Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carc...
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Autor*in:	Man Hsin Hung [verfasserIn] Joo Sang Lee [verfasserIn] Chi Ma [verfasserIn] Laurence P. Diggs [verfasserIn] Sophia Heinrich [verfasserIn] Ching Wen Chang [verfasserIn] Lichun Ma [verfasserIn] Marshonna Forgues [verfasserIn] Anuradha Budhu [verfasserIn] Jittiporn Chaisaingmongkol [verfasserIn] Mathuros Ruchirawat [verfasserIn] Eytan Ruppin [verfasserIn] Tim F. Greten [verfasserIn] Xin Wei Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 15
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-21804-1

Katalog-ID:	DOAJ066809789

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spelling	10.1038/s41467-021-21804-1 doi (DE-627)DOAJ066809789 (DE-599)DOAJa4410c080725408d9c0d3f511de3fd95 DE-627 ger DE-627 rakwb eng Man Hsin Hung verfasserin aut Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion. Science Q Joo Sang Lee verfasserin aut Chi Ma verfasserin aut Laurence P. Diggs verfasserin aut Sophia Heinrich verfasserin aut Ching Wen Chang verfasserin aut Lichun Ma verfasserin aut Marshonna Forgues verfasserin aut Anuradha Budhu verfasserin aut Jittiporn Chaisaingmongkol verfasserin aut Mathuros Ruchirawat verfasserin aut Eytan Ruppin verfasserin aut Tim F. Greten verfasserin aut Xin Wei Wang verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:15 https://doi.org/10.1038/s41467-021-21804-1 kostenfrei https://doaj.org/article/a4410c080725408d9c0d3f511de3fd95 kostenfrei https://doi.org/10.1038/s41467-021-21804-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 15
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allfieldsSound	10.1038/s41467-021-21804-1 doi (DE-627)DOAJ066809789 (DE-599)DOAJa4410c080725408d9c0d3f511de3fd95 DE-627 ger DE-627 rakwb eng Man Hsin Hung verfasserin aut Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion. Science Q Joo Sang Lee verfasserin aut Chi Ma verfasserin aut Laurence P. Diggs verfasserin aut Sophia Heinrich verfasserin aut Ching Wen Chang verfasserin aut Lichun Ma verfasserin aut Marshonna Forgues verfasserin aut Anuradha Budhu verfasserin aut Jittiporn Chaisaingmongkol verfasserin aut Mathuros Ruchirawat verfasserin aut Eytan Ruppin verfasserin aut Tim F. Greten verfasserin aut Xin Wei Wang verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:15 https://doi.org/10.1038/s41467-021-21804-1 kostenfrei https://doaj.org/article/a4410c080725408d9c0d3f511de3fd95 kostenfrei https://doi.org/10.1038/s41467-021-21804-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 15
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author	Man Hsin Hung
spellingShingle	Man Hsin Hung misc Science misc Q Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
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topic_title	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
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title	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
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author_browse	Man Hsin Hung Joo Sang Lee Chi Ma Laurence P. Diggs Sophia Heinrich Ching Wen Chang Lichun Ma Marshonna Forgues Anuradha Budhu Jittiporn Chaisaingmongkol Mathuros Ruchirawat Eytan Ruppin Tim F. Greten Xin Wei Wang
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title_sort	tumor methionine metabolism drives t-cell exhaustion in hepatocellular carcinoma
title_auth	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
abstract	Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion.
abstractGer	Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion.
abstract_unstemmed	Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion.
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title_short	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
url	https://doi.org/10.1038/s41467-021-21804-1 https://doaj.org/article/a4410c080725408d9c0d3f511de3fd95 https://doaj.org/toc/2041-1723
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