Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspec...
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Autor*in:	Julie Chaumeil [verfasserIn] Mariann Micsinai [verfasserIn] Panagiotis Ntziachristos [verfasserIn] Ludovic Deriano [verfasserIn] Joy M.-H. Wang [verfasserIn] Yanhong Ji [verfasserIn] Elphege P. Nora [verfasserIn] Matthew J. Rodesch [verfasserIn] Jeffrey A. Jeddeloh [verfasserIn] Iannis Aifantis [verfasserIn] Yuval Kluger [verfasserIn] David G. Schatz [verfasserIn] Jane A. Skok [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 3(2013), 2, Seite 359-370
Übergeordnetes Werk:	volume:3 ; year:2013 ; number:2 ; pages:359-370

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2013.01.024

Katalog-ID:	DOAJ065986822

Internformat


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520			\|a V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability.
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700	0		\|a Matthew J. Rodesch \|e verfasserin \|4 aut
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allfields	10.1016/j.celrep.2013.01.024 doi (DE-627)DOAJ065986822 (DE-599)DOAJ571dc859b7c94d3385ec771332135f2d DE-627 ger DE-627 rakwb eng QH301-705.5 Julie Chaumeil verfasserin aut Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability. Biology (General) Mariann Micsinai verfasserin aut Panagiotis Ntziachristos verfasserin aut Ludovic Deriano verfasserin aut Joy M.-H. Wang verfasserin aut Yanhong Ji verfasserin aut Elphege P. Nora verfasserin aut Matthew J. Rodesch verfasserin aut Jeffrey A. Jeddeloh verfasserin aut Iannis Aifantis verfasserin aut Yuval Kluger verfasserin aut David G. Schatz verfasserin aut Jane A. Skok verfasserin aut In Cell Reports Elsevier, 2015 3(2013), 2, Seite 359-370 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:3 year:2013 number:2 pages:359-370 https://doi.org/10.1016/j.celrep.2013.01.024 kostenfrei https://doaj.org/article/571dc859b7c94d3385ec771332135f2d kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124713000314 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 2 359-370
spelling	10.1016/j.celrep.2013.01.024 doi (DE-627)DOAJ065986822 (DE-599)DOAJ571dc859b7c94d3385ec771332135f2d DE-627 ger DE-627 rakwb eng QH301-705.5 Julie Chaumeil verfasserin aut Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability. Biology (General) Mariann Micsinai verfasserin aut Panagiotis Ntziachristos verfasserin aut Ludovic Deriano verfasserin aut Joy M.-H. Wang verfasserin aut Yanhong Ji verfasserin aut Elphege P. Nora verfasserin aut Matthew J. Rodesch verfasserin aut Jeffrey A. Jeddeloh verfasserin aut Iannis Aifantis verfasserin aut Yuval Kluger verfasserin aut David G. Schatz verfasserin aut Jane A. Skok verfasserin aut In Cell Reports Elsevier, 2015 3(2013), 2, Seite 359-370 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:3 year:2013 number:2 pages:359-370 https://doi.org/10.1016/j.celrep.2013.01.024 kostenfrei https://doaj.org/article/571dc859b7c94d3385ec771332135f2d kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124713000314 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 2 359-370
allfields_unstemmed	10.1016/j.celrep.2013.01.024 doi (DE-627)DOAJ065986822 (DE-599)DOAJ571dc859b7c94d3385ec771332135f2d DE-627 ger DE-627 rakwb eng QH301-705.5 Julie Chaumeil verfasserin aut Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability. Biology (General) Mariann Micsinai verfasserin aut Panagiotis Ntziachristos verfasserin aut Ludovic Deriano verfasserin aut Joy M.-H. Wang verfasserin aut Yanhong Ji verfasserin aut Elphege P. Nora verfasserin aut Matthew J. Rodesch verfasserin aut Jeffrey A. Jeddeloh verfasserin aut Iannis Aifantis verfasserin aut Yuval Kluger verfasserin aut David G. Schatz verfasserin aut Jane A. Skok verfasserin aut In Cell Reports Elsevier, 2015 3(2013), 2, Seite 359-370 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:3 year:2013 number:2 pages:359-370 https://doi.org/10.1016/j.celrep.2013.01.024 kostenfrei https://doaj.org/article/571dc859b7c94d3385ec771332135f2d kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124713000314 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 2 359-370
allfieldsGer	10.1016/j.celrep.2013.01.024 doi (DE-627)DOAJ065986822 (DE-599)DOAJ571dc859b7c94d3385ec771332135f2d DE-627 ger DE-627 rakwb eng QH301-705.5 Julie Chaumeil verfasserin aut Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability. Biology (General) Mariann Micsinai verfasserin aut Panagiotis Ntziachristos verfasserin aut Ludovic Deriano verfasserin aut Joy M.-H. Wang verfasserin aut Yanhong Ji verfasserin aut Elphege P. Nora verfasserin aut Matthew J. Rodesch verfasserin aut Jeffrey A. Jeddeloh verfasserin aut Iannis Aifantis verfasserin aut Yuval Kluger verfasserin aut David G. Schatz verfasserin aut Jane A. Skok verfasserin aut In Cell Reports Elsevier, 2015 3(2013), 2, Seite 359-370 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:3 year:2013 number:2 pages:359-370 https://doi.org/10.1016/j.celrep.2013.01.024 kostenfrei https://doaj.org/article/571dc859b7c94d3385ec771332135f2d kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124713000314 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 2 359-370
allfieldsSound	10.1016/j.celrep.2013.01.024 doi (DE-627)DOAJ065986822 (DE-599)DOAJ571dc859b7c94d3385ec771332135f2d DE-627 ger DE-627 rakwb eng QH301-705.5 Julie Chaumeil verfasserin aut Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability. Biology (General) Mariann Micsinai verfasserin aut Panagiotis Ntziachristos verfasserin aut Ludovic Deriano verfasserin aut Joy M.-H. Wang verfasserin aut Yanhong Ji verfasserin aut Elphege P. Nora verfasserin aut Matthew J. Rodesch verfasserin aut Jeffrey A. Jeddeloh verfasserin aut Iannis Aifantis verfasserin aut Yuval Kluger verfasserin aut David G. Schatz verfasserin aut Jane A. Skok verfasserin aut In Cell Reports Elsevier, 2015 3(2013), 2, Seite 359-370 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:3 year:2013 number:2 pages:359-370 https://doi.org/10.1016/j.celrep.2013.01.024 kostenfrei https://doaj.org/article/571dc859b7c94d3385ec771332135f2d kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124713000314 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 2 359-370
language	English
source	In Cell Reports 3(2013), 2, Seite 359-370 volume:3 year:2013 number:2 pages:359-370
sourceStr	In Cell Reports 3(2013), 2, Seite 359-370 volume:3 year:2013 number:2 pages:359-370
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Julie Chaumeil @@aut@@ Mariann Micsinai @@aut@@ Panagiotis Ntziachristos @@aut@@ Ludovic Deriano @@aut@@ Joy M.-H. Wang @@aut@@ Yanhong Ji @@aut@@ Elphege P. Nora @@aut@@ Matthew J. Rodesch @@aut@@ Jeffrey A. Jeddeloh @@aut@@ Iannis Aifantis @@aut@@ Yuval Kluger @@aut@@ David G. Schatz @@aut@@ Jane A. Skok @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ065986822
language_de	englisch
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callnumber-first	Q - Science
author	Julie Chaumeil
spellingShingle	Julie Chaumeil misc QH301-705.5 misc Biology (General) Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
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topic_title	QH301-705.5 Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
topic	misc QH301-705.5 misc Biology (General)
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title	Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
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title_full	Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
author_sort	Julie Chaumeil
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author_browse	Julie Chaumeil Mariann Micsinai Panagiotis Ntziachristos Ludovic Deriano Joy M.-H. Wang Yanhong Ji Elphege P. Nora Matthew J. Rodesch Jeffrey A. Jeddeloh Iannis Aifantis Yuval Kluger David G. Schatz Jane A. Skok
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title_sort	higher-order looping and nuclear organization of tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers
callnumber	QH301-705.5
title_auth	Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
abstract	V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability.
abstractGer	V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability.
abstract_unstemmed	V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3′ end of individual antigen receptor loci poised for rearrangement; however, it is not known whether focal binding is involved in regulating cleavage, and what mechanisms lead to enrichment of RAG in this region. Here, we show that monoallelic looping out of the 3′ end of the T cell receptor α (Tcra) locus, coupled with transcription and increased chromatin/nuclear accessibility, is linked to focal RAG binding and ATM-mediated regulation of monoallelic cleavage on looped-out 3′ regions. Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability.
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title_short	Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
url	https://doi.org/10.1016/j.celrep.2013.01.024 https://doaj.org/article/571dc859b7c94d3385ec771332135f2d http://www.sciencedirect.com/science/article/pii/S2211124713000314 https://doaj.org/toc/2211-1247
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Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

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