Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities

<p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitativ...
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Autor*in:	Geusens Piet [verfasserIn] Nieuwenhuijzen Kruseman Arie C [verfasserIn] Dumitrescu Bianca [verfasserIn] Heijckmann A Caroline [verfasserIn] Wolffenbuttel Bruce HR [verfasserIn] De Vries Jolanda [verfasserIn] Drent Marjolein [verfasserIn] Huijberts Maya SP [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Musculoskeletal Disorders - BMC, 2003, 9(2008), 1, p 72
Übergeordnetes Werk:	volume:9 ; year:2008 ; number:1, p 72

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2474-9-72

Katalog-ID:	DOAJ067294537

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p<
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allfields	10.1186/1471-2474-9-72 doi (DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f DE-627 ger DE-627 rakwb eng RC925-935 Geusens Piet verfasserin aut Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p< Diseases of the musculoskeletal system Nieuwenhuijzen Kruseman Arie C verfasserin aut Dumitrescu Bianca verfasserin aut Heijckmann A Caroline verfasserin aut Wolffenbuttel Bruce HR verfasserin aut De Vries Jolanda verfasserin aut Drent Marjolein verfasserin aut Huijberts Maya SP verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 9(2008), 1, p 72 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:9 year:2008 number:1, p 72 https://doi.org/10.1186/1471-2474-9-72 kostenfrei https://doaj.org/article/94b16a2ab26a42deaf6fa2ebbe99837f kostenfrei http://www.biomedcentral.com/1471-2474/9/72 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 72
spelling	10.1186/1471-2474-9-72 doi (DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f DE-627 ger DE-627 rakwb eng RC925-935 Geusens Piet verfasserin aut Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p< Diseases of the musculoskeletal system Nieuwenhuijzen Kruseman Arie C verfasserin aut Dumitrescu Bianca verfasserin aut Heijckmann A Caroline verfasserin aut Wolffenbuttel Bruce HR verfasserin aut De Vries Jolanda verfasserin aut Drent Marjolein verfasserin aut Huijberts Maya SP verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 9(2008), 1, p 72 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:9 year:2008 number:1, p 72 https://doi.org/10.1186/1471-2474-9-72 kostenfrei https://doaj.org/article/94b16a2ab26a42deaf6fa2ebbe99837f kostenfrei http://www.biomedcentral.com/1471-2474/9/72 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 72
allfields_unstemmed	10.1186/1471-2474-9-72 doi (DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f DE-627 ger DE-627 rakwb eng RC925-935 Geusens Piet verfasserin aut Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p< Diseases of the musculoskeletal system Nieuwenhuijzen Kruseman Arie C verfasserin aut Dumitrescu Bianca verfasserin aut Heijckmann A Caroline verfasserin aut Wolffenbuttel Bruce HR verfasserin aut De Vries Jolanda verfasserin aut Drent Marjolein verfasserin aut Huijberts Maya SP verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 9(2008), 1, p 72 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:9 year:2008 number:1, p 72 https://doi.org/10.1186/1471-2474-9-72 kostenfrei https://doaj.org/article/94b16a2ab26a42deaf6fa2ebbe99837f kostenfrei http://www.biomedcentral.com/1471-2474/9/72 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 72
allfieldsGer	10.1186/1471-2474-9-72 doi (DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f DE-627 ger DE-627 rakwb eng RC925-935 Geusens Piet verfasserin aut Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p< Diseases of the musculoskeletal system Nieuwenhuijzen Kruseman Arie C verfasserin aut Dumitrescu Bianca verfasserin aut Heijckmann A Caroline verfasserin aut Wolffenbuttel Bruce HR verfasserin aut De Vries Jolanda verfasserin aut Drent Marjolein verfasserin aut Huijberts Maya SP verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 9(2008), 1, p 72 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:9 year:2008 number:1, p 72 https://doi.org/10.1186/1471-2474-9-72 kostenfrei https://doaj.org/article/94b16a2ab26a42deaf6fa2ebbe99837f kostenfrei http://www.biomedcentral.com/1471-2474/9/72 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 72
allfieldsSound	10.1186/1471-2474-9-72 doi (DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f DE-627 ger DE-627 rakwb eng RC925-935 Geusens Piet verfasserin aut Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p< Diseases of the musculoskeletal system Nieuwenhuijzen Kruseman Arie C verfasserin aut Dumitrescu Bianca verfasserin aut Heijckmann A Caroline verfasserin aut Wolffenbuttel Bruce HR verfasserin aut De Vries Jolanda verfasserin aut Drent Marjolein verfasserin aut Huijberts Maya SP verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 9(2008), 1, p 72 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:9 year:2008 number:1, p 72 https://doi.org/10.1186/1471-2474-9-72 kostenfrei https://doaj.org/article/94b16a2ab26a42deaf6fa2ebbe99837f kostenfrei http://www.biomedcentral.com/1471-2474/9/72 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2008 1, p 72
language	English
source	In BMC Musculoskeletal Disorders 9(2008), 1, p 72 volume:9 year:2008 number:1, p 72
sourceStr	In BMC Musculoskeletal Disorders 9(2008), 1, p 72 volume:9 year:2008 number:1, p 72
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the musculoskeletal system
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container_title	BMC Musculoskeletal Disorders
authorswithroles_txt_mv	Geusens Piet @@aut@@ Nieuwenhuijzen Kruseman Arie C @@aut@@ Dumitrescu Bianca @@aut@@ Heijckmann A Caroline @@aut@@ Wolffenbuttel Bruce HR @@aut@@ De Vries Jolanda @@aut@@ Drent Marjolein @@aut@@ Huijberts Maya SP @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Geusens Piet
spellingShingle	Geusens Piet misc RC925-935 misc Diseases of the musculoskeletal system Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
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topic_title	RC925-935 Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
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topic_unstemmed	misc RC925-935 misc Diseases of the musculoskeletal system
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title	Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
ctrlnum	(DE-627)DOAJ067294537 (DE-599)DOAJ94b16a2ab26a42deaf6fa2ebbe99837f
title_full	Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
author_sort	Geusens Piet
journal	BMC Musculoskeletal Disorders
journalStr	BMC Musculoskeletal Disorders
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author_browse	Geusens Piet Nieuwenhuijzen Kruseman Arie C Dumitrescu Bianca Heijckmann A Caroline Wolffenbuttel Bruce HR De Vries Jolanda Drent Marjolein Huijberts Maya SP
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author-letter	Geusens Piet
doi_str_mv	10.1186/1471-2474-9-72
author2-role	verfasserin
title_sort	quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
callnumber	RC925-935
title_auth	Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
abstract	<p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inflammatory disease with an increased chance of having a vertebral fracture.</p< <p<Methods</p< <p<246 patients (mean age: 44 ± 12.4 years) with an inflammatory disease (sarcoidosis or inflammatory bowel disease (IBD)) were studied. QUS of the heel and BMD of the hip (by dual X-ray absorptiometry (DXA)) were measured. Furthermore lateral single energy densitometry of the spine for assessment of vertebral deformities was done. Logistic regression analysis was performed to assess the strength of association between the prevalence of a vertebral deformity and BMD and QUS parameters, adjusted for gender and age.</p< <p<Results</p< <p<Vertebral deformities (ratio of <0.80) were found in 72 vertebrae of 54 subjects (22%). In contrast to the QUS parameters BUA (broadband ultrasound attenuation) and SOS (speed of sound), T-score of QUS and T-scores of the femoral neck and trochanter (DXA) were lower in the group of patients with vertebral deformities. Logistic regression analysis showed that the vertebral deformity risk increases by about 60 to 90% per 1 SD reduction of BMD (T-score) determined with DXA but not with QUS.</p< <p<Conclusion</p< <p<Our findings imply that QUS measurements of the calcaneus in patients with an inflammatory condition, such as sarcoidosis and IBD, are likely of limited value to identify patients with a vertebral fracture.</p<
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title_short	Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities
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Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities

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