Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis

Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the stru...
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Autor*in:	Yaou Liu [verfasserIn] Yunyun Duan [verfasserIn] Huiqing Dong [verfasserIn] Frederik Barkhof [verfasserIn] Kuncheng Li [verfasserIn] Ni Shu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	multiple sclerosis clinically isolated syndrome diffusion MRI functional MRI graph theory brain network

Übergeordnetes Werk:	In: Frontiers in Human Neuroscience - Frontiers Media S.A., 2008, 12(2018)
Übergeordnetes Werk:	volume:12 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnhum.2018.00138

Katalog-ID:	DOAJ066832519

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520			\|a Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability.
650		4	\|a multiple sclerosis
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spelling	10.3389/fnhum.2018.00138 doi (DE-627)DOAJ066832519 (DE-599)DOAJa887e8a63b7543af9a1c9910eb9bc553 DE-627 ger DE-627 rakwb eng RC321-571 Yaou Liu verfasserin aut Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability. multiple sclerosis clinically isolated syndrome diffusion MRI functional MRI graph theory brain network Neurosciences. Biological psychiatry. Neuropsychiatry Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Huiqing Dong verfasserin aut Frederik Barkhof verfasserin aut Frederik Barkhof verfasserin aut Kuncheng Li verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:12 year:2018 https://doi.org/10.3389/fnhum.2018.00138 kostenfrei https://doaj.org/article/a887e8a63b7543af9a1c9910eb9bc553 kostenfrei http://journal.frontiersin.org/article/10.3389/fnhum.2018.00138/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
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allfieldsGer	10.3389/fnhum.2018.00138 doi (DE-627)DOAJ066832519 (DE-599)DOAJa887e8a63b7543af9a1c9910eb9bc553 DE-627 ger DE-627 rakwb eng RC321-571 Yaou Liu verfasserin aut Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability. multiple sclerosis clinically isolated syndrome diffusion MRI functional MRI graph theory brain network Neurosciences. Biological psychiatry. Neuropsychiatry Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Huiqing Dong verfasserin aut Frederik Barkhof verfasserin aut Frederik Barkhof verfasserin aut Kuncheng Li verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:12 year:2018 https://doi.org/10.3389/fnhum.2018.00138 kostenfrei https://doaj.org/article/a887e8a63b7543af9a1c9910eb9bc553 kostenfrei http://journal.frontiersin.org/article/10.3389/fnhum.2018.00138/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
allfieldsSound	10.3389/fnhum.2018.00138 doi (DE-627)DOAJ066832519 (DE-599)DOAJa887e8a63b7543af9a1c9910eb9bc553 DE-627 ger DE-627 rakwb eng RC321-571 Yaou Liu verfasserin aut Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability. multiple sclerosis clinically isolated syndrome diffusion MRI functional MRI graph theory brain network Neurosciences. Biological psychiatry. Neuropsychiatry Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yaou Liu verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Yunyun Duan verfasserin aut Huiqing Dong verfasserin aut Frederik Barkhof verfasserin aut Frederik Barkhof verfasserin aut Kuncheng Li verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut Ni Shu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:12 year:2018 https://doi.org/10.3389/fnhum.2018.00138 kostenfrei https://doaj.org/article/a887e8a63b7543af9a1c9910eb9bc553 kostenfrei http://journal.frontiersin.org/article/10.3389/fnhum.2018.00138/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
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authorswithroles_txt_mv	Yaou Liu @@aut@@ Yunyun Duan @@aut@@ Huiqing Dong @@aut@@ Frederik Barkhof @@aut@@ Kuncheng Li @@aut@@ Ni Shu @@aut@@
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callnumber-first	R - Medicine
author	Yaou Liu
spellingShingle	Yaou Liu misc RC321-571 misc multiple sclerosis misc clinically isolated syndrome misc diffusion MRI misc functional MRI misc graph theory misc brain network misc Neurosciences. Biological psychiatry. Neuropsychiatry Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
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topic_title	RC321-571 Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis multiple sclerosis clinically isolated syndrome diffusion MRI functional MRI graph theory brain network
topic	misc RC321-571 misc multiple sclerosis misc clinically isolated syndrome misc diffusion MRI misc functional MRI misc graph theory misc brain network misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc multiple sclerosis misc clinically isolated syndrome misc diffusion MRI misc functional MRI misc graph theory misc brain network misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
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title_full	Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
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title_sort	disrupted module efficiency of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis
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title_auth	Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
abstract	Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability.
abstractGer	Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability.
abstract_unstemmed	Recent studies have demonstrated disrupted topological organization of brain connectome in multiple sclerosis (MS). However, whether the communication efficiency between different functional systems is affected in the early stage of MS remained largely unknown. In this study, we constructed the structural connectivity (SC) and functional connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS patients and 35 healthy controls (HC) based on diffusion and resting-state functional MRI. To quantify the communication efficiency within and between different functional systems, we proposed two measures called intra- and inter-module efficiency. Based on the module parcellation of functional backbone network, the intra- and inter-module efficiency of SC and FC networks was calculated for each participant. For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. Therefore, our results demonstrated early SC changes between modules in CIS, and more widespread SC alterations and inter-module FC changes were observed in MS, which were further associated with cognitive impairment and physical disability.
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title_short	Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
url	https://doi.org/10.3389/fnhum.2018.00138 https://doaj.org/article/a887e8a63b7543af9a1c9910eb9bc553 http://journal.frontiersin.org/article/10.3389/fnhum.2018.00138/full https://doaj.org/toc/1662-5161
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up_date	2024-07-03T22:13:57.121Z
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For the SC network, CIS showed decreased inter-module efficiency between the sensory-motor network (SMN), the visual network (VN), the default-mode network (DMN) and the fronto-parietal network (FPN) compared with HC, while MS showed more widespread decreased module efficiency both within and between modules relative to HC and CIS. For the FC network, no differences were found between CIS and HC, and a decreased inter-module efficiency between SMN and FPN and between VN and FPN was identified in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of SC network were correlated with the disability and cognitive scores in MS. 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Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis

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