DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells

A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) ca...
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Autor*in:	Furkan Ayaz [verfasserIn] Rusmeenee Kheeree [verfasserIn] Qadar Ahmed Isse [verfasserIn] Ronak Haj Ersan [verfasserIn] Oztekin Algul [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Bis-benzoxazole breast cancer prostate cancer anti-proliferative anti-cancer MTT

Übergeordnetes Werk:	In: Journal of the Turkish Chemical Society, Section A: Chemistry - Turkish Chemical Society, 2017, 5(2018), 3, Seite 1145-1152
Übergeordnetes Werk:	volume:5 ; year:2018 ; number:3 ; pages:1145-1152

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.18596/jotcsa.429504

Katalog-ID:	DOAJ066980003

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spelling	10.18596/jotcsa.429504 doi (DE-627)DOAJ066980003 (DE-599)DOAJff63c9efd7264ab3a430ee37da4fea5d DE-627 ger DE-627 rakwb eng QD1-999 Furkan Ayaz verfasserin aut DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates. Bis-benzoxazole breast cancer prostate cancer anti-proliferative anti-cancer MTT Chemistry Rusmeenee Kheeree verfasserin aut Qadar Ahmed Isse verfasserin aut Ronak Haj Ersan verfasserin aut Oztekin Algul verfasserin aut In Journal of the Turkish Chemical Society, Section A: Chemistry Turkish Chemical Society, 2017 5(2018), 3, Seite 1145-1152 (DE-627)1006252061 21490120 nnns volume:5 year:2018 number:3 pages:1145-1152 https://doi.org/10.18596/jotcsa.429504 kostenfrei https://doaj.org/article/ff63c9efd7264ab3a430ee37da4fea5d kostenfrei http://dergipark.gov.tr/jotcsa/issue/37193/429504 kostenfrei https://doaj.org/toc/2149-0120 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2018 3 1145-1152
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callnumber-first	Q - Science
author	Furkan Ayaz
spellingShingle	Furkan Ayaz misc QD1-999 misc Bis-benzoxazole misc breast cancer misc prostate cancer misc anti-proliferative misc anti-cancer misc MTT misc Chemistry DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
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topic_title	QD1-999 DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells Bis-benzoxazole breast cancer prostate cancer anti-proliferative anti-cancer MTT
topic	misc QD1-999 misc Bis-benzoxazole misc breast cancer misc prostate cancer misc anti-proliferative misc anti-cancer misc MTT misc Chemistry
topic_unstemmed	misc QD1-999 misc Bis-benzoxazole misc breast cancer misc prostate cancer misc anti-proliferative misc anti-cancer misc MTT misc Chemistry
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title	DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
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title_full	DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
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title_sort	dna base bioisosteres, bis-benzoxazoles, exert anti-proliferative effect on human prostate and breast cancer cells
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title_auth	DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
abstract	A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates.
abstractGer	A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates.
abstract_unstemmed	A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates.
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title_short	DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
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