Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this...
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Autor*in:	Farid Abbasi [verfasserIn] Sareh Farhadi [verfasserIn] Mostafa Esmaili [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Bromhexine pilocarpine radiotherapy xerostomia

Übergeordnetes Werk:	In: Journal of Dental Research, Dental Clinics, Dental Prospects - Tabriz University of Medical Sciences, 2017, 7(2013), 2, Seite 86-90
Übergeordnetes Werk:	volume:7 ; year:2013 ; number:2 ; pages:86-90

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.5681/joddd.2013.015

Katalog-ID:	DOAJ065696654

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520			\|a Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region.
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spelling	10.5681/joddd.2013.015 doi (DE-627)DOAJ065696654 (DE-599)DOAJb020ae05b7b648d49ffd652193138f6d DE-627 ger DE-627 rakwb eng RK1-715 Farid Abbasi verfasserin aut Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region. Bromhexine pilocarpine radiotherapy xerostomia Dentistry Sareh Farhadi verfasserin aut Mostafa Esmaili verfasserin aut In Journal of Dental Research, Dental Clinics, Dental Prospects Tabriz University of Medical Sciences, 2017 7(2013), 2, Seite 86-90 (DE-627)608942731 (DE-600)2514725-0 20082118 nnns volume:7 year:2013 number:2 pages:86-90 https://doi.org/10.5681/joddd.2013.015 kostenfrei https://doaj.org/article/b020ae05b7b648d49ffd652193138f6d kostenfrei http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379/289 kostenfrei https://doaj.org/toc/2008-2118 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 2 86-90
allfields_unstemmed	10.5681/joddd.2013.015 doi (DE-627)DOAJ065696654 (DE-599)DOAJb020ae05b7b648d49ffd652193138f6d DE-627 ger DE-627 rakwb eng RK1-715 Farid Abbasi verfasserin aut Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region. Bromhexine pilocarpine radiotherapy xerostomia Dentistry Sareh Farhadi verfasserin aut Mostafa Esmaili verfasserin aut In Journal of Dental Research, Dental Clinics, Dental Prospects Tabriz University of Medical Sciences, 2017 7(2013), 2, Seite 86-90 (DE-627)608942731 (DE-600)2514725-0 20082118 nnns volume:7 year:2013 number:2 pages:86-90 https://doi.org/10.5681/joddd.2013.015 kostenfrei https://doaj.org/article/b020ae05b7b648d49ffd652193138f6d kostenfrei http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379/289 kostenfrei https://doaj.org/toc/2008-2118 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 2 86-90
allfieldsGer	10.5681/joddd.2013.015 doi (DE-627)DOAJ065696654 (DE-599)DOAJb020ae05b7b648d49ffd652193138f6d DE-627 ger DE-627 rakwb eng RK1-715 Farid Abbasi verfasserin aut Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region. Bromhexine pilocarpine radiotherapy xerostomia Dentistry Sareh Farhadi verfasserin aut Mostafa Esmaili verfasserin aut In Journal of Dental Research, Dental Clinics, Dental Prospects Tabriz University of Medical Sciences, 2017 7(2013), 2, Seite 86-90 (DE-627)608942731 (DE-600)2514725-0 20082118 nnns volume:7 year:2013 number:2 pages:86-90 https://doi.org/10.5681/joddd.2013.015 kostenfrei https://doaj.org/article/b020ae05b7b648d49ffd652193138f6d kostenfrei http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379/289 kostenfrei https://doaj.org/toc/2008-2118 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 2 86-90
allfieldsSound	10.5681/joddd.2013.015 doi (DE-627)DOAJ065696654 (DE-599)DOAJb020ae05b7b648d49ffd652193138f6d DE-627 ger DE-627 rakwb eng RK1-715 Farid Abbasi verfasserin aut Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region. Bromhexine pilocarpine radiotherapy xerostomia Dentistry Sareh Farhadi verfasserin aut Mostafa Esmaili verfasserin aut In Journal of Dental Research, Dental Clinics, Dental Prospects Tabriz University of Medical Sciences, 2017 7(2013), 2, Seite 86-90 (DE-627)608942731 (DE-600)2514725-0 20082118 nnns volume:7 year:2013 number:2 pages:86-90 https://doi.org/10.5681/joddd.2013.015 kostenfrei https://doaj.org/article/b020ae05b7b648d49ffd652193138f6d kostenfrei http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379/289 kostenfrei https://doaj.org/toc/2008-2118 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 2 86-90
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callnumber-first	R - Medicine
author	Farid Abbasi
spellingShingle	Farid Abbasi misc RK1-715 misc Bromhexine misc pilocarpine misc radiotherapy misc xerostomia misc Dentistry Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia
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topic_title	RK1-715 Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia Bromhexine pilocarpine radiotherapy xerostomia
topic	misc RK1-715 misc Bromhexine misc pilocarpine misc radiotherapy misc xerostomia misc Dentistry
topic_unstemmed	misc RK1-715 misc Bromhexine misc pilocarpine misc radiotherapy misc xerostomia misc Dentistry
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title	Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia
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title_full	Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia
author_sort	Farid Abbasi
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author_browse	Farid Abbasi Sareh Farhadi Mostafa Esmaili
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title_sort	efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia
callnumber	RK1-715
title_auth	Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia
abstract	Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region.
abstractGer	Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region.
abstract_unstemmed	Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its associated symptoms. Materials and methods. In this single-blind, randomized crossover study, pilocarpine and bromhexine tablets were used by twenty-five patients suffered from xerostomia, with a medical history of head and neck radiotherapy. At step A, the patients were treated with pilocarpine for 2 weeks. In addition, they were asked to take bromhexine for 2 weeks with a oneweek washout period. At step B, the inverse process was conducted (first bromhexine, then pilocarpine). Whole resting saliva was collected from patients before and after receiving each medication by precise measurements. Then, efficacy of the two drugs in the treatment of xerostomia and its related oral complications was evaluated using questionnaires by Dichotomous format. The results were statistically analyzed using t-student and Fisher’s exact and chi-squared tests. Statistical significance was set at P<0.05. Results. The difference between saliva secretion rates before and after medications was not significant for bromhexine users at two steps of the study (P=0.35); however, it was significant for pilocarpine users (P=0.0001). Users of both drugs showed significant differences in improvement of xerostomia, chewing, swallowing, tasting and mouth burning. Conclusion. Pilocarpine is probably more effective in improving xerostomia and its associated problems compared with bromhexine, although the use of the latter was also shown to ease some of the consequences of radiotherapy in the head and neck region.
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title_short	Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia
url	https://doi.org/10.5681/joddd.2013.015 https://doaj.org/article/b020ae05b7b648d49ffd652193138f6d http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/379/289 https://doaj.org/toc/2008-2118
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Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

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