Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities

Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms...
Ausführliche Beschreibung

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Autor*in:	Yuni Ahda [verfasserIn] Jörg Gromoll [verfasserIn] Purnomo Soeharso [verfasserIn] Septelia I. Wanandi [verfasserIn] Nukman Moeloek [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Übergeordnetes Werk:	In: Medical Journal of Indonesia - Faculty of Medicine Universitas Indonesia, 2013, 13(2004), 4
Übergeordnetes Werk:	volume:13 ; year:2004 ; number:4

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.13181/mji.v13i4.153

Katalog-ID:	DOAJ067495397

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520			\|a Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene.
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spelling	10.13181/mji.v13i4.153 doi (DE-627)DOAJ067495397 (DE-599)DOAJ726762b277674d129619ab35a5066248 DE-627 ger DE-627 rakwb eng R5-920 Yuni Ahda verfasserin aut Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene. Medicine (General) Jörg Gromoll verfasserin aut Purnomo Soeharso verfasserin aut Septelia I. Wanandi verfasserin aut Nukman Moeloek verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 13(2004), 4 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:13 year:2004 number:4 https://doi.org/10.13181/mji.v13i4.153 kostenfrei https://doaj.org/article/726762b277674d129619ab35a5066248 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/153 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2004 4
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allfieldsSound	10.13181/mji.v13i4.153 doi (DE-627)DOAJ067495397 (DE-599)DOAJ726762b277674d129619ab35a5066248 DE-627 ger DE-627 rakwb eng R5-920 Yuni Ahda verfasserin aut Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene. Medicine (General) Jörg Gromoll verfasserin aut Purnomo Soeharso verfasserin aut Septelia I. Wanandi verfasserin aut Nukman Moeloek verfasserin aut In Medical Journal of Indonesia Faculty of Medicine Universitas Indonesia, 2013 13(2004), 4 (DE-627)747137862 (DE-600)2716886-4 22528083 nnns volume:13 year:2004 number:4 https://doi.org/10.13181/mji.v13i4.153 kostenfrei https://doaj.org/article/726762b277674d129619ab35a5066248 kostenfrei http://mji.ui.ac.id/journal/index.php/mji/article/view/153 kostenfrei https://doaj.org/toc/0853-1773 Journal toc kostenfrei https://doaj.org/toc/2252-8083 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2004 4
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title	Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities
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title_full	Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities
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title_sort	single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities
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title_auth	Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities
abstract	Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene.
abstractGer	Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene.
abstract_unstemmed	Women of reproductive ages are varies in their responses to exogenous FSH stimulations. The difference of FSHR genotype due to the polymorphisms in exon 10 is one of its significant factors. To know further whether the core promoter of FSHR is also polymorphic and to know whether those polymorphisms influence the promoter activity, we did polymorphism screening of FSHR promoter to 262 women undergoing IVF/ICSI, followed by functional study to know the impact of polymorphisms to the promoter activity. This study indicated that the core promoter of human FSHR is polymorphic. We found five SNPs at positions –29, –37, –114, –123 and –138 in addition to the variety number of adenines. Polymorphism at position –123 significantly decreased the promoter activity, in contrast, polymorphism at position –37 and –138 significantly increased the promoter activity, whereas polymorphism at position –29, –114 and short adenines stretch did not significantly influence the promoter activity. The differences of the promoter activities due to polymorphisms might change the ovarian sensitivity to FSH. (Med J Indones 2004; 13: 205-14) Keywords: core promoter of human FSH receptor, single nucleotide polymorphisms, FSHR gene.
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title_short	Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities
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Single nucleotide polymorphisms of follicle-stimulating hormone receptor promoter and their impacts to the promoter activities

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