Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid

Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Desiderio Passali [verfasserIn] Chiara Cappello [verfasserIn] Giulio Cesare Passali [verfasserIn] Cemal Cingi [verfasserIn] Codrut Sarafoleanu [verfasserIn] Luisa Maria Bellussi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation

Übergeordnetes Werk:	In: Multidisciplinary Respiratory Medicine - Mattioli 1885, 2012, 12(2017), 1, Seite 6
Übergeordnetes Werk:	volume:12 ; year:2017 ; number:1 ; pages:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s40248-017-0110-7

Katalog-ID:	DOAJ066865077

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520			\|a Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.
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allfields	10.1186/s40248-017-0110-7 doi (DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63 DE-627 ger DE-627 rakwb eng RC705-779 Desiderio Passali verfasserin aut Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system Chiara Cappello verfasserin aut Giulio Cesare Passali verfasserin aut Cemal Cingi verfasserin aut Codrut Sarafoleanu verfasserin aut Luisa Maria Bellussi verfasserin aut In Multidisciplinary Respiratory Medicine Mattioli 1885, 2012 12(2017), 1, Seite 6 (DE-627)722238517 (DE-600)2677839-7 20496958 nnns volume:12 year:2017 number:1 pages:6 https://doi.org/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 kostenfrei http://link.springer.com/article/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/toc/2049-6958 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 6
spelling	10.1186/s40248-017-0110-7 doi (DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63 DE-627 ger DE-627 rakwb eng RC705-779 Desiderio Passali verfasserin aut Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system Chiara Cappello verfasserin aut Giulio Cesare Passali verfasserin aut Cemal Cingi verfasserin aut Codrut Sarafoleanu verfasserin aut Luisa Maria Bellussi verfasserin aut In Multidisciplinary Respiratory Medicine Mattioli 1885, 2012 12(2017), 1, Seite 6 (DE-627)722238517 (DE-600)2677839-7 20496958 nnns volume:12 year:2017 number:1 pages:6 https://doi.org/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 kostenfrei http://link.springer.com/article/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/toc/2049-6958 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 6
allfields_unstemmed	10.1186/s40248-017-0110-7 doi (DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63 DE-627 ger DE-627 rakwb eng RC705-779 Desiderio Passali verfasserin aut Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system Chiara Cappello verfasserin aut Giulio Cesare Passali verfasserin aut Cemal Cingi verfasserin aut Codrut Sarafoleanu verfasserin aut Luisa Maria Bellussi verfasserin aut In Multidisciplinary Respiratory Medicine Mattioli 1885, 2012 12(2017), 1, Seite 6 (DE-627)722238517 (DE-600)2677839-7 20496958 nnns volume:12 year:2017 number:1 pages:6 https://doi.org/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 kostenfrei http://link.springer.com/article/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/toc/2049-6958 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 6
allfieldsGer	10.1186/s40248-017-0110-7 doi (DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63 DE-627 ger DE-627 rakwb eng RC705-779 Desiderio Passali verfasserin aut Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system Chiara Cappello verfasserin aut Giulio Cesare Passali verfasserin aut Cemal Cingi verfasserin aut Codrut Sarafoleanu verfasserin aut Luisa Maria Bellussi verfasserin aut In Multidisciplinary Respiratory Medicine Mattioli 1885, 2012 12(2017), 1, Seite 6 (DE-627)722238517 (DE-600)2677839-7 20496958 nnns volume:12 year:2017 number:1 pages:6 https://doi.org/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 kostenfrei http://link.springer.com/article/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/toc/2049-6958 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 6
allfieldsSound	10.1186/s40248-017-0110-7 doi (DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63 DE-627 ger DE-627 rakwb eng RC705-779 Desiderio Passali verfasserin aut Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa. MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system Chiara Cappello verfasserin aut Giulio Cesare Passali verfasserin aut Cemal Cingi verfasserin aut Codrut Sarafoleanu verfasserin aut Luisa Maria Bellussi verfasserin aut In Multidisciplinary Respiratory Medicine Mattioli 1885, 2012 12(2017), 1, Seite 6 (DE-627)722238517 (DE-600)2677839-7 20496958 nnns volume:12 year:2017 number:1 pages:6 https://doi.org/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 kostenfrei http://link.springer.com/article/10.1186/s40248-017-0110-7 kostenfrei https://doaj.org/toc/2049-6958 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 6
language	English
source	In Multidisciplinary Respiratory Medicine 12(2017), 1, Seite 6 volume:12 year:2017 number:1 pages:6
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topic_facet	MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation Diseases of the respiratory system
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container_title	Multidisciplinary Respiratory Medicine
authorswithroles_txt_mv	Desiderio Passali @@aut@@ Chiara Cappello @@aut@@ Giulio Cesare Passali @@aut@@ Cemal Cingi @@aut@@ Codrut Sarafoleanu @@aut@@ Luisa Maria Bellussi @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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topic_title	RC705-779 Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid MCT Glycyrrhetinic acid HMGB1 Sirt 6 Nasal inflammation
topic	misc RC705-779 misc MCT misc Glycyrrhetinic acid misc HMGB1 misc Sirt 6 misc Nasal inflammation misc Diseases of the respiratory system
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title	Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid
ctrlnum	(DE-627)DOAJ066865077 (DE-599)DOAJ39d79e803a56409cb4b650381ed2da63
title_full	Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid
author_sort	Desiderio Passali
journal	Multidisciplinary Respiratory Medicine
journalStr	Multidisciplinary Respiratory Medicine
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author_browse	Desiderio Passali Chiara Cappello Giulio Cesare Passali Cemal Cingi Codrut Sarafoleanu Luisa Maria Bellussi
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doi_str_mv	10.1186/s40248-017-0110-7
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title_sort	nasal muco-ciliary transport time alteration: efficacy of 18 b glycyrrhetinic acid
callnumber	RC705-779
title_auth	Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid
abstract	Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.
abstractGer	Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.
abstract_unstemmed	Abstract Background Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.
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title_short	Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid
url	https://doi.org/10.1186/s40248-017-0110-7 https://doaj.org/article/39d79e803a56409cb4b650381ed2da63 http://link.springer.com/article/10.1186/s40248-017-0110-7 https://doaj.org/toc/2049-6958
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author2	Chiara Cappello Giulio Cesare Passali Cemal Cingi Codrut Sarafoleanu Luisa Maria Bellussi
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