Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways

We review the studies on the folding mechanism of the β-hairpin tryptophan zipper 2 (trpzip2) and present some additional computational results to refine the picture of folding heterogeneity and pathways. We show that trpzip2 can have a two-state or a multi-state folding pattern, depending on whethe...
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Gespeichert in:

Autor*in:	Yi He [verfasserIn] Yi Xiao [verfasserIn] Changjun Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	beta-hairpin trpzip2 folding heterogeneity transition state folding pathway

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 10(2009), 6, Seite 2838-2848
Übergeordnetes Werk:	volume:10 ; year:2009 ; number:6 ; pages:2838-2848

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms10062838

Katalog-ID:	DOAJ065644727

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language	English
source	In International Journal of Molecular Sciences 10(2009), 6, Seite 2838-2848 volume:10 year:2009 number:6 pages:2838-2848
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authorswithroles_txt_mv	Yi He @@aut@@ Yi Xiao @@aut@@ Changjun Chen @@aut@@
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callnumber-first	Q - Science
author	Yi He
spellingShingle	Yi He misc QH301-705.5 misc QD1-999 misc beta-hairpin misc trpzip2 misc folding heterogeneity misc transition state misc folding pathway misc Biology (General) misc Chemistry Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways
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topic_title	QH301-705.5 QD1-999 Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways beta-hairpin trpzip2 folding heterogeneity transition state folding pathway
topic	misc QH301-705.5 misc QD1-999 misc beta-hairpin misc trpzip2 misc folding heterogeneity misc transition state misc folding pathway misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc beta-hairpin misc trpzip2 misc folding heterogeneity misc transition state misc folding pathway misc Biology (General) misc Chemistry
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title	Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways
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title_sort	folding mechanism of beta-hairpin trpzip2: heterogeneity, transition state and folding pathways
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title_auth	Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways
abstract	We review the studies on the folding mechanism of the β-hairpin tryptophan zipper 2 (trpzip2) and present some additional computational results to refine the picture of folding heterogeneity and pathways. We show that trpzip2 can have a two-state or a multi-state folding pattern, depending on whether it folds within the native basin or through local state basins on the high-dimensional free energy surface; Trpzip2 can fold along different pathways according to the packing order of tryptophan pairs. We also point out some important problems related to the folding mechanism of trpzip2 that still need clarification, e.g., a wide distribution of the computed conformations for the transition state ensemble.
abstractGer	We review the studies on the folding mechanism of the β-hairpin tryptophan zipper 2 (trpzip2) and present some additional computational results to refine the picture of folding heterogeneity and pathways. We show that trpzip2 can have a two-state or a multi-state folding pattern, depending on whether it folds within the native basin or through local state basins on the high-dimensional free energy surface; Trpzip2 can fold along different pathways according to the packing order of tryptophan pairs. We also point out some important problems related to the folding mechanism of trpzip2 that still need clarification, e.g., a wide distribution of the computed conformations for the transition state ensemble.
abstract_unstemmed	We review the studies on the folding mechanism of the β-hairpin tryptophan zipper 2 (trpzip2) and present some additional computational results to refine the picture of folding heterogeneity and pathways. We show that trpzip2 can have a two-state or a multi-state folding pattern, depending on whether it folds within the native basin or through local state basins on the high-dimensional free energy surface; Trpzip2 can fold along different pathways according to the packing order of tryptophan pairs. We also point out some important problems related to the folding mechanism of trpzip2 that still need clarification, e.g., a wide distribution of the computed conformations for the transition state ensemble.
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title_short	Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways
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