres injectable through microcatheters 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter Medical technology Katsumi Saitou verfasserin aut Akira Takagi verfasserin aut Atsushi Maruyama verfasserin aut In Medical Devices: Evidence and Research Dove Medical Press, 2009 (2009), default, Seite 19-25 (DE-627)611726149 (DE-600)2520731-3 11791470 nnns year:2009 number:default pages:19-25 https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e kostenfrei http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 kostenfrei https://doaj.org/toc/1179-1470 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2009 default 19-25
allfieldsGer	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e DE-627 ger DE-627 rakwb eng R855-855.5 Noboru Yamashita verfasserin aut Preparation and characterization of gelatin sponge millispheres injectable through microcatheters 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter Medical technology Katsumi Saitou verfasserin aut Akira Takagi verfasserin aut Atsushi Maruyama verfasserin aut In Medical Devices: Evidence and Research Dove Medical Press, 2009 (2009), default, Seite 19-25 (DE-627)611726149 (DE-600)2520731-3 11791470 nnns year:2009 number:default pages:19-25 https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e kostenfrei http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 kostenfrei https://doaj.org/toc/1179-1470 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2009 default 19-25
allfieldsSound	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e DE-627 ger DE-627 rakwb eng R855-855.5 Noboru Yamashita verfasserin aut Preparation and characterization of gelatin sponge millispheres injectable through microcatheters 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter Medical technology Katsumi Saitou verfasserin aut Akira Takagi verfasserin aut Atsushi Maruyama verfasserin aut In Medical Devices: Evidence and Research Dove Medical Press, 2009 (2009), default, Seite 19-25 (DE-627)611726149 (DE-600)2520731-3 11791470 nnns year:2009 number:default pages:19-25 https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e kostenfrei http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 kostenfrei https://doaj.org/toc/1179-1470 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2009 default 19-25
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However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medical technology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katsumi Saitou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Takagi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsushi Maruyama</subfield><subfield code="e">verfasserin</subfield><subfield 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callnumber-first	R - Medicine
author	Noboru Yamashita
spellingShingle	Noboru Yamashita misc R855-855.5 misc Medical technology Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
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topic_title	R855-855.5 Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
topic	misc R855-855.5 misc Medical technology
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title	Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
ctrlnum	(DE-627)DOAJ065503422 (DE-599)DOAJ870623ce0f2948a58b740862f9f5d47e
title_full	Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
author_sort	Noboru Yamashita
journal	Medical Devices: Evidence and Research
journalStr	Medical Devices: Evidence and Research
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author_browse	Noboru Yamashita Katsumi Saitou Akira Takagi Atsushi Maruyama
class	R855-855.5
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author-letter	Noboru Yamashita
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title_sort	preparation and characterization of gelatin sponge millispheres injectable through microcatheters
callnumber	R855-855.5
title_auth	Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
abstract	Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter
abstractGer	Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter
abstract_unstemmed	Noboru Yamashita1, Katsumi Saitou1, Akira Takagi1, Atsushi Maruyama21Pharmaceutical Research and Technology Labs, Institute for Technology, Astellas Pharma Inc., 180 Ozumi, Yaizu-shi, Shizuoka-ken 425-0072, Japan; 2Institute for Materials Chemistry and Engineering, Kyushu University, 744-CE11 Motooka, Nishi-ku, Fukuoka 819-0395, JapanObjective: Millimeter size gelatin sponges are commonly used as an embolic agent for transcatheter arterial embolization (TAE). However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter
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title_short	Preparation and characterization of gelatin sponge millispheres injectable through microcatheters
url	https://doaj.org/article/870623ce0f2948a58b740862f9f5d47e http://www.dovepress.com/preparation-and-characterization-of-gelatin-sponge-millispheres-inject-a2806 https://doaj.org/toc/1179-1470
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up_date	2024-07-03T15:06:37.400Z
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However the preparation of the fragments is troublesome and carries a risk of contamination. The purpose of this study was to develop gelatin sponge millispheres (GSMs), a convenient and reliable agent, and characterize them in vitro.Method: The size of GSMs was controlled by modifying the previously reported method to include the use of caprylic triglyceride and isopropanol. Analytical and microbiological tests were conducted to detect impurities (caprylic triglyceride, isopropanol, endotoxins, bacteria, and fungus). The effects of syringe volume (1.0 to 5.0 ml) and contrast media viscosity (1.6 to 13.6 mPa * s) on the in vitro injectability of GSMs through microcatheters of various inner diameters (ID) (0. 43 to 0.53 mm) were examined via in-line pressure monitoring.Results: The GSMs were found to be water-insoluble particles containing interconnected pores. The short and long diameters of the GSMs were 1.82 +- 0.2 mm and 2.37 +- 0.3 mm, respectively. The results of tests for impurities indicated that GSMs have the general properties necessary for medical devices. The GSMs were successfully injected without clogging through a microcatheter (ID: 0.53 mm) attached to a 1.0 or 2.5 ml syringe.Conclusion: GSMs have the basic properties and injectability necessary to be considered reliable biomaterials (eg, embolic agents).Keywords: embolic agents, gelatin sponge millispheres, injectable scaffolds, interconnected pores, microcatheter</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medical technology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katsumi Saitou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Takagi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsushi Maruyama</subfield><subfield code="e">verfasserin</subfield><subfield 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Preparation and characterization of gelatin sponge millispheres injectable through microcatheters

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