Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma

Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or met...
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Gespeichert in:

Autor*in:	Kartik Anand [verfasserIn] Jason Roszik [verfasserIn] Dan Gombos [verfasserIn] Joshua Upshaw [verfasserIn] Vanessa Sarli [verfasserIn] Salyna Meas [verfasserIn] Anthony Lucci [verfasserIn] Carolyn Hall [verfasserIn] Sapna Patel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	uveal melanoma liquid biopsy circulating tumor cells pilot study

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 11(2019), 6, p 856
Übergeordnetes Werk:	volume:11 ; year:2019 ; number:6, p 856

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers11060856

Katalog-ID:	DOAJ066499844

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520			\|a Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes.
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allfieldsGer	10.3390/cancers11060856 doi (DE-627)DOAJ066499844 (DE-599)DOAJ582d525f371f4adcbd684379230ec39a DE-627 ger DE-627 rakwb eng RC254-282 Kartik Anand verfasserin aut Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes. uveal melanoma liquid biopsy circulating tumor cells pilot study Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jason Roszik verfasserin aut Dan Gombos verfasserin aut Joshua Upshaw verfasserin aut Vanessa Sarli verfasserin aut Salyna Meas verfasserin aut Anthony Lucci verfasserin aut Carolyn Hall verfasserin aut Sapna Patel verfasserin aut In Cancers MDPI AG, 2010 11(2019), 6, p 856 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:6, p 856 https://doi.org/10.3390/cancers11060856 kostenfrei https://doaj.org/article/582d525f371f4adcbd684379230ec39a kostenfrei https://www.mdpi.com/2072-6694/11/6/856 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 6, p 856
allfieldsSound	10.3390/cancers11060856 doi (DE-627)DOAJ066499844 (DE-599)DOAJ582d525f371f4adcbd684379230ec39a DE-627 ger DE-627 rakwb eng RC254-282 Kartik Anand verfasserin aut Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes. uveal melanoma liquid biopsy circulating tumor cells pilot study Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jason Roszik verfasserin aut Dan Gombos verfasserin aut Joshua Upshaw verfasserin aut Vanessa Sarli verfasserin aut Salyna Meas verfasserin aut Anthony Lucci verfasserin aut Carolyn Hall verfasserin aut Sapna Patel verfasserin aut In Cancers MDPI AG, 2010 11(2019), 6, p 856 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:6, p 856 https://doi.org/10.3390/cancers11060856 kostenfrei https://doaj.org/article/582d525f371f4adcbd684379230ec39a kostenfrei https://www.mdpi.com/2072-6694/11/6/856 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 6, p 856
language	English
source	In Cancers 11(2019), 6, p 856 volume:11 year:2019 number:6, p 856
sourceStr	In Cancers 11(2019), 6, p 856 volume:11 year:2019 number:6, p 856
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institution	findex.gbv.de
topic_facet	uveal melanoma liquid biopsy circulating tumor cells pilot study Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Kartik Anand @@aut@@ Jason Roszik @@aut@@ Dan Gombos @@aut@@ Joshua Upshaw @@aut@@ Vanessa Sarli @@aut@@ Salyna Meas @@aut@@ Anthony Lucci @@aut@@ Carolyn Hall @@aut@@ Sapna Patel @@aut@@
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callnumber-first	R - Medicine
author	Kartik Anand
spellingShingle	Kartik Anand misc RC254-282 misc uveal melanoma misc liquid biopsy misc circulating tumor cells misc pilot study misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
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topic_title	RC254-282 Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma uveal melanoma liquid biopsy circulating tumor cells pilot study
topic	misc RC254-282 misc uveal melanoma misc liquid biopsy misc circulating tumor cells misc pilot study misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc uveal melanoma misc liquid biopsy misc circulating tumor cells misc pilot study misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc uveal melanoma misc liquid biopsy misc circulating tumor cells misc pilot study misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
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title_full	Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
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author_browse	Kartik Anand Jason Roszik Dan Gombos Joshua Upshaw Vanessa Sarli Salyna Meas Anthony Lucci Carolyn Hall Sapna Patel
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title_sort	pilot study of circulating tumor cells in early-stage and metastatic uveal melanoma
callnumber	RC254-282
title_auth	Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
abstract	Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes.
abstractGer	Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes.
abstract_unstemmed	Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (<i<p</i< < 0.05). Within this small dataset, the presence of CTCs in early-stage UM predicted an increased risk of metastatic disease and was associated with worse outcomes.
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title_short	Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
url	https://doi.org/10.3390/cancers11060856 https://doaj.org/article/582d525f371f4adcbd684379230ec39a https://www.mdpi.com/2072-6694/11/6/856 https://doaj.org/toc/2072-6694
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up_date	2024-07-03T20:23:49.857Z
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