BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level a...
Ausführliche Beschreibung
Autor*in: |
Giuseppina D’Alessandro [verfasserIn] Donna Rose Whelan [verfasserIn] Sean Michael Howard [verfasserIn] Valerio Vitelli [verfasserIn] Xavier Renaudin [verfasserIn] Marek Adamowicz [verfasserIn] Fabio Iannelli [verfasserIn] Corey Winston Jones-Weinert [verfasserIn] MiYoung Lee [verfasserIn] Valentina Matti [verfasserIn] Wei Ting C. Lee [verfasserIn] Michael John Morten [verfasserIn] Ashok Raraakrishnan Venkitaraman [verfasserIn] Petr Cejka [verfasserIn] Eli Rothenberg [verfasserIn] Fabrizio d’Adda di Fagagna [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 17 |
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Übergeordnetes Werk: |
volume:9 ; year:2018 ; number:1 ; pages:17 |
Links: |
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DOI / URN: |
10.1038/s41467-018-07799-2 |
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Katalog-ID: |
DOAJ066798116 |
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10.1038/s41467-018-07799-2 doi (DE-627)DOAJ066798116 (DE-599)DOAJcc0c69fc66a743848c9213f81e369d2a DE-627 ger DE-627 rakwb eng Giuseppina D’Alessandro verfasserin aut BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs. Science Q Donna Rose Whelan verfasserin aut Sean Michael Howard verfasserin aut Valerio Vitelli verfasserin aut Xavier Renaudin verfasserin aut Marek Adamowicz verfasserin aut Fabio Iannelli verfasserin aut Corey Winston Jones-Weinert verfasserin aut MiYoung Lee verfasserin aut Valentina Matti verfasserin aut Wei Ting C. Lee verfasserin aut Michael John Morten verfasserin aut Ashok Raraakrishnan Venkitaraman verfasserin aut Petr Cejka verfasserin aut Eli Rothenberg verfasserin aut Fabrizio d’Adda di Fagagna verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:17 https://doi.org/10.1038/s41467-018-07799-2 kostenfrei https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a kostenfrei https://doi.org/10.1038/s41467-018-07799-2 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 17 |
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BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment |
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Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs. |
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Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs. |
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Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs. |
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