A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case

Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotyp...
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Autor*in:	Dawid Szpecht [verfasserIn] Jolanta Skalska-Sadowska [verfasserIn] Barbara Michniewicz [verfasserIn] Janusz Gadzinowski [verfasserIn] Ludmiła Machowska [verfasserIn] Anna Pieczonka [verfasserIn] Anna Przybyłowicz-Chalecka [verfasserIn] Zuzanna Kanduła [verfasserIn] Małgorzata Jarmuż-Szymczak [verfasserIn] Krzysztof Lewandowski [verfasserIn] Jacek Wachowiak [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	newborn congenital leukemia mixed phenotype acute leukemia

Übergeordnetes Werk:	In: Central European Journal of Immunology - Termedia Publishing House, 2017, 43(2018), 3, Seite 346-352
Übergeordnetes Werk:	volume:43 ; year:2018 ; number:3 ; pages:346-352

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5114/ceji.2018.80056

Katalog-ID:	DOAJ065640667

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allfields	10.5114/ceji.2018.80056 doi (DE-627)DOAJ065640667 (DE-599)DOAJadfa5830fb64411eac8c6fd6fa23eaf9 DE-627 ger DE-627 rakwb eng Dawid Szpecht verfasserin aut A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life. newborn congenital leukemia mixed phenotype acute leukemia Medicine R Jolanta Skalska-Sadowska verfasserin aut Barbara Michniewicz verfasserin aut Janusz Gadzinowski verfasserin aut Ludmiła Machowska verfasserin aut Anna Pieczonka verfasserin aut Anna Przybyłowicz-Chalecka verfasserin aut Zuzanna Kanduła verfasserin aut Małgorzata Jarmuż-Szymczak verfasserin aut Krzysztof Lewandowski verfasserin aut Jacek Wachowiak verfasserin aut In Central European Journal of Immunology Termedia Publishing House, 2017 43(2018), 3, Seite 346-352 (DE-627)511229127 (DE-600)2233185-2 16444124 nnns volume:43 year:2018 number:3 pages:346-352 https://doi.org/10.5114/ceji.2018.80056 kostenfrei https://doaj.org/article/adfa5830fb64411eac8c6fd6fa23eaf9 kostenfrei https://www.termedia.pl/A-newborn-with-congenital-mixed-phenotype-acute-leukemia-with-complex-translocation-t-10-11-p12-q23-with-KMT2A-MLLT10-rearranged-a-report-of-an-extremely-rare-case,10,34298,1,1.html kostenfrei https://doaj.org/toc/1426-3912 Journal toc kostenfrei https://doaj.org/toc/1644-4124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2018 3 346-352
spelling	10.5114/ceji.2018.80056 doi (DE-627)DOAJ065640667 (DE-599)DOAJadfa5830fb64411eac8c6fd6fa23eaf9 DE-627 ger DE-627 rakwb eng Dawid Szpecht verfasserin aut A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life. newborn congenital leukemia mixed phenotype acute leukemia Medicine R Jolanta Skalska-Sadowska verfasserin aut Barbara Michniewicz verfasserin aut Janusz Gadzinowski verfasserin aut Ludmiła Machowska verfasserin aut Anna Pieczonka verfasserin aut Anna Przybyłowicz-Chalecka verfasserin aut Zuzanna Kanduła verfasserin aut Małgorzata Jarmuż-Szymczak verfasserin aut Krzysztof Lewandowski verfasserin aut Jacek Wachowiak verfasserin aut In Central European Journal of Immunology Termedia Publishing House, 2017 43(2018), 3, Seite 346-352 (DE-627)511229127 (DE-600)2233185-2 16444124 nnns volume:43 year:2018 number:3 pages:346-352 https://doi.org/10.5114/ceji.2018.80056 kostenfrei https://doaj.org/article/adfa5830fb64411eac8c6fd6fa23eaf9 kostenfrei https://www.termedia.pl/A-newborn-with-congenital-mixed-phenotype-acute-leukemia-with-complex-translocation-t-10-11-p12-q23-with-KMT2A-MLLT10-rearranged-a-report-of-an-extremely-rare-case,10,34298,1,1.html kostenfrei https://doaj.org/toc/1426-3912 Journal toc kostenfrei https://doaj.org/toc/1644-4124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2018 3 346-352
allfields_unstemmed	10.5114/ceji.2018.80056 doi (DE-627)DOAJ065640667 (DE-599)DOAJadfa5830fb64411eac8c6fd6fa23eaf9 DE-627 ger DE-627 rakwb eng Dawid Szpecht verfasserin aut A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life. newborn congenital leukemia mixed phenotype acute leukemia Medicine R Jolanta Skalska-Sadowska verfasserin aut Barbara Michniewicz verfasserin aut Janusz Gadzinowski verfasserin aut Ludmiła Machowska verfasserin aut Anna Pieczonka verfasserin aut Anna Przybyłowicz-Chalecka verfasserin aut Zuzanna Kanduła verfasserin aut Małgorzata Jarmuż-Szymczak verfasserin aut Krzysztof Lewandowski verfasserin aut Jacek Wachowiak verfasserin aut In Central European Journal of Immunology Termedia Publishing House, 2017 43(2018), 3, Seite 346-352 (DE-627)511229127 (DE-600)2233185-2 16444124 nnns volume:43 year:2018 number:3 pages:346-352 https://doi.org/10.5114/ceji.2018.80056 kostenfrei https://doaj.org/article/adfa5830fb64411eac8c6fd6fa23eaf9 kostenfrei https://www.termedia.pl/A-newborn-with-congenital-mixed-phenotype-acute-leukemia-with-complex-translocation-t-10-11-p12-q23-with-KMT2A-MLLT10-rearranged-a-report-of-an-extremely-rare-case,10,34298,1,1.html kostenfrei https://doaj.org/toc/1426-3912 Journal toc kostenfrei https://doaj.org/toc/1644-4124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2018 3 346-352
allfieldsGer	10.5114/ceji.2018.80056 doi (DE-627)DOAJ065640667 (DE-599)DOAJadfa5830fb64411eac8c6fd6fa23eaf9 DE-627 ger DE-627 rakwb eng Dawid Szpecht verfasserin aut A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life. newborn congenital leukemia mixed phenotype acute leukemia Medicine R Jolanta Skalska-Sadowska verfasserin aut Barbara Michniewicz verfasserin aut Janusz Gadzinowski verfasserin aut Ludmiła Machowska verfasserin aut Anna Pieczonka verfasserin aut Anna Przybyłowicz-Chalecka verfasserin aut Zuzanna Kanduła verfasserin aut Małgorzata Jarmuż-Szymczak verfasserin aut Krzysztof Lewandowski verfasserin aut Jacek Wachowiak verfasserin aut In Central European Journal of Immunology Termedia Publishing House, 2017 43(2018), 3, Seite 346-352 (DE-627)511229127 (DE-600)2233185-2 16444124 nnns volume:43 year:2018 number:3 pages:346-352 https://doi.org/10.5114/ceji.2018.80056 kostenfrei https://doaj.org/article/adfa5830fb64411eac8c6fd6fa23eaf9 kostenfrei https://www.termedia.pl/A-newborn-with-congenital-mixed-phenotype-acute-leukemia-with-complex-translocation-t-10-11-p12-q23-with-KMT2A-MLLT10-rearranged-a-report-of-an-extremely-rare-case,10,34298,1,1.html kostenfrei https://doaj.org/toc/1426-3912 Journal toc kostenfrei https://doaj.org/toc/1644-4124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2018 3 346-352
allfieldsSound	10.5114/ceji.2018.80056 doi (DE-627)DOAJ065640667 (DE-599)DOAJadfa5830fb64411eac8c6fd6fa23eaf9 DE-627 ger DE-627 rakwb eng Dawid Szpecht verfasserin aut A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life. newborn congenital leukemia mixed phenotype acute leukemia Medicine R Jolanta Skalska-Sadowska verfasserin aut Barbara Michniewicz verfasserin aut Janusz Gadzinowski verfasserin aut Ludmiła Machowska verfasserin aut Anna Pieczonka verfasserin aut Anna Przybyłowicz-Chalecka verfasserin aut Zuzanna Kanduła verfasserin aut Małgorzata Jarmuż-Szymczak verfasserin aut Krzysztof Lewandowski verfasserin aut Jacek Wachowiak verfasserin aut In Central European Journal of Immunology Termedia Publishing House, 2017 43(2018), 3, Seite 346-352 (DE-627)511229127 (DE-600)2233185-2 16444124 nnns volume:43 year:2018 number:3 pages:346-352 https://doi.org/10.5114/ceji.2018.80056 kostenfrei https://doaj.org/article/adfa5830fb64411eac8c6fd6fa23eaf9 kostenfrei https://www.termedia.pl/A-newborn-with-congenital-mixed-phenotype-acute-leukemia-with-complex-translocation-t-10-11-p12-q23-with-KMT2A-MLLT10-rearranged-a-report-of-an-extremely-rare-case,10,34298,1,1.html kostenfrei https://doaj.org/toc/1426-3912 Journal toc kostenfrei https://doaj.org/toc/1644-4124 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2018 3 346-352
language	English
source	In Central European Journal of Immunology 43(2018), 3, Seite 346-352 volume:43 year:2018 number:3 pages:346-352
sourceStr	In Central European Journal of Immunology 43(2018), 3, Seite 346-352 volume:43 year:2018 number:3 pages:346-352
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	newborn congenital leukemia mixed phenotype acute leukemia Medicine R
isfreeaccess_bool	true
container_title	Central European Journal of Immunology
authorswithroles_txt_mv	Dawid Szpecht @@aut@@ Jolanta Skalska-Sadowska @@aut@@ Barbara Michniewicz @@aut@@ Janusz Gadzinowski @@aut@@ Ludmiła Machowska @@aut@@ Anna Pieczonka @@aut@@ Anna Przybyłowicz-Chalecka @@aut@@ Zuzanna Kanduła @@aut@@ Małgorzata Jarmuż-Szymczak @@aut@@ Krzysztof Lewandowski @@aut@@ Jacek Wachowiak @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	511229127
id	DOAJ065640667
language_de	englisch
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author	Dawid Szpecht
spellingShingle	Dawid Szpecht misc newborn misc congenital leukemia misc mixed phenotype acute leukemia misc Medicine misc R A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case
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topic_title	A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case newborn congenital leukemia mixed phenotype acute leukemia
topic	misc newborn misc congenital leukemia misc mixed phenotype acute leukemia misc Medicine misc R
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title	A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case
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title_full	A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case
author_sort	Dawid Szpecht
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author_browse	Dawid Szpecht Jolanta Skalska-Sadowska Barbara Michniewicz Janusz Gadzinowski Ludmiła Machowska Anna Pieczonka Anna Przybyłowicz-Chalecka Zuzanna Kanduła Małgorzata Jarmuż-Szymczak Krzysztof Lewandowski Jacek Wachowiak
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author-letter	Dawid Szpecht
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title_sort	newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with kmt2a/mllt10 rearranged – a report of an extremely rare case
title_auth	A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case
abstract	Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life.
abstractGer	Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life.
abstract_unstemmed	Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in < 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life.
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title_short	A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case
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up_date	2024-07-03T15:49:30.986Z
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A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case

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