Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?

Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is hypothesized that programmed cell death (PCD) is an additional adaptation whose or...
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Autor*in:	Jie Gao [verfasserIn] Sabrina Chau [verfasserIn] Marc D. Meneghini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	endonuclease g viral attenuation mitochondria yeast gametogenesis programmed cell death

Übergeordnetes Werk:	In: Microbial Cell - Shared Science Publishers OG, 2015, 7(2019), 2, Seite 32-35
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:2 ; pages:32-35

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.15698/mic2020.02.705

Katalog-ID:	DOAJ066215978

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allfieldsSound	10.15698/mic2020.02.705 doi (DE-627)DOAJ066215978 (DE-599)DOAJba073a41f893444686d58660e45d6dfc DE-627 ger DE-627 rakwb eng QH301-705.5 Jie Gao verfasserin aut Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is hypothesized that programmed cell death (PCD) is an additional adaptation whose origins reside in viral defense. A core event of apoptotic PCD is the regulated release of mitochondrial inter-membrane space proteins into the cytosol, following which these apoptogenic proteins bring about the demise of the cell. The most well studied example of this is found in animals, where the release of mitochondrial cytochrome C nucleates the formation of the apoptosome, which then activates caspase mediated cell death. The release of mitochondrial proteins contributes to PCD in diverse organisms lacking the apoptosome, indicating that regulated mitochondrial release predates the evolution of canonical apoptosis. Using the budding yeast Saccharomyces cerevisiae, we recently confirmed an early study showing that Nuc1, a homolog of the mitochondrial apoptotic driver protein Endonuclease G, attenuates cytosolic double stranded RNA (dsRNA) viruses, which are endemic to yeast and many other organisms. Viral attenuation by Nuc1 occurs most prominently during meiosis and in association with its developmentally programmed relocation from the mitochondria to the cytosol. Intriguingly, meiotic viral attenuation by Nuc1 occurs within the context of meiotic PCD of the superfluous mother cell that we have also discovered. These findings are discussed here. endonuclease g viral attenuation mitochondria yeast gametogenesis programmed cell death Biology (General) Sabrina Chau verfasserin aut Marc D. Meneghini verfasserin aut In Microbial Cell Shared Science Publishers OG, 2015 7(2019), 2, Seite 32-35 (DE-627)820688738 (DE-600)2814756-X 23112638 nnns volume:7 year:2019 number:2 pages:32-35 https://doi.org/10.15698/mic2020.02.705 kostenfrei https://doaj.org/article/ba073a41f893444686d58660e45d6dfc kostenfrei http://microbialcell.com/researcharticles/2019a-gao-rios-microbial-cell/ kostenfrei https://doaj.org/toc/2311-2638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 2 32-35
language	English
source	In Microbial Cell 7(2019), 2, Seite 32-35 volume:7 year:2019 number:2 pages:32-35
sourceStr	In Microbial Cell 7(2019), 2, Seite 32-35 volume:7 year:2019 number:2 pages:32-35
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topic_facet	endonuclease g viral attenuation mitochondria yeast gametogenesis programmed cell death Biology (General)
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container_title	Microbial Cell
authorswithroles_txt_mv	Jie Gao @@aut@@ Sabrina Chau @@aut@@ Marc D. Meneghini @@aut@@
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author	Jie Gao
spellingShingle	Jie Gao misc QH301-705.5 misc endonuclease g misc viral attenuation misc mitochondria misc yeast misc gametogenesis misc programmed cell death misc Biology (General) Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
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topic_title	QH301-705.5 Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death? endonuclease g viral attenuation mitochondria yeast gametogenesis programmed cell death
topic	misc QH301-705.5 misc endonuclease g misc viral attenuation misc mitochondria misc yeast misc gametogenesis misc programmed cell death misc Biology (General)
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title	Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
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title_full	Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
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title_sort	viral attenuation by endonuclease g during yeast gametogenesis: insights into ancestral roles of programmed cell death?
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title_auth	Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
abstract	Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is hypothesized that programmed cell death (PCD) is an additional adaptation whose origins reside in viral defense. A core event of apoptotic PCD is the regulated release of mitochondrial inter-membrane space proteins into the cytosol, following which these apoptogenic proteins bring about the demise of the cell. The most well studied example of this is found in animals, where the release of mitochondrial cytochrome C nucleates the formation of the apoptosome, which then activates caspase mediated cell death. The release of mitochondrial proteins contributes to PCD in diverse organisms lacking the apoptosome, indicating that regulated mitochondrial release predates the evolution of canonical apoptosis. Using the budding yeast Saccharomyces cerevisiae, we recently confirmed an early study showing that Nuc1, a homolog of the mitochondrial apoptotic driver protein Endonuclease G, attenuates cytosolic double stranded RNA (dsRNA) viruses, which are endemic to yeast and many other organisms. Viral attenuation by Nuc1 occurs most prominently during meiosis and in association with its developmentally programmed relocation from the mitochondria to the cytosol. Intriguingly, meiotic viral attenuation by Nuc1 occurs within the context of meiotic PCD of the superfluous mother cell that we have also discovered. These findings are discussed here.
abstractGer	Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is hypothesized that programmed cell death (PCD) is an additional adaptation whose origins reside in viral defense. A core event of apoptotic PCD is the regulated release of mitochondrial inter-membrane space proteins into the cytosol, following which these apoptogenic proteins bring about the demise of the cell. The most well studied example of this is found in animals, where the release of mitochondrial cytochrome C nucleates the formation of the apoptosome, which then activates caspase mediated cell death. The release of mitochondrial proteins contributes to PCD in diverse organisms lacking the apoptosome, indicating that regulated mitochondrial release predates the evolution of canonical apoptosis. Using the budding yeast Saccharomyces cerevisiae, we recently confirmed an early study showing that Nuc1, a homolog of the mitochondrial apoptotic driver protein Endonuclease G, attenuates cytosolic double stranded RNA (dsRNA) viruses, which are endemic to yeast and many other organisms. Viral attenuation by Nuc1 occurs most prominently during meiosis and in association with its developmentally programmed relocation from the mitochondria to the cytosol. Intriguingly, meiotic viral attenuation by Nuc1 occurs within the context of meiotic PCD of the superfluous mother cell that we have also discovered. These findings are discussed here.
abstract_unstemmed	Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is hypothesized that programmed cell death (PCD) is an additional adaptation whose origins reside in viral defense. A core event of apoptotic PCD is the regulated release of mitochondrial inter-membrane space proteins into the cytosol, following which these apoptogenic proteins bring about the demise of the cell. The most well studied example of this is found in animals, where the release of mitochondrial cytochrome C nucleates the formation of the apoptosome, which then activates caspase mediated cell death. The release of mitochondrial proteins contributes to PCD in diverse organisms lacking the apoptosome, indicating that regulated mitochondrial release predates the evolution of canonical apoptosis. Using the budding yeast Saccharomyces cerevisiae, we recently confirmed an early study showing that Nuc1, a homolog of the mitochondrial apoptotic driver protein Endonuclease G, attenuates cytosolic double stranded RNA (dsRNA) viruses, which are endemic to yeast and many other organisms. Viral attenuation by Nuc1 occurs most prominently during meiosis and in association with its developmentally programmed relocation from the mitochondria to the cytosol. Intriguingly, meiotic viral attenuation by Nuc1 occurs within the context of meiotic PCD of the superfluous mother cell that we have also discovered. These findings are discussed here.
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title_short	Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
url	https://doi.org/10.15698/mic2020.02.705 https://doaj.org/article/ba073a41f893444686d58660e45d6dfc http://microbialcell.com/researcharticles/2019a-gao-rios-microbial-cell/ https://doaj.org/toc/2311-2638
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