Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models

Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different...
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Autor*in:	Li Gao [verfasserIn] Shasha Cui [verfasserIn] Zhiqiang Huang [verfasserIn] Hailong Cui [verfasserIn] Tahani Awad Alahmadi [verfasserIn] Velu Manikandan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Nociception Butein Inflammation Tail immersion Capsaicin

Übergeordnetes Werk:	In: Saudi Journal of Biological Sciences - Elsevier, 2016, 28(2021), 12, Seite 7090-7097
Übergeordnetes Werk:	volume:28 ; year:2021 ; number:12 ; pages:7090-7097

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.sjbs.2021.08.006

Katalog-ID:	DOAJ067025129

Internformat


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520			\|a Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
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650		4	\|a Capsaicin
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700	0		\|a Shasha Cui \|e verfasserin \|4 aut
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700	0		\|a Hailong Cui \|e verfasserin \|4 aut
700	0		\|a Tahani Awad Alahmadi \|e verfasserin \|4 aut
700	0		\|a Velu Manikandan \|e verfasserin \|4 aut
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publishDate	2021
allfields	10.1016/j.sjbs.2021.08.006 doi (DE-627)DOAJ067025129 (DE-599)DOAJ64e931cef692420d829e95bcdebe4b97 DE-627 ger DE-627 rakwb eng QH301-705.5 Li Gao verfasserin aut Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models. Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) Shasha Cui verfasserin aut Zhiqiang Huang verfasserin aut Hailong Cui verfasserin aut Tahani Awad Alahmadi verfasserin aut Velu Manikandan verfasserin aut In Saudi Journal of Biological Sciences Elsevier, 2016 28(2021), 12, Seite 7090-7097 (DE-627)609401505 (DE-600)2515206-3 1319562X nnns volume:28 year:2021 number:12 pages:7090-7097 https://doi.org/10.1016/j.sjbs.2021.08.006 kostenfrei https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1319562X21006793 kostenfrei https://doaj.org/toc/1319-562X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 28 2021 12 7090-7097
spelling	10.1016/j.sjbs.2021.08.006 doi (DE-627)DOAJ067025129 (DE-599)DOAJ64e931cef692420d829e95bcdebe4b97 DE-627 ger DE-627 rakwb eng QH301-705.5 Li Gao verfasserin aut Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models. Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) Shasha Cui verfasserin aut Zhiqiang Huang verfasserin aut Hailong Cui verfasserin aut Tahani Awad Alahmadi verfasserin aut Velu Manikandan verfasserin aut In Saudi Journal of Biological Sciences Elsevier, 2016 28(2021), 12, Seite 7090-7097 (DE-627)609401505 (DE-600)2515206-3 1319562X nnns volume:28 year:2021 number:12 pages:7090-7097 https://doi.org/10.1016/j.sjbs.2021.08.006 kostenfrei https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1319562X21006793 kostenfrei https://doaj.org/toc/1319-562X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 28 2021 12 7090-7097
allfields_unstemmed	10.1016/j.sjbs.2021.08.006 doi (DE-627)DOAJ067025129 (DE-599)DOAJ64e931cef692420d829e95bcdebe4b97 DE-627 ger DE-627 rakwb eng QH301-705.5 Li Gao verfasserin aut Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models. Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) Shasha Cui verfasserin aut Zhiqiang Huang verfasserin aut Hailong Cui verfasserin aut Tahani Awad Alahmadi verfasserin aut Velu Manikandan verfasserin aut In Saudi Journal of Biological Sciences Elsevier, 2016 28(2021), 12, Seite 7090-7097 (DE-627)609401505 (DE-600)2515206-3 1319562X nnns volume:28 year:2021 number:12 pages:7090-7097 https://doi.org/10.1016/j.sjbs.2021.08.006 kostenfrei https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1319562X21006793 kostenfrei https://doaj.org/toc/1319-562X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 28 2021 12 7090-7097
allfieldsGer	10.1016/j.sjbs.2021.08.006 doi (DE-627)DOAJ067025129 (DE-599)DOAJ64e931cef692420d829e95bcdebe4b97 DE-627 ger DE-627 rakwb eng QH301-705.5 Li Gao verfasserin aut Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models. Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) Shasha Cui verfasserin aut Zhiqiang Huang verfasserin aut Hailong Cui verfasserin aut Tahani Awad Alahmadi verfasserin aut Velu Manikandan verfasserin aut In Saudi Journal of Biological Sciences Elsevier, 2016 28(2021), 12, Seite 7090-7097 (DE-627)609401505 (DE-600)2515206-3 1319562X nnns volume:28 year:2021 number:12 pages:7090-7097 https://doi.org/10.1016/j.sjbs.2021.08.006 kostenfrei https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1319562X21006793 kostenfrei https://doaj.org/toc/1319-562X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 28 2021 12 7090-7097
allfieldsSound	10.1016/j.sjbs.2021.08.006 doi (DE-627)DOAJ067025129 (DE-599)DOAJ64e931cef692420d829e95bcdebe4b97 DE-627 ger DE-627 rakwb eng QH301-705.5 Li Gao verfasserin aut Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models. Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) Shasha Cui verfasserin aut Zhiqiang Huang verfasserin aut Hailong Cui verfasserin aut Tahani Awad Alahmadi verfasserin aut Velu Manikandan verfasserin aut In Saudi Journal of Biological Sciences Elsevier, 2016 28(2021), 12, Seite 7090-7097 (DE-627)609401505 (DE-600)2515206-3 1319562X nnns volume:28 year:2021 number:12 pages:7090-7097 https://doi.org/10.1016/j.sjbs.2021.08.006 kostenfrei https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1319562X21006793 kostenfrei https://doaj.org/toc/1319-562X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 28 2021 12 7090-7097
language	English
source	In Saudi Journal of Biological Sciences 28(2021), 12, Seite 7090-7097 volume:28 year:2021 number:12 pages:7090-7097
sourceStr	In Saudi Journal of Biological Sciences 28(2021), 12, Seite 7090-7097 volume:28 year:2021 number:12 pages:7090-7097
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Nociception Butein Inflammation Tail immersion Capsaicin Biology (General)
isfreeaccess_bool	true
container_title	Saudi Journal of Biological Sciences
authorswithroles_txt_mv	Li Gao @@aut@@ Shasha Cui @@aut@@ Zhiqiang Huang @@aut@@ Hailong Cui @@aut@@ Tahani Awad Alahmadi @@aut@@ Velu Manikandan @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	609401505
id	DOAJ067025129
language_de	englisch
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Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. 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callnumber-first	Q - Science
author	Li Gao
spellingShingle	Li Gao misc QH301-705.5 misc Nociception misc Butein misc Inflammation misc Tail immersion misc Capsaicin misc Biology (General) Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
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topic_title	QH301-705.5 Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models Nociception Butein Inflammation Tail immersion Capsaicin
topic	misc QH301-705.5 misc Nociception misc Butein misc Inflammation misc Tail immersion misc Capsaicin misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Nociception misc Butein misc Inflammation misc Tail immersion misc Capsaicin misc Biology (General)
topic_browse	misc QH301-705.5 misc Nociception misc Butein misc Inflammation misc Tail immersion misc Capsaicin misc Biology (General)
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title	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
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title_full	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
author_sort	Li Gao
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author_browse	Li Gao Shasha Cui Zhiqiang Huang Hailong Cui Tahani Awad Alahmadi Velu Manikandan
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title_sort	antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
callnumber	QH301-705.5
title_auth	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
abstract	Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
abstractGer	Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
abstract_unstemmed	Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
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container_issue	12
title_short	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
url	https://doi.org/10.1016/j.sjbs.2021.08.006 https://doaj.org/article/64e931cef692420d829e95bcdebe4b97 http://www.sciencedirect.com/science/article/pii/S1319562X21006793 https://doaj.org/toc/1319-562X
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author2	Shasha Cui Zhiqiang Huang Hailong Cui Tahani Awad Alahmadi Velu Manikandan
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up_date	2024-07-03T23:11:39.981Z
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Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. 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Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models

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