Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.

Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clin...
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Autor*in:	Jacopo C. DiFrancesco [verfasserIn] Martina eLongoni [verfasserIn] Fabrizio ePiazza [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Immunotherapy Alzheimer’s disease BAN2401 solanezumab aducanumab Cerebrospinal fluid biomarker

Übergeordnetes Werk:	In: Frontiers in Neurology - Frontiers Media S.A., 2010, 6(2015)
Übergeordnetes Werk:	volume:6 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fneur.2015.00207

Katalog-ID:	DOAJ066632935

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allfieldsSound	10.3389/fneur.2015.00207 doi (DE-627)DOAJ066632935 (DE-599)DOAJf5034353d9f741f8a2417fefc8060d0a DE-627 ger DE-627 rakwb eng RC346-429 Jacopo C. DiFrancesco verfasserin aut Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clinical trials in prodromal and subjects at risk for AD are underway. The recent demonstration that cerebrospinal fluid (CSF) anti-Aβ autoantibodies play a key role in the development of the ARIA-like events characterizing cerebral amyloid angiopathy-related inflammation generated great interest in the field of immunotherapy. Herein, we critically review the growing body of evidence supporting the monitoring of CSF anti-A autoantibody as a promising candidate biomarker for ARIA in clinical trials. Immunotherapy Alzheimer’s disease BAN2401 solanezumab aducanumab Cerebrospinal fluid biomarker Neurology. Diseases of the nervous system Jacopo C. DiFrancesco verfasserin aut Martina eLongoni verfasserin aut Martina eLongoni verfasserin aut Fabrizio ePiazza verfasserin aut Fabrizio ePiazza verfasserin aut Fabrizio ePiazza verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 6(2015) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:6 year:2015 https://doi.org/10.3389/fneur.2015.00207 kostenfrei https://doaj.org/article/f5034353d9f741f8a2417fefc8060d0a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00207/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2015
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author	Jacopo C. DiFrancesco
spellingShingle	Jacopo C. DiFrancesco misc RC346-429 misc Immunotherapy misc Alzheimer’s disease misc BAN2401 misc solanezumab misc aducanumab misc Cerebrospinal fluid biomarker misc Neurology. Diseases of the nervous system Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.
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topic_title	RC346-429 Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy Immunotherapy Alzheimer’s disease BAN2401 solanezumab aducanumab Cerebrospinal fluid biomarker
topic	misc RC346-429 misc Immunotherapy misc Alzheimer’s disease misc BAN2401 misc solanezumab misc aducanumab misc Cerebrospinal fluid biomarker misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Immunotherapy misc Alzheimer’s disease misc BAN2401 misc solanezumab misc aducanumab misc Cerebrospinal fluid biomarker misc Neurology. Diseases of the nervous system
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title	Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.
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title_full	Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy
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title_sort	anti-aβ autoantibodies in amyloid related imaging abnormalities (aria): candidate biomarker for immunotherapy in alzheimer’s disease and cerebral amyloid angiopathy
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title_auth	Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.
abstract	Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clinical trials in prodromal and subjects at risk for AD are underway. The recent demonstration that cerebrospinal fluid (CSF) anti-Aβ autoantibodies play a key role in the development of the ARIA-like events characterizing cerebral amyloid angiopathy-related inflammation generated great interest in the field of immunotherapy. Herein, we critically review the growing body of evidence supporting the monitoring of CSF anti-A autoantibody as a promising candidate biomarker for ARIA in clinical trials.
abstractGer	Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clinical trials in prodromal and subjects at risk for AD are underway. The recent demonstration that cerebrospinal fluid (CSF) anti-Aβ autoantibodies play a key role in the development of the ARIA-like events characterizing cerebral amyloid angiopathy-related inflammation generated great interest in the field of immunotherapy. Herein, we critically review the growing body of evidence supporting the monitoring of CSF anti-A autoantibody as a promising candidate biomarker for ARIA in clinical trials.
abstract_unstemmed	Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD). Early biomarkers of ARIA represent an important challenge to ensure safe and beneficial effects of immunotherapies, given that different promising clinical trials in prodromal and subjects at risk for AD are underway. The recent demonstration that cerebrospinal fluid (CSF) anti-Aβ autoantibodies play a key role in the development of the ARIA-like events characterizing cerebral amyloid angiopathy-related inflammation generated great interest in the field of immunotherapy. Herein, we critically review the growing body of evidence supporting the monitoring of CSF anti-A autoantibody as a promising candidate biomarker for ARIA in clinical trials.
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title_short	Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.
url	https://doi.org/10.3389/fneur.2015.00207 https://doaj.org/article/f5034353d9f741f8a2417fefc8060d0a http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00207/full https://doaj.org/toc/1664-2295
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Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.

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