Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders
Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature orga...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ksenia Orekhova [verfasserIn] Sandro Mazzariol [verfasserIn] Beatrice Sussan [verfasserIn] Massimo Bucci [verfasserIn] Federico Bonsembiante [verfasserIn] Ranieri Verin [verfasserIn] Cinzia Centelleghe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
canine diacylglycerolkinase zeta |
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| Übergeordnetes Werk: |
In: Veterinary Sciences - MDPI AG, 2014, 8(2021), 10, p 203 |
|---|---|
| Übergeordnetes Werk: |
volume:8 ; year:2021 ; number:10, p 203 |
| Links: |
|---|
| DOI / URN: |
10.3390/vetsci8100203 |
|---|
| Katalog-ID: |
DOAJ067010970 |
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| 520 | |a Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. | ||
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10.3390/vetsci8100203 doi (DE-627)DOAJ067010970 (DE-599)DOAJfeb7e9adc89e4409bde2657630bd227e DE-627 ger DE-627 rakwb eng SF600-1100 Ksenia Orekhova verfasserin aut Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. seizures hypoxic brain injury canine diacylglycerolkinase zeta beta-amyloid precursor protein Apaf1 protein Bcl-2 protein Veterinary medicine Sandro Mazzariol verfasserin aut Beatrice Sussan verfasserin aut Massimo Bucci verfasserin aut Federico Bonsembiante verfasserin aut Ranieri Verin verfasserin aut Cinzia Centelleghe verfasserin aut In Veterinary Sciences MDPI AG, 2014 8(2021), 10, p 203 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:8 year:2021 number:10, p 203 https://doi.org/10.3390/vetsci8100203 kostenfrei https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e kostenfrei https://www.mdpi.com/2306-7381/8/10/203 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 10, p 203 |
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10.3390/vetsci8100203 doi (DE-627)DOAJ067010970 (DE-599)DOAJfeb7e9adc89e4409bde2657630bd227e DE-627 ger DE-627 rakwb eng SF600-1100 Ksenia Orekhova verfasserin aut Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. seizures hypoxic brain injury canine diacylglycerolkinase zeta beta-amyloid precursor protein Apaf1 protein Bcl-2 protein Veterinary medicine Sandro Mazzariol verfasserin aut Beatrice Sussan verfasserin aut Massimo Bucci verfasserin aut Federico Bonsembiante verfasserin aut Ranieri Verin verfasserin aut Cinzia Centelleghe verfasserin aut In Veterinary Sciences MDPI AG, 2014 8(2021), 10, p 203 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:8 year:2021 number:10, p 203 https://doi.org/10.3390/vetsci8100203 kostenfrei https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e kostenfrei https://www.mdpi.com/2306-7381/8/10/203 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 10, p 203 |
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10.3390/vetsci8100203 doi (DE-627)DOAJ067010970 (DE-599)DOAJfeb7e9adc89e4409bde2657630bd227e DE-627 ger DE-627 rakwb eng SF600-1100 Ksenia Orekhova verfasserin aut Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. seizures hypoxic brain injury canine diacylglycerolkinase zeta beta-amyloid precursor protein Apaf1 protein Bcl-2 protein Veterinary medicine Sandro Mazzariol verfasserin aut Beatrice Sussan verfasserin aut Massimo Bucci verfasserin aut Federico Bonsembiante verfasserin aut Ranieri Verin verfasserin aut Cinzia Centelleghe verfasserin aut In Veterinary Sciences MDPI AG, 2014 8(2021), 10, p 203 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:8 year:2021 number:10, p 203 https://doi.org/10.3390/vetsci8100203 kostenfrei https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e kostenfrei https://www.mdpi.com/2306-7381/8/10/203 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 10, p 203 |
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10.3390/vetsci8100203 doi (DE-627)DOAJ067010970 (DE-599)DOAJfeb7e9adc89e4409bde2657630bd227e DE-627 ger DE-627 rakwb eng SF600-1100 Ksenia Orekhova verfasserin aut Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. seizures hypoxic brain injury canine diacylglycerolkinase zeta beta-amyloid precursor protein Apaf1 protein Bcl-2 protein Veterinary medicine Sandro Mazzariol verfasserin aut Beatrice Sussan verfasserin aut Massimo Bucci verfasserin aut Federico Bonsembiante verfasserin aut Ranieri Verin verfasserin aut Cinzia Centelleghe verfasserin aut In Veterinary Sciences MDPI AG, 2014 8(2021), 10, p 203 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:8 year:2021 number:10, p 203 https://doi.org/10.3390/vetsci8100203 kostenfrei https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e kostenfrei https://www.mdpi.com/2306-7381/8/10/203 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 10, p 203 |
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10.3390/vetsci8100203 doi (DE-627)DOAJ067010970 (DE-599)DOAJfeb7e9adc89e4409bde2657630bd227e DE-627 ger DE-627 rakwb eng SF600-1100 Ksenia Orekhova verfasserin aut Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. seizures hypoxic brain injury canine diacylglycerolkinase zeta beta-amyloid precursor protein Apaf1 protein Bcl-2 protein Veterinary medicine Sandro Mazzariol verfasserin aut Beatrice Sussan verfasserin aut Massimo Bucci verfasserin aut Federico Bonsembiante verfasserin aut Ranieri Verin verfasserin aut Cinzia Centelleghe verfasserin aut In Veterinary Sciences MDPI AG, 2014 8(2021), 10, p 203 (DE-627)785698477 (DE-600)2768971-2 23067381 nnns volume:8 year:2021 number:10, p 203 https://doi.org/10.3390/vetsci8100203 kostenfrei https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e kostenfrei https://www.mdpi.com/2306-7381/8/10/203 kostenfrei https://doaj.org/toc/2306-7381 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 10, p 203 |
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Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders |
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Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. |
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Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. |
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Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the <i<MDR1</i<-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated by physiologically immature organs and other contributing pathologies require consideration before arriving at a diagnosis. This study analysed the brains of two male, 5-week-old Australian Shepherd siblings that died after displaying severe neurological symptoms upon administration of MilproVet<sup<®</sup< to treat severe intestinal helminth infection. Despite the initial symptoms being similar, their case histories varied in terms of the symptom duration, access to supportive therapy and post-mortem interval. Histopathology and immunohistochemistry were used to obtain more information about the phase of the pathological processes in the brain, employing protein markers associated with acute hypoxic damage (β-amyloid precursor protein/APP) and apoptosis (diacylglycerolkinase-ζ/DGK-ζ, apoptotic protease activating factor 1/Apaf1, and B-cell lymphoma related protein 2/Bcl-2). The results seem to reflect the course of the animals’ clinical deterioration, implicating that the hypoxic damage to the brains was incompatible with life, and suggesting the usefulness of the mentioned immunohistochemical markers in clarifying the cause of death in animals with acute neurological deficits. |
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