Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.

Gespeichert in:

Autor*in:	Daniel P. Duarte [verfasserIn] Allan J. Lamontanara [verfasserIn] Giuseppina La Sala [verfasserIn] Sukyo Jeong [verfasserIn] Yoo-Kyoung Sohn [verfasserIn] Alejandro Panjkovich [verfasserIn] Sandrine Georgeon [verfasserIn] Tim Kükenshöner [verfasserIn] Maria J. Marcaida [verfasserIn] Florence Pojer [verfasserIn] Marco De Vivo [verfasserIn] Dmitri Svergun [verfasserIn] Hak-Sung Kim [verfasserIn] Matteo Dal Peraro [verfasserIn] Oliver Hantschel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 15
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-16128-5

Katalog-ID:	DOAJ066569354

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spelling	10.1038/s41467-020-16128-5 doi (DE-627)DOAJ066569354 (DE-599)DOAJ35d89457e02f4b24aac8c29d22647799 DE-627 ger DE-627 rakwb eng Daniel P. Duarte verfasserin aut Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk. Science Q Allan J. Lamontanara verfasserin aut Giuseppina La Sala verfasserin aut Sukyo Jeong verfasserin aut Yoo-Kyoung Sohn verfasserin aut Alejandro Panjkovich verfasserin aut Sandrine Georgeon verfasserin aut Tim Kükenshöner verfasserin aut Maria J. Marcaida verfasserin aut Florence Pojer verfasserin aut Marco De Vivo verfasserin aut Dmitri Svergun verfasserin aut Hak-Sung Kim verfasserin aut Matteo Dal Peraro verfasserin aut Oliver Hantschel verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:15 https://doi.org/10.1038/s41467-020-16128-5 kostenfrei https://doaj.org/article/35d89457e02f4b24aac8c29d22647799 kostenfrei https://doi.org/10.1038/s41467-020-16128-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 15
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author	Daniel P. Duarte
spellingShingle	Daniel P. Duarte misc Science misc Q Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
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topic_title	Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
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title	Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
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title_full	Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
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author_browse	Daniel P. Duarte Allan J. Lamontanara Giuseppina La Sala Sukyo Jeong Yoo-Kyoung Sohn Alejandro Panjkovich Sandrine Georgeon Tim Kükenshöner Maria J. Marcaida Florence Pojer Marco De Vivo Dmitri Svergun Hak-Sung Kim Matteo Dal Peraro Oliver Hantschel
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title_sort	btk sh2-kinase interface is critical for allosteric kinase activation and its targeting inhibits b-cell neoplasms
title_auth	Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
abstract	Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.
abstractGer	Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.
abstract_unstemmed	Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.
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title_short	Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
url	https://doi.org/10.1038/s41467-020-16128-5 https://doaj.org/article/35d89457e02f4b24aac8c29d22647799 https://doaj.org/toc/2041-1723
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