The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes

Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription. How a small number of chemically distinct phosphoinositide signals are functionally amplified to exert sp...
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Autor*in:	Aby Grabon [verfasserIn] Vytas A. Bankaitis [verfasserIn] Mark I. McDermott [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	lipid signaling lipid and membrane trafficking cell signaling diseases lipids • membranes

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 60(2019), 2, Seite 242-268
Übergeordnetes Werk:	volume:60 ; year:2019 ; number:2 ; pages:242-268

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.R089730

Katalog-ID:	DOAJ067201423

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source	In Journal of Lipid Research 60(2019), 2, Seite 242-268 volume:60 year:2019 number:2 pages:242-268
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authorswithroles_txt_mv	Aby Grabon @@aut@@ Vytas A. Bankaitis @@aut@@ Mark I. McDermott @@aut@@
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callnumber-first	Q - Science
author	Aby Grabon
spellingShingle	Aby Grabon misc QD415-436 misc lipid signaling misc lipid and membrane trafficking misc cell signaling misc diseases misc lipids • membranes misc Biochemistry The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
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topic_title	QD415-436 The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes lipid signaling lipid and membrane trafficking cell signaling diseases lipids • membranes
topic	misc QD415-436 misc lipid signaling misc lipid and membrane trafficking misc cell signaling misc diseases misc lipids • membranes misc Biochemistry
topic_unstemmed	misc QD415-436 misc lipid signaling misc lipid and membrane trafficking misc cell signaling misc diseases misc lipids • membranes misc Biochemistry
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title	The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
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title_full	The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
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author_browse	Aby Grabon Vytas A. Bankaitis Mark I. McDermott
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title_sort	interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
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title_auth	The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
abstract	Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription. How a small number of chemically distinct phosphoinositide signals are functionally amplified to exert specific control over such a diverse set of biological outcomes remains incompletely understood. To this end, a novel mechanism is now taking shape, and it involves phosphatidylinositol (PtdIns) transfer proteins (PITPs). The concept that PITPs exert instructive regulation of PtdIns 4-OH kinase activities and thereby channel phosphoinositide production to specific biological outcomes, identifies PITPs as central factors in the diversification of phosphoinositide signaling. There are two evolutionarily distinct families of PITPs: the Sec14-like and the StAR-related lipid transfer domain (START)-like families. Of these two families, the START-like PITPs are the least understood. Herein, we review recent insights into the biochemical, cellular, and physiological function of both PITP families with greater emphasis on the START-like PITPs, and we discuss the underlying mechanisms through which these proteins regulate phosphoinositide signaling and how these actions translate to human health and disease.
abstractGer	Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription. How a small number of chemically distinct phosphoinositide signals are functionally amplified to exert specific control over such a diverse set of biological outcomes remains incompletely understood. To this end, a novel mechanism is now taking shape, and it involves phosphatidylinositol (PtdIns) transfer proteins (PITPs). The concept that PITPs exert instructive regulation of PtdIns 4-OH kinase activities and thereby channel phosphoinositide production to specific biological outcomes, identifies PITPs as central factors in the diversification of phosphoinositide signaling. There are two evolutionarily distinct families of PITPs: the Sec14-like and the StAR-related lipid transfer domain (START)-like families. Of these two families, the START-like PITPs are the least understood. Herein, we review recent insights into the biochemical, cellular, and physiological function of both PITP families with greater emphasis on the START-like PITPs, and we discuss the underlying mechanisms through which these proteins regulate phosphoinositide signaling and how these actions translate to human health and disease.
abstract_unstemmed	Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription. How a small number of chemically distinct phosphoinositide signals are functionally amplified to exert specific control over such a diverse set of biological outcomes remains incompletely understood. To this end, a novel mechanism is now taking shape, and it involves phosphatidylinositol (PtdIns) transfer proteins (PITPs). The concept that PITPs exert instructive regulation of PtdIns 4-OH kinase activities and thereby channel phosphoinositide production to specific biological outcomes, identifies PITPs as central factors in the diversification of phosphoinositide signaling. There are two evolutionarily distinct families of PITPs: the Sec14-like and the StAR-related lipid transfer domain (START)-like families. Of these two families, the START-like PITPs are the least understood. Herein, we review recent insights into the biochemical, cellular, and physiological function of both PITP families with greater emphasis on the START-like PITPs, and we discuss the underlying mechanisms through which these proteins regulate phosphoinositide signaling and how these actions translate to human health and disease.
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title_short	The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes
url	https://doi.org/10.1194/jlr.R089730 https://doaj.org/article/b7abfe2cbeaf4ce39b3c2c4bac1331d1 http://www.sciencedirect.com/science/article/pii/S0022227520326377 https://doaj.org/toc/0022-2275
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The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes

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