Proposed age-stratified reference intervals of FSH derived from normozoospermic men
Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Emily-Jane Waller [verfasserIn] Jason Conceicao [verfasserIn] Phillip Matson [verfasserIn] John L Yovich [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Asian Pacific Journal of Reproduction - Wolters Kluwer Medknow Publications, 2017, 10(2021), 4, Seite 162-167 |
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| Übergeordnetes Werk: |
volume:10 ; year:2021 ; number:4 ; pages:162-167 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.4103/2305-0500.321188 |
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| Katalog-ID: |
DOAJ067285139 |
|---|
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| 520 | |a Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. | ||
| 650 | 4 | |a male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia | |
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10.4103/2305-0500.321188 doi (DE-627)DOAJ067285139 (DE-599)DOAJ2aa31cc0d822471696fbd2750abce5c1 DE-627 ger DE-627 rakwb eng Emily-Jane Waller verfasserin aut Proposed age-stratified reference intervals of FSH derived from normozoospermic men 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia Medicine R Jason Conceicao verfasserin aut Phillip Matson verfasserin aut John L Yovich verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 10(2021), 4, Seite 162-167 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:10 year:2021 number:4 pages:162-167 https://doi.org/10.4103/2305-0500.321188 kostenfrei https://doaj.org/article/2aa31cc0d822471696fbd2750abce5c1 kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2021;volume=10;issue=4;spage=162;epage=167;aulast=Waller kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 10 2021 4 162-167 |
| spelling |
10.4103/2305-0500.321188 doi (DE-627)DOAJ067285139 (DE-599)DOAJ2aa31cc0d822471696fbd2750abce5c1 DE-627 ger DE-627 rakwb eng Emily-Jane Waller verfasserin aut Proposed age-stratified reference intervals of FSH derived from normozoospermic men 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia Medicine R Jason Conceicao verfasserin aut Phillip Matson verfasserin aut John L Yovich verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 10(2021), 4, Seite 162-167 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:10 year:2021 number:4 pages:162-167 https://doi.org/10.4103/2305-0500.321188 kostenfrei https://doaj.org/article/2aa31cc0d822471696fbd2750abce5c1 kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2021;volume=10;issue=4;spage=162;epage=167;aulast=Waller kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 10 2021 4 162-167 |
| allfields_unstemmed |
10.4103/2305-0500.321188 doi (DE-627)DOAJ067285139 (DE-599)DOAJ2aa31cc0d822471696fbd2750abce5c1 DE-627 ger DE-627 rakwb eng Emily-Jane Waller verfasserin aut Proposed age-stratified reference intervals of FSH derived from normozoospermic men 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia Medicine R Jason Conceicao verfasserin aut Phillip Matson verfasserin aut John L Yovich verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 10(2021), 4, Seite 162-167 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:10 year:2021 number:4 pages:162-167 https://doi.org/10.4103/2305-0500.321188 kostenfrei https://doaj.org/article/2aa31cc0d822471696fbd2750abce5c1 kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2021;volume=10;issue=4;spage=162;epage=167;aulast=Waller kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 10 2021 4 162-167 |
| allfieldsGer |
10.4103/2305-0500.321188 doi (DE-627)DOAJ067285139 (DE-599)DOAJ2aa31cc0d822471696fbd2750abce5c1 DE-627 ger DE-627 rakwb eng Emily-Jane Waller verfasserin aut Proposed age-stratified reference intervals of FSH derived from normozoospermic men 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia Medicine R Jason Conceicao verfasserin aut Phillip Matson verfasserin aut John L Yovich verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 10(2021), 4, Seite 162-167 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:10 year:2021 number:4 pages:162-167 https://doi.org/10.4103/2305-0500.321188 kostenfrei https://doaj.org/article/2aa31cc0d822471696fbd2750abce5c1 kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2021;volume=10;issue=4;spage=162;epage=167;aulast=Waller kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 10 2021 4 162-167 |
| allfieldsSound |
10.4103/2305-0500.321188 doi (DE-627)DOAJ067285139 (DE-599)DOAJ2aa31cc0d822471696fbd2750abce5c1 DE-627 ger DE-627 rakwb eng Emily-Jane Waller verfasserin aut Proposed age-stratified reference intervals of FSH derived from normozoospermic men 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia Medicine R Jason Conceicao verfasserin aut Phillip Matson verfasserin aut John L Yovich verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 10(2021), 4, Seite 162-167 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:10 year:2021 number:4 pages:162-167 https://doi.org/10.4103/2305-0500.321188 kostenfrei https://doaj.org/article/2aa31cc0d822471696fbd2750abce5c1 kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2021;volume=10;issue=4;spage=162;epage=167;aulast=Waller kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 10 2021 4 162-167 |
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Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). 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Emily-Jane Waller |
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Emily-Jane Waller misc male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia misc Medicine misc R Proposed age-stratified reference intervals of FSH derived from normozoospermic men |
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Proposed age-stratified reference intervals of FSH derived from normozoospermic men male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia |
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misc male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia misc Medicine misc R |
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misc male infertility; fsh; reference intervals; age; obstructive azoospermia; non-obstructive azoospermia misc Medicine misc R |
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proposed age-stratified reference intervals of fsh derived from normozoospermic men |
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Proposed age-stratified reference intervals of FSH derived from normozoospermic men |
| abstract |
Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. |
| abstractGer |
Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. |
| abstract_unstemmed |
Objective: To demonstrate that serum follicle-stimulating hormone (FSH) in men rises with age, and to explore FSH reference intervals of age-related partitioning. Methods: Men aged 20-50 years (n=1 190) underwent semen analysis according to World Health Organization (2010) methods. Serum was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur® XP immunoassay system. FSH central 95% intervals after logarithmic transformation based on age were derived from 1 037 normozoospermic men. These were then applied to oligozoospermic and azoospermic men. Men producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria, including genetic analysis and surgical exploration. Results: Serum FSH in normozoospermic men increased with age (P<0.05), and reference intervals were determined with 10-year brackets: 21-30 years [(1.0-8.2) IU/L], 31-40 years [(1.4-9.5) IU/L], 41-50 years [(1.9-12.0) IU/L]. The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men, which in turn was lower among azoospermic men (both P<0.01). The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia, and 86.4% (38/44) men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7% (1/15) men with obstructive azoospermia had high FSH levels, and this was significantly different (P<0.01). Conclusions: FSH concentrations increase in men between 20-50 years, and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals. |
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