Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages

Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evol...
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Autor*in:	Shichao Pang [verfasserIn] Yidi Sun [verfasserIn] Leilei Wu [verfasserIn] Liguang Yang [verfasserIn] Yi-Lei Zhao [verfasserIn] Zhen Wang [verfasserIn] Yixue Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 8(2018), 1, Seite 8
Übergeordnetes Werk:	volume:8 ; year:2018 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-018-20321-4

Katalog-ID:	DOAJ066820928

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520			\|a Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
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spelling	10.1038/s41598-018-20321-4 doi (DE-627)DOAJ066820928 (DE-599)DOAJ4c4f24f4e1ce4ac6b67c36ad432f09ea DE-627 ger DE-627 rakwb eng Shichao Pang verfasserin aut Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility. Medicine R Science Q Yidi Sun verfasserin aut Leilei Wu verfasserin aut Liguang Yang verfasserin aut Yi-Lei Zhao verfasserin aut Zhen Wang verfasserin aut Yixue Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 8(2018), 1, Seite 8 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:8 year:2018 number:1 pages:8 https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea kostenfrei https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2018 1 8
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allfieldsGer	10.1038/s41598-018-20321-4 doi (DE-627)DOAJ066820928 (DE-599)DOAJ4c4f24f4e1ce4ac6b67c36ad432f09ea DE-627 ger DE-627 rakwb eng Shichao Pang verfasserin aut Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility. Medicine R Science Q Yidi Sun verfasserin aut Leilei Wu verfasserin aut Liguang Yang verfasserin aut Yi-Lei Zhao verfasserin aut Zhen Wang verfasserin aut Yixue Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 8(2018), 1, Seite 8 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:8 year:2018 number:1 pages:8 https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea kostenfrei https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2018 1 8
allfieldsSound	10.1038/s41598-018-20321-4 doi (DE-627)DOAJ066820928 (DE-599)DOAJ4c4f24f4e1ce4ac6b67c36ad432f09ea DE-627 ger DE-627 rakwb eng Shichao Pang verfasserin aut Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility. Medicine R Science Q Yidi Sun verfasserin aut Leilei Wu verfasserin aut Liguang Yang verfasserin aut Yi-Lei Zhao verfasserin aut Zhen Wang verfasserin aut Yixue Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 8(2018), 1, Seite 8 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:8 year:2018 number:1 pages:8 https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea kostenfrei https://doi.org/10.1038/s41598-018-20321-4 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2018 1 8
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author	Shichao Pang
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topic_title	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
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title	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
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title_full	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
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title_sort	reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_auth	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
abstract	Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
abstractGer	Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
abstract_unstemmed	Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
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title_short	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
url	https://doi.org/10.1038/s41598-018-20321-4 https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea https://doaj.org/toc/2045-2322
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