Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation

<p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Martin Maureen V [verfasserIn] Rollins Brandi [verfasserIn] Sequeira P Adolfo [verfasserIn] Mesén Andrea [verfasserIn] Byerley William [verfasserIn] Stein Richard [verfasserIn] Moon Emily A [verfasserIn] Akil Huda [verfasserIn] Jones Edward G [verfasserIn] Watson Stanley J [verfasserIn] Barchas Jack [verfasserIn] DeLisi Lynn E [verfasserIn] Myers Richard M [verfasserIn] Schatzberg Alan [verfasserIn] Bunney William E [verfasserIn] Vawter Marquis P [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: BMC Medical Genomics - BMC, 2008, 2(2009), 1, p 62
Übergeordnetes Werk:	volume:2 ; year:2009 ; number:1, p 62

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1755-8794-2-62

Katalog-ID:	DOAJ066717922

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allfields	10.1186/1755-8794-2-62 doi (DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Martin Maureen V verfasserin aut Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Internal medicine Genetics Rollins Brandi verfasserin aut Sequeira P Adolfo verfasserin aut Mesén Andrea verfasserin aut Byerley William verfasserin aut Stein Richard verfasserin aut Moon Emily A verfasserin aut Akil Huda verfasserin aut Jones Edward G verfasserin aut Watson Stanley J verfasserin aut Barchas Jack verfasserin aut DeLisi Lynn E verfasserin aut Myers Richard M verfasserin aut Schatzberg Alan verfasserin aut Bunney William E verfasserin aut Vawter Marquis P verfasserin aut In BMC Medical Genomics BMC, 2008 2(2009), 1, p 62 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:2 year:2009 number:1, p 62 https://doi.org/10.1186/1755-8794-2-62 kostenfrei https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b kostenfrei http://www.biomedcentral.com/1755-8794/2/62 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1, p 62
spelling	10.1186/1755-8794-2-62 doi (DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Martin Maureen V verfasserin aut Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Internal medicine Genetics Rollins Brandi verfasserin aut Sequeira P Adolfo verfasserin aut Mesén Andrea verfasserin aut Byerley William verfasserin aut Stein Richard verfasserin aut Moon Emily A verfasserin aut Akil Huda verfasserin aut Jones Edward G verfasserin aut Watson Stanley J verfasserin aut Barchas Jack verfasserin aut DeLisi Lynn E verfasserin aut Myers Richard M verfasserin aut Schatzberg Alan verfasserin aut Bunney William E verfasserin aut Vawter Marquis P verfasserin aut In BMC Medical Genomics BMC, 2008 2(2009), 1, p 62 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:2 year:2009 number:1, p 62 https://doi.org/10.1186/1755-8794-2-62 kostenfrei https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b kostenfrei http://www.biomedcentral.com/1755-8794/2/62 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1, p 62
allfields_unstemmed	10.1186/1755-8794-2-62 doi (DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Martin Maureen V verfasserin aut Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Internal medicine Genetics Rollins Brandi verfasserin aut Sequeira P Adolfo verfasserin aut Mesén Andrea verfasserin aut Byerley William verfasserin aut Stein Richard verfasserin aut Moon Emily A verfasserin aut Akil Huda verfasserin aut Jones Edward G verfasserin aut Watson Stanley J verfasserin aut Barchas Jack verfasserin aut DeLisi Lynn E verfasserin aut Myers Richard M verfasserin aut Schatzberg Alan verfasserin aut Bunney William E verfasserin aut Vawter Marquis P verfasserin aut In BMC Medical Genomics BMC, 2008 2(2009), 1, p 62 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:2 year:2009 number:1, p 62 https://doi.org/10.1186/1755-8794-2-62 kostenfrei https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b kostenfrei http://www.biomedcentral.com/1755-8794/2/62 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1, p 62
allfieldsGer	10.1186/1755-8794-2-62 doi (DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Martin Maureen V verfasserin aut Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Internal medicine Genetics Rollins Brandi verfasserin aut Sequeira P Adolfo verfasserin aut Mesén Andrea verfasserin aut Byerley William verfasserin aut Stein Richard verfasserin aut Moon Emily A verfasserin aut Akil Huda verfasserin aut Jones Edward G verfasserin aut Watson Stanley J verfasserin aut Barchas Jack verfasserin aut DeLisi Lynn E verfasserin aut Myers Richard M verfasserin aut Schatzberg Alan verfasserin aut Bunney William E verfasserin aut Vawter Marquis P verfasserin aut In BMC Medical Genomics BMC, 2008 2(2009), 1, p 62 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:2 year:2009 number:1, p 62 https://doi.org/10.1186/1755-8794-2-62 kostenfrei https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b kostenfrei http://www.biomedcentral.com/1755-8794/2/62 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1, p 62
allfieldsSound	10.1186/1755-8794-2-62 doi (DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Martin Maureen V verfasserin aut Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p< Internal medicine Genetics Rollins Brandi verfasserin aut Sequeira P Adolfo verfasserin aut Mesén Andrea verfasserin aut Byerley William verfasserin aut Stein Richard verfasserin aut Moon Emily A verfasserin aut Akil Huda verfasserin aut Jones Edward G verfasserin aut Watson Stanley J verfasserin aut Barchas Jack verfasserin aut DeLisi Lynn E verfasserin aut Myers Richard M verfasserin aut Schatzberg Alan verfasserin aut Bunney William E verfasserin aut Vawter Marquis P verfasserin aut In BMC Medical Genomics BMC, 2008 2(2009), 1, p 62 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:2 year:2009 number:1, p 62 https://doi.org/10.1186/1755-8794-2-62 kostenfrei https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b kostenfrei http://www.biomedcentral.com/1755-8794/2/62 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1, p 62
language	English
source	In BMC Medical Genomics 2(2009), 1, p 62 volume:2 year:2009 number:1, p 62
sourceStr	In BMC Medical Genomics 2(2009), 1, p 62 volume:2 year:2009 number:1, p 62
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Internal medicine Genetics
isfreeaccess_bool	true
container_title	BMC Medical Genomics
authorswithroles_txt_mv	Martin Maureen V @@aut@@ Rollins Brandi @@aut@@ Sequeira P Adolfo @@aut@@ Mesén Andrea @@aut@@ Byerley William @@aut@@ Stein Richard @@aut@@ Moon Emily A @@aut@@ Akil Huda @@aut@@ Jones Edward G @@aut@@ Watson Stanley J @@aut@@ Barchas Jack @@aut@@ DeLisi Lynn E @@aut@@ Myers Richard M @@aut@@ Schatzberg Alan @@aut@@ Bunney William E @@aut@@ Vawter Marquis P @@aut@@
publishDateDaySort_date	2009-01-01T00:00:00Z
hierarchy_top_id	559080824
id	DOAJ066717922
language_de	englisch
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callnumber-first	R - Medicine
author	Martin Maureen V
spellingShingle	Martin Maureen V misc RC31-1245 misc QH426-470 misc Internal medicine misc Genetics Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
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topic_title	RC31-1245 QH426-470 Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
topic	misc RC31-1245 misc QH426-470 misc Internal medicine misc Genetics
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title	Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
ctrlnum	(DE-627)DOAJ066717922 (DE-599)DOAJ64c183d5b98e44e58d7263f1b185592b
title_full	Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
author_sort	Martin Maureen V
journal	BMC Medical Genomics
journalStr	BMC Medical Genomics
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author_browse	Martin Maureen V Rollins Brandi Sequeira P Adolfo Mesén Andrea Byerley William Stein Richard Moon Emily A Akil Huda Jones Edward G Watson Stanley J Barchas Jack DeLisi Lynn E Myers Richard M Schatzberg Alan Bunney William E Vawter Marquis P
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title_sort	exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
callnumber	RC31-1245
title_auth	Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
abstract	<p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.</p< <p<Methods</p< <p<LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.</p< <p<Results</p< <p<There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).</p< <p<Conclusion</p< <p<Experimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.</p<
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title_short	Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
url	https://doi.org/10.1186/1755-8794-2-62 https://doaj.org/article/64c183d5b98e44e58d7263f1b185592b http://www.biomedcentral.com/1755-8794/2/62 https://doaj.org/toc/1755-8794
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Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation

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