Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines

<p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a...
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Gespeichert in:

Autor*in:	Fusseder Nicolas [verfasserIn] Li Wei [verfasserIn] Sidney John [verfasserIn] Bui Huynh-Hoa [verfasserIn] Sette Alessandro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Übergeordnetes Werk:	In: BMC Bioinformatics - BMC, 2003, 8(2007), 1, p 361
Übergeordnetes Werk:	volume:8 ; year:2007 ; number:1, p 361

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2105-8-361

Katalog-ID:	DOAJ067037909

Internformat


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912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
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912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4335
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author_variant	f n fn l w lw s j sj b h h bhh s a sa
matchkey_str	article:14712105:2007----::eeomnoaeioeosracaayitotfclttteeinfptp
hierarchy_sort_str	2007
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publishDate	2007
allfields	10.1186/1471-2105-8-361 doi (DE-627)DOAJ067037909 (DE-599)DOAJa86f5655b29a4bcfb72636f9468956e2 DE-627 ger DE-627 rakwb eng R858-859.7 QH301-705.5 Fusseder Nicolas verfasserin aut Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p< Computer applications to medicine. Medical informatics Biology (General) Li Wei verfasserin aut Sidney John verfasserin aut Bui Huynh-Hoa verfasserin aut Sette Alessandro verfasserin aut In BMC Bioinformatics BMC, 2003 8(2007), 1, p 361 (DE-627)326644814 (DE-600)2041484-5 14712105 nnns volume:8 year:2007 number:1, p 361 https://doi.org/10.1186/1471-2105-8-361 kostenfrei https://doaj.org/article/a86f5655b29a4bcfb72636f9468956e2 kostenfrei http://www.biomedcentral.com/1471-2105/8/361 kostenfrei https://doaj.org/toc/1471-2105 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 1, p 361
spelling	10.1186/1471-2105-8-361 doi (DE-627)DOAJ067037909 (DE-599)DOAJa86f5655b29a4bcfb72636f9468956e2 DE-627 ger DE-627 rakwb eng R858-859.7 QH301-705.5 Fusseder Nicolas verfasserin aut Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p< Computer applications to medicine. Medical informatics Biology (General) Li Wei verfasserin aut Sidney John verfasserin aut Bui Huynh-Hoa verfasserin aut Sette Alessandro verfasserin aut In BMC Bioinformatics BMC, 2003 8(2007), 1, p 361 (DE-627)326644814 (DE-600)2041484-5 14712105 nnns volume:8 year:2007 number:1, p 361 https://doi.org/10.1186/1471-2105-8-361 kostenfrei https://doaj.org/article/a86f5655b29a4bcfb72636f9468956e2 kostenfrei http://www.biomedcentral.com/1471-2105/8/361 kostenfrei https://doaj.org/toc/1471-2105 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 1, p 361
allfields_unstemmed	10.1186/1471-2105-8-361 doi (DE-627)DOAJ067037909 (DE-599)DOAJa86f5655b29a4bcfb72636f9468956e2 DE-627 ger DE-627 rakwb eng R858-859.7 QH301-705.5 Fusseder Nicolas verfasserin aut Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p< Computer applications to medicine. Medical informatics Biology (General) Li Wei verfasserin aut Sidney John verfasserin aut Bui Huynh-Hoa verfasserin aut Sette Alessandro verfasserin aut In BMC Bioinformatics BMC, 2003 8(2007), 1, p 361 (DE-627)326644814 (DE-600)2041484-5 14712105 nnns volume:8 year:2007 number:1, p 361 https://doi.org/10.1186/1471-2105-8-361 kostenfrei https://doaj.org/article/a86f5655b29a4bcfb72636f9468956e2 kostenfrei http://www.biomedcentral.com/1471-2105/8/361 kostenfrei https://doaj.org/toc/1471-2105 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 1, p 361
allfieldsGer	10.1186/1471-2105-8-361 doi (DE-627)DOAJ067037909 (DE-599)DOAJa86f5655b29a4bcfb72636f9468956e2 DE-627 ger DE-627 rakwb eng R858-859.7 QH301-705.5 Fusseder Nicolas verfasserin aut Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p< Computer applications to medicine. Medical informatics Biology (General) Li Wei verfasserin aut Sidney John verfasserin aut Bui Huynh-Hoa verfasserin aut Sette Alessandro verfasserin aut In BMC Bioinformatics BMC, 2003 8(2007), 1, p 361 (DE-627)326644814 (DE-600)2041484-5 14712105 nnns volume:8 year:2007 number:1, p 361 https://doi.org/10.1186/1471-2105-8-361 kostenfrei https://doaj.org/article/a86f5655b29a4bcfb72636f9468956e2 kostenfrei http://www.biomedcentral.com/1471-2105/8/361 kostenfrei https://doaj.org/toc/1471-2105 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 1, p 361
allfieldsSound	10.1186/1471-2105-8-361 doi (DE-627)DOAJ067037909 (DE-599)DOAJa86f5655b29a4bcfb72636f9468956e2 DE-627 ger DE-627 rakwb eng R858-859.7 QH301-705.5 Fusseder Nicolas verfasserin aut Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p< Computer applications to medicine. Medical informatics Biology (General) Li Wei verfasserin aut Sidney John verfasserin aut Bui Huynh-Hoa verfasserin aut Sette Alessandro verfasserin aut In BMC Bioinformatics BMC, 2003 8(2007), 1, p 361 (DE-627)326644814 (DE-600)2041484-5 14712105 nnns volume:8 year:2007 number:1, p 361 https://doi.org/10.1186/1471-2105-8-361 kostenfrei https://doaj.org/article/a86f5655b29a4bcfb72636f9468956e2 kostenfrei http://www.biomedcentral.com/1471-2105/8/361 kostenfrei https://doaj.org/toc/1471-2105 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 1, p 361
language	English
source	In BMC Bioinformatics 8(2007), 1, p 361 volume:8 year:2007 number:1, p 361
sourceStr	In BMC Bioinformatics 8(2007), 1, p 361 volume:8 year:2007 number:1, p 361
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Computer applications to medicine. Medical informatics Biology (General)
isfreeaccess_bool	true
container_title	BMC Bioinformatics
authorswithroles_txt_mv	Fusseder Nicolas @@aut@@ Li Wei @@aut@@ Sidney John @@aut@@ Bui Huynh-Hoa @@aut@@ Sette Alessandro @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	326644814
id	DOAJ067037909
language_de	englisch
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callnumber-first	R - Medicine
author	Fusseder Nicolas
spellingShingle	Fusseder Nicolas misc R858-859.7 misc QH301-705.5 misc Computer applications to medicine. Medical informatics misc Biology (General) Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
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topic_title	R858-859.7 QH301-705.5 Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
topic	misc R858-859.7 misc QH301-705.5 misc Computer applications to medicine. Medical informatics misc Biology (General)
topic_unstemmed	misc R858-859.7 misc QH301-705.5 misc Computer applications to medicine. Medical informatics misc Biology (General)
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title	Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
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title_full	Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
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doi_str_mv	10.1186/1471-2105-8-361
author2-role	verfasserin
title_sort	development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
callnumber	R858-859.7
title_auth	Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
abstract	<p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.</p< <p<Results</p< <p<To assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at <url<http://tools.immuneepitope.org/tools/conservancy</url<.</p< <p<Conclusion</p< <p<An epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.</p<
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title_short	Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
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