Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility

<p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of...
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Autor*in:	Ciccodicola Alfredo [verfasserIn] Colson Natalie J [verfasserIn] Lea Rod A [verfasserIn] Esposito Teresa [verfasserIn] Fernandez Francesca [verfasserIn] Gianfrancesco Fernando [verfasserIn] Griffiths Lyn R [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Medical Genetics - BMC, 2003, 9(2008), 1, p 109
Übergeordnetes Werk:	volume:9 ; year:2008 ; number:1, p 109

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2350-9-109

Katalog-ID:	DOAJ066707978

Internformat


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allfields	10.1186/1471-2350-9-109 doi (DE-627)DOAJ066707978 (DE-599)DOAJ1c6bd357b08a45fb96df893aaa2a6d34 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Ciccodicola Alfredo verfasserin aut Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p< Internal medicine Genetics Colson Natalie J verfasserin aut Lea Rod A verfasserin aut Esposito Teresa verfasserin aut Fernandez Francesca verfasserin aut Gianfrancesco Fernando verfasserin aut Griffiths Lyn R verfasserin aut In BMC Medical Genetics BMC, 2003 9(2008), 1, p 109 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:9 year:2008 number:1, p 109 https://doi.org/10.1186/1471-2350-9-109 kostenfrei https://doaj.org/article/1c6bd357b08a45fb96df893aaa2a6d34 kostenfrei http://www.biomedcentral.com/1471-2350/9/109 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 109
spelling	10.1186/1471-2350-9-109 doi (DE-627)DOAJ066707978 (DE-599)DOAJ1c6bd357b08a45fb96df893aaa2a6d34 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Ciccodicola Alfredo verfasserin aut Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p< Internal medicine Genetics Colson Natalie J verfasserin aut Lea Rod A verfasserin aut Esposito Teresa verfasserin aut Fernandez Francesca verfasserin aut Gianfrancesco Fernando verfasserin aut Griffiths Lyn R verfasserin aut In BMC Medical Genetics BMC, 2003 9(2008), 1, p 109 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:9 year:2008 number:1, p 109 https://doi.org/10.1186/1471-2350-9-109 kostenfrei https://doaj.org/article/1c6bd357b08a45fb96df893aaa2a6d34 kostenfrei http://www.biomedcentral.com/1471-2350/9/109 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 109
allfields_unstemmed	10.1186/1471-2350-9-109 doi (DE-627)DOAJ066707978 (DE-599)DOAJ1c6bd357b08a45fb96df893aaa2a6d34 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Ciccodicola Alfredo verfasserin aut Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p< Internal medicine Genetics Colson Natalie J verfasserin aut Lea Rod A verfasserin aut Esposito Teresa verfasserin aut Fernandez Francesca verfasserin aut Gianfrancesco Fernando verfasserin aut Griffiths Lyn R verfasserin aut In BMC Medical Genetics BMC, 2003 9(2008), 1, p 109 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:9 year:2008 number:1, p 109 https://doi.org/10.1186/1471-2350-9-109 kostenfrei https://doaj.org/article/1c6bd357b08a45fb96df893aaa2a6d34 kostenfrei http://www.biomedcentral.com/1471-2350/9/109 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 109
allfieldsGer	10.1186/1471-2350-9-109 doi (DE-627)DOAJ066707978 (DE-599)DOAJ1c6bd357b08a45fb96df893aaa2a6d34 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Ciccodicola Alfredo verfasserin aut Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p< Internal medicine Genetics Colson Natalie J verfasserin aut Lea Rod A verfasserin aut Esposito Teresa verfasserin aut Fernandez Francesca verfasserin aut Gianfrancesco Fernando verfasserin aut Griffiths Lyn R verfasserin aut In BMC Medical Genetics BMC, 2003 9(2008), 1, p 109 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:9 year:2008 number:1, p 109 https://doi.org/10.1186/1471-2350-9-109 kostenfrei https://doaj.org/article/1c6bd357b08a45fb96df893aaa2a6d34 kostenfrei http://www.biomedcentral.com/1471-2350/9/109 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 109
allfieldsSound	10.1186/1471-2350-9-109 doi (DE-627)DOAJ066707978 (DE-599)DOAJ1c6bd357b08a45fb96df893aaa2a6d34 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Ciccodicola Alfredo verfasserin aut Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p< Internal medicine Genetics Colson Natalie J verfasserin aut Lea Rod A verfasserin aut Esposito Teresa verfasserin aut Fernandez Francesca verfasserin aut Gianfrancesco Fernando verfasserin aut Griffiths Lyn R verfasserin aut In BMC Medical Genetics BMC, 2003 9(2008), 1, p 109 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:9 year:2008 number:1, p 109 https://doi.org/10.1186/1471-2350-9-109 kostenfrei https://doaj.org/article/1c6bd357b08a45fb96df893aaa2a6d34 kostenfrei http://www.biomedcentral.com/1471-2350/9/109 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 109
language	English
source	In BMC Medical Genetics 9(2008), 1, p 109 volume:9 year:2008 number:1, p 109
sourceStr	In BMC Medical Genetics 9(2008), 1, p 109 volume:9 year:2008 number:1, p 109
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Internal medicine Genetics
isfreeaccess_bool	true
container_title	BMC Medical Genetics
authorswithroles_txt_mv	Ciccodicola Alfredo @@aut@@ Colson Natalie J @@aut@@ Lea Rod A @@aut@@ Esposito Teresa @@aut@@ Fernandez Francesca @@aut@@ Gianfrancesco Fernando @@aut@@ Griffiths Lyn R @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
hierarchy_top_id	326643788
id	DOAJ066707978
language_de	englisch
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callnumber-first	R - Medicine
author	Ciccodicola Alfredo
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topic_title	RC31-1245 QH426-470 Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
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title	Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
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title_full	Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
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author_browse	Ciccodicola Alfredo Colson Natalie J Lea Rod A Esposito Teresa Fernandez Francesca Gianfrancesco Fernando Griffiths Lyn R
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title_sort	investigation of gamma-aminobutyric acid (gaba) a receptors genes and migraine susceptibility
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title_auth	Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
abstract	<p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine.</p< <p<Methods</p< <p<We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene.</p< <p<Results</p< <p<Our study did not show any association between the examined SNPs in our test population (P < 0.05).</p< <p<Conclusion</p< <p<Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.</p<
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title_short	Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
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Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility

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