Tick and Host Derived Compounds Detected in the Cement Complex Substance

Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feed...
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Autor*in:	Margarita Villar [verfasserIn] Iván Pacheco [verfasserIn] Octavio Merino [verfasserIn] Marinela Contreras [verfasserIn] Lourdes Mateos-Hernández [verfasserIn] Eduardo Prado [verfasserIn] Dina Karen Barros-Picanço [verfasserIn] José Francisco Lima-Barbero [verfasserIn] Sara Artigas-Jerónimo [verfasserIn] Pilar Alberdi [verfasserIn] Isabel G. Fernández de Mera [verfasserIn] Agustín Estrada-Peña [verfasserIn] Alejandro Cabezas-Cruz [verfasserIn] José de la Fuente [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 10(2020), 4, p 555
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:4, p 555

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom10040555

Katalog-ID:	DOAJ066916011

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allfields	10.3390/biom10040555 doi (DE-627)DOAJ066916011 (DE-599)DOAJ1cedda24916541349e9e427cd6ec2072 DE-627 ger DE-627 rakwb eng QR1-502 Margarita Villar verfasserin aut Tick and Host Derived Compounds Detected in the Cement Complex Substance 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding. tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome Microbiology Iván Pacheco verfasserin aut Octavio Merino verfasserin aut Marinela Contreras verfasserin aut Lourdes Mateos-Hernández verfasserin aut Eduardo Prado verfasserin aut Dina Karen Barros-Picanço verfasserin aut José Francisco Lima-Barbero verfasserin aut Sara Artigas-Jerónimo verfasserin aut Pilar Alberdi verfasserin aut Isabel G. Fernández de Mera verfasserin aut Agustín Estrada-Peña verfasserin aut Alejandro Cabezas-Cruz verfasserin aut José de la Fuente verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 555 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 555 https://doi.org/10.3390/biom10040555 kostenfrei https://doaj.org/article/1cedda24916541349e9e427cd6ec2072 kostenfrei https://www.mdpi.com/2218-273X/10/4/555 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 555
spelling	10.3390/biom10040555 doi (DE-627)DOAJ066916011 (DE-599)DOAJ1cedda24916541349e9e427cd6ec2072 DE-627 ger DE-627 rakwb eng QR1-502 Margarita Villar verfasserin aut Tick and Host Derived Compounds Detected in the Cement Complex Substance 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding. tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome Microbiology Iván Pacheco verfasserin aut Octavio Merino verfasserin aut Marinela Contreras verfasserin aut Lourdes Mateos-Hernández verfasserin aut Eduardo Prado verfasserin aut Dina Karen Barros-Picanço verfasserin aut José Francisco Lima-Barbero verfasserin aut Sara Artigas-Jerónimo verfasserin aut Pilar Alberdi verfasserin aut Isabel G. Fernández de Mera verfasserin aut Agustín Estrada-Peña verfasserin aut Alejandro Cabezas-Cruz verfasserin aut José de la Fuente verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 555 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 555 https://doi.org/10.3390/biom10040555 kostenfrei https://doaj.org/article/1cedda24916541349e9e427cd6ec2072 kostenfrei https://www.mdpi.com/2218-273X/10/4/555 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 555
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allfieldsGer	10.3390/biom10040555 doi (DE-627)DOAJ066916011 (DE-599)DOAJ1cedda24916541349e9e427cd6ec2072 DE-627 ger DE-627 rakwb eng QR1-502 Margarita Villar verfasserin aut Tick and Host Derived Compounds Detected in the Cement Complex Substance 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding. tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome Microbiology Iván Pacheco verfasserin aut Octavio Merino verfasserin aut Marinela Contreras verfasserin aut Lourdes Mateos-Hernández verfasserin aut Eduardo Prado verfasserin aut Dina Karen Barros-Picanço verfasserin aut José Francisco Lima-Barbero verfasserin aut Sara Artigas-Jerónimo verfasserin aut Pilar Alberdi verfasserin aut Isabel G. Fernández de Mera verfasserin aut Agustín Estrada-Peña verfasserin aut Alejandro Cabezas-Cruz verfasserin aut José de la Fuente verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 555 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 555 https://doi.org/10.3390/biom10040555 kostenfrei https://doaj.org/article/1cedda24916541349e9e427cd6ec2072 kostenfrei https://www.mdpi.com/2218-273X/10/4/555 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 555
allfieldsSound	10.3390/biom10040555 doi (DE-627)DOAJ066916011 (DE-599)DOAJ1cedda24916541349e9e427cd6ec2072 DE-627 ger DE-627 rakwb eng QR1-502 Margarita Villar verfasserin aut Tick and Host Derived Compounds Detected in the Cement Complex Substance 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding. tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome Microbiology Iván Pacheco verfasserin aut Octavio Merino verfasserin aut Marinela Contreras verfasserin aut Lourdes Mateos-Hernández verfasserin aut Eduardo Prado verfasserin aut Dina Karen Barros-Picanço verfasserin aut José Francisco Lima-Barbero verfasserin aut Sara Artigas-Jerónimo verfasserin aut Pilar Alberdi verfasserin aut Isabel G. Fernández de Mera verfasserin aut Agustín Estrada-Peña verfasserin aut Alejandro Cabezas-Cruz verfasserin aut José de la Fuente verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 4, p 555 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:4, p 555 https://doi.org/10.3390/biom10040555 kostenfrei https://doaj.org/article/1cedda24916541349e9e427cd6ec2072 kostenfrei https://www.mdpi.com/2218-273X/10/4/555 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 4, p 555
language	English
source	In Biomolecules 10(2020), 4, p 555 volume:10 year:2020 number:4, p 555
sourceStr	In Biomolecules 10(2020), 4, p 555 volume:10 year:2020 number:4, p 555
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topic_facet	tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome Microbiology
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authorswithroles_txt_mv	Margarita Villar @@aut@@ Iván Pacheco @@aut@@ Octavio Merino @@aut@@ Marinela Contreras @@aut@@ Lourdes Mateos-Hernández @@aut@@ Eduardo Prado @@aut@@ Dina Karen Barros-Picanço @@aut@@ José Francisco Lima-Barbero @@aut@@ Sara Artigas-Jerónimo @@aut@@ Pilar Alberdi @@aut@@ Isabel G. Fernández de Mera @@aut@@ Agustín Estrada-Peña @@aut@@ Alejandro Cabezas-Cruz @@aut@@ José de la Fuente @@aut@@
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callnumber-first	Q - Science
author	Margarita Villar
spellingShingle	Margarita Villar misc QR1-502 misc tick misc cement misc proteomics misc dispersive energy X-ray spectroscopy misc sialome misc cementome misc Microbiology Tick and Host Derived Compounds Detected in the Cement Complex Substance
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topic_title	QR1-502 Tick and Host Derived Compounds Detected in the Cement Complex Substance tick cement proteomics dispersive energy X-ray spectroscopy sialome cementome
topic	misc QR1-502 misc tick misc cement misc proteomics misc dispersive energy X-ray spectroscopy misc sialome misc cementome misc Microbiology
topic_unstemmed	misc QR1-502 misc tick misc cement misc proteomics misc dispersive energy X-ray spectroscopy misc sialome misc cementome misc Microbiology
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title	Tick and Host Derived Compounds Detected in the Cement Complex Substance
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title_full	Tick and Host Derived Compounds Detected in the Cement Complex Substance
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author_browse	Margarita Villar Iván Pacheco Octavio Merino Marinela Contreras Lourdes Mateos-Hernández Eduardo Prado Dina Karen Barros-Picanço José Francisco Lima-Barbero Sara Artigas-Jerónimo Pilar Alberdi Isabel G. Fernández de Mera Agustín Estrada-Peña Alejandro Cabezas-Cruz José de la Fuente
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title_sort	tick and host derived compounds detected in the cement complex substance
callnumber	QR1-502
title_auth	Tick and Host Derived Compounds Detected in the Cement Complex Substance
abstract	Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding.
abstractGer	Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding.
abstract_unstemmed	Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of <i<Rhipicephalus microplus</i< salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding.
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container_issue	4, p 555
title_short	Tick and Host Derived Compounds Detected in the Cement Complex Substance
url	https://doi.org/10.3390/biom10040555 https://doaj.org/article/1cedda24916541349e9e427cd6ec2072 https://www.mdpi.com/2218-273X/10/4/555 https://doaj.org/toc/2218-273X
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author2	Iván Pacheco Octavio Merino Marinela Contreras Lourdes Mateos-Hernández Eduardo Prado Dina Karen Barros-Picanço José Francisco Lima-Barbero Sara Artigas-Jerónimo Pilar Alberdi Isabel G. Fernández de Mera Agustín Estrada-Peña Alejandro Cabezas-Cruz José de la Fuente
author2Str	Iván Pacheco Octavio Merino Marinela Contreras Lourdes Mateos-Hernández Eduardo Prado Dina Karen Barros-Picanço José Francisco Lima-Barbero Sara Artigas-Jerónimo Pilar Alberdi Isabel G. Fernández de Mera Agustín Estrada-Peña Alejandro Cabezas-Cruz José de la Fuente
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doi_str	10.3390/biom10040555
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up_date	2024-07-03T22:39:53.667Z
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Tick and Host Derived Compounds Detected in the Cement Complex Substance

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