Myocardial damage after continuous aerobic and anaerobic exercise in rats

<p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rostika Flora [verfasserIn] Frans Ferdinal [verfasserIn] Bethy S. Hernowo [verfasserIn] Septelia I. Wanandi [verfasserIn] Mohamad Sadikin [verfasserIn] Hans-Joachim Freisleben [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: Medical Journal of Indonesia - Faculty of Medicine Universitas Indonesia, 2013, 22(2013), 4, Seite 209-14
Übergeordnetes Werk:	volume:22 ; year:2013 ; number:4 ; pages:209-14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.13181/mji.v22i4.601

Katalog-ID:	DOAJ065812921

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allfields	10.13181/mji.v22i4.601 doi (DE-627)DOAJ065812921 (DE-599)DOAJcd233d49f8094e8589a317e3b415cb38 DE-627 ger DE-627 rakwb eng R5-920 Rostika Flora verfasserin aut Myocardial damage after continuous aerobic and anaerobic exercise in rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Medicine (General) Frans Ferdinal verfasserin aut Bethy S. Hernowo verfasserin aut Septelia I. Wanandi verfasserin aut Mohamad Sadikin verfasserin aut Hans-Joachim Freisleben verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 22(2013), 4, Seite 209-14 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:22 year:2013 number:4 pages:209-14 https://doi.org/10.13181/mji.v22i4.601 kostenfrei https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/601 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2013 4 209-14
spelling	10.13181/mji.v22i4.601 doi (DE-627)DOAJ065812921 (DE-599)DOAJcd233d49f8094e8589a317e3b415cb38 DE-627 ger DE-627 rakwb eng R5-920 Rostika Flora verfasserin aut Myocardial damage after continuous aerobic and anaerobic exercise in rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Medicine (General) Frans Ferdinal verfasserin aut Bethy S. Hernowo verfasserin aut Septelia I. Wanandi verfasserin aut Mohamad Sadikin verfasserin aut Hans-Joachim Freisleben verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 22(2013), 4, Seite 209-14 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:22 year:2013 number:4 pages:209-14 https://doi.org/10.13181/mji.v22i4.601 kostenfrei https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/601 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2013 4 209-14
allfields_unstemmed	10.13181/mji.v22i4.601 doi (DE-627)DOAJ065812921 (DE-599)DOAJcd233d49f8094e8589a317e3b415cb38 DE-627 ger DE-627 rakwb eng R5-920 Rostika Flora verfasserin aut Myocardial damage after continuous aerobic and anaerobic exercise in rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Medicine (General) Frans Ferdinal verfasserin aut Bethy S. Hernowo verfasserin aut Septelia I. Wanandi verfasserin aut Mohamad Sadikin verfasserin aut Hans-Joachim Freisleben verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 22(2013), 4, Seite 209-14 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:22 year:2013 number:4 pages:209-14 https://doi.org/10.13181/mji.v22i4.601 kostenfrei https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/601 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2013 4 209-14
allfieldsGer	10.13181/mji.v22i4.601 doi (DE-627)DOAJ065812921 (DE-599)DOAJcd233d49f8094e8589a317e3b415cb38 DE-627 ger DE-627 rakwb eng R5-920 Rostika Flora verfasserin aut Myocardial damage after continuous aerobic and anaerobic exercise in rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Medicine (General) Frans Ferdinal verfasserin aut Bethy S. Hernowo verfasserin aut Septelia I. Wanandi verfasserin aut Mohamad Sadikin verfasserin aut Hans-Joachim Freisleben verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 22(2013), 4, Seite 209-14 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:22 year:2013 number:4 pages:209-14 https://doi.org/10.13181/mji.v22i4.601 kostenfrei https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/601 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2013 4 209-14
allfieldsSound	10.13181/mji.v22i4.601 doi (DE-627)DOAJ065812921 (DE-599)DOAJcd233d49f8094e8589a317e3b415cb38 DE-627 ger DE-627 rakwb eng R5-920 Rostika Flora verfasserin aut Myocardial damage after continuous aerobic and anaerobic exercise in rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p< Medicine (General) Frans Ferdinal verfasserin aut Bethy S. Hernowo verfasserin aut Septelia I. Wanandi verfasserin aut Mohamad Sadikin verfasserin aut Hans-Joachim Freisleben verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 22(2013), 4, Seite 209-14 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:22 year:2013 number:4 pages:209-14 https://doi.org/10.13181/mji.v22i4.601 kostenfrei https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/601 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2013 4 209-14
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author_browse	Rostika Flora Frans Ferdinal Bethy S. Hernowo Septelia I. Wanandi Mohamad Sadikin Hans-Joachim Freisleben
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doi_str_mv	10.13181/mji.v22i4.601
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title_sort	myocardial damage after continuous aerobic and anaerobic exercise in rats
callnumber	R5-920
title_auth	Myocardial damage after continuous aerobic and anaerobic exercise in rats
abstract	<p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p<
abstractGer	<p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p<
abstract_unstemmed	<p<<strong<Background:</strong< Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. </p<<p<<strong<Methods:</strong< The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.</p<<p<<strong<Results:</strong< The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.</p<<p<<strong<Conclusion:</strong< Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage.<em<<strong< (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)</strong<</em<</p<<p<<strong<Keywords:</strong< <em<Cardiac muscle, cardiac muscle damage, histopathology, physical activity</em<</p<
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title_short	Myocardial damage after continuous aerobic and anaerobic exercise in rats
url	https://doi.org/10.13181/mji.v22i4.601 https://doaj.org/article/cd233d49f8094e8589a317e3b415cb38 http://mji.ui.ac.id/journal/index.php/mji/article/view/601 https://doaj.org/toc/0853-1773 https://doaj.org/toc/2252-8083
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author2	Frans Ferdinal Bethy S. Hernowo Septelia I. Wanandi Mohamad Sadikin Hans-Joachim Freisleben
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up_date	2024-07-03T16:43:35.723Z
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