Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male

Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease bu...
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Autor*in:	Ng Chong Beng [verfasserIn] Nik Ritza Kosai [verfasserIn] Lim Shyang Yee [verfasserIn] Srijit Das [verfasserIn] Subasri A [verfasserIn] Reynu Rajan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus

Übergeordnetes Werk:	In: Online Journal of Health & Allied Sciences - Light House Polyclinic Mangalore, 2003, 16(2017), 2
Übergeordnetes Werk:	volume:16 ; year:2017 ; number:2

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ067386318

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520			\|a Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus.
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spelling	(DE-627)DOAJ067386318 (DE-599)DOAJ725f8dbf76c94e919113989b33062858 DE-627 ger DE-627 rakwb eng Ng Chong Beng verfasserin aut Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus. Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus Medicine R Nik Ritza Kosai verfasserin aut Lim Shyang Yee verfasserin aut Srijit Das verfasserin aut Subasri A verfasserin aut Reynu Rajan verfasserin aut In Online Journal of Health & Allied Sciences Light House Polyclinic Mangalore, 2003 16(2017), 2 (DE-627)363752889 (DE-600)2105643-2 09725997 nnns volume:16 year:2017 number:2 https://doaj.org/article/725f8dbf76c94e919113989b33062858 kostenfrei http://www.ojhas.org/issue62/2017-2-13.html kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 2
allfields_unstemmed	(DE-627)DOAJ067386318 (DE-599)DOAJ725f8dbf76c94e919113989b33062858 DE-627 ger DE-627 rakwb eng Ng Chong Beng verfasserin aut Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus. Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus Medicine R Nik Ritza Kosai verfasserin aut Lim Shyang Yee verfasserin aut Srijit Das verfasserin aut Subasri A verfasserin aut Reynu Rajan verfasserin aut In Online Journal of Health & Allied Sciences Light House Polyclinic Mangalore, 2003 16(2017), 2 (DE-627)363752889 (DE-600)2105643-2 09725997 nnns volume:16 year:2017 number:2 https://doaj.org/article/725f8dbf76c94e919113989b33062858 kostenfrei http://www.ojhas.org/issue62/2017-2-13.html kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 2
allfieldsGer	(DE-627)DOAJ067386318 (DE-599)DOAJ725f8dbf76c94e919113989b33062858 DE-627 ger DE-627 rakwb eng Ng Chong Beng verfasserin aut Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus. Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus Medicine R Nik Ritza Kosai verfasserin aut Lim Shyang Yee verfasserin aut Srijit Das verfasserin aut Subasri A verfasserin aut Reynu Rajan verfasserin aut In Online Journal of Health & Allied Sciences Light House Polyclinic Mangalore, 2003 16(2017), 2 (DE-627)363752889 (DE-600)2105643-2 09725997 nnns volume:16 year:2017 number:2 https://doaj.org/article/725f8dbf76c94e919113989b33062858 kostenfrei http://www.ojhas.org/issue62/2017-2-13.html kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 2
allfieldsSound	(DE-627)DOAJ067386318 (DE-599)DOAJ725f8dbf76c94e919113989b33062858 DE-627 ger DE-627 rakwb eng Ng Chong Beng verfasserin aut Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus. Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus Medicine R Nik Ritza Kosai verfasserin aut Lim Shyang Yee verfasserin aut Srijit Das verfasserin aut Subasri A verfasserin aut Reynu Rajan verfasserin aut In Online Journal of Health & Allied Sciences Light House Polyclinic Mangalore, 2003 16(2017), 2 (DE-627)363752889 (DE-600)2105643-2 09725997 nnns volume:16 year:2017 number:2 https://doaj.org/article/725f8dbf76c94e919113989b33062858 kostenfrei http://www.ojhas.org/issue62/2017-2-13.html kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei https://doaj.org/toc/0972-5997 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 2
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authorswithroles_txt_mv	Ng Chong Beng @@aut@@ Nik Ritza Kosai @@aut@@ Lim Shyang Yee @@aut@@ Srijit Das @@aut@@ Subasri A @@aut@@ Reynu Rajan @@aut@@
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author	Ng Chong Beng
spellingShingle	Ng Chong Beng misc Ulcer misc Histopathology misc Anus misc Endocrine misc Langerhans cell misc Pituitary misc Skull misc Diabetes insipidus misc Medicine misc R Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male
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topic_title	Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male Ulcer Histopathology Anus Endocrine Langerhans cell Pituitary Skull Diabetes insipidus
topic	misc Ulcer misc Histopathology misc Anus misc Endocrine misc Langerhans cell misc Pituitary misc Skull misc Diabetes insipidus misc Medicine misc R
topic_unstemmed	misc Ulcer misc Histopathology misc Anus misc Endocrine misc Langerhans cell misc Pituitary misc Skull misc Diabetes insipidus misc Medicine misc R
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title	Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male
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title_full	Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male
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title_sort	perianal ulcer and diabetes insipidus: a rare presentation of langerhans cell histiocytosis in an adult male
title_auth	Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male
abstract	Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus.
abstractGer	Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus.
abstract_unstemmed	Langerhans cell histiocytosis (LCH), previously known as Histiocystosis X, is a rare idiopathic disease caused by a build-up of langerhan cells in the body. LCH has a heterogenous form of clinical presentation and presents with varying degree of severity. The severity often depends on the disease burden. LCH can manifest as a unifocal disease, multifocal-unisystem or multifocal-multisystem disease with the latter being more fatal than the rest. Risk organ involvement confers a grim prognosis. Perianal lesions are extremely rare skin manifestation of LCH with only few cases reported in the past. Vinca-alkaloids and steroid therapy have been shown to be effective in a large percentage of those presenting with LCH. This case report highlights the diagnosis and management of LCH presenting as a painful perianal ulcer in the background of newly diagnosed diabetes insipidus.
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title_short	Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male
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Perianal Ulcer and Diabetes Insipidus: A Rare Presentation of Langerhans Cell Histiocytosis in an Adult Male

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